Julie Mirpuri-Hathiramani, M.D.

Pediatrics - Neonatal-Perinatal
Neonatal-Perinatal Medicine

Biography

Julie Mirpuri-Hathiramani, M.D., is an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center. She specializes in neonatal-perinatal medicine.

Dr. Mirpuri-Hathiramani earned her medical degree at the University of Hong Kong. She completed her residency in pediatrics at Atlantic Health’s Goryeb Children’s Hospital in Morristown, New Jersey, followed by a fellowship in neonatal-perinatal medicine at Grady Memorial Hospital in Atlanta.

Certified by the American Board of Pediatrics in pediatrics and neonatal-perinatal medicine, she joined the UT Southwestern faculty in 2010.

A physician-scientist, Dr. Mirpuri-Hathiramani’s research focuses on neonatal mucosal immunology, neonatal microbiome development, and necrotizing enterocolitis with a goal of developing novel therapies to improve the health of babies. She has delivered national and regional invited lectures and published numerous academic articles related to her areas of expertise.

She is a member of the American Academy of Pediatrics, the Southern Society for Pediatric Research, the American Association of Immunologists, the Society for Pediatric Research, and the Perinatal Research Society.

Personal Note

When she’s not at work, Dr. Mirpuri-Hathiramani enjoys reading, doing advocacy work, cooking, and watching all things “Star Wars.”

Education & Training

Residency - Goryeb Children's Hospital - Atlantic Health (2004-2007), Pediatrics
Internship - Hospital Authority of Hong Kong (2000-2001), Rotating
Fellowship - Emory University School of Medicine/Grady Memorial Hospital (2007-2010), Neonatal-perinatal Medicine
Medical School - Univeristy of Hong Kong (1995-2000)

Professional Associations & Affiliations

American Academy of Pediatrics
American Association of Immunologists
Perinatal Research Society
Society for Pediatric Research
Southern Society for Pediatric Research

Honors & Awards

First Place Basic Science Young Investigator Award: Mentor for fellow Tuan Tran, M.D. 2023, Southern Society for Pediatric Research
Early Career Faculty Travel Grant 2019, American Association of Immunologists
NIH Young Investigator Award 2018, Perinatal Research Society
Dean’s LEAD Program Capstone Project Recognition Award 2016, UT Southwestern Office of Faculty Diversity & Development
Travel Scholarship 2011, Federation of American Societies for Experimental Biology
Basic Science Young Investigator Award 2010, Southern Society for Pediatric Research
Fellow Basic Science Research Award 2010, Society for Pediatric Research
Travel Award 2009, Southern Society for Pediatric Research

Books & Publications

Publications
- Maternal microbial factors that affect the fetus and subsequent offspring.
  Mirpuri J, Neu J, Seminars in perinatology 2021 10 45 6 151449
- Traffic generated emissions alter the lung microbiota by promoting the expansion of Proteobacteria in C57Bl/6 mice placed on a high-fat diet.
  Daniel S, Pusadkar V, McDonald J, Mirpuri J, Azad RK, Goven A, Lund AK, Ecotoxicology and environmental safety 2021 Apr 213 112035
- The emerging role of group 3 innate lymphoid cells in the neonate: interaction with the maternal and neonatal microbiome.
  Mirpuri J, Oxford open immunology 2021 2 1 iqab009
- Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet.
  Daniel S, Phillippi D, Schneider LJ, Nguyen KN, Mirpuri J, Lund AK, Particle and fibre toxicology 2021 01 18 1 3
- Evidence for maternal diet-mediated effects on the offspring microbiome and immunity: implications for public health initiatives.
  Mirpuri J, Pediatric research 2021 01 89 2 301-306
- Transient neonatal antibiotic exposure increases susceptibility to late-onset sepsis driven by microbiota-dependent suppression of type 3 innate lymphoid cells.
  Niu X, Daniel S, Kumar D, Ding EY, Savani RC, Koh AY, Mirpuri J, Scientific reports 2020 07 10 1 12974
- Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring.
  Babu ST, Niu X, Raetz M, Savani RC, Hooper LV, Mirpuri J JCI insight 2018 Oct 3 19
- Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi.
  Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F Cell 2016 Feb 164 5 827-8
- The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.
  Liao J, Kapadia VS, Brown LS, Cheong N, Longoria C, Mija D, Ramgopal M, Mirpuri J, McCurnin DC, Savani RC Nature communications 2015 6 8977
- Short-term outcomes for preterm infants with surgical necrotizing enterocolitis.
  Murthy K, Yanowitz TD, DiGeronimo R, Dykes FD, Zaniletti I, Sharma J, Sullivan KM, Mirpuri J, Evans JR, Wadhawan R, Piazza A, Adams-Chapman I, Asselin JM, Short BL, Padula MA, Durand DJ, Pallotto EK, Reber KM, Journal of perinatology : official journal of the California Perinatal Association 2014 Oct 34 10 736-40
- Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.
  Mirpuri J, Raetz M, Sturge CR, Wilhelm CL, Benson A, Savani RC, Hooper LV, Yarovinsky F Gut microbes 2013 Sep 5 1
- TLR-independent neutrophil-derived IFN-? is important for host resistance to intracellular pathogens.
  Sturge CR, Benson A, Raetz M, Wilhelm CL, Mirpuri J, Vitetta ES, Yarovinsky F Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 110 26 10711-6
- Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells.
  Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F Nature immunology 2013 Feb 14 2 136-42
- Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.
  McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, Denkers EY, Aliberti J, Herbert DR Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 189 6 3078-84
- B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.
  Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F Immunity 2012 Feb 36 2 228-38
- Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
  Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P PLoS pathogens 2012 8 11 e1003000
- IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii.
  Mirpuri J, Yarovinsky F Future microbiology 2012 Jan 7 1 13-6
- Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.
  Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA PloS one 2012 7 12 e51955
- Issues of prematurity and HIV infection.
  Mirpuri J, Jain L Clinics in perinatology 2010 Dec 37 4 887-905, xi
- Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine.
  Mirpuri J, Brazil JC, Berardinelli AJ, Nasr TR, Cooper K, Schnoor M, Lin PW, Parkos CA, Louis NA Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 184 12 7186-95

Research

Neonatal mucosal immunology
Neonatal microbiome
Necrotizing enterocolitis

Clinical Focus

Neonatal-Perinatal Medicine