Peter Tsai, M.D., Ph.D.

Peter O'Donnell Jr. Brain Institute

Neurology

Education & Training

Medical School - David Geffen School of Medicine at UCLA (1997-2005)
Residency - Harvard Medical School/Boston Children's Hospital (2005-2007), Pediatrics
Residency - Children's Hospital - Boston (2007-2010), Pediatric Neurology
Fellowship - Children's Hospital - Boston (2010-2011), Behavioral Neurology

Books & Publications

Publications
- Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models.
  Gibson JM, Vazquez AH, Yamashiro K, Jakkamsetti V, Ren C, Lei K, Dentel B, Pascual JM, Tsai PT, Cell reports 2023 Dec 42 12 113533
- Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
  Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, Umemori H, Tsai PT, Lipton JO, Science advances 2023 Oct 9 43 eadj1010
- Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model.
  Dentel B, Angeles-Perez L, Ren C, Jakkamsetti V, Holley AJ, Caballero D, Oh E, Gibson J, Pascual JM, Huber KM, Tu BP, Tsai PT, iScience 2022 May 25 5 104334
- A critical period for development of cerebellar-mediated autism-relevant social behavior.
  Gibson JM, Howland CP, Ren C, Howland C, Vernino A, Tsai PT, The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Feb
- Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors.
  Stoodley CJ, Tsai PT, Annual review of neuroscience 2021 Jul 44 475-493
- Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework.
  Kelly E, Escamilla CO, Tsai PT, Neuroscience 2021 05 462 274-287
- Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits.
  Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry RJ, Tan T, Ellegood J, Basson MA, Blakely RD, Dindot SV, Golzio C, Hahn MK, Katsanis N, Robins DM, Silverman JL, Singh KK, Wevrick R, Taylor MJ, Hammill C, Anagnostou E, Pfeiffer BE, Stoodley CJ, Lerch JP, du Lac S, Tsai PT, Nature neuroscience 2020 09 23 9 1102-1110
- Therapeutic Targeting of mTORC2 in mTORopathies.
  Dentel B, Escamilla CO, Tsai PT, Neuron 2019 12 104 6 1032-1033
- 4-integrin deficiency.
  Hussain RZ, Cravens PC, Doelger R, Dentel B, Herndon E, Loof N, Tsai P, Okuda DT, Racke MK, Stüve O Annals of clinical and translational neurology 2018 Dec 5 12 1543-1561
- Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors.
  Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr W, Sahin M Cell reports 2018 Oct 25 2 357-367.e4
- Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.
  Stoodley CJ, D'Mello AM, Ellegood J, Jakkamsetti V, Liu P, Nebel MB, Gibson JM, Kelly E, Meng F, Cano CA, Pascual JM, Mostofsky SH, Lerch JP, Tsai PT Nature neuroscience 2017 Dec 20 12 1744-1751
- Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy.
  Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M Cell reports 2017 Jul 20 4 868-880
- The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior: A Clinical Perspective.
  Salman MS, Tsai P Neuroimaging clinics of North America 2016 Aug 26 3 317-29
- Autism and cerebellar dysfunction: Evidence from animal models.
  Tsai PT Seminars in fetal & neonatal medicine 2016 May
- Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.
  Alexander MS, Gasperini MJ, Tsai PT, Gibbs DE, Spinazzola JM, Marshall JL, Feyder MJ, Pletcher MT, Chekler EL, Morris CA, Sahin M, Harms JF, Schmidt CJ, Kleiman RJ, Kunkel LM Translational psychiatry 2016 6 9 e901
- The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders.
  Mosconi MW, Wang Z, Schmitt LM, Tsai P, Sweeney JA Frontiers in neuroscience 2015 9 296
- Cerebellar associative sensory learning defects in five mouse autism models.
  Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS eLife 2015 4
- Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
  Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M Human molecular genetics 2014 Jul 23 14 3865-74
- Copy number variation plays an important role in clinical epilepsy.
  Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A Annals of neurology 2014 Jun 75 6 943-58
- Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice.
  Greene-Colozzi EA, Sadowski AR, Chadwick E, Tsai PT, Sahin M Epilepsy research and treatment 2014 2014 784137
- A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex.
  Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK Pediatric neurology 2013 Feb 48 2 105-10
- Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.
  Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M Behavior genetics 2013 Jan 43 1 51-9
- Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features.
  Yuan E, Tsai PT, Greene-Colozzi E, Sahin M, Kwiatkowski DJ, Malinowska IA Human molecular genetics 2012 Oct 21 19 4286-300
- Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.
  Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M Nature 2012 Aug 488 7413 647-51
- Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex.
  Tsai P, Sahin M Current opinion in neurology 2011 Apr 24 2 106-13
- Cognitive and behavioral characterization of 16p11.2 deletion syndrome.
  Hanson E, Nasir RH, Fong A, Lian A, Hundley R, Shen Y, Wu BL, Holm IA, Miller DT Journal of developmental and behavioral pediatrics : JDBP 2010 Oct 31 8 649-57
- A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery.
  Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jan 26 4 1269-74
- BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.
  Tsai PT, Lee RA, Wu H Blood 2003 Dec 102 12 3947-53
- P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development.
  Salzberg A, Prokopenko SN, He Y, Tsai P, Pál M, Maróy P, Glover DM, Deák P, Bellen HJ Genetics 1997 Dec 147 4 1723-41

Research

Cerebellar contribution to cognition and behavior
Autism and Neurodevelopmental Disorders
Neuronal circuits underlying behavioral disorders

Peter Tsai, M.D., Ph.D.

Education & Training

Books & Publications

Research

Links