Samir Parikh, M.D.

Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology
Robert Tucker Hayes Distinguished Chair in Nephrology, in Honor of Dr. Floyd C. Rector, Jr.

Internal Medicine - Nephrology
Acute Kidney Injury
Chronic Kidney Disease

New Patient Appointment or 214-645-1919

Biography

Samir Parikh, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and Chief of the Division of Nephrology. He specializes in acute kidney injury and chronic kidney disease.

Dr. Parikh earned his medical degree at Vanderbilt University School of Medicine. He completed both his residency in internal medicine and fellowship in nephrology at Beth Israel Deaconess Medical Center.

Certified by the American Board of Internal Medicine in nephrology, he joined the UT Southwestern faculty in 2021.

Dr. Parikh is a member of the American Society of Nephrology and the International Society of Nephrology. He serves on the editorial boards of the PLOS One and the Journal of the American Society of Nephrology, and he is the associate editor of Kidney 360.

He has delivered a wealth of presentations both nationally and internationally and has published widely in scholarly journals.

Among many other honors, in 2021 he received a faculty STARs Award from UT Southwestern.

Education & Training

Medical School - Vanderbilt University School of Medicine (1997-2001)
Internship - Beth Israel Deaconess Medical Center (2001-2002)
Residency - Beth Israel Deaconess Medical Center (2001-2003), Internal Medicine
Fellowship - Beth Israel Deaconess Medical Center (2003-2006), Nephrology

Professional Associations & Affiliations

American Society of Nephrology
International Society of Nephrology

Honors & Awards

UT Translational STARs Award 2021, UT Southwestern
Donald W. Seldin Young Investigator Award 2019, American Society of Nephrology and American Heart Association
Outstanding Investigator Award (OIA) 2018, National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
Sir William Osler Award 2018, Interurban Clinical Club
Gordon J. Strewler Award 2016, Beth Israel Deaconess Medical Center
Carl Gottschalk Award 2008, American Society of Nephrology
Excellence in Tutoring Award 2008, Harvard Medical School
Young Investigator Award 2008, Amgen Medical Institute
Kaufman Prize 2001, Vanderbilt University School of Medicine
Valedictorian/Founder’s Medal Awardee 2001, Vanderbilt University School of Medicine

Books & Publications

Publications
- Intrinsic endothelial hyper-responsiveness to inflammatory mediators drives acute episodes in models of Clarkson disease.
  Ablooglu AJ, Chen WS, Xie Z, Desai A, Paul S, Lack JB, Scott LA, Eisch AR, Dudek AZ, Parikh SM, Druey KM, The Journal of clinical investigation 2024 Mar
- Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.
  Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, FitzGerald GA, Zurakowski D, Liao M, Flaumenhaft R, Gümüs ZH, Hla T, Science signaling 2024 Feb 17 824 eadg9256
- Mitochondrial genetic variation and risk of chronic kidney disease and acute kidney injury in UK Biobank participants.
  Jotwani V, Yang SY, Thiessen-Philbrook H, Parikh CR, Katz R, Tranah GJ, Ix JH, Cummings S, Waikar SS, Shlipak MG, Sarnak MJ, Parikh SM, Arking DE, Human genetics 2024 Feb 143 2 151-157
- Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.
  Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, Joshi R, Huang H, Wang Y, Zivny A, Mehta J, Parikh SM, Szabo G, Hepatology (Baltimore, Md.) 2023 Sep
- Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
  Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM, Kidney international 2023 Sep
- Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
  Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, eLife 2023 Aug 12
- Energy Metabolism in CKD: Running Low on Fuel.
  Saade MC, Parikh SM, Kidney360 2023 Aug 4 8 1014-1016
- Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial.
  Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi MN, Chase M, Gong MN, Gong J, Parikh SM, Ngo L, Berlin N, Donnino MW, American journal of respiratory and critical care medicine 2023 Jun
- TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
  Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, The Journal of clinical investigation 2023 Jun 133 11
- Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy.
  Raines NH, Leone DA, O'Callaghan-Gordo C, Ramirez-Rubio O, Amador JJ, Lopez Pilarte D, Delgado IS, Leibler JH, Embade N, Gil-Redondo R, Bruzzone C, Bizkarguenaga M, Scammell MK, Parikh SM, Millet O, Brooks DR, Friedman DJ, Metabolites 2023 Feb 13 3
- NAD⁺ precursor nutritional supplements sensitize the brain to future ischemic events.
  Qu W, Ralto KM, Qin T, Cheng Y, Zong W, Luo X, Perez-Pinzon M, Parikh SM, Ayata C, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2023 Feb 271678X231156500
- Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.
  Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR, The Journal of clinical investigation 2022 Dec 132 23
- A new chapter in lipid signaling and kidney fibrosis.
  Idowu TO, Parikh SM, Science translational medicine 2022 Aug 14 658 eadd2826
- Fostering Scientific Innovation to Impact AKI: A Roadmap from ASN's AKINow Basic Science Workgroup.
  Parikh SM, Agarwal A, Bajwa A, Kumar S, Mansour SG, Okusa MD, Cerda J, Kidney360 2022 Aug 3 8 1445-1448
- New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
  Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT, American journal of respiratory cell and molecular biology 2022 Jun
- Mind the Cast: FENa versus Microscopy in AKI.
  Hoenig MP, Parikh SM, Kidney360 2022 Apr 3 4 583-585
- Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury.
  Mansour SG, Bhatraju PK, Coca SG, Obeid W, Wilson FP, Stanaway IB, Jia Y, Thiessen-Philbrook H, Go AS, Ikizler TA, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Reeves WB, Liu KD, Kimmel PL, Kaufman JS, Wurfel MM, Himmelfarb J, Parikh SM, Parikh CR, Journal of the American Society of Nephrology : JASN 2022 Mar 33 3 613-627
- Association of Kidney Function With 30-Day Mortality Following SARS-CoV-2 Infection in Nursing Home Residents: A Retrospective Cohort Study.
  Thorsness R, Raines NH, White EM, Santostefano CM, Parikh SM, Riester MR, Feifer RA, Mor V, Zullo AR, American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Oct
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward.
  Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Oct
- NAD+ biosynthetic impairment and urinary metabolomic alterations observed in hospitalized adults with COVID-19-related acute kidney injury.
  Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM, Kidney international reports 2021 Sep
- Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
  Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, JCI insight 2021 Sep
- Skimming the fat in diabetic kidney disease: KIM-1 and tubular fatty acid uptake.
  Huang H, Parikh SM, Kidney international 2021 Jul
- Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
  Schmaier AA, Hurtado GP, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Gerszten RE, Yu XG, Peters K, Flaumenhaft R, Parikh SM, medRxiv : the preprint server for health sciences 2021 May
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study.
  Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Clinical and translational gastroenterology 2021 May 12 5 e00359
- Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1a.
  Clark AJ, Parikh SM, Kidney international 2021 04 99 4 828-840
- Role of endothelial microRNA 155 on capillary leakage in systemic inflammation.
  Etzrodt V, Idowu TO, Schenk H, Seeliger B, Prasse A, Thamm K, Pape T, Müller-Deile J, van Meurs M, Thum T, Garg A, Geffers R, Stahl K, Parikh SM, Haller H, David S, Critical care (London, England) 2021 02 25 1 76
- Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study.
  Raines NH, Ganatra S, Nissaisorakarn P, Pandit A, Morales A, Asnani A, Sadrolashrafi M, Maheshwari R, Patel R, Bang V, Shreyder K, Brar S, Singh A, Dani SS, Knapp S, Poyan Mehr A, Brown RS, Zeidel ML, Bhargava R, Schlondorff J, Steinman TI, Mukamal KJ, Parikh SM, Kidney360 2021 Jan 2 1 33-41
- Endothelial Biomarkers Are Associated With Indirect Lung Injury in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome.
  Whitney JE, Feng R, Koterba N, Chen F, Bush J, Graham K, Lacey SF, Melenhorst JJ, Parikh SM, Weiss SL, Yehya N, Critical care explorations 2020 Dec 2 12 e0295
- Mitochondrial transplantation by intra-arterial injection for acute kidney injury.
  Doulamis IP, Guariento A, Duignan T, Kido T, Orfany A, Saeed MY, Weixler VH, Blitzer D, Shin B, Snay ER, Inkster JA, Packard AB, Zurakowski D, Rousselle T, Bajwa A, Parikh SM, Stillman IE, Del Nido PJ, McCully JD, American journal of physiology. Renal physiology 2020 09 319 3 F403-F413
- TFEB-driven lysosomal biogenesis is pivotal for PGC1?a??-dependent renal stress resistance.
  Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM, JCI insight 2020 08 5 15
- Nicotinamide riboside with pterostilbene (NRPT) increases NAD⁺ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI.
  Simic P, Vela Parada XF, Parikh SM, Dellinger R, Guarente LP, Rhee EP, BMC nephrology 2020 08 21 1 342
- Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma.
  Gupta S, Seethapathy H, Strohbehn IA, Frigault MJ, O'Donnell EK, Jacobson CA, Motwani SS, Parikh SM, Curhan GC, Reynolds KL, Leaf DE, Sise ME, American journal of kidney diseases : the official journal of the National Kidney Foundation 2020 07 76 1 63-71
- The Angiopoietin-Tie2 Pathway in Critical Illness.
  Sack KD, Kellum JA, Parikh SM, Critical care clinics 2020 Apr 36 2 201-216
- Mitochondrial Metabolism in Acute Kidney Injury.
  Clark AJ, Parikh SM, Seminars in nephrology 2020 03 40 2 101-113
- NAD⁺ homeostasis in renal health and disease.
  Ralto KM, Rhee EP, Parikh SM, Nature reviews. Nephrology 2020 02 16 2 99-111
- Neutrophil activation in systemic capillary leak syndrome (Clarkson disease).
  Xie Z, Kuhns DB, Gu X, Otu HH, Libermann TA, Gallin JI, Parikh SM, Druey KM, Journal of cellular and molecular medicine 2019 08 23 8 5119-5127
- An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.
  Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell metabolism 2019 07 30 1 190-200.e6
- TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance.
  Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM, JCI insight 2019 03 5
- Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis.
  Allegretti AS, Vela Parada X, Ortiz GA, Long J, Krinsky S, Zhao S, Fuchs BC, Sojoodi M, Zhang D, Karumanchi SA, Kalim S, Nigwekar SU, Thadhani RI, Parikh SM, Chung RT, Hepatology (Baltimore, Md.) 2019 02 69 2 729-741
- Decreased PGC-1a Post-Cardiopulmonary Bypass Leads to Impaired Oxidative Stress in Diabetic Patients.
  Mahmood E, Jeganathan J, Feng R, Saraf M, Khabbaz K, Mahmood F, Venkatachalam S, Liu D, Chu L, Parikh SM, Matyal R, The Annals of thoracic surgery 2019 02 107 2 467-476
- A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).
  Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM, Communications biology 2019 2 398
- Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.
  Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R, Laboratory investigation; a journal of technical methods and pathology 2019 01 99 1 138-145
- Metabolic Stress Resistance in Acute Kidney Injury: Evidence for a PPAR-Gamma-Coactivator-1 Alpha-Nicotinamide Adenine Dinucleotide Pathway.
  Parikh SM, Nephron 2019 143 3 184-187
- Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
  Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100
- Increased synthesis of a coenzyme linked to longevity can combat disease.
  Parikh SM, Nature 2018 11 563 7731 332-333
- Molecular Regulation of Acute Tie2 Suppression in Sepsis.
  Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S, Critical care medicine 2018 09 46 9 e928-e936
- De novo NAD⁺ biosynthetic impairment in acute kidney injury in humans.
  Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nature medicine 2018 09 24 9 1351-1359
- Tie2 protects the vasculature against thrombus formation in systemic inflammation.
  Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, The Journal of clinical investigation 2018 04 128 4 1471-1484
- Reply.
  Druey KM, Arai AE, Parikh SM, The Journal of allergy and clinical immunology 2018 04 141 4 1540-1541
- PGC1a in the kidney.
  Lynch MR, Tran MT, Parikh SM, American journal of physiology. Renal physiology 2018 01 314 1 F1-F8
- Renal PGC1a May Be Associated with Recovery after Delayed Graft Function.
  Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM, Nephron 2018 138 4 303-309
- Esmolol infusion in patients with septic shock and tachycardia: a prospective, single-arm, feasibility study.
  Brown SM, Beesley SJ, Lanspa MJ, Grissom CK, Wilson EL, Parikh SM, Sarge T, Talmor D, Banner-Goodspeed V, Novack V, Thompson BT, Shahul S, Pilot and feasibility studies 2018 4 132
- PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.
  De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R, Proceedings of the National Academy of Sciences of the United States of America 2018 01 115 5 E982-E991
- Idiopathic systemic capillary leak syndrome (Clarkson disease).
  Druey KM, Parikh SM, The Journal of allergy and clinical immunology 2017 Sep 140 3 663-670
- Angiopoietins and Tie2 in vascular inflammation.
  Parikh SM, Current opinion in hematology 2017 Sep 24 5 432-438
- The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation.
  Parikh SM, Journal of the American Society of Nephrology : JASN 2017 Jul 28 7 1973-1982
- Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis.
  Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S, Scientific reports 2017 03 7 44113
- KLF2 and KLF4 control endothelial identity and vascular integrity.
  Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK, JCI insight 2017 02 2 4 e91700
- PPAR?-Coactivator-1a, Nicotinamide Adenine Dinucleotide and Renal Stress Resistance.
  Poyan Mehr A, Parikh SM, Nephron 2017 137 4 253-255
- Mitochondrial dysfunction in inherited renal disease and acute kidney injury.
  Emma F, Montini G, Parikh SM, Salviati L, Nature reviews. Nephrology 2016 May 12 5 267-80
- Cellular and Molecular Mechanisms of AKI.
  Agarwal A, Dong Z, Harris R, Murray P, Parikh SM, Rosner MH, Kellum JA, Ronco C, Journal of the American Society of Nephrology : JASN 2016 May 27 5 1288-99
- Targeting Tie2 and the host vascular response in sepsis.
  Parikh SM, Science translational medicine 2016 04 8 335 335fs9
- A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
  Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z, Nature medicine 2016 Apr 22 4 421-6
- Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.
  Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM, Proceedings of the National Academy of Sciences of the United States of America 2016 Mar 113 9 2472-7
- PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection.
  Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM, Nature 2016 Mar 531 7595 528-32
- Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea.
  Maski MR, Thomas RJ, Karumanchi SA, Parikh SM, PloS one 2016 11 5 e0154503
- Mitochondria in Acute Kidney Injury.
  Ralto KM, Parikh SM, Seminars in nephrology 2016 Jan 36 1 8-16
- Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.
  Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM, Critical care medicine 2015 Jul 43 7 e230-40
- Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.
  Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R, Blood 2015 Mar 125 12 1976-85
- Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense.
  Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM, PloS one 2015 10 3 e0119577
- The authors reply.
  Thamm K, Stiehl T, Parikh SM, David S, Critical care medicine 2015 Jan 43 1 e32-3
- The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation.
  Milam KE, Parikh SM, Tissue barriers 2015 3 1-2 e957508
- Mitochondrial function and disturbances in the septic kidney.
  Parikh SM, Yang Y, He L, Tang C, Zhan M, Dong Z, Seminars in nephrology 2015 Jan 35 1 108-19
- Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.
  Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S, Critical care medicine 2014 Oct 42 10 e654-62
- Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease.
  Xie Z, Ghosh CC, Parikh SM, Druey KM, American journal of respiratory and critical care medicine 2014 May 189 9 1145-7
- Mitochondrial biogenesis in the acutely injured kidney.
  Tran M, Parikh SM, Nephron. Clinical practice 2014 127 1-4 42-5
- Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease).
  Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, Young M, Parikh SM, Druey KM, Journal of clinical & cellular immunology 2014 5 1000213
- Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury.
  Parikh SM, Current opinion in critical care 2013 Dec 19 6 554-9
- Moving forward in sepsis research.
  Karumanchi SA, Parikh SM, American journal of respiratory and critical care medicine 2013 Nov 188 10 1264-5
- Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS.
  Parikh SM, Virulence 2013 Aug 4 6 517-24
- Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis.
  David S, Kümpers P, van Slyke P, Parikh SM, The Journal of pharmacology and experimental therapeutics 2013 Apr 345 1 2-6
- Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass.
  Clajus C, Lukasz A, David S, Hertel B, Lichtinghagen R, Parikh SM, Simon A, Ismail I, Haller H, Kümpers P, Cytokine 2012 Nov 60 2 352-9
- Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*.
  David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM, Critical care medicine 2012 Nov 40 11 3034-41
- Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity.
  Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012 Jul 60 7 521-9
- Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
  Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 109 25 10024-9
- Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis.
  van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K, Shock (Augusta, Ga.) 2012 Apr 37 4 392-8
- Circulating mediators of focal segmental glomerulosclerosis: soluble urokinase plasminogen activator receptor in context.
  Parikh SM, American journal of kidney diseases : the official journal of the National Kidney Foundation 2012 Mar 59 3 336-9
- Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia.
  Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA, Hypertension (Dallas, Tex. : 1979) 2012 Feb 59 2 256-64
- Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.
  Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P, Free radical biology & medicine 2012 Jan 52 2 497-506
- Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.
  David S, Ghosh CC, Mukherjee A, Parikh SM, Arteriosclerosis, thrombosis, and vascular biology 2011 Nov 31 11 2643-52
- PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice.
  Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM, The Journal of clinical investigation 2011 Oct 121 10 4003-14
- Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.
  David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM, American journal of physiology. Lung cellular and molecular physiology 2011 Jun 300 6 L851-62
- The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.
  Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N, Critical care (London, England) 2011 15 5 R261
- VEGF receptors and glomerular function.
  Parikh SM, Pollak MR, Journal of the American Society of Nephrology : JASN 2010 Oct 21 10 1599-600
- Leptin exacerbates sepsis-mediated morbidity and mortality.
  Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K, Journal of immunology (Baltimore, Md. : 1950) 2010 Jul 185 1 517-24
- The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis.
  Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC, Critical care (London, England) 2010 14 5 R182
- Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.
  Yuan HT, Khankin EV, Karumanchi SA, Parikh SM, Molecular and cellular biology 2009 Apr 29 8 2011-22
- Putting pressure on pre-eclampsia.
  Parikh SM, Karumanchi SA, Nature medicine 2008 Aug 14 8 810-2
- Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome.
  Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D, Sukhatme VP, Shock (Augusta, Ga.) 2008 Jun 29 6 656-61
- Admission angiopoietin levels in children with septic shock.
  Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS, Shock (Augusta, Ga.) 2007 Dec 28 6 650-654
- Images in clinical medicine. Calcinosis associated with renal failure.
  Cohen RA, Parikh SM, The New England journal of medicine 2007 Dec 357 25 2615
- Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.
  Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP, The Journal of biological chemistry 2007 Aug 282 33 23910-8
- Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak.
  Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP, Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Apr 13 7 2115-20
- Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans.
  Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP, PLoS medicine 2006 Mar 3 3 e46
- The nature of the autonomic dysfunction in multiple system atrophy.
  Parikh SM, Diedrich A, Biaggioni I, Robertson D, Journal of the neurological sciences 2002 Aug 200 1-2 1-10
- Morbidity after procurement of radial arteries in diabetic patients and the elderly undergoing coronary revascularization.
  Reddy VS, Parikh SM, Drinkwater DC, Lo A, Rauth TP, Moleski RM, Chang PA, The Annals of thoracic surgery 2002 Mar 73 3 803-7; discussion 807-8

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