- Fellowship - UT Southwestern Medical Center (1993-1996), Gastroenterology
- Residency - University of California, Irvine (1991-1993), Internal Medicine
- Internship - University of California, Irvine (1990-1991), Internal Medicine
- Medical School - Baylor College of Medicine
Marlyn Mayo, M.D.
- Internal Medicine - Digestive and Liver Diseases
- Liver Disease
- Liver Transplant Medicine
Marlyn Mayo, M.D., obtained her medical degree from Baylor College of Medicine in Houston, Texas, in 1990. After her internship and residency in internal medicine at University of California, Irvine, she completed a fellowship in gastroenterology/hepatology at UT Southwestern Medical Center.
Dr. Mayo became interested in primary biliary cirrhosis (PBC) because of her interest in autoimmune diseases. She found it very curious that the body would attack itself. Although she was initially interested in lupus and scleroderma, an attending physician she worked with during her residency inspired her to follow him into hepatology. Dr. Mayo then came to UT Southwestern to do research and work on the largest PBC trial at the time with Burton Combs, M.D., who started the liver unit at UT Southwestern. She had the opportunity to work with many patients as well as do basic lab research on the causes of PBC.
Later, Dr. Mayo worked with Peter Lipsky, M.D., to conduct research on intrahepatic cholestasis of pregnancy (ICP). She became interested in this disease because it is similar to PBC. Current research is finding some of the genes that cause this disease, which may later help her find causes of PBC. From there, Dr. Mayo started to treat other diseases that relate to pregnancy and liver diseases.
Currently, Dr. Mayo's research focuses on the pathogenesis of autoimmune liver diseases. The molecular events involved in bile duct damage in primary biliary cirrhosis and development of cryoglobulins in hepatitis C are current areas of investigation. She studies how the T cell receptors and other co-stimulatory molecules on the surface of B and T lymphocytes participate in the genesis and chronic perpetuation of autoimmune diseases. Dr. Mayo also conducts clinical trials in the UT Southwestern General Clinical Research Center investigating new treatments for primary biliary cirrhosis.
Not only does Dr. Mayo practice medicine, she also teaches it. She finds it fun to be involved in training of fellows and is now the training director for the Division of Digestive and Liver Diseases. All of UT Southwestern’s Division of Digestive and Liver Disease fellows publish papers before they leave, and some may play a role in shifting current standard medical practices. One student research project examined the causes of jaundice in pregnancy and challenges the current paradigm of viral hepatitis testing. Data from this research project suggests that patients should instead be examined by ultrasound for gallstones and treated right away.
In addition, Dr. Mayo has been involved in setting the standards for medical education. These standards are moving away from the concept of competency by numbers to conceptual competency-based evaluation. Fellows are no longer evaluated on the number of procedures they perform, but on milestones that determine a fellow is capable of working at a specialist level. Milestones include scoping with ease and comfort, as well as intake and diagnosis at a specialist level. There is also no set time period to finish their training. If a fellow takes longer to become competent, he or she will not complete their fellowship until ready. As an educator, Dr. Mayo is able to determine some of the milestones fellows must reach.
Most importantly, Dr. Mayo understands the value of active listening and good communication. To be an effective teacher and physician, she knows she must be able to listen to her students and patients and effectively explain issues to them. “Some patients know their bodies very well, and physicians can figure out their issue if they just listen,” she says.
Dr. Mayo was included in D Magazine's Best Doctors list for 2018.
Meet Dr. Mayo
Liver Disease Specialist
Marlyn Mayo, M.D., specializes in the diagnosis and management of acute and chronic liver diseases, and she enjoys establishing a friendly and supportive relationship with her patients. Dr. Mayo has a keen interest in immune-mediated liver diseases such as primary biliary cirrhosis (PBC), autoimmune hepatitis, primary sclerosing cholangitis, overlap syndromes, and liver diseases in pregnancy. She also has a special interest in the management of itching from liver disease.
"Every time a patient dies from an autoimmune disease, I want to work harder to find a cure."
Since some immune-mediated liver diseases primarily affect women, Dr. Mayo has a particular interest in evaluating pregnant women and is involved in a research study examining jaundice in pregnant women.
Dr. Mayo finds it gratifying to take a patient who was probably told she could never get pregnant, or should not get pregnant, and work with her to deal with her chronic disease. “It only takes nine months to see a baby at the end, instead of years and years of research to see results,” she says.
- American Association for the Study of Liver Diseases (AASLD), Fellow, Cholestasis SIG Steering Committee
- European Association for the Study of Liver Diseases (EASL), Member
- Anerican College of Gastroenterology(ACG), Fellow
- American Gastroenterological Association (AGA), Fellow
- D Magazine Best Doctors, Hepatology 2010-2016, Peer-nominated top 5 Hepatologists in the Dallas-Forth Worth area
Budd-Chiari Syndrome, Portal Vein Thrombosis and Other Vascular Disorders of the Liver. in Handbook of Liver Diseases
Mayo MJ and Mitchell MC (2016)
Complications of Cholestasis in Cholestatic Liver Disease 2nd edition
Ahmed A and Mayo MJ (2014), Humana Press
Primary Biliary Cirrhosis in Yamada's Textbook of Gastroenterology, 7th edition
Mayo MJ and Thiele DL (2015), Wily Blackwell
Primary Biliary Cirrhosis in Yamada's Atlas of Gastroenterology, 6th edition
Mayo MJ, Thiele DL (2015), Wily Blackwell
- Budd-Chiari Syndrome, Portal Vein Thrombosis and Other Vascular Disorders of the Liver. in Handbook of Liver Diseases
Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited scleroderma.
Mayo MJ, Jenkins RN, Combes B, Lipsky PE Hepatology (Baltimore, Md.) 1999 Jun 29 6 1635-42
Patients and patience: the pitfalls of primary biliary cirrhosis trials.
Mayo MJ Nature clinical practice. Gastroenterology & hepatology 2005 Dec 2 12 552-3
Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis.
Combes B, Emerson SS, Flye NL, Munoz SJ, Luketic VA, Mayo MJ, McCashland TM, Zetterman RK, Peters MG, Di Bisceglie AM, Benner KG, Kowdley KV, Carithers RL, Rosoff L, Garcia-Tsao G, Boyer JL, Boyer TD, Martinez EJ, Bass NM, Lake JR, Barnes DS, Bonacini M, Lindsay KL, Mills AS, Markin RS, Rubin R, West AB, Wheeler DE, Contos MJ, Hofmann AF Hepatology (Baltimore, Md.) 2005 Nov 42 5 1184-93
Natural history of primary biliary cirrhosis.
Mayo MJ Clinics in liver disease 2008 May 12 2 277-88; viii
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay.
Mayo MJ, Parkes J, Adams-Huet B, Combes B, Mills AS, Markin RS, Rubin R, Wheeler D, Contos M, West AB, Saldana S, Getachew Y, Butsch R, Luketic V, Peters M, Di Bisceglie A, Bass N, Lake J, Boyer T, Martinez E, Boyer J, Garcia-Tsao G, Barnes D, Rosenberg WM Hepatology (Baltimore, Md.) 2008 Nov 48 5 1549-57
Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production.
Omenetti A, Syn WK, Jung Y, Francis H, Porrello A, Witek RP, Choi SS, Yang L, Mayo MJ, Gershwin ME, Alpini G, Diehl AM Hepatology (Baltimore, Md.) 2009 Aug 50 2 518-27
American Association for the Study of Liver Diseases endpoints conference: design and endpoints for clinical trials in primary biliary cirrhosis.
Silveira MG, Brunt EM, Heathcote J, Gores GJ, Lindor KD, Mayo MJ Hepatology (Baltimore, Md.) 2010 Jul 52 1 349-59
The 5-D itch scale: a new measure of pruritus.
Elman S, Hynan LS, Gabriel V, Mayo MJ The British journal of dermatology 2010 Mar 162 3 587-93
Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Lasalle JM, Gershwin ME Frontiers in immunology 2014 5 128
Corrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis.
Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, LaSalle JM, Gershwin ME Frontiers in immunology 2014 5 371
Levels of Alkaline Phosphatase and Bilirubin are Surrogate Endpoints of Outcomes of Patients with Primary Biliary Cirrhosis - an International Follow-up Study.
Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HL, Invernizzi P, Mason AL, Ponsioen CY, Floreani A, Corpechot C, Mayo MJ, Battezzati PM, Parés A, Nevens F, Burroughs AK, Kowdley KV, Trivedi PJ, Kumagi T, Cheung A, Lleo A, Imam MH, Boonstra K, Cazzagon N, Franceschet I, Poupon R, Caballeria L, Pieri G, Kanwar PS, Lindor KD, Hansen BE Gastroenterology 2014 Aug
Development of a Successful Scholarly Activity and Research Program for Subspecialty Trainees.
Mayo MJ, Rockey DC The American journal of the medical sciences 2015 May
The Beneficial Effect of Beta-Blockers in Patients With Cirrhosis, Portal Hypertension and Ascites.
Aday AW, Mayo MJ, Elliott A, Rockey DC The American journal of the medical sciences 2016 Feb 351 2 169-76
Updated Etiology and Significance of Elevated Bilirubin During Pregnancy: Changes Parallel Shift in Demographics and Vaccination Status.
Duraiswamy S, Sheffield JS, Mcintire D, Leveno K, Mayo MJ Digestive diseases and sciences 2016 Sep
Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis.
Mayo MJ, Lipsky PE, Miller SN, Stastny P, Combes B Digestive diseases and sciences 2001 Feb 46 2 345-51
Sertraline as a first-line treatment for cholestatic pruritus.
Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ Hepatology (Baltimore, Md.) 2007 Mar 45 3 666-74
Hereditary haemorrhagic telangiectasia involving the bone marrow and liver.
Willis J, Mayo MJ, Rogers TE, Chen W British journal of haematology 2009 Apr 145 2 150
Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis.
Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S, Gordon S, Podda M, Gershwin ME, Selmi C, LaSalle JM Epigenetics : official journal of the DNA Methylation Society 2011 Jan 6 1 95-102
Does Preeclampsia Involve the Pancreas?, A report of original research.
Nelson DB, Duraiswamy S, McIntire DD, Mayo MJ, Leveno KJ The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2014 Jun 1-10
Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.
Trivedi PJ, Lammers WJ, van Buuren HR, Parés A, Floreani A, Janssen HL, Invernizzi P, Battezzati PM, Ponsioen CY, Corpechot C, Poupon R, Mayo MJ, Burroughs AK, Nevens F, Mason AL, Kowdley KV, Lleo A, Caballeria L, Lindor KD, Hansen BE, Hirschfield GM Gut 2015 Jan
T-cell receptor Vbeta gene utilization in primary biliary cirrhosis.
Mayo MJ, Combes B, Jenkins RN Hepatology (Baltimore, Md.) 1996 Nov 24 5 1148-55
Long term efficacy of sertraline: as a treatment for cholestatic pruritus
Browning J, Combes B, Mayo MJ Am J Gastroenterol 2003 98 2736-2741
Extrahepatic manifestations of hepatitis C
Mayo MJ American Journal of Medical Sciences 2003 325 135-148
Primary Biliary Cirrhosis
Mayo MJ, Saboorian H, Thiele DL Atlas of Gastroenterology 2003 3rd edition 2374-2387
PBC: The future
Mayo MJ Clin Liv Dis 2003 7 957-969
Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis.
Browning J, Combes B, Mayo MJ The American journal of gastroenterology 2003 Dec 98 12 2736-41
Exercise-induced weight loss preferentially reduces abdominal fat.
Mayo MJ, Grantham JR, Balasekaran G Medicine and science in sports and exercise 2003 Feb 35 2 207-13
Extrahepatic manifestations of hepatitis C infection.
Mayo MJ The American journal of the medical sciences 2003 Mar 325 3 135-48
Primary biliary cirrhosis: the future.
Mayo MJ Clinics in liver disease 2003 Nov 7 4 957-69
Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment
Selmi C, Mayo MJ, Bach M, Ishibashi H, Invernizzi P, Gish RG, Gordon SC, Wright H, Zweiban B, Podda M, Gerswhin ME Gastroenterology 2004 127 485-492
Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment.
Selmi C, Mayo MJ, Bach N, Ishibashi H, Invernizzi P, Gish RG, Gordon SC, Wright HI, Zweiban B, Podda M, Gershwin ME Gastroenterology 2004 Aug 127 2 485-92
The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases.
Mayo MJ, Mosby JM, Jeyarajah R, Combes B, Khilnani S, Al-halimi M, Handem I, Grammer AC, Lipsky PE Liver international : official journal of the International Association for the Study of the Liver 2006 Mar 26 2 187-96
Portal hypertension in primary biliary cirrhosis: a potentially reversible harbinger of demise.
Mayo MJ Gastroenterology 2008 Nov 135 5 1450-1
Safety and utility of ERCP during pregnancy.
Tang SJ, Mayo MJ, Rodriguez-Frias E, Armstrong L, Tang L, Sreenarasimhaiah J, Lara LF, Rockey DC Gastrointestinal endoscopy 2009 Mar 69 3 Pt 1 453-61
Acute pancreatitis during pregnancy.
Tang SJ, Rodriguez-Frias E, Singh S, Mayo MJ, Jazrawi SF, Sreenarasimhaiah J, Lara LF, Rockey DC Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2010 Jan 8 1 85-90
Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people.
Ferucci ED, Hurlburt KJ, Mayo MJ, Livingston S, Deubner H, Gove J, Plotnik J, McMahon BJ Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2011 Jan 25 1 21-7
Management of autoimmune hepatitis.
Mayo MJ Current opinion in gastroenterology 2011 May 27 3 224-30
Cholestatic liver disease overlap syndromes.
Mayo MJ Clinics in liver disease 2013 May 17 2 243-53
Primary biliary cirrhosis in 2014.
Flores A, Mayo MJ Current opinion in gastroenterology 2014 May 30 3 245-52
Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.
Lammers WJ, Hirschfield GM, Corpechot C, Nevens F, Lindor KD, Janssen HL, Floreani A, Ponsioen CY, Mayo MJ, Invernizzi P, Battezzati PM, Parés A, Burroughs AK, Mason AL, Kowdley KV, Kumagi T, Harms MH, Trivedi PJ, Poupon R, Cheung A, Lleo A, Caballeria L, Hansen BE, van Buuren HR Gastroenterology 2015 Aug
Predicting Outcomes of Primary Biliary Cholangitis Using the GLOBE Score.
Mayo MJ Gastroenterology & hepatology 2015 Dec 11 12 842-4
Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to Ursodeoxycholic Acid: a proof-of-concept study.
Hirschfield GM, Gershwin ME, Strauss R, Mayo MJ, Levy C, Zou B, Johanns J, Nnane IP, Dasgupta B, Li K, Selmi C, Marschall HU, Jones D, Lindor K Hepatology (Baltimore, Md.) 2015 Nov
Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases.
Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M, Hepatology (Baltimore, Md.) 2019 01 69 1 394-419
A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis.
Mayo MJ, Pockros PJ, Jones D, Bowlus CL, Levy C, Patanwala I, Bacon B, Luketic V, Vuppalanchi R, Medendorp S, Dorenbaum A, Kennedy C, Novak P, Gu J, Apostol G, Hirschfield GM, Hepatology communications 2019 Mar 3 3 365-381
NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Mayo MJ, Wigg AJ, Leggett BA, Arnold H, Thompson AJ, Weltman M, Carey EJ, Muir AJ, Ling L, Rossi SJ, DePaoli AM Hepatology communications 2018 Sep 2 9 1037-1050
Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the study of liver diseases.
Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ, Hepatology (Baltimore, Md.) 2019 Dec
- Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited scleroderma.
- Primary biliary cirrhosis
- Liver Disease in Pregnancy
- Autoimmune liver diseases
- Liver Disease
- Liver Transplant Medicine
- Cancer Screening
Q&A by Dr. Mayo
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