Nikhil Munshi, M.D., Ph.D.

Internal Medicine - Cardiology

Biography

Nikhil Munshi, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He serves as the Assistant Director of the Division of Cardiology’s Physician Scientist Training Program and specializes in general cardiology.

Dr. Munshi earned his medical degree and his doctorate in biochemistry at Columbia University. He completed his residency in internal medicine and fellowship in cardiology at UT Southwestern. In addition, he performed postdoctoral fellowships in molecular cardiology and developmental biology at Columbia and UT Southwestern.

Certified by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 2011.

Dr. Munshi’s research focuses on cardiac rhythms in health and disease.

He is a member of the Alpha Omega Alpha Honor Medical Society, the American College of Cardiology, the American Heart Association, the American Medical Association, the Dallas County Medical Society, and the Texas Medical Association.

Education & Training

Residency - UT Southwestern Medical Center (2005-2006), Internal Medicine
Internship - UT Southwestern Medical Center (2004-2005), Internal Medicine
Fellowship - UT Southwestern Medical Center (2006-2011), Cardiology
Medical School - Columbia University Medical Center (1995-2003)
Graduate School - Columbia University College of Physicians and Surgeons (1977-2001), Biochemistry

Professional Associations & Affiliations

Texas Medical Association
Dallas County Medical Society
American Medical Association
American Heart Association
American College of Cardiology
Alpha Omega Alpha

Honors & Awards

Fellows Basic Science Winner - Northwestern Cardiovascular Young Investigators’ Forum 2008
Young Investigator Award for Basic Science - American Association of Indian Cardiologists 2011
Jo Ann McWhorter Award for Clinical Cardiology 2011
Disease Oriented Clinical Scholar (DOCS) Award 2011
Career Award for Medical Scientists (CAMS) - Burroughs Wellcome Foundation 2011

Books & Publications

Publications
- Inducible cardiomyocyte injury within the atrioventricular conduction system uncovers latent regenerative capacity in mice.
  Wang L, Bhakta M, Fernandez-Perez A, Munshi NV, The Journal of clinical investigation 2021 Oct 131 19
- Development of the Cardiac Conduction System.
  Bhattacharyya S, Munshi NV, Cold Spring Harbor perspectives in biology 2020 Jan
- Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.
  Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV Scientific reports 2019 Feb 9 1 2106
- pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.
  Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV Developmental dynamics : an official publication of the American Association of Anatomists 2019 Feb 248 2 173-188
- Hand2 selectively reorganizes chromatin accessibility to induce pacemaker-like transcriptional reprogramming
  Fernandez-Perez A, Sathe AA,Bhakta M,Leggett K,Xing C,Munshi NV Cell Reports 2019 27 1-16
- Rational reprogramming of cellular states by combinatorial perturbation
  Duan J, Li B, Bhakta M, Xie S, Zhou P, Munshi NV*, Hon GC* Cell Reports 2019
- PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues.
  Bhattacharyya S, Sathe AA, Bhakta M, Xing C, Munshi NV, PloS one 2019 14 4 e0214677
- Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device.
  Lam KH, Fernandez-Perez A, Schmidtke DW, Munshi NV Biomedical microdevices 2018 Jun 20 3 52
- High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.
  Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ Scientific reports 2018 Jan 8 1 1258
- Resident Macrophages: Near and Dear to Your Heart.
  Munshi NV Cell 2017 Apr 169 3 376-377
- The Promise of Cardiac Regeneration by In Situ Lineage Conversion.
  Nam YJ, Munshi NV Circulation 2017 Mar 135 10 914-916
- Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.
  Fernandez-Perez A, Munshi NV Journal of visualized experiments : JoVE 2017 Mar 121
- Phenotypically silent Cre recombination within the postnatal ventricular conduction system.
  Bhattacharyya S, Bhakta M, Munshi NV PloS one 2017 12 3 e0174517
- CRISPR (Clustered Regularly Interspaced Palindromic Repeat)/Cas9 System: A Revolutionary Disease-Modifying Technology.
  Munshi NV Circulation 2016 Sep 134 11 777-9
- MyoR Modulates Cardiac Conduction by Repressing Gata4.
  Harris JP, Bhakta M, Bezprozvannaya S, Wang L, Lubczyk C, Olson EN, Munshi NV Molecular and cellular biology 2015 Feb 35 4 649-61
- Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.
  Nam YJ, Lubczyk C, Bhakta M, Zang T, Fernandez-Perez A, McAnally J, Bassel-Duby R, Olson EN, Munshi NV Development (Cambridge, England) 2014 Oct
- Translational medicine. Improving cardiac rhythm with a biological pacemaker.
  Munshi NV, Olson EN Science (New York, N.Y.) 2014 Jul 345 6194 268-9
- Gene regulatory networks in cardiac conduction system development.
  Munshi NV Circulation research 2012 May 110 11 1525-37
- Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay.
  Munshi NV, McAnally J, Bezprozvannaya S, Berry JM, Richardson JA, Hill JA, Olson EN Development (Cambridge, England) 2009 Aug 136 15 2665-74
- Coordination of a transcriptional switch by HMGI(Y) acetylation.
  Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D Science (New York, N.Y.) 2001 Aug 293 5532 1133-6
- Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.
  Fedele M, Pierantoni GM, Berlingieri MT, Battista S, Baldassarre G, Munshi N, Dentice M, Thanos D, Santoro M, Viglietto G, Fusco A Cancer research 2001 Jun 61 11 4583-90
- The architectural transcription factor high mobility group I(Y) participates in photoreceptor-specific gene expression.
  Chau KY, Munshi N, Keane-Myers A, Cheung-Chau KW, Tai AK, Manfioletti G, Dorey CK, Thanos D, Zack DJ, Ono SJ The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Oct 20 19 7317-24
- An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.
  O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A Molecular and cellular biology 2000 Oct 20 20 7572-82
- The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.
  Yie J, Merika M, Munshi N, Chen G, Thanos D The EMBO journal 1999 Jun 18 11 3074-89
- The IFN-beta enhancer: a paradigm for understanding activation and repression of inducible gene expression.
  Munshi N, Yie Y, Merika M, Senger K, Lomvardas S, Agalioti T, Thanos D Cold Spring Harbor symposia on quantitative biology 1999 64 149-59

Research

Transcriptional Regulation
Single-cell genomics
Serum Biomarkers
Reprogramming
Regeneration
Microfluidics
Cardiac Dysrhythmia
Cardiac Development

Links

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