Kenneth Chen, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pediatrics - Hematology-Oncology

Biography

Kenneth S. Chen, M.D., is an Assistant Professor of Pediatrics at UT Southwestern, and an Attending Physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas, TX.

He received his B.S.E. in biomedical engineering from Johns Hopkins University and M.D. from UT Southwestern. He then completed a pediatric residency and pediatric hematology-oncology fellowship at UT Southwestern, where he joined the laboratory of James F. Amatruda.

As a physician-scientist, he divides his time between his research laboratory and Children’s Medical Center in Dallas, where he specializes in the care of children with cancer and blood disorders. His research interests in the laboratory focus on understanding the genetic drivers of childhood cancers, especially Wilms tumor and germ cell tumors, and new strategies for treating them.

In 2019 and 2020, Dr. Chen was named a Texas Monthly Super Doctor Rising Star.

Education & Training

Medical School - UT Southwestern Medical School (2002-2006)
Internship - UT Southwestern/Children's Medical Center (2006-2007), Pediatrics
Residency - UT Southwestern/Children's Medical Center (2007-2009), Pediatrics
Fellowship - UT Southwestern/Children's Medical Center (2010-2013), Pediatric Hematology/oncology

Professional Associations & Affiliations

American Society of Pediatric Hematology and Oncology (2010)
American Association for Cancer Research (2012)
American Society of Hematology (2010)
American Society of Clinical Oncology (2010)

Honors & Awards

Texas Monthly Super Doctors, Rising Star 2020
Texas Monthly Super Doctors, Rising Star 2019
W.W. Caruth Scholar 2013, Childrens Medical Center Foundation
Damon Runyon-Sohn Pediatric Cancer Fellow 2013
First Place, Critical Appraisal of Literature 2008, Resident Section Poster Contest, Texas Pediatric Society

Books & Publications

Publications
- Ectopic PLAG1 induces muscular dystrophy in the mouse.
  Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen K, Burns DK, Zheng Y, Biochemical and biophysical research communications 2023 Jul 665 159-168
- Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence.
  Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJM, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LHJ, Draper BW, Frazier AL, Amatruda JF, Nature communications 2023 May 14 1 2636
- Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
  Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D, Pediatric blood & cancer 2022 Feb 69 2 e29451
- Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis And Tumor Models.
  Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D, Journal of pediatric hematology/oncology 2022 Feb
- Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis.
  Medvedev KE, Savelyeva AV, Chen KS, Bagrodia A, Jia L, Grishin NV, Cancer informatics 2022 21 11769351221132634
- Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1
  Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF Genes & development 2018 Jul
- EGF Receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors.
  Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF Molecular cancer therapeutics 2018 Feb
- A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma.
  Chen KS, Kwon WS, Kim J, Heo SJ, Kim HS, Kim HK, Kim SH, Lee WS, Chung HC, Rha SY, Hwang TH Cold Spring Harbor molecular case studies 2016 Sep 2 5 a000992
- p53 genes function to restrain mobile elements.
  Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM Genes & development 2015 Dec
- Invited reply to amikacin ototoxicity in children with cancer: the problem is the administration schedule.
  Chen K, Bach A, Shoup A, Winick N Pediatric blood & cancer 2014 Feb 61 2 191
- Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.
  Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nature communications 2014 2 4802
- Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides.
  Chen KS, Bach A, Shoup A, Winick NJ Pediatric blood & cancer 2013 Jun
- A big catch for germ cell tumour research.
  Chen KS, Amatruda JF PLoS genetics 2013 Apr 9 4 e1003481
- DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors.
  Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN BMC cancer 2013 13 1 313
- Hemolytic non-uremic syndrome.
  Chen KS, Neunert CE, Crary SE, Buchanan GR Pediatric blood & cancer 2012 Jul 59 1 167-9
- A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse.
  Singleton K, Parvaze N, Dama KR, Chen KS, Jennings P, Purtic B, Sjaastad MD, Gilpin C, Davis MM, Wülfing C Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 177 7 4402-13
- Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.
  Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA Blood 2001 May 97 10 3146-51

Research

Wilms tumor
Germ cell tumors

Links

New Patient Appointment