Peter Tsai, M.D., Ph.D.

Peter O'Donnell Jr. Brain Institute

Neurology

Education & Training

Medical School - David Geffen School of Medicine at UCLA (1997-2005)
Residency - Harvard Medical School/Boston Children's Hospital (2005-2007), Pediatrics
Residency - Children's Hospital - Boston (2007-2010), Pediatric Neurology
Fellowship - Children's Hospital - Boston (2010-2011), Behavioral Neurology

Books & Publications

Publications
- Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors
  Dentel B, Angeles-Perez L, Flores AY, Lei K, Ren C, Sanchez AP, Tsai PT Neurobiology of Disease 2025 Feb 205
- Consensus Paper: Cerebellum and Reward
  Manto M, Adamaszek M, Apps R, Carlson E, Guarque-Chabrera J, Heleven E, Kakei S, Khodakhah K, Kuo SH, Lin CY, Joshua M, Miquel M, Mitoma H, Larry N, Péron JA, Pickford J, Schutter DJ, Singh MK, Tan T, Tanaka H, Tsai P, Van Overwalle F, Yamashiro K Cerebellum 2024 Oct 23 2169-2192
- Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models
  Gibson JM, Vazquez AH, Yamashiro K, Jakkamsetti V, Ren C, Lei K, Dentel B, Pascual JM, Tsai PT Cell Reports 2023 Dec 42
- Electroencephalographic (EEG) Biomarkers in Genetic Neurodevelopmental Disorders
  Goodspeed K, Armstrong D, Dolce A, Evans P, Said R, Tsai P, Sirsi D Journal of child neurology 2023 May 38 466-477
- Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
  Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, Umemori H, Tsai PT, Lipton JO Science Advances 2023 9
- Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
  Dentel B, Angeles-Perez L, Ren C, Jakkamsetti V, Holley AJ, Caballero D, Oh E, Gibson J, Pascual JM, Huber KM, Tu BP, Tsai PT iScience 2022 May 25
- A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior
  Gibson JM, Howland CP, Ren C, Howland C, Vernino A, Tsai PT Journal of Neuroscience 2022 Mar 42 2804-2823
- Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors
  Stoodley CJ, Tsai PT Annual Review of Neuroscience 2021 Jul 44 475-493
- Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework
  Kelly E, Escamilla CO, Tsai PT Neuroscience 2021 May 462 274-287
- Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
  Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry RJ, Tan T, Ellegood J, Albert Basson M, Blakely RD, Dindot SV, Golzio C, Hahn MK, Katsanis N, Robins DM, Silverman JL, Singh KK, Wevrick R, Taylor MJ, Hammill C, Anagnostou E, Pfeiffer BE, Stoodley CJ, Lerch JP, du Lac S, Tsai PT Nature neuroscience 2020 Sep 23 1102-1110
- Therapeutic Targeting of mTORC2 in mTORopathies
  Dentel B, Escamilla CO, Tsai PT Neuron 2019 Dec 104 1032-1033
- Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
  Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr W, Sahin M Cell Reports 2018 Oct 25 357-367.e4
- Author Correction: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice (Nature Neuroscience DOI: 10.1038/s41593-017-0004-1)
  Stoodley CJ, D’Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT Nature neuroscience 2018 Jul 21 1016
- Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
  Stoodley CJ, D'Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT Nature neuroscience 2017 Dec 20 1744-1751
- Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy
  Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M Cell Reports 2017 Jul 20 868-880
- Autism and cerebellar dysfunction: Evidence from animal models
  Tsai PT Seminars in Fetal and Neonatal Medicine 2016 Oct 21 349-355
- Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
  Alexander MS, Gasperini MJ, Tsai PT, Gibbs DE, Spinazzola JM, Marshall JL, Feyder MJ, Pletcher MT, Chekler EL, Morris CA, Sahin M, Harms JF, Schmidt CJ, Kleiman RJ, Kunkel LM Translational psychiatry 2016 Sep 6
- The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior: A Clinical Perspective
  Salman MS, Tsai P Neuroimaging Clinics of North America 2016 Aug 26 317-329
- Cerebellar associative sensory learning defects in five mouse autism models
  Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Agarikano OP, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS eLife 2015 Jul 4
- The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders
  Mosconi MW, Wang Z, Schmitt LM, Tsai P, Sweeney JA Frontiers in Neuroscience 2015 9
- Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1
  Nardo AD, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M Human molecular genetics 2014 Jul 23 1-10
- Copy number variation plays an important role in clinical epilepsy
  Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A Annals of Neurology 2014 Jun 75 943-958
- A magnetic resonance imaging study of Cerebellar volume in tuberous sclerosis complex
  Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK Pediatric Neurology 2013 Feb 48 105-110
- Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57Bl/6 Mice
  Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M Behavior Genetics 2013 Jan 43 51-59
- Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features
  Yuan E, Tsai PT, Greene-colozzi E, Sahin M, Kwiatkowski DJ, Malinowska IA Human molecular genetics 2012 Oct 21 4286-4300
- Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
  Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M Nature 2012 Aug 488 647-651
- Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex
  Tsai P, Sahin M Current opinion in neurology 2011 Apr 24 106-113
- A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery
  Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST Journal of Neuroscience 2006 Jan 26 1269-1274
- BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
  Tsai PT, Lee RA, Wu H Blood 2003 Dec 102 3947-3953

Research

Cerebellar contribution to cognition and behavior
Autism and Neurodevelopmental Disorders
Neuronal circuits underlying behavioral disorders

Peter Tsai, M.D., Ph.D.

Education & Training

Books & Publications

Research

Links