Marco Da Cunha Pinho, M.D.

Associate Chief, Neuroradiology; Medical Director of Neuroradiology, Meadows Imaging Center

Peter O'Donnell Jr. Brain Institute

Radiology - Neuroradiology

Biography

Marco Pinho, M.D., is an Associate Professor of Radiology at UT Southwestern Medical Center and Associate Chief of its Neuroradiology Division. His clinical interests include cross-sectional imaging of neurological diseases and oncologic imaging.

Dr. Pinho earned his medical degree at Universidade Estadual De Campinas in São Paulo, Brazil. He completed his radiology residency at Universidade De São Paulo, where he also received advanced training through a fellowship in neuroradiology. He also completed a research fellowship at Massachusetts General Hospital in Boston.

Dr. Pinho’s research is currently focused on the development and validation of magnetic resonance imaging (MRI) techniques to evaluate central nervous system malignancies, and response assessment in clinical trials in collaboration with basic scientists, neuro-oncologists, and neurosurgeons at UT Southwestern. He has published multiple articles, reports, and reviews.

At UT Southwestern, Dr. Pinho serves on several committees, including the Radiology Resident Selection Committee, the Clinical Competency Committee, the Brain Tumor Committee, and the Intracranial Pressure Disorder IPT.

A dedicated educator, Dr. Pinho previously served as the Associate Program Director of the Radiology Residency Program, and also coordinated the Global Health Teleradiology program.

Dr. Pinho is an active member of national and international professional organizations, including the Radiological Society of North America, the International Society of Magnetic Resonance in Medicine, the American Society of Neuroradiology, the American Society of Spine Radiology, the American Society of Functional Neuroradiology, and the Sociedade Paulista de Radiologia.

Education & Training

Fellowship - A.A. Martinos Ctr. for Biomedical Imaging (2010-2011), Neuroradiology
Fellowship - Instituto de Radiologia - Hospital das Clinicas - Univ. de Sao Paulo (2006-2007), Neuroradiology
Residency - Instituto de Radiologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (2003-2006), Diagnostic Radiology
Medical School - Universidade Estadual De Campinas (1997-2002)

Professional Associations & Affiliations

Radiological Society of North America (2003)
International Society for Magnetic Resonance in Medicine (2013)
American Society of Neuroradiology (2013)
American Society of Spine Radiology (2016)
American Society of Functional Neuroradiology (2017)

Books & Publications

Books
- Intra-axial Brain Tumors in Diagnostic Imaging of Encephalic Diseases 2nd Edition
  Leite CC, Pinho MC, Garcia MR, Martins MCB, Pincerato RCM, Felix MM, Shibao S, Lucato LT (2010), Sao Paulo - Brazil, Guanabara Koogan
- Abdominal Sonographic Anatomy in Abdominal Sonography
  Kay FU, Pinho MC, Amaro Jr E, Bordalo-Rodrigues M, Kodaira SK (2009), Sao Paulo - Brazil, Guanabara Koogan
- White Matter Diseases and Inborn Error of Metabolism in Diagnostic Imaging of Encephalic Diseases
  Leite CC, Nagae LM, Pinho MC, Kay FU, Martins MCB, Amaral RPG, Kok F (2008), Sao Paulo, Brazil, Guanabara Koogan
- Parapharyngeal Space in Radiology and Diagnostic Imaging of the Head and Neck
  Gebrim EMMS, Pinho MC (2010), Sao Paulo - Brazil, Guanabara Koogan
- Angiotomography of the cervical and intracranial arteries in Cardiovascular CT and MRI
  Pinho MC, Kay FU (2013), Sao Paulo, Brazil, Manole
Publications
- Cerebrovascular reactivity mapping without gas challenges.
  Liu P, Li Y, Pinho M, Park DC, Welch BG, Lu H NeuroImage 2016 Nov
- Robust pCASL perfusion imaging using a 3D Cartesian acquisition with spiral profile reordering (CASPR).
  Greer JS, Wang X, Wang Y, Pinho MC, Maldjian JA, Pedrosa I, Madhuranthakam AJ, Magnetic resonance in medicine 2019 Jun
- In vivo detection of citrate in brain tumors by (1) H magnetic resonance spectroscopy at 3T.
  Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013 Oct
- Microstructural correlates of 3D steady-state inhomogeneous magnetization transfer (ihMT) in the human brain white matter assessed by myelin water imaging and diffusion tensor imaging.
  Ercan E, Varma G, Mädler B, Dimitrov IE, Pinho MC, Xi Y, Wagner BC, Davenport EM, Maldjian JA, Alsop DC, Lenkinski RE, Vinogradov E Magnetic resonance in medicine 2018 Apr
- Cerebrovascular Reactivity Mapping Using Resting-State BOLD Functional MRI in Healthy Adults and Patients with Moyamoya Disease.
  Liu P, Liu G, Pinho MC, Lin Z, Thomas BP, Rundle M, Park DC, Huang J, Welch BG, Lu H, Radiology 2021 Mar 203568
- Brain tumor IDH, 1p/19q, and MGMT molecular classification using MRI-based deep learning: an initial study on the effect of motion and motion correction.
  Nalawade SS, Yu FF, Bangalore Yogananda CG, Murugesan GK, Shah BR, Pinho MC, Wagner BC, Xi Y, Mickey B, Patel TR, Fei B, Madhuranthakam AJ, Maldjian JA, Journal of medical imaging (Bellingham, Wash.) 2022 Jan 9 1 016001
- Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema.
  Mallery RM, Rehmani OF, Woo JH, Chen YJ, Reddi S, Salzman KL, Pinho MC, Ledbetter L, Tamhankar MA, Shindler KS, Digre KB, Friedman DI, Liu GT, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2019 Feb
- Spiral T1 Spin-Echo for Routine Postcontrast Brain MRI Exams: A Multicenter Multireader Clinical Evaluation.
  Ooi MB, Li Z, Robison RK, Wang D, Anderson AG, Zwart NR, Bakhru A, Nagaraj S, Mathews T, Hey S, Koonen JJ, Dimitrov IE, Friel HT, Lu Q, Obara M, Saha I, Wang H, Wang Y, Zhao Y, Temkit M, Hu HH, Chenevert TL, Togao O, Tkach JA, Nagaraj UD, Pinho MC, Gupta RK, Small JE, Kunst MM, Karis JP, Andre JB, Miller JH, Pinter NK, Pipe JG, AJNR. American journal of neuroradiology 2020 Feb 41 2 238-245
- Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
  Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 110 47 19059-64
- Two Unique Mutations in HTRA1-Related Cerebral Small Vessel Disease in North America and Africa and Literature Review.
  Shang T, Pinho M, Ray D, Khera A, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2021 Aug 30 11 106029
- Complications of liver transplantation: multimodality imaging approach.
  Caiado AH, Blasbalg R, Marcelino AS, da Cunha Pinho M, Chammas MC, da Costa Leite C, Cerri GG, de Oliveira AC, Bacchella T, Machado MC Radiographics : a review publication of the Radiological Society of North America, Inc 2007 Sep-Oct 27 5 1401-17
- Interhemispheric asymmetry of corticomotor excitability after chronic cerebellar infarcts.
  Farias da Guarda SN, Cohen LG, da Cunha Pinho M, Yamamoto FI, Marchiori PE, Scaff M, Conforto AB Cerebellum (London, England) 2010 Sep 9 3 398-404
- Clinical and Pathologic Factors Predictive of Positive Radiologic Findings in High-Risk Cutaneous Squamous Cell Carcinoma.
  Marrazzo G, Thorpe R, Condie D, Pinho MC, Srivastava D Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2015 Oct
- Machine learning in pre-operative glioma MRI: Survival predictions by perfusion-based SVM outperforms traditional MRI
  Emblem KE, Due-Tonnessen P, Hald JK, Bjornerud A, Pinho MC, Scheie D, Schad LR, Meling TR, Zoellner FG Journal of Magnetic Resonance Imaging 2013 Epub
- Three-Dimensional Shape and Surface Features Distinguish Multiple Sclerosis Lesions from Nonspecific White Matter Disease.
  Newton BD, Wright K, Winkler MD, Bovis F, Takahashi M, Dimitrov IE, Sormani MP, Pinho MC, Okuda DT Journal of neuroimaging : official journal of the American Society of Neuroimaging 2017 May
- Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population.
  Khan NI, Saherwala AA, Chen M, Salehian S, Salahuddin H, Welch BG, Pinho MC, Shang T, Cerebrovascular diseases extra 2019 Dec 9 3 139-147
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
  Tiwari V, Daoud EV, Hatanpaa KJ, Gao A, Zhang S, An Z, Ganji SK, Raisanen JM, Lewis CM, Askari P, Baxter J, Levy M, Dimitrov I, Thomas BP, Pinho MC, Madden CJ, Pan E, Patel TR, DeBerardinis RJ, Sherry AD, Mickey BE, Malloy CR, Maher EA, Choi C, Neuro-oncology 2020 Feb
- Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation.
  Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER The oncologist 2014 19 1 75-81
- Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
  Madan A, Ganji SK, An Z, Choe KS, Pinho MC, Bachoo RM, Maher EM, Choi C Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2014 Jul
- Basic MR relaxation mechanisms and contrast agent design.
  De León-Rodríguez LM, Martins AF, Pinho MC, Rofsky NM, Sherry AD Journal of magnetic resonance imaging : JMRI 2015 May
- Detection of 2-hydroxyglutarate in brain tumors by triple-refocusing MR spectroscopy at 3T in vivo.
  An Z, Ganji SK, Tiwari V, Pinho MC, Patel T, Barnett S, Pan E, Mickey BE, Maher EA, Choi C Magnetic resonance in medicine 2016 Jul
- In vivo detection of 2-hydroxyglutarate in brain tumors by optimized point-resolved spectroscopy (PRESS) at 7T.
  Ganji SK, An Z, Tiwari V, McNeil S, Pinho MC, Pan E, Mickey BE, Maher EA, Choi C Magnetic resonance in medicine 2016 Mar
- Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI.
  Liu P, Welch BG, Li Y, Gu H, King D, Yang Y, Pinho M, Lu H NeuroImage 2016 Sep
- Computer-Extracted Texture Features to Distinguish Cerebral Radionecrosis from Recurrent Brain Tumors on Multiparametric MRI: A Feasibility Study.
  Tiwari P, Prasanna P, Wolansky L, Pinho M, Cohen M, Nayate AP, Gupta A, Singh G, Hattanpaa K, Sloan A, Rogers L, Madabhushi A AJNR. American journal of neuroradiology 2016 Sep
- Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.
  Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT NPJ precision oncology 2017 1
- Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: Application for 2-hydroxyglutarate imaging in glioma patients.
  An Z, Tiwari V, Ganji SK, Baxter J, Levy M, Pinho MC, Pan E, Maher EA, Patel TR, Mickey BE, Choi C Magnetic resonance in medicine 2017 Aug
- Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression.
  Hansen MR, Pan E, Wilson A, McCreary M, Wang Y, Stanley T, Pinho MC, Guo X, Okuda DT Journal of neuro-oncology 2018 Jun
- Determining Etiology of Facial Nerve Paralysis With MRI: Challenges in Malignancy Detection.
  Tolisano AM, Hunter JB, Sakai M, Kutz JW, Moore W, Pinho M, Isaacson B, The Annals of otology, rhinology, and laryngology 2019 May 3489419848462
- Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis.
  Sivakolundu DK, Hansen MR, West KL, Wang Y, Stanley T, Wilson A, McCreary M, Turner MP, Pinho MC, Newton BD, Guo X, Rypma B, Okuda DT, Journal of neuroimaging : official journal of the American Society of Neuroimaging 2019 May
- Classification of brain tumor isocitrate dehydrogenase status using MRI and deep learning.
  Nalawade S, Murugesan GK, Vejdani-Jahromi M, Fisicaro RA, Bangalore Yogananda CG, Wagner B, Mickey B, Maher E, Pinho MC, Fei B, Madhuranthakam AJ, Maldjian JA, Journal of medical imaging (Bellingham, Wash.) 2019 Oct 6 4 046003
- Preoperative imaging of glioblastoma patients using hyperpolarized ¹³C pyruvate: Potential role in clinical decision making.
  Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Pena S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE, Park JM, Neuro-oncology advances 2021 Jan-Dec 3 1 vdab092
- Dynamic ¹³ C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans.
  Ma J, Pinho MC, Harrison CE, Chen J, Sun C, Hackett EP, Liticker J, Ratnakar J, Reed GD, Chen AP, Sherry AD, Malloy CR, Wright SM, Madden CJ, Park JM, Magnetic resonance in medicine 2021 Oct
- The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma.
  Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A, Scientific reports 2019 Dec 9 1 19898
- Evaluating Multisite rCBV Consistency from DSC-MRI Imaging Protocols and Postprocessing Software Across the NCI Quantitative Imaging Network Sites Using a Digital Reference Object (DRO).
  Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC Tomography (Ann Arbor, Mich.) 2019 Mar 5 1 110-117
- Non-contrast hemodynamic imaging of Moyamoya disease with MR fingerprinting ASL: A feasibility study.
  Su P, Liu P, Pinho MC, Thomas BP, Qiao Y, Huang J, Welch BG, Lu H, Magnetic resonance imaging 2022 Feb
- Evaluation of cerebrovascular reserve in patients with cerebrovascular diseases using resting-state MRI: A feasibility study.
  Taneja K, Lu H, Welch BG, Thomas BP, Pinho M, Lin D, Hillis AE, Liu P, Magnetic resonance imaging 2019 Jun 59 46-52
- Multiparametric estimation of brain hemodynamics with MR fingerprinting ASL.
  Su P, Mao D, Liu P, Li Y, Pinho MC, Welch BG, Lu H Magnetic resonance in medicine 2016 Dec
- Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings.
  Nakamura OK, Pinho Mda C, Odone Filho V, Rosemberg S Einstein (São Paulo, Brazil) 2012 Apr-Jun 10 2 236-8
- Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.
  Tiwari V, An Z, Ganji SK, Baxter J, Patel TR, Pan E, Mickey BE, Maher EA, Pinho MC, Choi C NMR in biomedicine 2017 May
- Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
  Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK, Nature biomedical engineering 2019 Mar 3 3 230-245
- Nonnecrotizing systemic granulomatous panniculitis involving the breast: imaging correlation of a breast cancer mimicker.
  Pinho MC, Souza F, Endo E, Chala LF, Carvalho FM, de Barros N AJR. American journal of roentgenology 2007 Jun 188 6 1573-6
- Assessment of irradiated brain metastases using dynamic contrast-enhanced magnetic resonance imaging.
  Almeida-Freitas DB, Pinho MC, Otaduy MC, Braga HF, Meira-Freitas D, da Costa Leite C Neuroradiology 2014 Mar
- External laryngocele: sonographic appearance - a case report
  Pinho MC, Viana PC, Omokawa M, Simões C, Gebrim EMMS, Cerri GG, Chammas MC Radiologia Brasileira 2007 40 4 279?282
- Intracranial Vessel Wall MRI in Clinical Practice: Technical Considerations, Current and Emerging Applications, and Clinical Pearls and Pitfalls
  Pinho, M.C.; Hall, J.T.; Cross, J.C.; Shang, T.; Madhuranthakam, A.J.; Moore, W.A Neurographics 2018 8 2 97-118(22)
- Multimodality Imaging of Cerebral Crystal-Storing Histiocytosis: Distinguishing Imaging Characteristics and a Literature Review of a Very Rare Entity
  Garg V, Mendelsohn D, Cai C, Chicoine MR, Wang TF, Pinho MC Neurographics 2019 9 1 pp. 55-61(7)
- Alterations in the RB Pathway With Inactivation of RB1 Characterize Glioblastomas With a Primitive Neuronal Component.
  Chkheidze R, Raisanen J, Gagan J, Richardson TE, Pinho MC, Raj K, Achilleos M, Slepicka C, White CL, Evers BM, Patel TR, Malter JS, Hatanpaa KJ, Journal of neuropathology and experimental neurology 2021 Dec 80 12 1092-1098
- Postsurgical Temporal Bone: A Pictorial Essay of Commonly Encountered Neuro-otologic Surgical Approaches and Postoperative Imaging Appearance
  M. Penta, M.C. Pinho, B. Isaacson, J.W. Kutz, C.L. Perez Neurographics 2016 6 May 2016 138-150(13)
- Automatic assessment of glioma burden: A deep learning algorithm for fully automated volumetric and bi-dimensional measurement.
  Chang K, Beers AL, Bai HX, Brown JM, Ly KI, Li X, Senders JT, Kavouridis VK, Boaro A, Su C, Bi WL, Rapalino O, Liao W, Shen Q, Zhou H, Xiao B, Wang Y, Zhang PJ, Pinho MC, Wen PY, Batchelor TT, Boxerman JL, Arnaout O, Rosen BR, Gerstner ER, Yang L, Huang RY, Kalpathy-Cramer J, Neuro-oncology 2019 Jun
- Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings.
  Prasanna P, Rogers L, Lam TC, Cohen M, Siddalingappa A, Wolansky L, Pinho M, Gupta A, Hatanpaa KJ, Madabhushi A, Tiwari P AJNR. American journal of neuroradiology 2019 Feb
- The defining pathology of the new clinical and histopathologic entity ACTA2-related cerebrovascular disease.
  Georgescu MM, Pinho Mda C, Richardson TE, Torrealba J, Buja LM, Milewicz DM, Raisanen JM, Burns DK Acta neuropathologica communications 2015 3 1 81
- Further diffusion tensor imaging contribution in horizontal gaze palsy and progressive scoliosis.
  Otaduy MC, Leite Cda C, Nagae LM, Pinho Mda C, Bueno C, Reed UC, Kok F Arquivos de neuro-psiquiatria 2009 Dec 67 4 1054-6
- A Novel Fully Automated Mri-Based Deep Learning Method for Classification of Idh Mutation Status in Brain Gliomas.
  Yogananda CGB, Shah BR, Vejdani-Jahromi M, Nalawade SS, Murugesan GK, Yu FF, Pinho MC, Wagner BC, Mickey B, Patel TR, Fei B, Madhuranthakam AJ, Maldjian JA, Neuro-oncology 2019 Oct
- Perforated diverticulitis of the appendix: ultrasonographic diagnosis
  Lourenço RB, Pinho MC, Schraibman V, Macedo ALV, Neto MJF, Funari MBG Einstein 2011 9 1 75-7
- Letter by Shang et al Regarding Article, "High-Resolution Magnetic Resonance Wall Imaging Findings of Moyamoya Disease"
  Shang T, Welch B, Pinho M Stroke; a journal of cerebral circulation 2014 Oct
- A generic support vector machine model for preoperative glioma survival associations.
  Emblem KE, Pinho MC, Zöllner FG, Due-Tonnessen P, Hald JK, Schad LR, Meling TR, Rapalino O, Bjornerud A Radiology 2015 Apr 275 1 228-34

Research

Neurovascular Disease
Magnetic Resonance Imaging
Head and Neck Imaging
Computed Tomography
Central Nervous System Neoplasms