Michael Shiloh, M.D., Ph.D.

James P. Luby, M.D. Professorship in Infectious Diseases

Internal Medicine - Infectious Diseases and Geographic Medicine
Infectious Diseases

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Biography

Michael Shiloh, M.D., Ph.D., is an Associate Professor in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center. He specializes in infectious disease treatment and research, and he holds the James P. Luby, M.D. Professorship in Infectious Diseases.

Dr. Shiloh earned his medical degree and his doctorate in immunology at Cornell University in New York. He completed his internal medicine residency training, a fellowship in infectious diseases, and a molecular medicine fellowship at the University of California, San Francisco.

Certified in internal medicine and infectious diseases by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 2011.

Dr. Shiloh is a Fellow of the Infectious Diseases Society of America and a member of The American Society for Clinical Investigation, The American Association of Immunologists, and the American Society for Microbiology. In addition, he serves as an ad hoc reviewer for a number of scholarly journals, including the Journal of Experimental Medicine, The Journal of Clinical Investigation, and The Journal of Immunology.

At UT Southwestern, Dr. Shiloh serves on the Biosafety Committee and the Medical Scientist Training Program (MSTP) Steering Committee. In his laboratory, his long-term research goal is to discover the mechanisms by which Mycobacterium tuberculosis (Mtb) causes disease in humans. His findings have resulted in numerous articles in peer-reviewed publications, invited lectures, reviews, and book chapters.

Personal Note

When he’s not at work, Dr. Shiloh enjoys hiking, running, playing soccer, traveling, and cooking.

Education & Training

Medical School - Cornell University Medical College (1993-2001)
Residency - University of California, San Francisco (2001-2003), Internal Medicine
Fellowship - University of California at San Francisco (2003-2007), Infectious Diseases

Professional Associations & Affiliations

The American Association of Immunologists
The American Society for Clinical Investigation
American Society for Microbiology
Infectious Diseases Society of America

Honors & Awards

Disease Oriented Clinical Scholar Award 2011, UT Southwestern
Investigator in the Pathogenesis of Infectious Diseases 2018, Burroughs Wellcome Fund
Fellow 2021, Infectious Diseases Society of America
Elected member 2021, The American Society for Clinical Investigation

Books & Publications

Books
- Infectious diseases in Hospitalist Handbook
  Marciano D, Shiloh MU, Newman M (2002), San Francisco, Department of Medicine, University of California at San Francisco
- Antimicrobial mechanisms of macrophages in Phagocytosis: The Host
  Shiloh MU and Nathan C (1999), Greenwich, CT, JAI Press, Inc.
Publications
- Pathogenicity and virulence of Mycobacterium tuberculosis.
  Rahlwes KC, Dias BRS, Campos PC, Alvarez-Arguedas S, Shiloh MU, Virulence 2023 Dec 14 1 2150449
- CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses.
  Thinwa JW, Zou Z, Parks E, Sebti S, Hui KK, Wei Y, Goodarzi M, Singh V, Urquhart G, Jewell JL, Pfeiffer JK, Levine B, Reese TA, Shiloh MU, The Journal of clinical investigation 2023 Nov
- Infectious and Inflammatory Pathways to Cough.
  Naqvi KF, Mazzone SB, Shiloh MU, Annual review of physiology 2022 Sep
- BECN1^F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.
  Sebti S, Zou Z, Shiloh MU, Autophagy 2022 Aug 1-9
- Bag it, tag it: ubiquitin ligases and host resistance to Mycobacterium tuberculosis.
  Campos PC, Cunha DT, Souza-Costa LP, Shiloh MU, Franco LH, Trends in microbiology 2022 Apr
- Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis.
  Khan HS, Nair VR, Ruhl CR, Alvarez-Arguedas S, Galvan Rendiz JL, Franco LH, Huang L, Shaul PW, Kim J, Xie Y, Mitchell RB, Shiloh MU, eLife 2020 Mar 9
- Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough.
  Ruhl CR, Pasko BL, Khan HS, Kindt LM, Stamm CE, Franco LH, Hsia CC, Zhou M, Davis CR, Qin T, Gautron L, Burton MD, Mejia GL, Naik DK, Dussor G, Price TJ, Shiloh MU, Cell 2020 Mar
- Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector.
  Stamm CE, Pasko BL, Chaisavaneeyakorn S, Franco LH, Nair VR, Weigele BA, Alto NM, Shiloh MU, mSphere 2019 Jun 4 3
- A baculovirus-conjugated mimotope vaccine targeting Mycobacterium tuberculosis lipoarabinomannan.
  Shin HJ, Franco LH, Nair VR, Collins AC, Shiloh MU PloS one 2017 12 10 e0185945
- The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
  Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B Cell host & microbe 2016 Dec
- Mechanisms of mycobacterial transmission: how does Mycobacterium tuberculosis enter and escape from the human host.
  Shiloh MU Future microbiology 2016 Dec 11 1503-1506
- Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
  Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU Cell reports 2016 Jul
- Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection.
  Scharn CR, Collins AC, Nair VR, Stamm CE, Marciano DK, Graviss EA, Shiloh MU Journal of immunology (Baltimore, Md. : 1950) 2016 Jun 196 11 4641-9
- Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
  Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU Cell host & microbe 2015 Jun
- Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus.
  Stamm CE, Collins AC, Shiloh MU Immunological reviews 2015 Mar 264 1 204-19
- EBV-driven HIV-associated diffuse large B-cell lymphoma causing profound lactic acidosis.
  Prokesch BC, Shiloh MU Blood 2014 Aug 124 6 842
- The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
  Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS Nature 2013 Sep 501 7468 512-6
- cor, a Novel Carbon Monoxide Resistance Gene, Is Essential for Mycobacterium tuberculosis Pathogenesis.
  Zacharia VM, Manzanillo PS, Nair VR, Marciano DK, Kinch LN, Grishin NV, Cox JS, Shiloh MU mBio 2013 4 6
- Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.
  Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS Cell host & microbe 2012 May 11 5 469-80
- Effect of carbon monoxide on Mycobacterium tuberculosis pathogenesis.
  Zacharia VM, Shiloh MU Medical gas research 2012 2 1 30
- Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
  Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS Cell host & microbe 2010 Mar 7 3 210-20
- To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?
  Shiloh MU, DiGiuseppe Champion PA Current opinion in microbiology 2010 Feb 13 1 86-92
- Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
  Shiloh MU, Manzanillo P, Cox JS Cell host & microbe 2008 May 3 5 323-30
- A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
  Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C Molecular microbiology 2005 Jun 56 5 1234-45
- Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens.
  Nathan C, Shiloh MU Proceedings of the National Academy of Sciences of the United States of America 2000 Aug 97 16 8841-8
- Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia.
  Grobmyer SR, Barie PS, Nathan CF, Fuortes M, Lin E, Lowry SF, Wright CD, Weyant MJ, Hydo L, Reeves F, Shiloh MU, Ding A Critical care medicine 2000 May 28 5 1276-82
- Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria.
  Shiloh MU, Nathan CF Current opinion in microbiology 2000 Feb 3 1 35-42
- Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both.
  Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF Shock (Augusta, Ga.) 1999 Apr 11 4 253-8
- Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.
  Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C Immunity 1999 Jan 10 1 29-38
- Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.
  De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC Proceedings of the National Academy of Sciences of the United States of America 1997 Dec 94 25 13997-4001
- A novel antioxidant gene from Mycobacterium tuberculosis.
  Ehrt S, Shiloh MU, Ruan J, Choi M, Gunzburg S, Nathan C, Xie Q, Riley LW The Journal of experimental medicine 1997 Dec 186 11 1885-96
- Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay.
  Shiloh MU, Ruan J, Nathan C Infection and immunity 1997 Aug 65 8 3193-8

Research

Autophagy
Innate immune response to intracellular pathogens
Microbial pathogenesis
Mucosal immunology
Mycobacterium tuberculosis
Neuroimmunology

Clinical Focus

Infectious Diseases

Links

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