Ramesh Saxena, M.D., Ph.D.

Internal Medicine - Nephrology
Chronic Kidney Disease
Glomerulonephritis

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New Patient Appointment or 214-645-1919

Biography

Ramesh Saxena, M.D., Ph.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He specializes in the treatment of lupus nephritis, glomerulonephritis, and peritoneal dialysis.

Originally from India, Dr. Saxena earned his medical degree at Maulana Azad Medical College in New Delhi, and his doctoral degree in autoimmune glomerulonephritis at Lund University in Sweden. He completed his residency in internal medicine at Northeastern Ohio University College of Medicine in Canton, and received advanced training through a postdoctoral fellowship at Case Western Reserve University in Cleveland and a nephrology fellowship at The Ohio State University Hospitals in Columbus, Ohio.

Certified by the American Board of Internal Medicine in nephrology, he joined the UT Southwestern faculty in 1999.

Among other roles, Dr. Saxena is Medical Director of UT Southwestern’s Davita Irving Dialysis Center. He serves on the Clinician Educator Compensation Plan Committee and the Clinical Competency Committee for Renal Fellows at UT Southwestern, where he is also a Clinical Documentation Improvement Provider Champion in Nephrology. In addition, since 2009 he has provided patient care at the Denton County India Culture Association’s Annual Free Clinic.

He is a Fellow of the American Society of Nephrology and a member of the International Society of Peritoneal Dialysis and other professional organizations, and he serves on the editorial board of the Journal of Vascular Access.

Dr. Saxena has delivered scores of lectures, published numerous peer-reviewed articles, and contributed chapters to several books, including Andreoli & Carpenter’s Cecil Essentials of Medicine and Silva’s Diagnostic Renal Pathology.

In 2012 and 2015, he received UT Southwestern’s Excellence in Teaching Award in Nephrology.

Education & Training

Fellowship - Ohio State University Hospitals (1997-1999), Nephrology
Residency - Aultman Hospital - NEOUCOM (1995-1997), Internal Medicine
Internship - Aultman Hospital - NEOUCOM (1994-1995), Internal Medicine
Medical School - Delhi University/Maulana Azad Medical College (1980-1986)

Professional Associations & Affiliations

American Society of Nephrology
Dallas County Medical Society
International Society of Nephrology
International Society of Peritoneal Dialysis
National Kidney Foundation
Texas Medical Association

Honors & Awards

D Magazine Best Doctor 2021
Excellence in Teaching Award, (2012, 2015) UT Southwestern Medical Center
Anna Greta Crafoord Prize for best PhD thesis at Lund University 1991, Crafoord Foundation
Fellow 2015, American Society of Nephrology

Books & Publications

Publications
- Quantitative planar array screen of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis.
  Vanarsa K, Soomro S, Zhang T, Strachan B, Pedroza C, Nidhi M, Cicalese P, Gidley C, Dasari S, Mohan S, Thai N, Truong VTT, Jordan N, Saxena R, Putterman C, Petri M, Mohan C, Annals of the rheumatic diseases 2020 Jul
- Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities.
  Stanley S, Vanarsa K, Soliman S, Habazi D, Pedroza C, Gidley G, Zhang T, Mohan S, Der E, Suryawanshi H, Tuschl T, Buyon J, Putterman C, Mok CC, Petri M, Saxena R, Mohan C, Nature communications 2020 May 11 1 2197
- Chemokine releasing particle implants for trapping circulating prostate cancer cells.
  Huang Y, Hakamivala A, Li S, Nair A, Saxena R, Hsieh JT, Tang L, Scientific reports 2020 Mar 10 1 4433
- Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages.
  Zhang T, Li H, Vanarsa K, Gidley G, Mok CC, Petri M, Saxena R, Mohan C, Frontiers in immunology 2020 11 671
- Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis.
  Qin L, Stanley S, Ding H, Zhang T, Truong V, Celhar T, Fairhurst AM, Pedroza C, Petri M, Saxena R, Mohan C, Arthritis research & therapy 2019 Jul 21 1 176
- Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE.
  Ye Y, Wu T, Zhang T, Han J, Habazi D, Saxena R, Mohan C, Clinical immunology (Orlando, Fla.) 2019 May 205 43-48
- Identification of Low-Abundance Urinary Biomarkers in Lupus Nephritis using Electrochemiluminescence Immunoassays.
  Stanley S, Mok CC, Vanarsa K, Habazi D, Li J, Predoza C, Saxena R, Mohan C Arthritis & rheumatology (Hoboken, N.J.) 2019 Jan
- A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.
  Rovin BH, Solomons N, Pendergraft WF, Dooley MA, Tumlin J, Romero-Diaz J, Lysenko L, Navarra SV, Huizinga RB, Kidney international 2019 01 95 1 219-231
- Peritoneal Dialysis Is Feasible as a Bridge to Combined Liver-Kidney Transplant.
  Jones RE, Liang Y, MacConmara M, Hwang C, Saxena R Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2018 Jan-Feb 38 1 63-65
- Urine angiostatin and VCAM-1 surpass conventional metrics in predicting elevated renal pathology activity indices in lupus nephritis.
  Soliman S, Mohamed FA, Ismail FM, Stanley S, Saxena R, Mohan C International journal of rheumatic diseases 2017 Oct
- Prognostic significance of repeat biopsy in lupus nephritis: Histopathologic worsening and a short time between biopsies is associated with significantly increased risk for end stage renal disease and death.
  Arriens C, Chen S, Karp DR, Saxena R, Sambandam K, Chakravarty E, James JA, Merrill JT Clinical immunology (Orlando, Fla.) 2016 Dec
- Antibody array based proteomic screening of serum markers in systemic lupus erythematosus - a discovery study.
  Wu T, Ding H, Han J, Arriens C, Wei C, Han W, Pedroza C, Jiang S, Anolik J, Petri M, Sanz I, Saxena R, Mohan C Journal of proteome research 2016 May
- Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.
  Wu T, Xie C, Han J, Ye Y, Singh S, Zhou J, Li Y, Ding H, Li QZ, Zhou X, Putterman C, Saxena R, Mohan C PloS one 2016 11 3 e0151491
- IGFBP-2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis.
  Ding H, Kharboutli M, Saxena R, Wu T Clinical and experimental immunology 2015 Nov
- Characteristics and Outcomes of Renal Transplant Recipients with Hemolytic Uremic Syndrome in the United States.
  Tanriover B, Lakhia R, Shen YM, Sandikci B, Saxena R, MacConmara M, Soyombo AA, Rajora N, Hardy MA Transplantation direct 2015 Nov 1 10
- Novel source of human hematopoietic stem cells from peritoneal dialysis effluents.
  Shen J, Zheng J, Saxena R, Zhang C, Tang L Stem cell research 2015 Jul 15 2 299-304
- Resistin as a potential marker of renal disease in lupus nephritis.
  Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, Mohan C, Wu T Clinical and experimental immunology 2014 Oct
- Peritoneal Dialysis: Misperceptions and Reality.
  Saxena R The American journal of the medical sciences 2014 May
- Tissue engineering bone using autologous progenitor cells in the peritoneum.
  Shen J, Nair A, Saxena R, Zhang CC, Borrelli J, Tang L PloS one 2014 9 3 e93514
- The effect of erythropoietin on autologous stem cell-mediated bone regeneration.
  Nair AM, Tsai YT, Shah KM, Shen J, Weng H, Zhou J, Sun X, Saxena R, Borrelli J, Tang L Biomaterials 2013 Oct 34 30 7364-71
- Urinary Angiostatin - a novel marker of renal pathology chronicity in lupus nephritis.
  Wu T, Du Y, Han J, Singh S, Xie C, Guo Y, Zhou XJ, Ahn C, Saxena R, Mohan C Molecular & cellular proteomics : MCP 2013 Jan
- Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis.
  Singh S, Wu T, Xie C, Vanarsa K, Han J, Mahajan T, Oei HB, Ahn C, Zhou XJ, Putterman C, Saxena R, Mohan C Arthritis research & therapy 2012 Jul 14 4 R164
- Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway.
  Min SY, Fu Y, Hutcheson J, Wu T, Khobahy E, Zhu J, Vanarsa K, Du Y, Park MJ, Park HS, Saxena R, Kim HY, Mohan C Clinical immunology (Orlando, Fla.) 2012 Apr 143 1 59-72
- Metabolic disturbances associated with systemic lupus erythematosus.
  Wu T, Xie C, Han J, Ye Y, Weiel J, Li Q, Blanco I, Ahn C, Olsen N, Putterman C, Saxena R, Mohan C PloS one 2012 7 6 e37210
- Lupus Nephritis: A Retrospective Analysis of Clinical Presentation and Outcomes From a Single Center.
  Singh S, Zhou XJ, Ahn C, Saxena R The American journal of the medical sciences 2011 Jun
- Lupus nephritis: current update.
  Saxena R, Mahajan T, Mohan C Arthritis research & therapy 2011 13 5 240
- Risk factors associated with peritoneal dialysis catheter survival: a 9-year single-center study in 315 patients.
  Singh N, Davidson I, Minhajuddin A, Gieser S, Nurenberg M, Saxena R The journal of vascular access 2010 Oct-Dec 11 4 316-22
- A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression.
  Rovin BH, Lu L, Saxena R, Biochemical and biophysical research communications 1999 Jun 259 2 344-8
- Protein kinase C beta II isoform is up-regulated in human proliferative glomerulonephritis.
  Ganz MB, Abu-Nader R, Saxena R, Grond J, Experimental nephrology 1997 May-Jun 5 3 225-32
- PDGF and IL-1 induce and activate specific protein kinase C isoforms in mesangial cells.
  Ganz MB, Saksa B, Saxena R, Hawkins K, Sedor JR, The American journal of physiology 1996 Jul 271 1 Pt 2 F108-13
- Circulating autoantibodies as serological markers in the differential diagnosis of pulmonary renal syndrome.
  Saxena R, Bygren P, Arvastson B, Wieslander J, Journal of internal medicine 1995 Aug 238 2 143-52
- Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin.
  Khan SG, Saxena R, Bickers DR, Mukhtar H, Agarwal R, Molecular carcinogenesis 1995 Apr 12 4 205-12
- Significance of anti-entactin antibodies in patients with systemic lupus erythematosus and related disorders.
  Saxena R, Sturfelt G, Nived O, Wieslander J, Annals of the rheumatic diseases 1994 Oct 53 10 659-65
- Activation of Na/H exchanger in mesangial cells is associated with translocation of PKC isoforms.
  Saxena R, Saksa BA, Fields AP, Ganz MB, The American journal of physiology 1993 Jul 265 1 Pt 2 F53-60
- Circulating anti-entactin antibodies in patients with glomerulonephritis.
  Saxena R, Bygren P, Cederholm B, Wieslander J, Kidney international 1991 May 39 5 996-1004
- Entactin: a possible auto-antigen in the pathogenesis of non-Goodpasture anti-GBM nephritis.
  Saxena R, Bygren P, Butkowski R, Wieslander J, Kidney international 1990 Aug 38 2 263-72
- Specificity of kidney-bound antibodies in Goodpasture's syndrome.
  Saxena R, Bygren P, Butkowski R, Wieslander J, Clinical and experimental immunology 1989 Oct 78 1 31-6
- A rapid assay for circulating anti-glomerular basement membrane antibodies in Goodpasture syndrome.
  Saxena R, Isaksson B, Bygren P, Wieslander J, Journal of immunological methods 1989 Mar 118 1 73-8

Research

Lupus Nephritis
Glomerulonephritis
Peritoneal Dialysis

Clinical Focus

Chronic Kidney Disease
Glomerulonephritis
Kidney Disease (Nephrology)
Lupus nephritis
Peritoneal dialysis

Links