- Residency - Washington University in St. Louis (1984-1986), Internal Medicine
- Fellowship - Washington University in St. Louis (1985-1986), Hematology/oncology
- Internship - Washington University in St. Louis (1983-1984), Internal Medicine
- Medical School - Washington University in St. Louis (1977-1983)
![Sandy Hofmann, M.D., Ph.D.](https://s3-us-west-2.amazonaws.com/utsw-patientcare-web-production/original_images/hofmann-sandra-13259-200x200.jpg)
Sandy Hofmann, M.D., Ph.D.
- Internal Medicine - Hematology/Oncology
- General Hematology/Oncology
- General Internal Medicine
Biography
Sandra L. Hofmann, M.D., Ph.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She specializes in hematology and oncology.
Dr. Hofmann earned her medical degree and a doctoral degree in molecular biology at Washington University in St. Louis, where she also performed her residency in internal medicine and a fellowship in hematology and oncology. She received advanced training in molecular genetics through a postdoctoral fellowship at UT Southwestern.
Certified by the American Board of Internal Medicine, Dr. Hofmann joined the UT Southwestern faculty in 1989.
Dr. Hofmann’s research interests focus on the metabolism of proteins that are modified by lipids. Her laboratory has conducted pioneering work that has led to a greater understanding of a group of hereditary brain disorders known as the neuronal ceroid lipofuscinoses (NCL, or Batten disease).
She is a member of the American Association for the Advancement of Science, the Association of American Physicians, the American Society for Biochemistry and Molecular Biology, the American Society for Clinical Investigation, and the American Society of Hematology.
Education & Training
Professional Associations & Affiliations
- American Association for the Advancement of Science
- Association of American Physicians
- American Society for Biochemistry and Molecular Biology
- American Society for Clinical Investigation
- American Society of Hematology
Honors & Awards
- Avanti Award in Lipids 2014, Amerian Society for Biochemistry and Molecular Biology
- Fellow 2013, American Association for the Advancement of Science
- Javits Neuroscience Investigator (MERIT) Award 2004-2011, NINDS, National Institutes of Health
- Scholar in Medical Science 1991-1994, Charles E. Culpeper Foundation
- Alpha Omega Alpha 1983, Washington University School of Medicine
- Sigma Xi Award 1977, University of Virginia (Chemistry)
- Phi Beta Kappa 1976, University of Virginia
Books & Publications
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Publications
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Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle.
Lin MJ, Fine M, Lu JY, Hofmann SL, Frazier G, Hilgemann DW eLife 2013 2 0 -
Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis.
Hu J, Lu JY, Wong AM, Hynan LS, Birnbaum SG, Yilmaz DS, Streit BM, Lenartowicz EM, Thompson TC, Cooper JD, Hofmann SL Molecular genetics and metabolism 2012 Sep 107 1-2 213-21 -
DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.
Li Y, Martin BR, Cravatt BF, Hofmann SL The Journal of biological chemistry 2012 Jan 287 1 523-30 -
Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis.
Lu JY, Hu J, Hofmann SL Molecular genetics and metabolism 2010 Apr 99 4 374-8 -
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.
Li Y, Hu J, Höfer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL The Journal of biological chemistry 2010 Apr 285 17 13022-31 -
Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins.
Kyttälä A, Lahtinen U, Braulke T, Hofmann SL Biochimica et biophysica acta 2006 Oct 1762 10 920-33 -
Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-modified proteins.
Lu JY, Hofmann SL Journal of lipid research 2006 Jul 47 7 1352-7
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Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle.
Research
- Protein Lipidation
- Batten Disease
Clinical Focus
- General Hematology/Oncology
- General Internal Medicine