- Member, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2012)
- Member, Crohn's and Colitis Foundation of America (2014)
- Crohn's and Colitis Foundation of America, North Texas Dallas Chapter Medical Advisory Committee (2016)
Luis Sifuentes-Dominguez, M.D.
- Pediatrics - Gastroenterology
Biography
Dr. Luis Sifuentes-Dominguez is studying basic mechanisms of inflammatory bowel disease. He is supported by a departmental, NIH-sponsored Child Health Research Career Development Award and is working closely with Dr. Ezra Burstein in UT Southwestern’s Department of Internal Medicine’s Division of Gastroenterology to understand the molecular basis of early-onset IBD. Using cutting-edge genomic and proteomic approaches, together they have identified novel genes that play a role in early-onset IBD.
Education & Training
- Fellowship - UT Southwestern/Children's Medical Center (2012-2015), Pediatric Gastroenterology
- Residency - University of Connecticut Health Center (2010-2012), Pediatrics
- Residency - Hospital Infantil de Mexico Federico Gomez (2005-2008), Pediatrics
- Medical School - Universidad La Salle Medical School (1999-2005)
Professional Associations & Affiliations
Honors & Awards
- Teaching Resident Award 2012, University of Connecticut School of Medicine
- W.W. Caruth Scholar 2015, Children's Medical Center Foundation
- Excellence in Research Award 2015, UTSW Department of Pediatrics Senior Fellows Research Day
- Endoscopy Prize 2014, NASPGHAN
Books & Publications
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Publications
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Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E Nature Metabolism 2024 Jun 6 1076-1091 -
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection
Hu Z, Zhang C, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA, Hooper LV Science 2021 Nov 374 -
Augmented ustekinumab dosing is needed to achieve clinical response in patients with anti-TNF refractory pediatric Crohn's disease: A retrospective chart review
Do P, Andersen J, Patel A, Semrin G, Sifuentes-Dominguez L, Luu P, Gurram B F1000Research 2021 9 -
Paneth cell-derived growth factors support tumorigenesis in the small intestine
Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E Life Science Alliance 2020 Dec 4 -
In-vitro GLP-1 Release Assay Using STC-1 Cells
Qi L, Shuai T, Da J, Ezra B, Luis SD Bio-protocol 2020 Aug 10 -
Structural and mechanistic insights into secretagogin-mediated exocytosis
Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 117 6559-6570 -
NK cell defects in X-linked pigmentary reticulate disorder
Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E JCI Insight 2019 Nov 4 -
SCGN deficiency results in colitis susceptibility
Sifuentes-Dominguez L, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, K V, Baker LA, Jia D, Burstein E eLife 2019 Oct 8 -
Mosaic tetrasomy 9p associated with inflammatory bowel disease
Sifuentes-Dominguez L, Starokadomskyy P, Welch J, Gurram B, Park JY, Koduru P, Burstein E Journal of Crohn's and Colitis 2019 Oct 13 1474-1478 -
Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer
Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE Journal of Experimental Medicine 2019 216 2378-2393 -
Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation
Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E Cell Reports 2018 Aug 24 2342-2355 -
Precision editing of the gut microbiota ameliorates colitis
Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, De Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 208-211 -
Evolution of the skin manifestations of X-linked pigmentary reticulate disorder
Starokadomskyy P, Sifuentes-Dominguez L, Gemelli T, Zinn AR, Dossi MT, Mellado C, Bertrand P, Borzutzky A, Burstein E British Journal of Dermatology 2017 Nov 177 e200-e201 -
Genetics and Therapeutics in Pediatric Ulcerative Colitis: The Past, Present and Future
Patel AS, Sifuentes-Dominguez L F1000Research 2016 5 -
Endosomal sorting of notch receptors through COM MD9-dependent pathways modulates notch signaling
Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, Van de Sluis B, Cleaver O, Burstein E Journal of Cell Biology 2015 Nov 211 605-617 -
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Van De Sluis B, Billadeau DD, Burstein E Molecular Biology of the Cell 2015 Jan 26 91-103
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Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
Research
- Role of enteroendocrine cells in inflammatory bowel disease pathogenesis
- Identifying the genetic causes of early onset Inflammatory Bowel Disease
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas