Mingyi Chen, M.D., Ph.D.

Pathology

Education & Training

Other Post Graduate Training - Kyoto University, Japan (1995-2001)
Fellowship - City of Hope National Medical Center (2009-2010), Hematopathology
Residency - Loma Linda University Medical Center (2006-2009), Pathology
Medical School - Peking University Health Science Center, China (1986-1992)
Graduate School - Kyoto University, Japan (1995-2001), Pharmacology
Internship - UC San Diego Health (2005-2006), Pathology
Postdoctoral Fellowship - UCLA/Howard Hughes Medical Institute (2001-2005), Pathology/lab Medicine

Books & Publications

Books
- Molecular Biology of Glycogen Storage Diseases in Molecular Pathology of Liver Diseases
  Chen M. (2010), Springer's ISBN 978-1-4419-7106-7, pp. 677-682., P.S. Monga. eds. Philip T. Cagle, editor., (ed),
- Hematological disorders following bariatric surgery. in Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects.
  Qiu H, Green R, Chen M (2016), Victor Preedy, (ed), Academic Press.
Publications
- Small Proline-Rich Protein 2A and 2D Are Regulated by the RBM38-p73 Axis and Associated with p73-Dependent Suppression of Chronic Inflammation.
  Kong X, Wang D, Sun W, Chen M, Chen J, Shi J, Zhang J, Chen X, Cancers 2021 Jun 13 11
- FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
  Zhang J, Kong X, Zhang Y, Sun W, Wang J, Chen M, Chen X, The Journal of pathology 2020 Apr
- Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes.
  Lu T, Wang S, Xu L, Zhou Q, Singla N, Gao J, Manna S, Pop L, Xie Z, Chen M, Luke JJ, Brugarolas J, Hannan R, Wang T, Science immunology 2020 Feb 5 44
- Evolving myelodysplastic syndrome in an HIV patient with history of anal cancer and chemotherapy
  Shi M, Hu X, Chen M Journal of Hematopathology, 2019 (4) 12 213-214
- Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
  Chen M, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T, Arteriosclerosis, thrombosis, and vascular biology 2000 Apr 20 4 1107-15
- Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.
  Zhang Y, Feng X, Zhang J, Chen M, Huang E, Chen X, Oncogene 2019 Jul
- Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.
  Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P, The Journal of biological chemistry 2005 Aug 280 32 29256-62
- A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
  Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T Cell metabolism 2005 Mar 1 3 201-13
- Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
  Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J, Cancer discovery 2019 Jun
- CD123 a novel biomaker for diagnosis and treatment of leukemia.
  Shi M, Jeanna Su R, Parmar KP, Chaudhry R, Sun K, Rao J, Chen M, Cardiovascular & hematological disorders drug targets 2019 Jun
- Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression.
  Lucchesi CA, Zhang J, Ma B, Chen M, Chen X Cancer research 2018 Dec
- Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
  Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L The Journal of clinical investigation 2018 Dec
- PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
  Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX The Journal of clinical investigation 2018 Feb 128 2 580-588
- Erythrophagocytosis by T-cell lymphoma cells in a patient with hereditary spherocytosis post-splenectomy.
  Frame IJ, Coberly J, Fuda FS, Chen M British journal of haematology 2017 Nov
- Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner.
  Yang HJ, Zhang J, Yan W, Cho SJ, Lucchesi C, Chen M, Huang EC, Scoumanne A, Zhang W, Chen X Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 114 43 11500-11505
- Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma.
  Canter RJ, Ames E, Mac S, Grossenbacher SK, Chen M, Li CS, Borys D, Smith RC, Tellez J, Sayers TJ, Monjazeb AM, Murphy WJ BMC cancer 2014 14 1 756
- Detection of Epstein-Barr virus (EBV) in human lymphoma tissue by a novel microbial detection array.
  Tellez J, Jaing C, Wang J, Green R, Chen M Biomarker research 2014 2 1 24
- Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia.
  Su RJ, Jonas BA, Welborn J, Gregg JP, Chen M Human pathology (New York) 2016 Sep 5 6-9
- The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.
  Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X Oncogene 2018 Mar
- Circulating plasma cells with Russell bodies in osteosclerotic myeloma.
  Chen M, Green R Blood 2013 Jul 122 2 160
- Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells.
  Ames E, Canter RJ, Grossenbacher SK, Mac S, Smith RC, Monjazeb AM, Chen M, Murphy WJ Oncoimmunology 2015 Sep 4 9 e1036212
- Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors.
  Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff RD, Imai DM, Wisner E, Chen X Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 111 52 18637-42
- Colonic graft-versus-host disease (GVHD) manifesting as eosinophilic colitis following autologous hematopoietic stem cell transplantation.
  Chen M, Olson K Blood 2013 May 121 20 4020
- Special issue on diagnosis of primary hematolymphoid disease of the lung and pleura.
  Chen M, Seminars in diagnostic pathology 2020 Jun
- Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
  Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ Journal for immunotherapy of cancer 2017 Dec 5 1 98
- Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.
  Hannan R, Mohamad O, Diaz de Leon A, Manna S, Pop LM, Zhang Z, Mannala S, Christie A, Christley S, Monson N, Ishihara D, Hsu EJ, Ahn C, Kapur P, Chen M, Arriaga Y, Courtney K, Cantarel B, Wakeland EK, Fu YX, Pedrosa I, Cowell L, Wang T, Margulis V, Choy H, Timmerman RD, Brugarolas J, Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Sep
- A Machine Learning Tool Using Digital Microscopy (Morphogo) for the Identification of Abnormal Lymphocytes in the Bone Marrow.
  Tang G, Fu X, Wang Z, Chen M, Acta cytologica 2021 Jul 65 4 354-357
- Mice deficient in the RNA binding protein Zfp871 are prone to early death and steatohepatitis in part through the p53-Mdm2 axis.
  Mohibi S, Zhang J, Chen M, Chen X, Molecular cancer research : MCR 2021 Jul
- Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38.
  Sun W, Laubach K, Lucchessi C, Zhang Y, Chen M, Zhang J, Chen X, Genes & development 2021 Mar
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
  Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, Cancer cell 2020 Dec
- DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
  Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, Ren Z, Liang Y, Liu Z, Han C, Liu L, Cao X, Zhang A, Qiao J, Batten K, Chen M, Castrillon DH, Wang T, Li B, Diaz LA, Li GM, Fu YX, Cancer cell 2020 Nov
- Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
  Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ, Science translational medicine 2020 Nov 12 571
- PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade.
  Peng Q, Qiu X, Zhang Z, Zhang S, Zhang Y, Liang Y, Guo J, Peng H, Chen M, Fu YX, Tang H, Nature communications 2020 09 11 1 4835
- Application of flow cytometry in the analysis of lymphoid disease in the lung and pleural space.
  May F, Malary M, Jaclyn B, Weina C, Mingyi C, Franklin F, Seminars in diagnostic pathology 2020 Jun
- Morphogo: An Automatic Bone Marrow Cell Classification System on Digital Images Analyzed by Artificial Intelligence.
  Fu X, Fu M, Li Q, Peng X, Lu J, Fang F, Chen M, Acta cytologica 2020 Jul 1-9
- NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.
  Ames E, Canter RJ, Grossenbacher SK, Mac S, Chen M, Smith RC, Hagino T, Perez-Cunningham J, Sckisel GD, Urayama S, Monjazeb AM, Fragoso RC, Sayers TJ, Murphy WJ, Journal of immunology (Baltimore, Md. : 1950) 2015 Oct 195 8 4010-9
- Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.
  Chen M, Narumiya S, Masaki T, Sawamura T, The Biochemical journal 2001 Apr 355 Pt 2 289-96
- LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
  Chen M, Masaki T, Sawamura T, Pharmacology & therapeutics 2002 Jul 95 1 89-100
- Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.
  Zhang J, Sun W, Kong X, Zhang Y, Yang HJ, Ren C, Jiang Y, Chen M, Chen X, Proceedings of the National Academy of Sciences of the United States of America 2019 Nov
- Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity.
  Liu Z, Han C, Dong C, Shen A, Hsu E, Ren Z, Lu C, Liu L, Zhang A, Timmerman C, Pu Y, Wang Y, Chen M, Qiao J, Fu YX, Science immunology 2019 Aug 4 38
- Philadelphia chromosome-negative acute leukemia in chronic myeloid leukemia.
  Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S, American journal of hematology 2019 Jul
- The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
  Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P Molecular and cellular biology 2003 Mar 23 6 2182-91
- Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
  Chen M, Beaven S, Tontonoz P, Journal of lipid research 2005 Dec 46 12 2570-9
- Phosphorylation of the liver X receptors.
  Chen M, Bradley MN, Beaven SW, Tontonoz P, FEBS letters 2006 Sep 580 20 4835-41
- Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
  Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P, The Journal of clinical investigation 2007 Aug 117 8 2337-46
- Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
  Yuan J, Li S, Liu X, Su RJ, Chen M, Wu X, Zheng G, Smith LM, Wang L, Li Y, Liu C, Zhou J, Shen Q, Zhang L, Wang E, Xu ML, Pan Z, American journal of clinical pathology 2019 May
- Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
  Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ Blood 2012 Feb 119 6 1590-8
- Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation.
  Chen M, Krishnamurthy A, Mohamed AR, Green R BioMed research international 2013 2013 205467
- Murine natural killer cell licensing and regulation by T regulatory cells in viral responses.
  Sungur CM, Tang-Feldman YJ, Ames E, Alvarez M, Chen M, Longo DL, Pomeroy C, Murphy WJ Proceedings of the National Academy of Sciences of the United States of America 2013 Apr
- Therapeutic benefit of bortezomib on acute GVHD is tissue specific and is associated with IL-6 levels.
  Steven Pai CC, Hsiao HH, Sun K, Chen M, Hagino T, Tellez J, Mall C, Blazar BR, Monjazeb A, Abedi M, Murphy WJ Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2014 Jul
- Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD).
  Matsukuma KE, Wei D, Sun K, Ramsamooj R, Chen M Journal of gastrointestinal oncology 2016 Apr 7 Suppl 1 S21-31
- Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer.
  Mall C, Sckisel GD, Proia DA, Mirsoian A, Grossenbacher SK, Pai CS, Chen M, Monjazeb AM, Kelly K, Blazar BR, Murphy WJ Oncoimmunology 2016 Feb 5 2 e1075114
- Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies.
  Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, T N Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Sep 22 17 4328-40
- An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.
  Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J Cancer discovery 2018 Jun
- Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
  Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Huang E, Lloyd K, Duan Y, Wang J, Liu G, Chen X Genes & development 2017 Jul
- Lymphadenopathy with florid lymphoid and Langerhans cell hyperplasia and hemophagocytosis mimicking lymphoma after COVID-19 mRNA vaccination.
  Tintle S, Chen M, EJHaem 2021 Aug
- Myeloid/lymphoid neoplasm with FGFR1 rearrangement.
  Germans SK, Chen M, Blood 2021 Sep 138 10 912
- Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.
  Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L Immunity 2019 Feb
- Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas.
  Henderson T, Chen M, Darrow MA, Li CS, Chiu CL, Monjazeb AM, Murphy WJ, Canter RJ The Journal of surgical research 2018 Mar 223 207-214
- Enumeration of bone marrow plasmacytoid dendritic cells by multiparameter flow cytometry as a prognostic marker following allogeneic hematopoietic stem cell transplantation.
  Su RJ, Green R, Chen M Blood cells, molecules & diseases 2017 Oct
- CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall.
  Pan Z, Chen M, Zhang Q, Wang E, Yin L, Xu Y, Huang Q, Yuan Y, Zhang X, Zheng G, Yuan J Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Jan
- Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
  Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ The Journal of experimental medicine 2013 Oct 210 11 2223-37
- Increased antitumor effects using IL-2 with anti-TGF-ß reveals competition between mouse NK and CD8 T cells.
  Alvarez M, Bouchlaka MN, Sckisel GD, Sungur CM, Chen M, Murphy WJ Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 193 4 1709-16
- Treatment of chronic graft versus host disease with bortezomib.
  Pai CC, Chen M, Mirsoian A, Grossenbacher SK, Tellez J, Ames E, Sun K, Jagdeo J, Blazar BR, Murphy WJ, Abedi M Blood 2014 Jul
- Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
  Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ The Journal of experimental medicine 2014 Nov 211 12 2373-83
- Acute Myeloid Leukemia with Isolated Trisomy 19 Associated with Diffuse Myelofibrosis and Osteosclerosis.
  Stelling A, Jonas BA, Rashidi HH, Abedi M, Chen M Cancers 2015 Dec 7 4 2459-65
- Expression of Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy
  Chen M, Qiu H, Lin X, Nam D, Ogbu-Nwobodo L, Archibald H, Joslin A, Wun T, Sawamura T, Green R Blood Cells, Molecules and Diseases 2016 60 September 44-8

Research

Viral infections and cancergenesis, and cancer stem cells
Sickle cell disease, thrombosis, and vascular biology
Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD