- Medical School - Federal University of Rio Grande Do Sul - Brazil (1978-1984)
- Residency - University of Arizona Health Sciences Center (1987-1989), Pediatrics
- Fellowship - Cincinnati Children's Hospital Medical Center (1990-1993), Pediatric Gastroenterology
Jorge Bezerra, M.D.
- Robert L. Moore Chair in Pediatrics
- Pediatrics - Gastroenterology
- Liver Disease
- Transplant Hepatology
Biography
Jorge A. Bezerra, M.D., is Professor and Chair of the Department of Pediatrics at UT Southwestern Medical Center. He specializes in pediatric gastroenterology and holds the Robert L. Moore Chair in Pediatrics.
Dr. Bezerra earned his medical degree from the Federal University of Rio Grande do Norte School of Medicine in Brazil. After a pediatrics residency at the University of Arizona Health Sciences, he completed clinical and research fellowships in pediatric gastroenterology, hepatology, and nutrition at Cincinnati Children’s Hospital Medical Center. There, he would also serve as Director of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition; Medical Director of the Pediatric Liver Care Center; and Director of the Digestive Health Center.
Certified by the American Board of Pediatrics in pediatric gastroenterology and pediatric transplant hepatology, he joined UT Southwestern in 2022.
As department Chair and a practicing pediatric gastroenterologist, Dr. Bezerra provides strategic vision and operational leadership for the pediatric clinical, research, and training programs at UT Southwestern. He also serves as Pediatrician-in-Chief for Children’s Medical Center Dallas, overseeing the quality of pediatric patient care and the integration of clinical and academic activities.
Dr. Bezerra is the principal investigator of multiple grants from the National Institutes of Health that are focused on preclinical and translational research on biliary atresia, the most common cause of chronic liver disease in children. His scientific achievements include the discovery of a key immunologic signature in the liver of children with biliary atresia. This discovery led to a test, now transitioning to clinical use, that facilitates diagnosis of biliary atresia and shortens the time to surgical treatment.
A prolific author and lecturer, he has published more than 100 peer-reviewed articles and scores of book chapters, invited papers, and abstracts. He is a Co-Editor of Liver Disease in Children, 5th Edition, and he serves as a reviewer for numerous scholarly journals.
Dr. Bezerra is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He is also a Fellow of the American Gastroenterological Association and in 2020 served as the seventy-first President of the American Association for the Study of Liver Diseases. In addition, he served as Chairman of the Board of Scientific Counselors of the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases in 2021-2022.
Education & Training
Professional Associations & Affiliations
- American Association for the Advancement of Science
- American Association for the Study of Liver Diseases
- American Gastroenterological Association
- American Pediatric Society
- American Society for Clinical Investigation
- Association of American Physicians
- North American Society for Pediatric Gastroenterology and Nutrition
- Society for Pediatric Research
Honors & Awards
- Chairman 2021, Board of Scientific Councilors, Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
- Honorary Member 2021, Academy of Medicine, Federal University of Rio Grande do Norte School of Medicine, Natal, Brazil
- The Klatskin Lecturer 2021, Yale University
- President 2020, American Association for the Study of Liver Diseases
- The Best Doctors in America, 2005, 2008-2021
- Castle Conolly Top Doctors in America 2018-2021
- Top Doctor, Pediatrics, 2014-2015, 2017-2021, Cincinnati Magazine
- Chairman 2017, National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, ZRG1 DKUS-P (03)
- Trustee 2016-2018, Foundation of the American Association for the Study of Liver Diseases
- Councilor and Governing Board Member 2016, American Association for the Study of Liver Diseases
- Fellow 2015, American Gastroenterological Association
- Fellow 2014, American Association for the Study of Liver Diseases
- Award for distinguished scientific accomplishments 2014, 15th Brazilian Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Natal, Brazil
- Mentorship Achievement Award 2014, Cincinnati Children’s Hospital Medical Center
- Associate Editor 2012, Hepatology
- William and Rebecca Balistreri Chair of Pediatric Hepatology 2009-2022, Cincinnati Children’s Hospital Medical Center
- Pediatric Resident Research Award 1989, American Academy of Pediatrics
- Graduating Resident Award for Excellence in Research 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Graduating Resident Award for Excellence in Clinical Service 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Graduating Resident Award for Excellence in Teaching 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Best Graduating Student, Merit Medal 1984, Federal University of Rio Grande do Norte School of Medicine
Books & Publications
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Books
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Cirrhosis in Current Pediatric Therapy. Vol 14
Bezerra JA, Balistreri W (1993), Philadelphia, W.B. Saunders Co. -
Transplantation for cholestatic liver disease in Transplantation of the Liver
Bezerra JA, Balistreri W (1996), Philadelphia, W.B. Saunders Co. -
Metabolic diseases in children in Liver Diseases
D’Agata I, Bezerra JA (2001), Brazil, Editora Atheneu -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2002) -
Gastrointestinal evaluation in immunodeficient children in Endoscopia Pediatrica (Pediatric Endoscopy)
Guthery S, Bezerra JA (2004), Rio de Janeiro, Brazil, Guanabara Koogan -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Campbell K, Bezerra JA (2004), Lewiston, NY, BC Decker -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Bezerra JA (2008), BC Decker Inc -
Biliary atresia in Molecular Pathology of Liver Diseases
Bezerra JA (2011), Springer -
Textbook of Clinical Pediatrics
Vitolla B, Bezerra JA (2011), Springer -
Disorders of protein metabolism in Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento
Bezerra JA (2012), Sao Paulo, Brazil, Editora Manole -
Congenital disorders of glycosylation in Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento
Bezerra JA (2012), Sao Paulo, Brazil, Editora Manole -
Biliary atresia in Pediatric Liver Disease
Balistreri WF, Bezerra JA, Ryckman FR -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Bezerra JA (Submitted), BC Decker Inc -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2015) -
Transplantation for cholestatic liver disease in children in Transplantation of the Liver
Ibrahim SH, Bezerra JA, Balistreri WF (2015), Elsevier -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2016) -
Biliary atresia – An Update 2019 in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2019) -
Biliary atresia in Liver Disease in Children
Bezerra JA, Asai A, Mulappadi B, Tiao G, Balistreri WF (2019)
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Cirrhosis in Current Pediatric Therapy. Vol 14
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Publications
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Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia.
Russi AE, Shivakumar P, Luo Z, Bezerra JA, Hepatology (Baltimore, Md.) 2023 Oct 78 4 1035-1049 -
Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report.
Pandurangi S, Kim S, Asai A, Bondoc A, Balistreri W, Campbell K, Miethke A, Peters A, Rogers M, Taylor A, Attia SL, Gibbons T, Mullapudi B, Sheridan R, Tiao G, Bezerra JA, Journal of pediatric surgery 2023 Aug 58 8 1483-1488 -
Serum Bile Acids as a New Prognostic Biomarker in Biliary Atresia Following Kasai Portoenterostomy.
Harpavat S, Hawthorne K, Setchell KDR, Narvaez Rivas M, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL, Hepatology (Baltimore, Md.) 2022 Sep -
Serum Biomarkers Correlated with Liver Stiffness Assessed in a Multi-center Study of Pediatric Cholestatic Liver Disease.
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen S, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Hepatology (Baltimore, Md.) 2022 Sep -
Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome.
Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL, Rosenthal P, Squires RH, Sokol RJ, Hepatology communications 2022 Aug 6 8 1910-1921 -
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia.
Osborn J, Mourya R, Thanekar U, Su W, Fei L, Shivakumar P, Bezerra JA, Hepatology communications 2022 05 6 5 995-1004 -
The Liver Biopsy in Neonatal Cholestasis: Just a Cherry on Top?
Russi AE, Pandurangi S, Bezerra JA, Clinical liver disease 2022 Mar 19 3 111-113 -
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Amarachintha SP, Mourya R, Ayabe H, Yang L, Luo Z, Li X, Thanekar U, Shivakumar P, Bezerra JA, Hepatology (Baltimore, Md.) 2022 01 75 1 89-103 -
Maternal regulation of biliary disease in neonates via gut microbial metabolites.
Jee JJ, Yang L, Shivakumar P, Xu PP, Mourya R, Thanekar U, Yu P, Zhu Y, Pan Y, Wang H, Duan X, Ye Y, Wang B, Jin Z, Liu Y, Cao Z, Watanabe-Chailland M, Romick-Rosendale LE, Wagner M, Fei L, Luo Z, Ollberding NJ, Tang ST, Bezerra JA, Nature communications 2022 01 13 1 18 -
The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence.
Ghany MG, Lok ASF, Dienstag JL, Feinstone SM, Hoofnagle JH, Jake Liang T, Seeff LB, Cohen DE, Bezerra JA, Chung RT, Hepatology (Baltimore, Md.) 2021 11 74 5 2813-2823 -
Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study.
Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA, Bull LN, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA, Schwarz KB, Turmelle YP, Rosenthal P, Magee JC, Sokol RJ, Journal of pediatric gastroenterology and nutrition 2021 10 73 4 478-484 -
High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants.
Mohanty SK, Donnelly B, Temple H, Ortiz-Perez A, Mowery S, Lobeck I, Dupree P, Poling HM, McNeal M, Mourya R, Jenkins T, Bansal R, Bezerra J, Tiao G, Hepatology (Baltimore, Md.) 2021 Aug 74 2 864-878 -
A single-cell view of biliary atresia.
Russi AE, Bezerra JA, Nature reviews. Gastroenterology & hepatology 2021 04 18 4 219-220 -
Autoimmune Hepatitis: Predictors of Native Liver Survival in Children and Adolescents.
Porta G, de Carvalho E, Santos JL, Gama J, Bezerra JA, The Journal of pediatrics 2021 02 229 95-101.e3 -
Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age.
Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ, Hepatology communications 2020 Dec 4 12 1824-1834 -
Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease.
Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH, Karpen SJ, Kamath BM, Cavallo L, Wang K, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC, Hepatology communications 2020 Nov 4 11 1694-1707 -
Natural Course of Pediatric Portal Hypertension.
Kassam AF, Goddard GR, Johnston ME, Cortez AR, Trout AT, Jenkins TM, Miethke AG, Campbell KM, Bezerra JA, Balistreri WF, Nathan JD, Alonso MH, Tiao GM, Bondoc AJ, Hepatology communications 2020 Sep 4 9 1346-1352 -
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement.
Fix OK, Hameed B, Fontana RJ, Kwok RM, McGuire BM, Mulligan DC, Pratt DS, Russo MW, Schilsky ML, Verna EC, Loomba R, Cohen DE, Bezerra JA, Reddy KR, Chung RT, Hepatology (Baltimore, Md.) 2020 07 72 1 287-304 -
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
Yang L, Shivakumar P, Kinder J, Way SS, Donnelly B, Mourya R, Luo Z, Bezerra JA, JCI insight 2020 06 5 11 -
Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver.
Squires JE, Ng VL, Hawthorne K, Henn LL, Sorensen LG, Fredericks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ, Journal of pediatric gastroenterology and nutrition 2020 01 70 1 79-86 -
Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.
Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM, Rosenthal P, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ, Hepatology (Baltimore, Md.) 2019 09 70 3 899-910 -
Prospective Assessment of Ultrasound Shear Wave Elastography for Discriminating Biliary Atresia from other Causes of Neonatal Cholestasis.
Dillman JR, DiPaola FW, Smith SJ, Barth RA, Asai A, Lam S, Campbell KM, Bezerra JA, Tiao GM, Trout AT, The Journal of pediatrics 2019 09 212 60-65.e3 -
A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia.
Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ, Journal of pediatric gastroenterology and nutrition 2019 04 68 4 495-501 -
Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia.
Yang L, Mizuochi T, Shivakumar P, Mourya R, Luo Z, Gutta S, Bezerra JA, Journal of hepatology 2018 Nov 69 5 1136-1144 -
Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.
Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ, The Journal of pediatrics 2018 05 196 139-147.e3 -
Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.
Luo Z, Jegga AG, Bezerra JA, Hepatology (Baltimore, Md.) 2018 02 67 2 676-689 -
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia.
Lertudomphonwanit C, Mourya R, Fei L, Zhang Y, Gutta S, Yang L, Bove KE, Shivakumar P, Bezerra JA, Science translational medicine 2017 Nov 9 417 -
Preferential TNFa signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia.
Shivakumar P, Mizuochi T, Mourya R, Gutta S, Yang L, Luo Z, Bezerra JA, JCI insight 2017 03 2 5 e88747 -
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.
Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Phelan K, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA, Development (Cambridge, England) 2017 03 144 6 1056-1064 -
Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia.
Jee J, Mourya R, Shivakumar P, Fei L, Wagner M, Bezerra JA, PloS one 2017 12 8 e0182089 -
Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia?
Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ, PloS one 2017 12 5 e0176275 -
Biliary atresia and other cholestatic childhood diseases: Advances and future challenges.
Verkade HJ, Bezerra JA, Davenport M, Schreiber RA, Mieli-Vergani G, Hulscher JB, Sokol RJ, Kelly DA, Ure B, Whitington PF, Samyn M, Petersen C, Journal of hepatology 2016 09 65 3 631-42 -
MDR3 mutation analysis: A step closer to precision medicine.
Bezerra JA, Hepatology (Baltimore, Md.) 2016 May 63 5 1421-3 -
Increased frequency of double and triple heterozygous gene variants in children with intrahepatic cholestasis.
Goldschmidt ML, Mourya R, Connor J, Dexheimer P, Karns R, Miethke A, Sheridan R, Zhang K, Bezerra JA, Hepatology research : the official journal of the Japan Society of Hepatology 2016 Apr 46 4 306-11 -
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.
Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ, The Journal of pediatrics 2016 Mar 170 211-7.e1-2 -
Effect of diet on intestinal sucrose (su) lactase (la), and maltase (ma) activity in pigs.
Flores C, Bezerra J, Goda T, Bustamante S, Pongratz G, Koldovsky O. 2016 43 124 -
Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes.
Asai A, Miethke A, Bezerra JA, Nature reviews. Gastroenterology & hepatology 2015 Jun 12 6 342-52 -
Reply: To PMID 24493287.
Mourya R, Bessho K, Shivakumar P, Bezerra JA, Hepatology (Baltimore, Md.) 2015 Feb 61 2 732-3 -
Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia.
Squires JE, Shivakumar P, Mourya R, Bessho K, Walters S, Bezerra JA, PloS one 2015 10 5 e0127191 -
Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.
Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE, Journal of pediatric gastroenterology and nutrition 2014 Dec 59 6 702-7 -
Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a north american multicenter consortium.
Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ The Journal of pediatrics 2014 Sep 165 3 539-546.e2 -
Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.
Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Rao M, Jegga AG, Bezerra JA, Hepatology (Baltimore, Md.) 2014 Jul 60 1 211-23 -
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
Li J, Razumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, Bessho K, Wang YH, Glaser SS, Shivakumar P, Bezerra JA, The Journal of clinical investigation 2014 Jul 124 7 3241-51 -
Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial.
Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, JAMA 2014 May 311 17 1750-9 -
Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia.
Tsai EA, Grochowski CM, Loomes KM, Bessho K, Hakonarson H, Bezerra JA, Russo PA, Haber BA, Spinner NB, Devoto M, Human genetics 2014 Feb 133 2 235-43 -
Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.
Shivakumar P, Mourya R, Bezerra JA, Journal of hepatology 2014 Feb 60 2 370-6 -
Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study.
Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC, Hepatology (Baltimore, Md.) 2013 Nov 58 5 1724-31 -
Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.
Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA, BMC systems biology 2013 Oct 7 104 -
Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice.
DiPaola F, Shivakumar P, Pfister J, Walters S, Sabla G, Bezerra JA, Hepatology (Baltimore, Md.) 2013 Oct 58 4 1486-1496 -
Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia.
Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ, Pediatrics 2012 Sep 130 3 e607-14 -
The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study.
Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM, Annals of surgery 2012 Mar 255 3 570-6 -
Conditional removal of SV40T from transformed primary human hepatocytes recovers selective CYP gene expression.
Liu C, Bezerra JA. 2012 2 15-32 -
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.
Li J, Bessho K, Shivakumar P, Mourya R, Mohanty SK, Dos Santos JL, Miura IK, Porta G, Bezerra JA, The Journal of clinical investigation 2011 Nov 121 11 4244-56 -
Dendritic cells regulate natural killer cell activation and epithelial injury in experimental biliary atresia.
Saxena V, Shivakumar P, Sabla G, Mourya R, Chougnet C, Bezerra JA, Science translational medicine 2011 Sep 3 102 102ra94 -
Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.
Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K, PloS one 2011 6 7 e21979 -
Analysis of gene mutations in children with cholestasis of undefined etiology.
Matte U, Mourya R, Miethke A, Liu C, Kauffmann G, Moyer K, Zhang K, Bezerra JA, Journal of pediatric gastroenterology and nutrition 2010 Oct 51 4 488-493 -
Staging of biliary atresia at diagnosis by molecular profiling of the liver.
Moyer K, Kaimal V, Pacheco C, Mourya R, Xu H, Shivakumar P, Chakraborty R, Rao M, Magee JC, Bove K, Aronow BJ, Jegga AG, Bezerra JA, Genome medicine 2010 May 2 5 33 -
Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2.
Mohanty SK, Ivantes CA, Mourya R, Pacheco C, Bezerra JA, Pediatric research 2010 Apr 67 4 345-51 -
Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia.
Shivakumar P, Sabla GE, Whitington P, Chougnet CA, Bezerra JA, The Journal of clinical investigation 2009 Aug 119 8 2281-90 -
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.
Shanmukhappa K, Matte U, Degen JL, Bezerra JA, The Journal of biological chemistry 2009 May 284 19 12917-23 -
Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia.
Erickson N, Mohanty SK, Shivakumar P, Sabla G, Chakraborty R, Bezerra JA, Hepatology (Baltimore, Md.) 2008 May 47 5 1567-77 -
Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research Consortium.
DeRusso PA, Ye W, Shepherd R, Haber BA, Shneider BL, Whitington PF, Schwarz KB, Bezerra JA, Rosenthal P, Karpen S, Squires RH, Magee JC, Robuck PR, Sokol RJ, Hepatology (Baltimore, Md.) 2007 Nov 46 5 1632-8 -
Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop.
Sokol RJ, Shepherd RW, Superina R, Bezerra JA, Robuck P, Hoofnagle JH, Hepatology (Baltimore, Md.) 2007 Aug 46 2 566-81 -
Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia.
Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA, Gastroenterology 2007 Jul 133 1 268-77 -
Effect of rotavirus strain on the murine model of biliary atresia.
Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM, Journal of virology 2007 Feb 81 4 1671-9 -
High prevalence of alpha-1-antitrypsin heterozygosity in children with chronic liver disease.
Campbell KM, Arya G, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Bezerra JA, Journal of pediatric gastroenterology and nutrition 2007 Jan 44 1 99-103 -
Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis.
Liu C, Aronow BJ, Jegga AG, Wang N, Miethke A, Mourya R, Bezerra JA, Gastroenterology 2007 Jan 132 1 119-26 -
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor.
Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA, BMC gastroenterology 2006 Nov 6 40 -
Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.
Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ, Gastroenterology 2006 Sep 131 3 885-99 -
A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000.
Shneider BL, Brown MB, Haber B, Whitington PF, Schwarz K, Squires R, Bezerra J, Shepherd R, Rosenthal P, Hoofnagle JH, Sokol RJ, The Journal of pediatrics 2006 Apr 148 4 467-474 -
Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia.
Mohanty SK, Shivakumar P, Sabla G, Bezerra JA, BMC gastroenterology 2006 Apr 6 14 -
Genetic modifiers of cholestatic liver disease: an evolving field.
Bezerra J, Shneider BL, Journal of pediatric gastroenterology and nutrition 2006 Jan 42 1 7-8 -
Analysis of the biliary transcriptome in experimental biliary atresia.
Carvalho E, Liu C, Shivakumar P, Sabla G, Aronow B, Bezerra JA, Gastroenterology 2005 Aug 129 2 713-7 -
Intrahepatic cholestasis: summary of an American Association for the Study of Liver Diseases single-topic conference.
Balistreri WF, Bezerra JA, Jansen P, Karpen SJ, Shneider BL, Suchy FJ, Hepatology (Baltimore, Md.) 2005 Jul 42 1 222-35 -
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice.
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA, Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 102 29 10182-7 -
Hepatic gene expression profile and clinical phenotypes: Letter to the editor.
Bezerra JA, Sokol RJ. 2005 41 403-405 -
Liver transplantation in children younger than 1 year--the Cincinnati experience.
Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F, Journal of pediatric surgery 2005 Jan 40 1 268-73 -
Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia.
Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA, The Journal of clinical investigation 2004 Aug 114 3 322-9 -
Biliary atresia and Th1 function: linking lymphocytes and bile ducts: commentary on the article by Mack et al. on page 79.
Shivakumar P, Bezerra JA, Pediatric research 2004 Jul 56 1 9-10 -
Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia.
Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA, Hepatology (Baltimore, Md.) 2004 Apr 39 4 954-62 -
Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction.
Campbell KM, Sabla GE, Bezerra JA, Journal of hepatology 2004 Jan 40 1 14-23 -
Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.
Currier AR, Sabla G, Locaputo S, Melin-Aldana H, Degen JL, Bezerra JA, American journal of physiology. Gastrointestinal and liver physiology 2003 Mar 284 3 G508-15 -
Gene expression profiling in biliary atresia – author reply
Bezerra JA, Aronow BA 2003 361 971-972 -
Genetic induction of proinflammatory immunity in children with biliary atresia.
Bezerra JA, Tiao G, Ryckman FC, Alonso M, Sabla GE, Shneider B, Sokol RJ, Aronow BJ, Lancet (London, England) 2002 Nov 360 9346 1653-9 -
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis.
Bates MD, Erwin CR, Sanford LP, Wiginton D, Bezerra JA, Schatzman LC, Jegga AG, Ley-Ebert C, Williams SS, Steinbrecher KA, Warner BW, Cohen MB, Aronow BJ, Gastroenterology 2002 May 122 5 1467-82 -
Independent and overlapping transcriptional activation during liver development and regeneration in mice.
Kelley-Loughnane N, Sabla GE, Ley-Ebert C, Aronow BJ, Bezerra JA, Hepatology (Baltimore, Md.) 2002 Mar 35 3 525-34 -
Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury.
Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA, The American journal of pathology 2001 Dec 159 6 2179-86 -
Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury.
Ng VL, Sabla GE, Melin-Aldana H, Kelley-Loughnane N, Degen JL, Bezerra JA, Journal of hepatology 2001 Dec 35 6 781-9 -
Plasminogen activators direct reorganization of the liver lobule after acute injury.
Bezerra JA, Currier AR, Melin-Aldana H, Sabla G, Bugge TH, Kombrinck KW, Degen JL, The American journal of pathology 2001 Mar 158 3 921-9 -
Genetic manipulation of fibrinogen and fibrinolysis in mice.
Degen JL, Drew AF, Palumbo JS, Kombrinck KW, Bezerra JA, Danton MJ, Holmbäck K, Suh TT, Annals of the New York Academy of Sciences 2001 936 276-90 -
Long-term outcome after partial external biliary diversion for intractable pruritus in patients with intrahepatic cholestasis.
Ng VL, Ryckman FC, Porta G, Miura IK, de Carvalho E, Servidoni MF, Bezerra JA, Balistreri WF, Journal of pediatric gastroenterology and nutrition 2000 Feb 30 2 152-6 -
Intrahepatic cholestasis: order out of chaos.
Bezerra JA, Balistreri WF, Gastroenterology 1999 Dec 117 6 1496-8 -
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver.
Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL, Proceedings of the National Academy of Sciences of the United States of America 1999 Dec 96 26 15143-8 -
Insights. Pylephlebitis.
Pohl JF, Murarka P, Farrell MK, Bezerra J, The Journal of pediatrics 1999 Oct 135 4 529 -
Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice.
Locaputo S, Carrick TL, Bezerra JA, Hepatology (Baltimore, Md.) 1999 Apr 29 4 1106-13 -
Image of the month. What is the etiology of these ulcers?
Rudolph JA, Bezerra J, Alonso M, Gastroenterology 1999 Apr 116 4 788, 1018 -
Molecular and enzymatic analyses of lysosomal acid lipase in cholesteryl ester storage disease.
Du H, Sheriff S, Bezerra J, Leonova T, Grabowski GA, Molecular genetics and metabolism 1998 Jun 64 2 126-34 -
Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.
Bezerra JA, Carrick TL, Degen JL, Witte D, Degen SJ, The Journal of clinical investigation 1998 Mar 101 5 1175-83 -
Expansion of transplanted hepatocytes during liver regeneration.
Yazigi NA, Carrick TL, Bucuvalas JC, Schmidt CS, Balistreri WF, Bezerra JA, Transplantation 1997 Sep 64 6 816-20 -
Effects of protein malnutrition on liver cytochrome P450s
Lee P-C, Struve MF, Bezerra JA, Duncan B 1997 17 1577-1587 -
Hepatocyte transplantation: "Only the strong survive.".
Bezerra JA, Balistreri WF, Hepatology (Baltimore, Md.) 1996 Nov 24 5 1321-3 -
Use of a single solution for oral rehydration and maintenance therapy of infants with diarrhea and mild to moderate dehydration.
Cohen MB, Mezoff AG, Laney DW, Bezerra JA, Beane BM, Drazner D, Baker R, Moran JR, Pediatrics 1995 May 95 5 639-45 -
Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation.
Bezerra JA, Laney DW, Degen SJ, Biochemical and biophysical research communications 1994 Aug 203 1 666-73 -
Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver.
Laney DW, Bezerra JA, Kosiba JL, Degen SJ, Cohen MB, The American journal of physiology 1994 May 266 5 Pt 1 G899-906 -
Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.
Bezerra JA, Witte DP, Aronow BJ, Degen SJ, Hepatology (Baltimore, Md.) 1993 Aug 18 2 394-9 -
Are hepatocyte growth factor-like protein and macrophage stimulating protein the same protein?
Bezerra JA, Han S, Danton MJ, Degen SJ, Protein science : a publication of the Protein Society 1993 Apr 2 4 666-8 -
Treatment of infants with acute diarrhea: what's recommended and what's practiced.
Bezerra JA, Stathos TH, Duncan B, Gaines JA, Udall JN, Pediatrics 1992 Jul 90 1 Pt 1 1-4 -
A one-month-old infant who had a 'double bubble'.
Bezerra JA, Duncan B, Anderson F, Hospital practice (Office ed.) 1992 Apr 27 4 255, 257-8 -
Age-related changes in sucrase and lactase activity in the small intestine of 3- and 10-week-old obese mice (C57BL/6Jobob).
Flores CA, Bezerra J, Bustamante SA, Goda T, MacDonald MP, Kaplan ML, Koldovský O, Journal of the American College of Nutrition 1990 Jun 9 3 255-60 -
Intestinal permeability to intact lactose in newborns and adults.
Bezerra JA, Thompson SH, Morse M, Koldovský O, Udall JN, Biology of the neonate 1990 58 6 334-42 -
Assessment of lactose absorption by measurement of urinary galactose.
Grant JD, Bezerra JA, Thompson SH, Lemen RJ, Koldovsky O, Udall JN, Gastroenterology 1989 Oct 97 4 895-9 -
Effect of diet on intestinal and pancreatic enzyme activities in the pig.
Flores CA, Brannon PM, Bustamante SA, Bezerra J, Butler KT, Goda T, Koldovský O, Journal of pediatric gastroenterology and nutrition 1988 7 6 914-21 -
Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice.
Lee SM, Bustamante S, Flores C, Bezerra J, Goda T, Koldovský O, The Journal of pharmacology and experimental therapeutics 1987 Jan 240 1 132-7 -
Measurement of the rate of fat-absorption by the C14 triolein breath test.
Flores C, Bezerra J, Wells M, Koldovsky O. 1986 45 538 -
Effect of a high-dextrose diet on sucrase and lactase activity in jejunum of obese mice (C57BL/6J obob).
Flores CA, Bezerra J, Goda T, Bustamante S, MacDonald MP, Kaplan M, Koldovský O, Journal of the American College of Nutrition 1986 5 6 565-75 -
Postweaning changes of jejunal protein and activity of disaccharidases in obese mice and lean littermates.
Goda T, Bezerra J, Bustamante S, Flores C, Kaplan M, Koldovsky, MacDonald MP 1985 1165 44 -
Letter: Acupuncture.
Matsumoto T, Levy B, JAMA 1974 Jul 229 2 140
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Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia.
Research
- Biliary atresia
- Inherited liver diseases
- Viral hepatitis
- Cholestatic liver diseases
Clinical Focus
- Liver Disease
- Transplant Hepatology