- American Society of Pediatric Hematology and Oncology (2010)
- American Association for Cancer Research (2012)
- American Society of Hematology (2010)
- American Society of Clinical Oncology (2010)
Kenneth Chen, M.D.
- Pediatrics - Hematology-Oncology
Biography
Kenneth S. Chen, M.D., is an Assistant Professor of Pediatrics at UT Southwestern, and an Attending Physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas, TX.
He received his B.S.E. in biomedical engineering from Johns Hopkins University and M.D. from UT Southwestern. He then completed a pediatric residency and pediatric hematology-oncology fellowship at UT Southwestern, where he joined the laboratory of James F. Amatruda.
As a physician-scientist, he divides his time between his research laboratory and Children’s Medical Center in Dallas, where he specializes in the care of children with cancer and blood disorders. His research interests in the laboratory focus on understanding the genetic drivers of childhood cancers, especially Wilms tumor and germ cell tumors, and new strategies for treating them.
In 2019 and 2020, Dr. Chen was named a Texas Monthly Super Doctor Rising Star.
Education & Training
- Medical School - UT Southwestern Medical School (2002-2006)
- Internship - UT Southwestern/Children's Medical Center (2006-2007), Pediatrics
- Residency - UT Southwestern/Children's Medical Center (2007-2009), Pediatrics
- Fellowship - UT Southwestern/Children's Medical Center (2010-2013), Pediatric Hematology/oncology
Professional Associations & Affiliations
Honors & Awards
- Texas Monthly Super Doctors, Rising Star 2020
- Texas Monthly Super Doctors, Rising Star 2019
- W.W. Caruth Scholar 2013, Childrens Medical Center Foundation
- Damon Runyon-Sohn Pediatric Cancer Fellow 2013
- First Place, Critical Appraisal of Literature 2008, Resident Section Poster Contest, Texas Pediatric Society
Books & Publications
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Publications
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Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults
Flores-Toro J, Jagu S, Smith M, Shern J, Hawkins DS, Mardis ER, Rudzinski E, Alonzo TA, Beeles T, Ramirez N, Thomas DL, Cottrell CE, Parbhoo K, Janeway KA, Leary S, Fouladi M, Oberoi S, Venkatramani R, Irwin M, Laetsch TW, Chen KS, Bailey K, Davis JL, Sullivan MB, Boja E, Lowy D, Guidry Auvil JM, Wideman B, Kibbe W, Doroshow J, Reaman GH Journal of the National Cancer Institute 2026 Feb 118 199-204 -
Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee
Englum BR, Piao J, Younis L, Baertschiger RM, Chen KS, Christison-Lagay E, Dholaria H, Gartrell R, Hicks MJ, Kamihara J, Mitchell SG, Orjuela-Grimm M, Pashankar F, Potter SL, Aldrink JH, Rosenblum J, Sargen MR, Schultz KA, Seynnaeve BK, Wedekind M, Laetsch TW Pediatric Blood and Cancer 2026 Feb 73 -
RAS pathway targeted therapy in patients with DICER1-associated sarcomas
Zhang L, Mallinger PH, Zhou S, Makri SC, Gross JM, Lucas CH, Zou YS, Mize W, Olson DR, Munnikhuysen SR, Rawwas J, Messinger Y, Chen KS, Schultz KA, Pratilas CA npj Precision Oncology 2025 Dec 9 -
Feasibility of Atezolizumab in Combination With Chemotherapy for Children With Relapsed or Refractory Solid Tumors
Campbell ME, Stutzman S, Primeaux S, Sida D, Lee M, Shah AT, Sadanand A, Sokol E, Collins NB, Turpin B, Navai S, Albert K, Laetsch TW, Rakheja D, Chen KS, Gerber DE, Koh AY Pediatric Blood and Cancer 2025 Dec 72 -
PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor
Tiburcio PD, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS Pediatric Blood and Cancer 2025 Sep 72 -
One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma
Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KA, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD Clinical Cancer Research 2025 Aug 31 3124-3132 -
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS Genes and Development 2025 Jun 39 727-750 -
Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
Tiburcio PD, Chen K, Xu L, Chen KS Cell Reports Medicine 2025 May 6 -
Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries
Harris AK, Nelson AT, Watson D, Mallinger PH, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KA Cancer 2025 May 131 -
Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Sholler GS, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Parsons DW, Plon SE, Schultz KA, Onel K Clinical Cancer Research 2025 Apr 31 1491-1503 -
Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell Tumor
Nelson AT, Watson D, Chen KS, Olson DR, Stall JN, Devins KM, Young RH, Kamihara J, Mallinger PH, Kim J, Hatton JN, Messinger YH, Frazier AL, Stewart DR, Schneider DT, Harris AK, Dehner LP, Hill DA, Schultz KA JCO Precision Oncology 2025 Apr 9 -
Pleuropulmonary blastoma and DICER1 -related tumor predisposition: From clinicopathologic observations to clinical trial
Nelson AT, Chen KS, Schultz KA Current opinion in pediatrics 2025 Feb 37 48-55 -
DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies
Schultz KA, Nelson AT, Mallinger PH, Harris AK, Kamihara J, Baldinger S, Chen KS, Pond D, Hatton JN, Dybvik AG, Mitchell SG, Perrino MR, Ben-Ami T, Kachanov D, Su Y, Duan C, Olson DR, Watson D, Field AL, Harney LA, Carr AG, Frazier AL, Schneider DT, Wilson DB, MacFarland SP, Schoettler PJ, Bauer AJ, Dehner LP, Hill DA, Stewart DR, Messinger YH Clinical Cancer Research 2024 Dec 30 5681-5692 -
Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry
Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KA Pediatric Blood and Cancer 2024 Aug 71 -
DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Tiburcio PD, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Xu L, Chen KS Molecular Cancer Research 2024 Aug 22 711-720 -
Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PH, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KA Gynecologic oncology 2024 Jul 186 117-125 -
Rare tumors: Opportunities and challenges from the Children's Oncology Group perspective
Schultz KA, Chintagumpala M, Piao J, Chen KS, Shah R, Gartrell RD, Christison-Lagay E, Pashnakar F, Berry JL, O'Neill AF, Vasta LM, Flynn A, Mitchell SG, Seynnaeve BK, Rosenblum J, Potter SL, Kamihara J, Rodriguez-Galindo C, Hawkins DS, Laetsch TW EJC Paediatric Oncology 2023 Dec 2 -
Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains
Medvedev KE, Schaeffer RD, Chen KS, Grishin NV Scientific reports 2023 Dec 13 -
Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence
Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJ, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LH, Draper BW, Frazier AL, Amatruda JF Nature communications 2023 Dec 14 -
Intronic Germline DICER1 Variants in Patients with Sertoli-Leydig Cell Tumor
Fraire CR, Mallinger PR, Hatton JN, Kim J, Dickens DS, Argenta PA, Milanovich S, Hartshorne T, Carey DJ, Haley JS, Urban G, Lee J, Hill DA, Stewart DR, Schultz KA, Chen KS JCO Precision Oncology 2023 Oct 7 -
Children's Oncology Group's 2023 blueprint for research: Rare tumors
Author Collaboration tC, Schultz KA, Chintagumpala M, Piao J, Chen KS, Gartrell R, Christison-Lagay E, Berry JL, Shah R, Laetsch TW Pediatric Blood and Cancer 2023 Sep 70 -
Ectopic PLAG1 induces muscular dystrophy in the mouse
Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen K, Burns DK, Zheng Y Biochemical and Biophysical Research Communications 2023 Jul 665 159-168 -
Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation
Hatton JN, Frone MN, Cox HC, Crowley SB, Hiraki S, Yokoyama NN, Abul-Husn NS, Amatruda JF, Anderson MJ, Bofill-De Ros X, Carr AG, Chao EC, Chen KS, Gu S, Higgs C, Machado J, Ritter D, Schultz KA, Soper ER, Wu MK, Mester JL, Kim J, Foulkes WD, Witkowski L, Stewart DR Human mutation 2023 2023 -
Extrarenal Anaplastic Wilms Tumor: A Case Report with Genomic Analysis and Tumor Models
Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D Journal of Pediatric Hematology/Oncology 2022 May 44 147-154 -
Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D Pediatric Blood and Cancer 2022 Feb 69 -
Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis
Medvedev KE, Savelyeva AV, Chen KS, Bagrodia A, Jia L, Grishin NV Cancer Informatics 2022 Jan 21 -
WT-CLS1 is a rhabdoid tumor cell line and can be inhibited by miR-16
Stroup EK, Yeu Y, Budhipramono A, Hwang TH, Rakheja D, Erdreich-Epstein A, Laetsch TW, Amatruda JF, Chen KS Cancer Reports 2019 Jun 2 -
Mutations in microRNA processing genes in wilms tumors derepress the IGF2 regulator PLAG1
Chen K, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF Genes and Development 2018 Aug 32 996-1007 -
EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors
Chen K, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LH, Laetsch TW, Rakheja D, Amatruda JF Molecular Cancer Therapeutics 2018 May 17 1079-1089 -
Distinct DICER1 hotspot mutations identify bilateral tumors as separate eventss
Chen KS, Stuart SH, Stroup EK, Shukla AS, Wang J, Rajaram V, Vujanic GM, Slone T, Rakheja D, Amatruda JF JCO Precision Oncology 2018 1-9 -
Erratum: Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours
Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nature communications 2017 8 16177 -
p53 genes function to restrain mobile elements
Wylie A, Jones AE, D’Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen K, Hammer RE, Comerford SA, Amatruda JF, Abrams JM Genes and Development 2016 Jan 30 64-77 -
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours
Rakheja D, Chen K, Liu Y, Shukla AA, Schmid V, Chang T, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nature communications 2014 Sep 2 -
Invited reply to Amikacin ototoxicity in children with cancer: The problem is the administration schedule
Chen K, Bach A, Shoup A, Winick N Pediatric Blood and Cancer 2014 Feb 61 191 -
Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides
Chen KS, Bach A, Shoup A, Winick NJ Pediatric Blood and Cancer 2013 Nov 60 1772-1777 -
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen K, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN BMC Cancer 2013 Jun 13 -
A Big Catch for Germ Cell Tumour Research
Chen KS, Amatruda JF PLoS genetics 2013 Apr 9 -
Hemolytic non-uremic syndrome
Chen KS, Neunert CE, Crary SE, Buchanan GR Pediatric Blood and Cancer 2012 Jul 59 167-169 -
A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse
Singleton K, Parvaze N, Dama KR, Chen KS, Jennings P, Purtic B, Sjaastad MD, Gilpin C, Davis MM, Wülfing C Journal of Immunology 2006 Oct 177 4402-4413 -
Human natural killer cells: A unique innate immunoregulatory role for the CD56bright subset
Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA Blood 2001 May 97 3146-3151
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Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults
Research
- Wilms tumor
- Germ cell tumors
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas