- American Society of Pediatric Hematology and Oncology (2010)
- American Association for Cancer Research (2012)
- American Society of Hematology (2010)
- American Society of Clinical Oncology (2010)
Kenneth Chen, M.D.
- Pediatrics - Hematology-Oncology
Biography
Kenneth S. Chen, M.D., is an Assistant Professor of Pediatrics at UT Southwestern, and an Attending Physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas, TX.
He received his B.S.E. in biomedical engineering from Johns Hopkins University and M.D. from UT Southwestern. He then completed a pediatric residency and pediatric hematology-oncology fellowship at UT Southwestern, where he joined the laboratory of James F. Amatruda.
As a physician-scientist, he divides his time between his research laboratory and Children’s Medical Center in Dallas, where he specializes in the care of children with cancer and blood disorders. His research interests in the laboratory focus on understanding the genetic drivers of childhood cancers, especially Wilms tumor and germ cell tumors, and new strategies for treating them.
In 2019 and 2020, Dr. Chen was named a Texas Monthly Super Doctor Rising Star.
Education & Training
- Medical School - UT Southwestern Medical School (2002-2006)
- Internship - UT Southwestern/Children's Medical Center (2006-2007), Pediatrics
- Residency - UT Southwestern/Children's Medical Center (2007-2009), Pediatrics
- Fellowship - UT Southwestern/Children's Medical Center (2010-2013), Pediatric Hematology/oncology
Professional Associations & Affiliations
Honors & Awards
- Texas Monthly Super Doctors, Rising Star 2020
- Texas Monthly Super Doctors, Rising Star 2019
- W.W. Caruth Scholar 2013, Childrens Medical Center Foundation
- Damon Runyon-Sohn Pediatric Cancer Fellow 2013
- First Place, Critical Appraisal of Literature 2008, Resident Section Poster Contest, Texas Pediatric Society
Books & Publications
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Publications
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PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor.
Tiburcio PDB, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS, Pediatric blood & cancer 2025 Jun e31852 -
One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma.
Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KAP, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD, Clinical cancer research : an official journal of the American Association for Cancer Research 2025 May -
Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries.
Harris AK, Nelson AT, Watson D, Mallinger PHR, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KAP, Cancer 2025 May 131 9 e35862 -
Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor.
Tiburcio PDB, Chen K, Xu L, Chen KS, Cell reports. Medicine 2025 May 6 5 102133 -
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.
Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS, Genes & development 2025 Apr -
Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell Tumor.
Nelson AT, Watson D, Chen KS, Olson DR, Stall JN, Devins KM, Young RH, Kamihara J, Mallinger PHR, Kim J, Hatton JN, Messinger YH, Frazier AL, Stewart DR, Schneider DT, Harris AK, Dehner LP, Hill DA, Schultz KAP, JCO precision oncology 2025 Apr 9 e2400902 -
Germline pathogenic DROSHA variants are linked to pineoblastoma and Wilms tumor predisposition.
Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Saulnier Sholler G, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Williams Parsons D, Plon SE, Schultz KAP, Onel K, Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Feb -
Pleuropulmonary blastoma and DICER1-related tumor predisposition: from clinicopathologic observations to clinical trial.
Nelson AT, Chen KS, Schultz KAP, Current opinion in pediatrics 2025 Feb 37 1 48-55 -
DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Nelson AT, Mallinger PHR, Harris AK, Kamihara J, Baldinger S, Chen KS, Pond D, Hatton JN, Dybvik A, Mitchell SG, Perrino MR, Ben-Ami T, Kachanov D, Su Y, Duan C, Olson DR, Watson D, Field AL, Harney LA, Garrity Carr A, Frazier AL, Schneider DT, Wilson DB, MacFarland SP, Schoettler PJ, Bauer AJ, Dehner LP, Hill DA, Stewart DR, Messinger YH, Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Oct -
Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry.
Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KAP, Pediatric blood & cancer 2024 May e31090 -
Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP, Gynecologic oncology 2024 Apr 186 117-125 -
DROSHA regulates mesenchymal gene expression in Wilms tumor.
Tiburcio PDB, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Xu L, Chen KS, Molecular cancer research : MCR 2024 Apr -
Rare Tumors: Opportunities and challenges from the Children's Oncology Group perspective.
Schultz KAP, Chintagumpala M, Piao J, Chen KS, Shah R, Gartrell RD, Christison-Lagay E, Pashnakar F, Berry JL, O'Neill AF, Vasta LM, Flynn A, Mitchell SG, Seynnaeve BK, Rosenblum J, Potter SL, Kamihara J, Rodriguez-Galindo C, Hawkins DS, Laetsch TW, EJC paediatric oncology 2023 Dec 2 -
Intronic Germline DICER1 Variants in Patients With Sertoli-Leydig Cell Tumor.
Fraire CR, Mallinger PR, Hatton JN, Kim J, Dickens DS, Argenta PA, Milanovich S, Hartshorne T, Carey DJ, Haley JS, Urban G, Lee J, Hill DA, Stewart DR, Schultz KAP, Chen KS, JCO precision oncology 2023 Sep 7 e2300189 -
Ectopic PLAG1 induces muscular dystrophy in the mouse.
Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen K, Burns DK, Zheng Y, Biochemical and biophysical research communications 2023 Jul 665 159-168 -
Children's Oncology Group's 2023 blueprint for research: Rare tumors.
Schultz KAP, Chintagumpala M, Piao J, Chen KS, Gartrell R, Christison-Lagay E, Berry JL, Shah R, Laetsch TW, Pediatric blood & cancer 2023 Jul e30574 -
Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains.
Medvedev KE, Schaeffer RD, Chen KS, Grishin NV, Scientific reports 2023 Jul 13 1 11988 -
Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence.
Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJM, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LHJ, Draper BW, Frazier AL, Amatruda JF, Nature communications 2023 May 14 1 2636 -
Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D, Pediatric blood & cancer 2022 Feb 69 2 e29451 -
Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis And Tumor Models.
Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D, Journal of pediatric hematology/oncology 2022 Feb -
Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis.
Medvedev KE, Savelyeva AV, Chen KS, Bagrodia A, Jia L, Grishin NV, Cancer informatics 2022 21 11769351221132634 -
Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1
Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF Genes & development 2018 Jul -
EGF Receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors.
Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF Molecular cancer therapeutics 2018 Feb -
A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma.
Chen KS, Kwon WS, Kim J, Heo SJ, Kim HS, Kim HK, Kim SH, Lee WS, Chung HC, Rha SY, Hwang TH Cold Spring Harbor molecular case studies 2016 Sep 2 5 a000992 -
p53 genes function to restrain mobile elements.
Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM Genes & development 2015 Dec -
Invited reply to amikacin ototoxicity in children with cancer: the problem is the administration schedule.
Chen K, Bach A, Shoup A, Winick N Pediatric blood & cancer 2014 Feb 61 2 191 -
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.
Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nature communications 2014 2 4802 -
Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides.
Chen KS, Bach A, Shoup A, Winick NJ Pediatric blood & cancer 2013 Jun -
A big catch for germ cell tumour research.
Chen KS, Amatruda JF PLoS genetics 2013 Apr 9 4 e1003481 -
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors.
Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN BMC cancer 2013 13 1 313 -
Hemolytic non-uremic syndrome.
Chen KS, Neunert CE, Crary SE, Buchanan GR Pediatric blood & cancer 2012 Jul 59 1 167-9 -
A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse.
Singleton K, Parvaze N, Dama KR, Chen KS, Jennings P, Purtic B, Sjaastad MD, Gilpin C, Davis MM, Wülfing C Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 177 7 4402-13 -
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.
Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA Blood 2001 May 97 10 3146-51
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PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor.
Research
- Wilms tumor
- Germ cell tumors
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas