Joseph Crossno, M.D., Ph.D.

Internal Medicine - Pulmonary and Critical Care Medicine
End-Stage Lung Disease
Lung Transplantation and Cardiopulmonary Support

New Patient Appointment Accepting Virtual Visits or 214-645-6616

Biography

Joseph Crossno, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He specializes in pulmonary vascular development and repair, end-stage lung disease, cardiopulmonary support, and lung transplantation.

Dr. Crossno earned his medical degree and a doctoral degree in biochemistry at the University of Tennessee Health Science Center. He completed a residency in internal medicine at Virginia Commonwealth University Medical Center in Richmond, Virginia, and gained advanced subspecialty training in pulmonary and critical care medicine through a fellowship at the University of Colorado Health Sciences Center in Denver.

He is certified by the American Board of Internal Medicine in Pulmonary and Critical Care Medicine, and he joined the UT Southwestern faculty in 2024.

Dr. Crossno previously served as Medical Director of Lung Transplantation at INTEGRIS Health Baptist Medical Center in Oklahoma City.

He is a Fellow of the American College of Chest Physicians, the American Thoracic Society, the International Society for Heart and Lung Transplantation, and the American Society of Transplantation. He has delivered presentations, contributed to books including Current Diagnosis and Treatment in Pulmonary Medicine, and published several academic articles related to his areas of expertise.

Personal Note

Outside of work, Dr. Crossno enjoys traveling, playing golf, spending time with his family, watching college sports, cooking, and food and wine pairing.

Education & Training

Medical School - University of Tennessee Health Science Center (1988-1996)
Residency - Virginia Commonwealth University Health System (1996-1999), Internal Medicine
Fellowship - University of Colorado School of Medicine (1999-2002), Pulmonary & Critical Care Medicine

Professional Associations & Affiliations

American College of Chest Physicians
American Society of Transplantation
American Thoracic Society
International Society for Heart and Lung Transplantation

Honors & Awards

Scientific Breakthrough of the Year Award: Stem Cells and Regenerative Medicine 2010, American Thoracic Society

Books & Publications

Books
- Procedures in pulmonary medicine in Current Diagnosis and Treatment in Pulmonary Medicine
  Crossno JT Jr. (2003), New York, NY, McGraw-Hill Medical Publishing
- CD9 structure and function in Platelets, Thrombosis, and the Vessel Wall (Advances in Vascular Biology)
  Jennings LK, Crossno JT Jr, and White MM (1997), London, UK, Gordon and Breach, Inc.
- CD9 cluster workshop report: Cell surface binding and functional analysis in Leukocyte Typing V White Cell Differentiation Antigens, Volume II
  Jennings LK, Crossno JT Jr, White MM (1995), Oxford, UK, Oxford University Press
Publications
- Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
  Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA, The European respiratory journal 2023 Jun 61 6
- Liver Transplantation for Decompensated Cirrhosis Secondary to Telomerase Reverse Transcriptase Mutation.
  Kolb JM, Conzen K, Wachs M, Crossno J, McMahon B, Abidi MZ, Pomfret EA, Kriss M, Hepatology (Baltimore, Md.) 2020 Jul 72 1 356-358
- Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case report.
  Firstenberg MS, Stahel PF, Hanna J, Kotaru C, Crossno J, Forrester J, Patient safety in surgery 2020 14 20
- Airway epithelial cell PPARγ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice.
  Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ, American journal of physiology. Lung cellular and molecular physiology 2015 Aug 309 3 L293-304
- Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia.
  Irwin DC, Garat CV, Crossno JT, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ, Pulmonary circulation 2014 Dec 4 4 638-53
- Late-onset cytomegalovirus (CMV) in lung transplant recipients: can CMV serostatus guide the duration of prophylaxis?
  Schoeppler KE, Lyu DM, Grazia TJ, Crossno JT, Vandervest KM, Zamora MR, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Feb 13 2 376-82
- A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak.
  Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC, Free radical biology & medicine 2009 Jul 47 1 55-61
- Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.
  Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC, Circulation research 2008 May 102 9 1036-45
- Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
  Crossno JT, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ, American journal of physiology. Lung cellular and molecular physiology 2007 Apr 292 4 L885-97
- Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension.
  Case D, Irwin D, Ivester C, Harral J, Morris K, Imamura M, Roedersheimer M, Patterson A, Carr M, Hagen M, Saavedra M, Crossno J, Young KA, Dempsey EC, Poirier F, West J, Majka S, American journal of physiology. Lung cellular and molecular physiology 2007 Jan 292 1 L154-64
- Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2.
  Fox KE, Fankell DM, Erickson PF, Majka SM, Crossno JT, Klemm DJ, The Journal of biological chemistry 2006 Dec 281 52 40341-53
- Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.
  Crossno JT, Majka SM, Grazia T, Gill RG, Klemm DJ, The Journal of clinical investigation 2006 Dec 116 12 3220-8
- Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.
  Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA, The Journal of biological chemistry 2006 Sep 281 37 26943-50
- Pleiotropic role of VEGF-A in regulating fetal pulmonary mesenchymal cell turnover.
  Majka S, Fox K, McGuire B, Crossno J, McGuire P, Izzo A, American journal of physiology. Lung cellular and molecular physiology 2006 Jun 290 6 L1183-92
- Attenuation of hypoxia-induced pulmonary artery remodeling by a peroxisome proliferator-activated receptor-gamma agonist.
  Crossno JT, Morris KG, Klemm DJ, Chest 2005 Dec 128 6 Suppl 580S
- Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly.
  Cook GA, Longhurst CM, Grgurevich S, Cholera S, Crossno JT, Jennings LK, Blood 2002 Dec 100 13 4502-11
- Chinese hamster ovary cell motility to fibronectin is modulated by the second extracellular loop of CD9. Identification of a putative fibronectin binding site.
  Longhurst CM, Jacobs JD, White MM, Crossno JT, Fitzgerald DA, Bao J, Fitzgerald TJ, Raghow R, Jennings LK, The Journal of biological chemistry 2002 Sep 277 36 32445-52
- The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin.
  Cook GA, Wilkinson DA, Crossno JT, Raghow R, Jennings LK, Experimental cell research 1999 Sep 251 2 356-71
- Platelet p24/CD9, a member of the tetraspanin family of proteins.
  Jennings LK, Crossno JT, Fox CF, White MM, Green CA, Annals of the New York Academy of Sciences 1994 Apr 714 175-84

Research

Lung repair and regeneration

Clinical Focus

End-Stage Lung Disease
Lung Transplantation and Cardiopulmonary Support
Pulmonary Vascular Development and Repair

New Patient Appointment Accepting Virtual Visits or 214-645-6616