Luis Sifuentes-Dominguez, M.D.

Pediatrics - Gastroenterology

Biography

Dr. Luis Sifuentes-Dominguez is studying basic mechanisms of inflammatory bowel disease. He is supported by a departmental, NIH-sponsored Child Health Research Career Development Award and is working closely with Dr. Ezra Burstein in UT Southwestern’s Department of Internal Medicine’s Division of Gastroenterology to understand the molecular basis of early-onset IBD. Using cutting-edge genomic and proteomic approaches, together they have identified novel genes that play a role in early-onset IBD.

Education & Training

Fellowship - UT Southwestern/Children's Medical Center (2012-2015), Pediatric Gastroenterology
Residency - University of Connecticut Health Center (2010-2012), Pediatrics
Residency - Hospital Infantil de Mexico Federico Gomez (2005-2008), Pediatrics
Medical School - Universidad La Salle Medical School (1999-2005)

Professional Associations & Affiliations

Member, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2012)
Member, Crohn's and Colitis Foundation of America (2014)
Crohn's and Colitis Foundation of America, North Texas Dallas Chapter Medical Advisory Committee (2016)

Honors & Awards

Teaching Resident Award 2012, University of Connecticut School of Medicine
Endoscopy Prize 2014, NASPGHAN
W.W. Caruth Scholar 2015, Children's Medical Center Foundation
Excellence in Research Award 2015, UTSW Department of Pediatrics Senior Fellows Research Day

Books & Publications

Publications
- Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
  Hu Z, Zhang C, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA, Hooper LV, Science (New York, N.Y.) 2021 11 374 6568 eabe6723
- Paneth cell-derived growth factors support tumorigenesis in the small intestine.
  Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E, Life science alliance 2021 Mar 4 3
- Structural and mechanistic insights into secretagogin-mediated exocytosis.
  Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D, Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 117 12 6559-6570
- NK cell defects in X-linked pigmentary reticulate disorder.
  Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E, JCI insight 2019 Nov 4 21
- SCGN deficiency results in colitis susceptibility.
  Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E, eLife 2019 Oct 8
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
  Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE, The Journal of experimental medicine 2019 Jul
- Mosaic Tetrasomy 9p Associated With Inflammatory Bowel Disease.
  Sifuentes-Dominguez L, Starokadomskyy P, Welch J, Gurram B, Park JY, Koduru P, Burstein E, Journal of Crohn's & colitis 2019 Apr
- Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation.
  Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E Cell reports 2018 Aug 24 9 2342-2355
- Precision editing of the gut microbiota ameliorates colitis.
  Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211
- Evolution of the skin manifestations of X-linked Pigmentary Reticulate Disorder.
  Starokadomskyy P, Sifuentes-Dominguez L, Gemelli T, Zinn AR, Dossi MT, Mellado C, Bertrand P, Borzutzky A, Burstein E The British journal of dermatology 2017 Apr
- Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future.
  Sifuentes-Dominguez L, Patel AS F1000Research 2016 5
- Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
  Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E The Journal of cell biology 2015 Nov 211 3 605-17
- COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
  Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E Molecular biology of the cell 2015 Jan 26 1 91-103

Research

Role of enteroendocrine cells in inflammatory bowel disease pathogenesis
Identifying the genetic causes of early onset Inflammatory Bowel Disease

Links

New Patient Appointment or 469-497-2505