Ruben Jauregui, M.D.

Ophthalmology
Optic Neuropathies
Ocular Motor Abnormalities

New Patient Appointment or 214-645-2020

Biography

Ruben Jauregui, M.D., is an Assistant Professor in the Department of Ophthalmology and the Department of Neurology at UT Southwestern Medical Center. He specializes in optic neuropathies, ocular motor abnormalities, and genetic neuro-ophthalmologic diseases.

Dr. Jauregui earned his medical degree with honors in research at Weill Cornell Medical College in New York City. He completed a residency in neurology, serving as Chief Resident, and received advanced training through a neuro-ophthalmology clinical fellowship, both at NYU Langone Health.

Certified by the American Board of Psychiatry and Neurology, he joined the UT Southwestern faculty in 2025.

Dr. Jauregui’s research interests include optic neuropathies and eye movements, especially genetic disorders that affect the sensory and motor systems. He has delivered presentations at national conferences and published more than 35 academic articles related to his areas of expertise.

Personal Note

When he’s not at work, Dr. Jauregui enjoys traveling, discovering new restaurants, and expanding his culinary experiences. He also likes soccer.

Education & Training

Medical School - Weill Cornell Medicine (2014-2020)
Internship - NYU Langone Health (2020-2021), Internal Medicine
Residency - NYU Langone Health (2021-2024), Neurology
Fellowship - NYU Langone Health (2024-2025), Neuro-ophthalmology

Professional Associations & Affiliations

North American Neuro-Ophthalmology Society
American Academy of Neurology

Honors & Awards

Leadership Development Award 2024, NYU Department of Neurology
Enhanced Resident Leadership Program 2024, American Academy of Neurology
Chief Resident 2023-2024, NYU Department of Neurology
Patient Oriented Research Curriculum Award 2023, NYU Department of Neurology

Books & Publications

Publications
- Teaching NeuroImage: Traumatic Avulsion of the Abducens Nerve
  Jauregui R, Stein EG, Blace N, Galetta SL Neurology 2025 Nov 105
- Relation of Visual Function, Retinal Thickness by Optical Coherence Tomography, and MRI Brain Volume in Pediatric-Onset Multiple Sclerosis
  Sosa A, O'Neill KA, Jauregui R, Nwigwe U, Billiet T, Kenney R, Krupp LB, Galetta SL, Balcer LJ, Grossman SN Neurology: Neuroimmunology and NeuroInflammation 2025 Nov 12
- The Neuro-Ophthalmologic Manifestations of SPG7-Associated Disease
  Jauregui R, Diaz Curbelo C, Galetta SL, Grossman SN Journal of Personalized Medicine 2025 Oct 15
- Multiple Hypovitaminoses Presenting as Optic Disc Swelling in a Child with Autism Spectrum Disorder and Restrictive Eating
  Nagajothi N, Jauregui R, Grossman SN Journal of child neurology 2025 Sep 40 700-703
- Downbeat Nystagmus: Case Report, Updated Review, Therapeutics, and Neurorehabilitation
  Parker TM, Jauregui R, Grossman SN, Galetta SL Brain Sciences 2025 Aug 15
- Alexia without agraphia: From infarctions to malignancies
  Jauregui R, Greenberg J, Kuball P, Newbold DJ, Patel R, Staudinger R Practical Neurology 2025 Jun 25 246-249
- Anti-RGS8 Paraneoplastic Neurologic Syndrome Presenting with Skew Deviation and Mild Cerebellar Dysfunction
  Jauregui R, Evens AM, Zekeridou A, Steriade C, Hudson T, Voelbel GT, Galetta SL, Rucker JC Cerebellum 2025 Jun 24
- Chronic Neuropsychiatric Sequelae Associated with Kambo Intoxication
  Jauregui R, Spiegler KM, Kim N JAMA neurology 2025 Apr 82 418-419
- Ophthalmic artery occlusion: A rare, vision-threatening complication from middle meningeal artery embolization for subdural hematomas
  Jauregui R, Galetta SL Journal of the Neurological Sciences 2025 Apr 471
- Teaching Video NeuroImage: Globe Retraction in Duane Syndrome
  Jauregui R, Grossman SN Neurology 2025 Mar 104 e213409
- Metachromatic Leukodystrophy Presenting with Multiple Cranial Nerve and Lumbosacral Nerve Root Enhancement Without White Matter Changes
  Jauregui R, Garcia MR, Mehuron T, Galetta SL, Segal D Neurology International 2025 Feb 17
- Clinical Reasoning: An 83-Year-Old Female Patient With a Pupil-Involving Oculomotor Nerve Palsy
  Riegel DC, Jauregui R, Dugue A Neurology 2025 Jan 105
- “Inverted V” sign in subacute combined degeneration of the spinal cord after recreational use of nitrous oxide: A rising and popular trend among young adults
  Jauregui R, Patel R, Pleninger P Journal of Clinical Neuroscience 2024 Aug 126 245-246
- Treatment of Periodic Alternating Nystagmus as a Consequence of Ataxia-Telangiectasia
  Jauregui R, Bhagat D, Garcia MR, Miller C, Grossman SN Journal of Neuro-Ophthalmology 2024 Mar 44 E151-E152
- Idiopathic Intracranial Hypertension.
  Jauregui R, Busis NA New England Journal of Medicine 2023 Dec 389 2467
- Neuro-Ophthalmologic Variability in Presentation of Genetically Confirmed Wolfram Syndrome: A Case Series and Review
  Jauregui R, Abreu NJ, Golan S, Panarelli JF, Sigireddi M, Nayak GK, Gold DM, Rucker JC, Galetta SL, Grossman SN Brain Sciences 2023 Jul 13
- Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization
  Author Collaboration tN, Frontera JA, Sabadia S, Yang D, de Havenon A, Yaghi S, Lewis A, Lord AS, Melmed K, Thawani S, Balcer LJ, Wisniewski T, Galetta SL, Agarwal S, Andino A, Arena V, Baskharoun S, Bauman K, Bell L, Berger S, Bhagat D, Bokhari M, Bondi S, Canizares M, Chervinsky A, Czeisler BM, Dygert L, Fang T, Flusty B, Friedman D, Friedman D, Fuchs B, Granger A, Gratch D, Gurin L, Gutman J, Hasanaj L, Holmes M, Horng J, Huang J, Ishii H, Jauregui R, Ji Y, Kahn DE, Koch E, Krieger P, Kvernland A, Lalchan R, Lillemoe K, Lin J, Liu SB Journal of the Neurological Sciences 2022 Dec 443
- Trajectories of Neurologic Recovery 12 Months after Hospitalization for COVID-19: A Prospective Longitudinal Study
  Frontera JA, Yang D, Medicherla C, Baskharoun S, Bauman K, Bell L, Bhagat D, Bondi S, Chervinsky A, Dygert L, Fuchs B, Gratch D, Hasanaj L, Horng J, Huang J, Jauregui R, Ji Y, Kahn DE, Koch E, Lin J, Liu S, Olivera A, Rosenthal J, Snyder T, Stainman R, Talmasov D, Thomas B, Valdes E, Zhou T, Zhu Y, Lewis A, Lord AS, Melmed K, Meropol SB, Thawani S, Troxel AB, Yaghi S, Balcer LJ, Wisniewski T, Galetta S Neurology 2022 Jul 99 E33-E45
- Stage-dependent choriocapillaris impairment in Best vitelliform macular dystrophy characterized by optical coherence tomography angiography
  Jauregui R, Parmann R, Nuzbrokh Y, Tsang SH, Sparrow JR Scientific reports 2021 Dec 11
- A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications
  Frontera JA, Yang D, Lewis A, Patel P, Medicherla C, Arena V, Fang T, Andino A, Snyder T, Madhavan M, Gratch D, Fuchs B, Dessy A, Canizares M, Jauregui R, Thomas B, Bauman K, Olivera A, Bhagat D, Sonson M, Park G, Stainman R, Sunwoo B, Talmasov D, Tamimi M, Zhu Y, Rosenthal J, Dygert L, Ristic M, Ishii H, Valdes E, Omari M, Gurin L, Huang J, Czeisler BM, Kahn DE, Zhou T, Lin J, Lord AS, Melmed K, Meropol S, Troxel AB, Petkova E, Wisniewski T, Balcer L, Morrison C, Yaghi S, Galetta S Journal of the Neurological Sciences 2021 Jul 426
- Shared features in retinal disorders with involvement of retinal pigment epithelium
  Sparrow JR, Parmann R, Tsang SH, Allikmets R, Chang S, Jauregui R Investigative Ophthalmology and Visual Science 2021 Jun 62
- Retinal pigment epithelium atrophy in recessive stargardt disease as measured by short-wavelength and near-infrared autofluorescence
  Jauregui R, Nuzbrokh Y, Su PY, Zernant J, Allikmets R, Tsang SH, Sparrow JR Translational Vision Science and Technology 2021 Jan 10 1-11
- Treatment-Emergent Adverse Events in Gene Therapy Trials for Inherited Retinal Diseases: A Narrative Review
  Nuzbrokh Y, Kassotis AS, Ragi SD, Jauregui R, Tsang SH Ophthalmology and Therapy 2020 Dec 9 709-724
- Presumed chloroquine retinopathywith short-term therapy for glioblastoma multiforme
  Nuzbrokh Y, Jauregui R, Oh JK, Moazami G, Sparrow JR, Tsang SH JAMA Ophthalmology 2020 Nov 138 1215-1217
- Progressive choriocapillaris impairment in ABCA4 maculopathy is secondary to retinal pigment epithelium atrophy
  Jauregui R, Cho A, Lee W, Zernant J, Allikmets R, Sparrow JR, Tsang SH Investigative Ophthalmology and Visual Science 2020 Apr 61
- Quasidominance in autosomal recessive RDH12-Leber congenital amaurosis
  Jauregui R, Cho A, Xu CL, Tanaka AJ, Sparrow JR, Tsang SH Ophthalmic Genetics 2020 Mar 41 198-200
- Phenotypic expansion of autosomal dominant retinitis pigmentosa associated with the D477G mutation in RPE65
  Jauregui R, Cho A, Oh JK, Tanaka AJ, Sparrow JR, Tsang SH Cold Spring Harbor Molecular Case Studies 2020 Feb 6
- Disease asymmetry and hyperautofluorescent ring shape in retinitis pigmentosa patients
  Jauregui R, Chan L, Oh JK, Cho A, Sparrow JR, Tsang SH Scientific reports 2020 Feb 10 3364
- Spectral-domain optical coherence tomography is more sensitive for hydroxychloroquine-related structural abnormalities than short-wavelength and near-infrared autofluorescence
  Jauregui R, Parmann R, Nuzbrokh Y, Tsang SH, Sparrow JR Translational Vision Science and Technology 2020 9 1-10
- Fundoscopy-directed genetic testing to re-evaluate negative whole exome sequencing results
  Cho A, Lima De Carvalho JR, Tanaka AJ, Jauregui R, Levi SR, Bassuk AG, Mahajan VB, Tsang SH Orphanet Journal of Rare Diseases 2020 Jan 15
- Hyperautofluorescent Dots are Characteristic in Ceramide Kinase Like-associated Retinal Degeneration
  Sengillo JD, Cho GY, Paavo M, Lee W, White E, Jauregui R, Sparrow JR, Allikmets R, Tsang SH Scientific reports 2019 Dec 9
- Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance
  Jauregui R, Takahashi VK, Park KS, Cui X, Takiuti JT, Lima de Carvalho JR, Tsang SH Scientific reports 2019 Dec 9
- Spectrum of Disease Severity and Phenotype in Choroideremia Carriers
  Jauregui R, Park KS, Tanaka AJ, Cho A, Paavo M, Zernant J, Francis JH, Allikmets R, Sparrow JR, Tsang SH American journal of ophthalmology 2019 Nov 207 77-86
- Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients
  Takahashi VK, Takiuti JT, Jauregui R, Xu CL, Duong JK, Lima LH, Tsang SH Graefe's Archive for Clinical and Experimental Ophthalmology 2019 Aug 257 1601-1609
- Non-paraneoplastic related retinopathy: clinical challenges and review
  Takiuti JT, Takahashi VK, Xu CL, Jauregui R, Tsang SH Ophthalmic Genetics 2019 Jul 40 293-297
- Optical coherence tomography angiography of RPGR-associated retinitis pigmentosa suggests foveal avascular zone is a biomarker for vision loss
  Tang PH, Jauregui R, Tsang SH, Bassuk AG, Mahajan VB Ophthalmic Surgery Lasers and Imaging Retina 2019 Feb 50 E44-E48
- SCAPER-associated nonsyndromic autosomal recessive retinitis pigmentosa
  Jauregui R, Thomas AL, Liechty B, Velez G, Mahajan VB, Clark L, Tsang SH American Journal of Medical Genetics, Part A 2019 Feb 179 312-316
- Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography
  Jauregui R, Park KS, Duong JK, Mahajan VB, Tsang SH Scientific reports 2018 Dec 8
- Rates of Bone Spicule Pigment Appearance in Patients With Retinitis Pigmentosa Sine Pigmento
  Takahashi VK, Takiuti JT, Jauregui R, Mahajan VB, Tsang SH American journal of ophthalmology 2018 Nov 195 176-180
- Quantitative Comparison of Near-infrared Versus Short-wave Autofluorescence Imaging in Monitoring Progression of Retinitis Pigmentosa
  Jauregui R, Park KS, Duong JK, Sparrow JR, Tsang SH American journal of ophthalmology 2018 Oct 194 120-125
- Structural disease progression in PDE6-associated autosomal recessive retinitis pigmentosa
  Takahashi VK, Takiuti JT, Jauregui R, Lima LH, Tsang SH Ophthalmic Genetics 2018 Sep 39 610-614
- Gene therapy in inherited retinal degenerative diseases, a review
  Takahashi VK, Takiuti JT, Jauregui R, Tsang SH Ophthalmic Genetics 2018 Sep 39 560-568
- Clustered Regularly Interspaced Short Palindromic Repeats-Based Genome Surgery for the Treatment of Autosomal Dominant Retinitis Pigmentosa
  Tsai YT, Wu WH, Lee TT, Wu WP, Xu CL, Park KS, Cui X, Justus S, Lin CS, Jauregui R, Su PY, Tsang SH Ophthalmology 2018 Sep 125 1421-1430
- Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa
  Zhang L, Cui X, Jauregui R, Park KS, Justus S, Tsai YT, Duong JK, Hsu CW, Wu WH, Xu CL, Lin CS, Tsang SH Molecular Therapy 2018 Aug 26 1953-1964
- Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity
  Liu KY, Sengillo JD, Velez G, Jauregui R, Sakai LY, Maumenee IH, Bassuk AG, Mahajan VB, Tsang SH Orphanet Journal of Rare Diseases 2018 Aug 13
- Deferoxamine-induced electronegative ERG responses
  Jauregui R, Park KS, Bassuk AG, Mahajan VB, Tsang SH Documenta Ophthalmologica 2018 Aug 137 15-23
- Two-year progression analysis of RPE65 autosomal dominant retinitis pigmentosa
  Jauregui R, Park KS, Tsang SH Ophthalmic Genetics 2018 Jul 39 544-549
- Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy
  Cui X, Jauregui R, Park KS, Tsang SH Ophthalmic Genetics 2018 Jul 39 512-516
- Caring for hereditary childhood retinal blindness
  Jauregui R, Cho GY, Takahashi VK, Takiuti JT, Bassuk AG, Mahajan VB, Tsang SH Asia-Pacific Journal of Ophthalmology 2018 May 7 183-191

Research

Neuro-ophthalmology

Clinical Focus

Optic Neuropathies
Ocular Motor Abnormalities
Genetic Neuro-Ophthalmologic Diseases