Makoto Ishii, M.D., Ph.D.

Neurology

New Patient Appointment Accepting Virtual Visits or 214-645-8800

New Patient Appointment or 214-645-8800

Education & Training

Residency - New York Presbyterian Hospital - Weill Cornell Medical Center (2008-2012), Neurology
Medical School - Weill Cornell Medical College (2002-2008)

Books & Publications

Publications
- Comparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records
  Xu J, Wang F, Zang C, Zhang H, Niotis K, Liberman AL, Stonnington CM, Ishii M, Adekkanattu P, Luo Y, Mao C, Rasmussen LV, Xu Z, Brandt P, Pacheco JA, Peng Y, Jiang G, Isaacson R, Pathak J Scientific reports 2023 Dec 13
- What is good for the heart is good for brain glucose metabolism
  Ishii M The Lancet Healthy Longevity 2023 Sep 4 e448-e449
- Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease
  Eruysal E, Ravdin L, Zhang C, Kamel H, Iadecola C, Ishii M Journal of Alzheimer's Disease 2023 91 1073-1083
- Midlife dyslipidaemia as a modifiable risk factor for later-life dementia
  Ishii M The Lancet Healthy Longevity 2021 Aug 2 e453-e454
- Pituitary Apoplexy
  Seitz AP, Ishii M 2021 Jan 259-274
- A Novel Neurovascular Liaison Governing the Blood-Brain Barrier
  Ishii M, Iadecola C Neuron 2020 Jul 107 205-207
- Risk factor for Alzheimer's disease breaks the blood-brain barrier
  Ishii M, Iadecola C Nature 2020 May 581 31-32
- Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease
  Eruysal E, Ravdin L, Kamel H, Iadecola C, Ishii M Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 2019 Dec 11 646-653
- Amyloid-beta modulates low-threshold activated voltagegated l-type calcium channels of arcuate neuropeptide y neurons leading to calcium dysregulation and hypothalamic dysfunction
  Ishii M, Hiller AJ, Pham L, McGuire MJ, Iadecola C, Wang G Journal of Neuroscience 2019 Oct 39 8816-8825
- McLeod syndrome: Five new pedigrees with novel mutations
  Weaver J, Sarva H, Barone D, Bobker S, Bushara K, Hiller A, Ishii M, Jankovic J, Lakhani S, Niotis K, Scharre DW, Tuite P, Stutz A, Westhoff CM, Walker RH Parkinsonism and Related Disorders 2019 Jul 64 293-299
- Apolipoprotein B as a New Link between Cholesterol and Alzheimer Disease
  Ishii M JAMA neurology 2019 Jul 76 751-752
- Retinol Binding Protein 4 Levels Are Not Altered in Preclinical Alzheimer's Disease and Not Associated with Cognitive Decline or Incident Dementia
  Ishii M, Kamel H, Iadecola C Journal of Alzheimer's Disease 2019 67 257-263
- Disorders of body weight, sleep and circadian rhythm as manifestations of hypothalamic dysfunction in Alzheimer’s disease
  Hiller AJ, Ishii M Frontiers in Cellular Neuroscience 2018 Dec 12
- Endocrine emergencies with neurologic manifestations
  Ishii M CONTINUUM Lifelong Learning in Neurology 2017 23 778-801
- Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology
  Ishii M, Iadecola C Biochimica et Biophysica Acta - Molecular Basis of Disease 2016 May 1862 966-974
- Leptin Dysfunction and Alzheimer’s Disease: Evidence from Cellular, Animal, and Human Studies
  McGuire MJ, Ishii M Cellular and Molecular Neurobiology 2016 Mar 36 203-217
- Metabolic and Non-Cognitive Manifestations of Alzheimers Disease: The Hypothalamus as Both Culprit and Target of Pathology
  Ishii M, Iadecola C Cell Metabolism 2015 Nov 22 761-776
- Neurologic complications of nondiabetic endocrine disorders
  Ishii M CONTINUUM Lifelong Learning in Neurology 2014 Jun 20 560-579
- Amyloid β-Related Central Nervous System Angiitis Presenting With an Isolated Seizure
  Ishii M, Kamel H, Iadecola C, Navi BB, Lavi E, Gupta A The Neurohospitalist 2014 Apr 4 86-89
- Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide y neurons
  Ishii M, Wang G, Racchumi G, Dyke JP, Iadecola C Journal of Neuroscience 2014 34 9096-9106
- Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory
  Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T PloS one 2011 6
- Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2
  Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J Cell Metabolism 2009 Feb 9 191-202
- Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities
  Aikawa S, Ishii M, Yanagisawa M, Sakakibara Y, Sakurai T Regulatory Peptides 2008 Nov 151 147-152
- The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion
  Hondo M, Ishii M, Sakurai T 2008 239-256
- Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain
  Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams SC, Yanagisawa M, Sakurai T Brain Research 2006 Jun 1093 123-134
- Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity
  Ishii M, Fei H, Friedman JM Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 100 10540-10545
- Mechanism-based inhibition of the melatonin rhythm enzyme: Pharmacologic exploitation of active site functional plasticity
  Khalil EM, De Angelis J, Ishii M, Cole PA Proceedings of the National Academy of Sciences of the United States of America 1999 Oct 96 12418-12423
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
  Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M Cell 1998 Mar 92 1 page following 696
- Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
  Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M Cell 1998 Feb 92 573-585

New Patient Appointment Accepting Virtual Visits or 214-645-8800