Mingyi Chen, M.D., Ph.D.

Harold C. Simmons Comprehensive Cancer Center

Pathology
Hematopathology and Molecular Pathology

Biography

Mingyi Chen, M.D., Ph.D., is a Professor in the Department of Pathology at UT Southwestern Medical Center. He specializes in hematopathology and has a special interest in hematolymphoid disease that involves the pulmonary and gastrointestinal systems, as well as bone marrow transplants.

Dr. Chen earned his medical degree at Peking University Health Science Center in China and his doctoral degree in pharmacology at Kyoto University in Japan. He completed a residency in pathology at University of California, San Diego and Loma Linda University Medical Center and received advanced training through a hematopathology fellowship at City of Hope National Medical Center. He also completed a postdoctoral fellowship in pathology at the University of California, Los Angeles and the Howard Hughes Medical Institute.

Certified by the American Board of Pathology in hematology and anatomic and clinical pathology, he joined the UT Southwestern faculty in 2016.

Dr. Chen’s research interests include biomarker development for cancer diagnosis, cancer stem cells, and immunotherapy; molecular pathogenesis of lymphoma and leukemia, tumor immunology, and graft-versus-host disease (GVHD); and atherosclerosis, thrombosis, vascular biology, sickle cell disease, and lipid metabolism. He is active in several research projects, including serving as Co-Investigator for a National Institutes of Health-funded study exploring the p53-Rbm38-elF4E pathway to suppress tumors.

He has contributed to numerous books, including most recently Translational Immunology, Atlas of Sinonasal Tract Pathology, and Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach. He has published more than 140 academic articles related to his areas of expertise.

Dr. Chen is a member of the United States and Canadian Academy of Pathology, the American Society of Hematology, and the American Society of Clinical Oncology. He also serves on the editorial boards of the Journal of Hematopathology, Frontiers in Oncology, and Seminars in Diagnostic Pathology. He serves as an expert reviewer for many journals and grant agencies.

Personal Note

When he’s not at work, Dr. Chen enjoys basketball and golfing.

Education & Training

Other Post Graduate Training - Kyoto University, Japan (1995-2001)
Postdoctoral Fellowship - UCLA/Howard Hughes Medical Institute (2001-2005), Pathology/lab Medicine
Fellowship - City of Hope National Medical Center (2009-2010), Hematopathology
Residency - Loma Linda University Medical Center (2006-2009), Pathology
Medical School - Peking University Health Science Center, China (1986-1992)
Graduate School - Kyoto University, Japan (1995-2001), Pharmacology
Internship - UC San Diego Health (2005-2006), Pathology

Professional Associations & Affiliations

American Society of Clinical Oncology
American Society of Hematology
United States and Canadian Academy of Pathology

Honors & Awards

Presentation Award 2014, International Society of Hematology
Travel Award 2012, American Society of Clinical Oncology

Books & Publications

Books
- Flow cytometry in the diagnosis of autoimmune related lymphoproliferative disorder and lymphoma in the head and neck region in Translational Immunology
  He L, Fuda F, Chen MY (2022), New York, NY, Elsevier
- Hematolymphoid tumors of the sinonasal tract in Atlas of Sinonasal Tract Pathology
  Rosado FGN, Chen MY (2022), Springer
- Diagnosis and management of gastrointestinal lymphoma in Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach
  Xu J, Rizivi S, Chen MY (2022), Wiley Online Books, Blackwell Publishing
- Enumeration of bone marrow plasmacytoid dendritic cells by flow cytometry in Immunophenotyping: Methods and Protocols, Methods in Molecular Biology
  Alsuwaidan A, Fuda F, Chen W, Chen MY (2019), New York, NY, Springer
- Gamma-delta T-cell lymphoma in Case Studies in Hematology and Coagulation
  Su JR, Chen MY (2018), Chicago, IL, ASCP Press
- Hematological disorders following bariatric surgery in Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects
  Qiu H, Green R, Chen MY (2016), Academic Press
- Diagnosis of primary gastrointestinal lymphomas and mimics in Oncology Series
  Chen MY, Semrad T, Wang J (2013), iConcept Press
- LOX-1, an endothelial receptor for oxidized LDL in Lipoprotein Metabolism and Atherogenesis
  Sawamura T, Chen MY, Masaki T (1998), Springer Press
- T-cell prolymphocytic leukemia (T-PLL) in Case Studies in Hematology and Coagulation
  Chen MY, Chang K (2012), Chicago, IL, ASCP Press
- Molecular biology of glycogen storage diseases in Molecular Pathology of Liver Diseases
  Chen MY (2010), Springer
- LOX-1, a potential inflammatory mediator in atherosclerosis in Inflammatory and Infectious Basis of Atherosclerosis
  Chen MY, Sawamura T (2001), Switzerland, Birkhäuser Verlag Press AG
- Northern blot analysis to quantify gene expression in vascular disease in Method in Molecular Medicine
  Chen MY, Sawamura T (1999), NJ, USA, Humana Press Inc
Publications
- Severely polarized extracellular acidity around tumour cells.
  Feng Q, Bennett Z, Grichuk A, Pantoja R, Huang T, Faubert B, Huang G, Chen M, DeBerardinis RJ, Sumer BD, Gao J, Nature biomedical engineering 2024 Mar
- Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis.
  Zhang J, Kong X, Yang HJ, Zhang W, Chen M, Chen X, The American journal of pathology 2024 Feb
- Ferredoxin 1 is essential for embryonic development and lipid homeostasis.
  Mohibi S, Zhang Y, Perng V, Chen M, Zhang J, Chen X, eLife 2024 Jan 13
- Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin.
  Kong X, Yan W, Sun W, Zhang Y, Yang HJ, Chen M, Chen H, de Vere White RW, Zhang J, Chen X, eLife 2023 Aug 12
- Clinical Features and Risk Stratification of Multiple Myeloma Patients with COVID-19.
  Zheng R, Mieth K, Bennett C, Miller C, Anderson LD, Chen M, Cao J, Cancers 2023 Jul 15 14
- Advances in molecular evaluation of myeloproliferative neoplasms.
  Li N, Chen M, Yin CC, Seminars in diagnostic pathology 2023 Apr
- Preface: Artificial intelligence (AI), machine learning ML) and digital pathology integration are the next major chapter in our diagnostic pathology and laboratory medicine arena.
  Rashidi HH, Chen M, Seminars in diagnostic pathology 2023 Mar
- Artificial intelligence in clinical multiparameter flow cytometry and mass cytometry-key tools and progress.
  Fuda F, Chen M, Chen W, Cox A, Seminars in diagnostic pathology 2023 Mar 40 2 120-128
- Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription.
  Botten G, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, Imanci A, Droin NM, Cao H, Kaphle P, Dickerson KE, Kumar KR, Chen M, Chen W, Solary E, Ly P, Zhou J, Xu J, Blood 2023 Mar
- Deep learning in digital pathology for personalized treatment plans of cancer patients.
  Wen Z, Wang S, Yang DM, Xie Y, Chen M, Bishop J, Xiao G, Seminars in diagnostic pathology 2023 Feb
- Digital pathology and artificial intelligence as the next chapter in diagnostic hematopathology.
  Lin E, Fuda F, Luu HS, Cox AM, Fang F, Feng J, Chen M, Seminars in diagnostic pathology 2023 Feb
- TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response.
  Zhang J, Sun W, Yan W, Kong X, Shen T, Laubach K, Chen M, Chen X, Cell death & disease 2023 Jan 14 1 14
- Clinical Features and Risk Stratification of Multiple Myeloma Patients with COVID-19
  Zheng R, Mieth K, Bennett C, Miller C, Anderson LD Jr, Chen M, Cao J. Cancers 2023 14 15 3598
- Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
  Patrick M, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J, Nature metabolism 2022 Nov
- Distinct mutational and clinicopathologic profiles characterize acute myeloid leukemia with cup-like nuclei.
  Oertling E, Fuda F, Koduru P, Chen M, Weinberg O, Juntilla M, Jaso J, Vusirikala M, Chung S, Geethakumari PR, Madanat YF, Collins R, Gagan J, Chen W, Leukemia research 2022 Nov 124 106995
- Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
  Mohibi S, Chen M, Chen X, Zhang J, Biochimica et biophysica acta. Molecular basis of disease 2022 Oct 1869 1 166587
- Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
  Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, Cancer discovery 2022 Oct
- CD138- Plasmablastic Lymphoma.
  Choudhuri J, Pan Z, Yuan J, Chen M, Wu X, Zheng G, Zhao C, Yuan Y, Agarwal B, Liu J, Ma MY, Wang Y, Shi Y, Archives of pathology & laboratory medicine 2022 Sep
- Preface of the Special Issue "COVID-19 Infection and Hematological Malignancies".
  Chen M, Anderson LD, Cancers 2022 Sep 14 18
- Epstein-Barr Virus-Positive Plasma Cell Neoplasm of Nasal Cavity in an Immunocompetent Adult.
  He L, Ryan MW, Chen M, JAMA otolaryngology-- head & neck surgery 2022 Aug
- Sprod for de-noising spatially resolved transcriptomics data based on position and image information.
  Wang Y, Song B, Wang S, Chen M, Xie Y, Xiao G, Wang L, Wang T, Nature methods 2022 Aug 19 8 950-958
- Hematologic Complications in Patients Hospitalized with COVID-19 Infection.
  Lin E, Araj E, Markantonis J, Luu H, Chen M, Hematology reports 2022 Jul 14 3 228-234
- A Combined Biomarker of Bright CD38 and MYC =55% Is Highly Predictive of Double-/Triple-Hit High-Grade B-Cell Lymphoma.
  Alsuwaidan A, Koduru P, Fuda F, Manuel Jaso J, Chen M, Rosado F, Luu HS, Sweed N, Garcia R, Doucet M, Desai NB, Kumar KA, Awan FT, Ramakrishnan Geethakumari P, Chen W, American journal of clinical pathology 2022 May
- p73a1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.
  Laubach KN, Yan W, Kong X, Sun W, Chen M, Zhang J, Chen X, Proceedings of the National Academy of Sciences of the United States of America 2022 May 119 22 e2123202119
- SARS-CoV-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia.
  Lee NC, Patel BA, Etra AM, Bat T, Ibrahim IF, Vusirikala M, Chen M, Rosado F, Jaso JM, Young NS, Chen W, Blood advances 2022 Apr
- Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature.
  Matsumoto NP, Yuan J, Wang J, Shen Q, Chen X, Kim Y, Zuppan CW, Chang CC, Cui W, Chen D, Shi M, Gisriel SD, Chen M, Xu ML, Pan Z, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Feb
- Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway.
  Zhang Y, Mohibi S, Vasilatis DM, Chen M, Zhang J, Chen X, Oncogene 2022 Feb
- The RNA-binding protein RBM24 regulates lipid metabolism and SLC7A11 mRNA stability to modulate ferroptosis and inflammatory response
  Jin Zhang, Xiangmudong Kong, Wenqiang Sun, Leyi Wang, Mingyi Chen, and Xinbin Chen Frontiers in Cell and Developmental Biology 2022
- Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics
  Gisriel SD, Yuan J, Braunberger RC, Maracaja DLV, Chen X, Wu X, McCracken J, Chen M, Xie Y, Brown LE, Li P, Zhou Y, Sethi T, McHenry A, Hauser RG, Paulson N, Tang H, Hsi ED, Wang E, Zhang QY, Young KH, Xu ML, Pan Z. Mod Pathol 2022 . 2022 May 13. doi: 10.1038/s41379-022-01091-x
- The Utility of Flow Cytometry in the Diagnosis of Pulmonary Hematolymphoid Neoplasms: Single Institution Experience
  Yang, L., Mani, M., Fu, M., Chen, W., Fuda, F. S. and Chen, M Hematopathology 2022 7 2 p.11?15.
- Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.
  Hannan R, Mohamad O, Diaz de Leon A, Manna S, Pop LM, Zhang Z, Mannala S, Christie A, Christley S, Monson N, Ishihara D, Hsu EJ, Ahn C, Kapur P, Chen M, Arriaga Y, Courtney K, Cantarel B, Wakeland EK, Fu YX, Pedrosa I, Cowell L, Wang T, Margulis V, Choy H, Timmerman RD, Brugarolas J, Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Sep
- Myeloid/lymphoid neoplasm with FGFR1 rearrangement.
  Germans SK, Chen M, Blood 2021 Sep 138 10 912
- Lymphadenopathy with florid lymphoid and Langerhans cell hyperplasia and hemophagocytosis mimicking lymphoma after COVID-19 mRNA vaccination.
  Tintle S, Chen M, EJHaem 2021 Aug
- A Machine Learning Tool Using Digital Microscopy (Morphogo) for the Identification of Abnormal Lymphocytes in the Bone Marrow.
  Tang G, Fu X, Wang Z, Chen M, Acta cytologica 2021 Jul 65 4 354-357
- Mice deficient in the RNA binding protein Zfp871 are prone to early death and steatohepatitis in part through the p53-Mdm2 axis.
  Mohibi S, Zhang J, Chen M, Chen X, Molecular cancer research : MCR 2021 Jul
- Small Proline-Rich Protein 2A and 2D Are Regulated by the RBM38-p73 Axis and Associated with p73-Dependent Suppression of Chronic Inflammation.
  Kong X, Wang D, Sun W, Chen M, Chen J, Shi J, Zhang J, Chen X, Cancers 2021 Jun 13 11
- Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38.
  Sun W, Laubach K, Lucchessi C, Zhang Y, Chen M, Zhang J, Chen X, Genes & development 2021 Mar
- Circulating dividing plasma cells with giant dumbbell-shaped nuclei
  Elisa Lin, Prasad Koduru, Mingyi Chen eJHaem. 2021 2 https://doi.org/10.1002/jha2.330 867?868
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
  Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, Cancer cell 2020 Dec
- Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
  Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ, Science translational medicine 2020 Nov 12 571
- DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
  Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, Ren Z, Liang Y, Liu Z, Han C, Liu L, Cao X, Zhang A, Qiao J, Batten K, Chen M, Castrillon DH, Wang T, Li B, Diaz LA, Li GM, Fu YX, Cancer cell 2020 Nov
- PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade.
  Peng Q, Qiu X, Zhang Z, Zhang S, Zhang Y, Liang Y, Guo J, Peng H, Chen M, Fu YX, Tang H, Nature communications 2020 09 11 1 4835
- Morphogo: An Automatic Bone Marrow Cell Classification System on Digital Images Analyzed by Artificial Intelligence.
  Fu X, Fu M, Li Q, Peng X, Lu J, Fang F, Chen M, Acta cytologica 2020 Jul 1-9
- Application of flow cytometry in the analysis of lymphoid disease in the lung and pleural space.
  May F, Malary M, Jaclyn B, Weina C, Mingyi C, Franklin F, Seminars in diagnostic pathology 2020 Jun
- Special issue on diagnosis of primary hematolymphoid disease of the lung and pleura.
  Chen M, Seminars in diagnostic pathology 2020 Jun
- FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
  Zhang J, Kong X, Zhang Y, Sun W, Wang J, Chen M, Chen X, The Journal of pathology 2020 Apr
- Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes.
  Lu T, Wang S, Xu L, Zhou Q, Singla N, Gao J, Manna S, Pop L, Xie Z, Chen M, Luke JJ, Brugarolas J, Hannan R, Wang T, Science immunology 2020 Feb 5 44
- Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.
  Zhang J, Sun W, Kong X, Zhang Y, Yang HJ, Ren C, Jiang Y, Chen M, Chen X, Proceedings of the National Academy of Sciences of the United States of America 2019 Nov
- Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity.
  Liu Z, Han C, Dong C, Shen A, Hsu E, Ren Z, Lu C, Liu L, Zhang A, Timmerman C, Pu Y, Wang Y, Chen M, Qiao J, Fu YX, Science immunology 2019 Aug 4 38
- Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.
  Zhang Y, Feng X, Zhang J, Chen M, Huang E, Chen X, Oncogene 2019 Jul
- Philadelphia chromosome-negative acute leukemia in chronic myeloid leukemia.
  Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S, American journal of hematology 2019 Jul
- Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
  Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J, Cancer discovery 2019 Jun
- CD123 a novel biomaker for diagnosis and treatment of leukemia.
  Shi M, Jeanna Su R, Parmar KP, Chaudhry R, Sun K, Rao J, Chen M, Cardiovascular & hematological disorders drug targets 2019 Jun
- Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
  Yuan J, Li S, Liu X, Su RJ, Chen M, Wu X, Zheng G, Smith LM, Wang L, Li Y, Liu C, Zhou J, Shen Q, Zhang L, Wang E, Xu ML, Pan Z, American journal of clinical pathology 2019 May
- Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.
  Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L Immunity 2019 Feb
- Evolving myelodysplastic syndrome in an HIV patient with history of anal cancer and chemotherapy
  Shi M, Hu X, Chen M Journal of Hematopathology, 2019 (4) 12 213-214
- Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
  Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L The Journal of clinical investigation 2018 Dec
- Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression.
  Lucchesi CA, Zhang J, Ma B, Chen M, Chen X Cancer research 2018 Dec
- An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.
  Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J Cancer discovery 2018 Jun
- Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas.
  Henderson T, Chen M, Darrow MA, Li CS, Chiu CL, Monjazeb AM, Murphy WJ, Canter RJ The Journal of surgical research 2018 Mar 223 207-214
- The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.
  Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X Oncogene 2018 Mar
- PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
  Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX The Journal of clinical investigation 2018 Feb 128 2 580-588
- CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall.
  Pan Z, Chen M, Zhang Q, Wang E, Yin L, Xu Y, Huang Q, Yuan Y, Zhang X, Zheng G, Yuan J Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Jan
- Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
  Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ Journal for immunotherapy of cancer 2017 Dec 5 1 98
- Erythrophagocytosis by T-cell lymphoma cells in a patient with hereditary spherocytosis post-splenectomy.
  Frame IJ, Coberly J, Fuda FS, Chen M British journal of haematology 2017 Nov
- Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner.
  Yang HJ, Zhang J, Yan W, Cho SJ, Lucchesi C, Chen M, Huang EC, Scoumanne A, Zhang W, Chen X Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 114 43 11500-11505
- Enumeration of bone marrow plasmacytoid dendritic cells by multiparameter flow cytometry as a prognostic marker following allogeneic hematopoietic stem cell transplantation.
  Su RJ, Green R, Chen M Blood cells, molecules & diseases 2017 Oct
- Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
  Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Huang E, Lloyd K, Duan Y, Wang J, Liu G, Chen X Genes & development 2017 Jul
- Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia.
  Su RJ, Jonas BA, Welborn J, Gregg JP, Chen M Human pathology (New York) 2016 Sep 5 6-9
- Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies.
  Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, T N Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Sep 22 17 4328-40
- Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD).
  Matsukuma KE, Wei D, Sun K, Ramsamooj R, Chen M Journal of gastrointestinal oncology 2016 Apr 7 Suppl 1 S21-31
- Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer.
  Mall C, Sckisel GD, Proia DA, Mirsoian A, Grossenbacher SK, Pai CS, Chen M, Monjazeb AM, Kelly K, Blazar BR, Murphy WJ Oncoimmunology 2016 Feb 5 2 e1075114
- Expression of Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy
  Chen M, Qiu H, Lin X, Nam D, Ogbu-Nwobodo L, Archibald H, Joslin A, Wun T, Sawamura T, Green R Blood Cells, Molecules and Diseases 2016 60 September 44-8
- Acute Myeloid Leukemia with Isolated Trisomy 19 Associated with Diffuse Myelofibrosis and Osteosclerosis.
  Stelling A, Jonas BA, Rashidi HH, Abedi M, Chen M Cancers 2015 Dec 7 4 2459-65
- NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.
  Ames E, Canter RJ, Grossenbacher SK, Mac S, Chen M, Smith RC, Hagino T, Perez-Cunningham J, Sckisel GD, Urayama S, Monjazeb AM, Fragoso RC, Sayers TJ, Murphy WJ, Journal of immunology (Baltimore, Md. : 1950) 2015 Oct 195 8 4010-9
- Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells.
  Ames E, Canter RJ, Grossenbacher SK, Mac S, Smith RC, Monjazeb AM, Chen M, Murphy WJ Oncoimmunology 2015 Sep 4 9 e1036212
- Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors.
  Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff RD, Imai DM, Wisner E, Chen X Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 111 52 18637-42
- Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
  Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ The Journal of experimental medicine 2014 Nov 211 12 2373-83
- Increased antitumor effects using IL-2 with anti-TGF-? reveals competition between mouse NK and CD8 T cells.
  Alvarez M, Bouchlaka MN, Sckisel GD, Sungur CM, Chen M, Murphy WJ Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 193 4 1709-16
- Therapeutic benefit of bortezomib on acute GVHD is tissue specific and is associated with IL-6 levels.
  Steven Pai CC, Hsiao HH, Sun K, Chen M, Hagino T, Tellez J, Mall C, Blazar BR, Monjazeb A, Abedi M, Murphy WJ Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2014 Jul
- Treatment of chronic graft versus host disease with bortezomib.
  Pai CC, Chen M, Mirsoian A, Grossenbacher SK, Tellez J, Ames E, Sun K, Jagdeo J, Blazar BR, Murphy WJ, Abedi M Blood 2014 Jul
- Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma.
  Canter RJ, Ames E, Mac S, Grossenbacher SK, Chen M, Li CS, Borys D, Smith RC, Tellez J, Sayers TJ, Monjazeb AM, Murphy WJ BMC cancer 2014 14 1 756
- Detection of Epstein-Barr virus (EBV) in human lymphoma tissue by a novel microbial detection array.
  Tellez J, Jaing C, Wang J, Green R, Chen M Biomarker research 2014 2 1 24
- Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
  Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ The Journal of experimental medicine 2013 Oct 210 11 2223-37
- Circulating plasma cells with Russell bodies in osteosclerotic myeloma.
  Chen M, Green R Blood 2013 Jul 122 2 160
- Colonic graft-versus-host disease (GVHD) manifesting as eosinophilic colitis following autologous hematopoietic stem cell transplantation.
  Chen M, Olson K Blood 2013 May 121 20 4020
- Murine natural killer cell licensing and regulation by T regulatory cells in viral responses.
  Sungur CM, Tang-Feldman YJ, Ames E, Alvarez M, Chen M, Longo DL, Pomeroy C, Murphy WJ Proceedings of the National Academy of Sciences of the United States of America 2013 Apr
- Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation.
  Chen M, Krishnamurthy A, Mohamed AR, Green R BioMed research international 2013 2013 205467
- Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
  Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ Blood 2012 Feb 119 6 1590-8
- Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
  Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P, The Journal of clinical investigation 2007 Aug 117 8 2337-46
- Phosphorylation of the liver X receptors.
  Chen M, Bradley MN, Beaven SW, Tontonoz P, FEBS letters 2006 Sep 580 20 4835-41
- Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
  Chen M, Beaven S, Tontonoz P, Journal of lipid research 2005 Dec 46 12 2570-9
- Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.
  Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P, The Journal of biological chemistry 2005 Aug 280 32 29256-62
- A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
  Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T Cell metabolism 2005 Mar 1 3 201-13
- The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
  Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P Molecular and cellular biology 2003 Mar 23 6 2182-91
- LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
  Chen M, Masaki T, Sawamura T, Pharmacology & therapeutics 2002 Jul 95 1 89-100
- Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.
  Chen M, Narumiya S, Masaki T, Sawamura T, The Biochemical journal 2001 Apr 355 Pt 2 289-96
- Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
  Chen M, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T, Arteriosclerosis, thrombosis, and vascular biology 2000 Apr 20 4 1107-15

Research

Biomarker development for cancer diagnosis, cancer stem cells, and immunotherapy
Molecular pathogenesis of lymphoma and leukemia, tumor immunology, and graft-versus-host disease
Atherosclerosis, thrombosis, vascular biology, sickle cell disease, and lipid metabolism

Clinical Focus

Hematopathology and Molecular Pathology