Samir Parikh, M.D.

Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology
Robert Tucker Hayes Distinguished Chair in Nephrology, in Honor of Dr. Floyd C. Rector, Jr.

Internal Medicine - Nephrology
Acute Kidney Injury
Chronic Kidney Disease

New Patient Appointment or 214-645-1919

Biography

Samir Parikh, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and Chief of the Division of Nephrology. He specializes in acute kidney injury and chronic kidney disease.

Dr. Parikh earned his medical degree at Vanderbilt University School of Medicine. He completed both his residency in internal medicine and fellowship in nephrology at Beth Israel Deaconess Medical Center.

Certified by the American Board of Internal Medicine in nephrology, he joined the UT Southwestern faculty in 2021.

Dr. Parikh is a member of the American Society of Nephrology and the International Society of Nephrology. He serves on the editorial boards of the PLOS One and the Journal of the American Society of Nephrology, and he is the associate editor of Kidney 360.

He has delivered a wealth of presentations both nationally and internationally and has published widely in scholarly journals.

Among many other honors, in 2021 he received a faculty STARs Award from UT Southwestern.

Education & Training

Medical School - Vanderbilt University School of Medicine (1997-2001)
Internship - Beth Israel Deaconess Medical Center (2001-2002)
Residency - Beth Israel Deaconess Medical Center (2001-2003), Internal Medicine
Fellowship - Beth Israel Deaconess Medical Center (2003-2006), Nephrology

Professional Associations & Affiliations

American Society of Nephrology
International Society of Nephrology

Honors & Awards

UT Translational STARs Award 2021, UT Southwestern
Donald W. Seldin Young Investigator Award 2019, American Society of Nephrology and American Heart Association
Outstanding Investigator Award (OIA) 2018, National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
Sir William Osler Award 2018, Interurban Clinical Club
Gordon J. Strewler Award 2016, Beth Israel Deaconess Medical Center
Carl Gottschalk Award 2008, American Society of Nephrology
Excellence in Tutoring Award 2008, Harvard Medical School
Young Investigator Award 2008, Amgen Medical Institute
Kaufman Prize 2001, Vanderbilt University School of Medicine
Valedictorian/Founder’s Medal Awardee 2001, Vanderbilt University School of Medicine

Books & Publications

Publications
- Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
  Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, eLife 2023 Aug 12
- TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
  Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, The Journal of clinical investigation 2023 Jun 133 11
- Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.
  Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR, The Journal of clinical investigation 2022 Dec 132 23
- A new chapter in lipid signaling and kidney fibrosis.
  Idowu TO, Parikh SM, Science translational medicine 2022 Aug 14 658 eadd2826
- Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
  Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, JCI insight 2021 Sep
- An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.
  Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM, Cell metabolism 2019 07 30 1 190-200.e6
- Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
  Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, Nature 2019 01 565 7737 96-100
- Increased synthesis of a coenzyme linked to longevity can combat disease.
  Parikh SM, Nature 2018 11 563 7731 332-333
- De novo NAD⁺ biosynthetic impairment in acute kidney injury in humans.
  Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, Nature medicine 2018 09 24 9 1351-1359
- Tie2 protects the vasculature against thrombus formation in systemic inflammation.
  Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, The Journal of clinical investigation 2018 04 128 4 1471-1484
- Targeting Tie2 and the host vascular response in sepsis.
  Parikh SM, Science translational medicine 2016 04 8 335 335fs9
- Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.
  Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM, Proceedings of the National Academy of Sciences of the United States of America 2016 Mar 113 9 2472-7
- PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection.
  Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM, Nature 2016 Mar 531 7595 528-32
- Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
  Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 109 25 10024-9
- PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice.
  Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM, The Journal of clinical investigation 2011 Oct 121 10 4003-14

Clinical Focus

Acute Kidney Injury
Chronic Kidney Disease

New Patient Appointment or 214-645-1919