- American Society of Neurology
- Child Neurology Society
Biography
Linda Nguyen, M.D., Ph.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center.
Dr. Nguyen earned her medical degree and a doctoral degree in pharmaceutical and pharmacological sciences at the University of West Virginia School of Medicine. She completed a residency in pediatric neurology at the University of California San Diego, where she served as Chief Resident. She received advanced training through a fellowship in pediatric neuroimmunology at UT Southwestern.
Certified by the American Board of Psychiatry and Neurology in child neurology, she joined the UT Southwestern faculty in 2024.
She is a member of the American Society of Neurology and the Child Neurology Society.
Dr. Nguyen is actively involved in research, focusing on a condition called MOG antibody-associated disease. This is an autoimmune disease in which the immune system gets confused and makes MOG antibodies, attacking the brain, spinal cord and optic nerves. This can cause problems such as blurry vision, trouble walking, and seizures. Her work explores how to predict which patients go on to have relapses and treat it more effectively.
She is a recipient of the National Institute of Neurological Disorders and Stroke (NINDS)-funded Child Neurology Career Development Program K12 Award and the Pediatric Epilepsy Research Foundation Elterman Award.
Education & Training
- Medical School - West Virginia University School of Medicine (2011-2017)
- Residency - University of California (San Diego) Medical Center (2017-2022), Pediatric Neurology
- Fellowship - UT Southwestern Medical Center (2022-2024), Neuroimmunology
Professional Associations & Affiliations
Honors & Awards
- O'Donnell Brain Institute Travel Award 2023, UT Southwestern Medical Center
- Pediatric Epilepsy Research Foundation Excellence in Research and Scholarly Activity Award 2023, UT Southwestern Medical Center
- Fred Baskin Young Investigatory Award 2023, UT Southwestern Medical Center
- Rady Children’s Hospital Annual Pediatric Research Symposium Clinical Science Poster Award 2022, University of California San Diego
Books & Publications
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Publications
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Amygdala enlargement in pediatric epilepsy: A clinically meaningful finding?
Hakim M, Joshi C, Veltkamp D, Sirsi D, Nguyen L, Bhatia S, Armstrong D, Prabhu N, Talai A Epilepsy Research 2026 Jun 224 -
Clinical, Radiologic, and Optical Coherence Tomographic Features of Pediatric Acute Disseminated Encephalomyelitis: Comparison of Myelin Oligodendrocyte Glycoprotein Antibody–Positive and –Negative Cases
Nguyen L, Singh S, Wang CX, Greenberg BM Pediatric Neurology 2025 Oct 171 86-91 -
Delayed diagnosis in pediatric-onset aquaporin-4 positive neuromyelitis optica spectrum disorder with isolated area postrema syndrome
Mandle Q, Nguyen L, Horn PS, Wheeler YS, Wu H, Poisson KE European Journal of Paediatric Neurology 2025 May 56 6-9 -
Late Relapse After Autologous Hematopoietic Stem Cell Transplantation in AQP4-IgG–Positive NMOSD
Vorasoot N, Blackburn KM, Nguyen L, Bush ML, Jenkins SM, Jitprapaikulsan J, Fryer JP, Irani SR, Flanagan EP, Pittock SJ JAMA Network Open 2025 Apr 8 -
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Associated With Rhabdomyolysis: A Case Report
Nguyen L, Strozzi I, Hegde S, Greenberg BM Pediatric Neurology 2025 Apr 165 40-42 -
Current and emerging therapies for autoimmune encephalitis
Dinov D, Nguyen L, Blackburn K, Vernino S Expert review of neurotherapeutics 2025 25 555-565 -
Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis
Smith C, Telesford KM, Piccirillo SG, Licon-Munoz Y, Zhang W, Tse KM, Rivas JR, Joshi C, Shah DS, Wu AX, Trivedi R, Christley S, Qian Y, Cowell LG, Scheuermann RH, Stowe AM, Nguyen L, Greenberg BM, Monson NL Journal of Neuroinflammation 2024 Dec 21 -
Racial, Ethnic, and Socioeconomic Disparities in Pediatric Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder
Poisson KE, Nguyen L, Horn PS, Beck AF, Wu H, Wesselkamper K, Ness JM, Wheeler YS Pediatric Neurology 2024 Dec 161 194-200 -
The positive predictive value of MOG-IgG testing based on the 2023 diagnostic criteria for MOGAD
Nguyen L, Singh S, Feltrin FS, Tardo LM, Clarke RL, Wang CX, Greenberg BM Multiple Sclerosis Journal - Experimental, Translational and Clinical 2024 Jul 10 -
Clinical analysis of myelin oligodendrocyte glycoprotein antibody-associated disease in a diverse cohort of children: A single-center observational study
Nguyen L, Wang CX, Hernandez RS, Greenberg BM Multiple Sclerosis and Related Disorders 2024 Apr 84 -
Survival Analysis of Immunotherapy Effects on Relapse Rate in Pediatric and Adult Autoimmune Encephalitis
Yang JH, Liu EN, Nguyen L, Dunn-Pirio A, Graves JS Neurology 2023 Nov 101 E2300-E2313 -
Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Nguyen L, Miles DK, Harder L, Singh S, Whittemore BA, Greenberg BM, Wang CX Neurology: Neuroimmunology and NeuroInflammation 2023 Oct 11 -
Subclinical optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease
Nguyen L, Wang CX, Conger DL, Sguigna PV, Singh S, Greenberg BM Multiple Sclerosis and Related Disorders 2023 Aug 76 -
Anti-N-Methyl-D-Aspartate Receptor Encephalitis Presenting Atypically as a Mimic of Rapidly Progressive Neurodegenerative Disorder in a Toddler: A Case Report
Nguyen L, Varnet M, Talai A, Williams K, Wang C Pediatric Neurology 2023 Aug 145 132-134 -
Anti-NMDA Receptor Autoimmune Encephalitis: Diagnosis and Management Strategies
Nguyen L, Wang C International Journal of General Medicine 2023 16 7-21 -
Restricted diffusion of the callosal splenium is highly specific for seizures in neonates
Nguyen L, Chen DY, Vinocur DN, Gold JJ BMC Neurology 2022 Dec 22 -
A systematic review and quantitative synthesis of the long-term psychiatric sequelae of pediatric autoimmune encephalitis
Nguyen L, Yang JH, Goyal S, Irani N, Graves JS Journal of affective disorders 2022 Jul 308 449-457 -
Triacetyluridine treats epileptic encephalopathy from CAD mutations: a case report and review
Frederick A, Sherer K, Nguyen L, Ali S, Garg A, Haas R, Sahagian M, Bui J Annals of Clinical and Translational Neurology 2021 Jan 8 284-287 -
Posterior Reversible Encephalopathy Syndrome Mimicking Tumor Recurrence in a Patient With Multiply Recurrent Neuroblastoma
Nguyen L, Crawford JR Pediatric Neurology 2020 Sep 110 92-94 -
Pediatric Paraneoplastic Necrotizing Encephalitis Associated With Acute Lymphoblastic Leukemia
Nguyen L, Crawford JR Pediatric Neurology 2020 Apr 105 55-58 -
The psychopharmacology of pseudobulbar affect
Nguyen L, Matsumoto RR 2019 243-251 -
Neonatal diabetes mellitus due to a novel variant in the INS gene
Laurenzano SE, McFall C, Nguyen L, Savla D, Coufal NG, Wright MS, Tokita M, Dimmock D, Kingsmore SF, Newfield RS Cold Spring Harbor Molecular Case Studies 2019 5 -
Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine + naloxone exposure
Nguyen L, Lander LR, O'Grady KE, Marshalek PJ, Schmidt A, Kelly AK, Jones HE American Journal on Addictions 2018 Mar 27 92-96 -
Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury
Lucke-Wold BP, Logsdon AF, Nguyen L, Eltanahay A, Turner RC, Bonasso P, Knotts C, Moeck A, Maroon JC, Bailes JE, Rosen CL Nutritional Neuroscience 2018 Feb 21 79-91 -
Pineoblastoma in a child with 22q11.2 deletion syndrome
Nguyen L, Crawford JR BMJ Case Reports 2018 2018 -
Deuterated (d6)-dextromethorphan elicits antidepressant-like effects in mice
Nguyen L, Scandinaro AL, Matsumoto RR Pharmacology Biochemistry and Behavior 2017 Oct 161 30-37 -
Hippocampus-specific deficiency of IL-15Rα contributes to greater anxiety-like behaviors in mice
Nguyen L, Bohlen J, Stricker J, Chahal I, Zhang H, Pistilli EE Metabolic Brain Disease 2017 Apr 32 297-302 -
Sigma-1 receptors and neurodegenerative diseases: Towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection
Nguyen L, Lucke-Wold BP, Mookerjee S, Kaushal N, Matsumoto RR Advances in experimental medicine and biology 2017 964 133-152 -
Corrigendum to "Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms"
Singh R, Turner RC, Nguyen L, Motwani K, Swatek M, Lucke-Wold BP, Qaiser R Behavioural neurology 2017 Jan 2017 5652160 -
Behavioral and biochemical effects of ketamine and dextromethorphan relative to its antidepressant-like effects in Swiss Webster mice
Nguyen L, Lucke-Wold BP, Logsdon AF, Scandinaro AL, Huber JD, Matsumoto RR NeuroReport 2016 Sep 27 1004-1011 -
Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy
Lucke-Wold BP, Turner RC, Logsdon AF, Nguyen L, Bailes JE, Lee JM, Robson MJ, Omalu BI, Huber JD, Rosen CL Journal of neurosurgery 2016 Mar 124 687-702 -
Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders
Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR Pharmacology and Therapeutics 2016 Mar 159 1-22 -
Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms
Singh R, Turner RC, Nguyen L, Motwani K, Swatek M, Lucke-Wold BP Behavioural neurology 2016 2016 -
Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury
Logsdon AF, Lucke-Wold BP, Nguyen L, Matsumoto RR, Turner RC, Rosen CL, Huber JD Brain Research 2016 1643 140-151 -
Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice
Nguyen L, Matsumoto RR Behavioural Brain Research 2015 Dec 295 26-34 -
Off-label use of transmucosal ketamine as a rapid-acting antidepressant: A retrospective chart review
Nguyen L, Marshalek PJ, Weaver CB, Cramer KJ, Pollard SE, Matsumoto RR Neuropsychiatric Disease and Treatment 2015 Oct 11 2667-2673 -
Sleep disruption and the sequelae associated with traumatic brain injury
Lucke-Wold BP, Smith KE, Nguyen L, Turner RC, Logsdon AF, Jackson GJ, Huber JD, Rosen CL, Miller DB Neuroscience and Biobehavioral Reviews 2015 Aug 55 68-77 -
Traumatic brain injury and epilepsy: Underlying mechanisms leading to seizure
Lucke-Wold BP, Nguyen L, Turner RC, Logsdon AF, Chen YW, Smith KE, Huber JD, Matsumoto R, Rosen CL, Tucker ES, Richter E Seizure 2015 33 13-23 -
Role of sigma-1 receptors in neurodegenerative diseases
Nguyen L, Lucke-Wold BP, Mookerjee SA, Cavendish JZ, Robson MJ, Scandinaro AL, Matsumoto RR Journal of Pharmacological Sciences 2015 Jan 127 17-29 -
Sigma receptors as potential therapeutic targets for neuroprotection
Nguyen L, Kaushal N, Robson MJ, Matsumoto RR European Journal of Pharmacology 2014 Nov 743 42-47 -
Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia
Matsumoto RR, Seminerio MJ, Turner RC, Robson MJ, Nguyen L, Miller DB, O'Callaghan JP Pharmacology and Therapeutics 2014 Oct 144 28-40 -
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan
Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR PloS one 2014 Feb 9 -
Sigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects
Matsumoto RR, Nguyen L, Kaushal N, Robson MJ 2014 323-386 -
Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway
Xu Y, Pan J, Chen L, Zhang C, Sun J, Li J, Nguyen L, Nair N, Zhang H, O'Donnell JM International Journal of Neuropsychopharmacology 2013 May 16 835-847
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Amygdala enlargement in pediatric epilepsy: A clinically meaningful finding?
Children's Medical Center of Dallas
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