Shani Shastri, M.D.

Internal Medicine - Nephrology
Chronic Kidney Disease
Peritoneal dialysis

New Patient Appointment Accepting Virtual Visits or 214-645-1919

New Patient Appointment or 214-645-1919

Biography

Shani Shastri, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She specializes in chronic kidney disease, end-stage renal disease (ESRD) including hemodialysis, and peritoneal dialysis.

Dr. Shastri earned her medical degree at the K.J. Somaiya Medical College in Mumbai, India. She completed her residency in internal medicine at the University of Massachusetts and gained advanced training in nephrology through a fellowship at Tufts Medical Center. She also holds a master’s degree in public health from Loma Linda University and a master’s degree in clinical research from Tufts University.

Certified by the American Board of Internal Medicine in nephrology, she joined the UT Southwestern faculty in 2011.

Dr. Shastri is the Medical Director of the UT Southwestern/DaVita Preston Joint Venture Hemodialysis and Peritoneal Dialysis Unit. At UT Southwestern, she serves as Chair of the Nephrology Fellowship Clinical Competency Committee and is a member of the Pharmacy and Therapeutics Committee and the Fellowship Recruitment Committee.

Dr. Shastri’s research focuses on epidemiology and outcomes in chronic kidney disease and hemodialysis, peritoneal dialysis, cardiovascular outcomes in kidney disease, and aging. She has published articles in numerous peer-reviewed journals and co-authored chapters in several books, including Major Nonglomerular Disorders of the Kidney and Comprehensive Clinical Nephrology.

In 2021, Dr. Shastri received the Accountability Core Value Award from DaVita’s Physician Leadership as well as the Outstanding Patient Care Award in Nephrology from UT Southwestern.

Education & Training

Medical School - Sackler School of Graduate Biomedical Sciences (2008-2010), Research
Medical School - Loma Linda University (1998-1999)
Internship - Frankford Hospital of Philadelphia (2004-2005), Transitional Year
Fellowship - Tufts Medical Center (2008-2011), Nephrology
Residency - University of Massachusetts Medical Center (2005-2008), Internal Medicine
Medical School - K.J. Somaiya Medical College, India (1991-1997)

Professional Associations & Affiliations

American Society of Nephrology
International Society for Peritoneal Dialysis
Medical Council of India

Honors & Awards

Accountability Core Value Award 2021, DaVita’s Physician Leadership
Outstanding Patient Care Award in Nephrology 2021, UT Southwestern Medical Center
Texas Super Doctors 2015, Texas Monthly Magazine

Books & Publications

Books
- Major Nonglomerular Disorders of the Kidney in Andreoli and Carpenter’s Cecil Essentials of Medicine, 10th Edition
  Rajora N, Shastri S, Koowal P, Saxena R, In press
- Kidney Stones in ABIM review
  Shastri S, O Moe (2015)
- Assessment of Renal Function in Comprehensive Clinical Nephrology, 4th Ed.
  Stevens LA, Shastri S, Levey AS (2009)
Publications
- Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.
  Friedman AN, Guirguis J, Kapoor R, Gupta S, Leaf DE, Timsina LR, Obesity (Silver Spring, Md.) 2021 Jun
- Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.
  Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE, Intensive care medicine 2021 02 47 2 208-221
- Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.
  Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, Sosa MA, Renaghan AD, Melamed ML, Wilson FP, Neyra JA, Rashidi A, Boyle SM, Anand S, Christov M, Thomas LF, Edmonston D, Leaf DE, American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 02 77 2 190-203.e1
- Idiopathic hypokalemia in lupus nephritis - A newly recognized entity
  Adomako EA , Bilal S, Liu Y, Malik A, Van Buren PN, Shastri S and Sambandam KK Kidney360 2021
- Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19.
  Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE, JAMA internal medicine 2021 01 181 1 41-51
- Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States.
  Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 11 20 11 3061-3071
- AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.
  Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE, Journal of the American Society of Nephrology : JASN 2020 10
- In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study.
  Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE, BMJ (Clinical research ed.) 2020 09 371 m3513
- Assessing Extracellular Volume in Hemodialysis Patients Using Intradialytic Blood Pressure Slopes.
  Liu H, Lu R, Shastri S, Sonderman M, Van Buren PN Nephron 2018 Feb
- Lifetime risk of chronic kidney disease stage 3-5 in a community-based sample in Iceland
  Inker LA, Tighiouart H, Aspelund T, Gudnason V, Harris T, Indridason OS, Palsson R, Shastri S, Levey AS, Sarnak MJ. Clin J Am Soc Nephrol 2015 10 9 1575-1584
- Risk factors for cardiovascular disease across the spectrum of older age: The Cardiovascular Health Study.
  Odden MC, Shlipak MG, Whitson HE, Katz R, Kearney PM, Defilippi C, Shastri S, Sarnak MJ, Siscovick DS, Cushman M, Psaty BM, Newman AB Atherosclerosis 2014 Sep 237 1 336-342
- Fibroblast growth factor 23, the ankle-brachial index, and incident peripheral artery disease in the Cardiovascular Health Study.
  Garimella PS, Ix JH, Katz R, Chonchol MB, Kestenbaum BR, de Boer IH, Siscovick DS, Shastri S, Hiramoto JS, Shlipak MG, Sarnak MJ Atherosclerosis 2014 Mar 233 1 91-6
- Kidney function and mortality in octogenarians: Cardiovascular Health Study All Stars.
  Shastri S, Katz R, Rifkin DE, Fried LF, Odden MC, Peralta CA, Chonchol M, Siscovick D, Shlipak MG, Newman AB, Sarnak MJ Journal of the American Geriatrics Society 2012 Jul 60 7 1201-7
- Recovery of kidney function following delayed use of theralite™ dialyzer in a patient with myeloma cast nephropathy.
  Dahal K, Shastri S, Narayanasami U, Bijol V, Rider K, Strom A, Jaber L Clinical nephrology 2012 Apr
- New perspectives on blood pressure variability in hemodialysis patients.
  Van Buren PN, Shastri S, Inrig JK American journal of kidney diseases : the official journal of the National Kidney Foundation 2012 Mar 59 3 333-5
- Predictors of sudden cardiac death: a competing risk approach in the hemodialysis study.
  Shastri S, Tangri N, Tighiouart H, Beck GJ, Vlagopoulos P, Ornt D, Eknoyan G, Kusek JW, Herzog C, Cheung AK, Sarnak MJ Clinical journal of the American Society of Nephrology : CJASN 2012 Jan 7 1 123-30
- Effect of beta blockers on sudden cardiac death: A propensity score analysis of the HEMO study
  Tangri N, Shastri S, Tighiouart H, Beck GJ, Cheung A, Eknoyan G, Sarnak M American Journal of Kidney Disease Dec 2011 58 (6) 939-45
- Chronic kidney disease: High eGFR and mortality: high true GFR or a marker of frailty?
  Shastri S, Sarnak MJ Nature reviews. Nephrology 2011 Dec 7 12 680-2
- Predictors of sudden cardiac: A competing risk model in the HEMO Study
  Shastri S, Tangri N, Tighiouart H, Cheung A, Beck G, Eknoyan G, Sarnak M Clinical Journal of American Society of Nephrology 2011 November 10
- Cystatin C and albuminuria as risk factors for incident chronic kidney disease: The multi-ethnic study of atherosclerosis
  Shastri S, Katz R, Shlipak M, Kestenbaum B, Peralta C, Kramer H, Jacobs D, de Boer I, Cushman M, Siscovick D, Sarnak M American Journal of Kidney Disease June 2011 57 (6) 832-40
- Chronic kidney desease in octogenarians
  Shastri S, Tighiouart H, Katz R, Rifkin D, Fried L, Shlipak M, Newman A, Sarnak MJ Clinical Journal of American Society of Nephrology June 2011 6 (6) 1410-17
- Chronic kidney disease in octogenarians.
  Shastri S, Tighiouart H, Katz R, Rifkin DE, Fried LF, Shlipak MG, Newman AB, Sarnak MJ Clinical journal of the American Society of Nephrology : CJASN 2011 Jun 6 6 1410-7
- Cystatin C and albuminuria as risk factors for development of CKD stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA).
  Shastri S, Katz R, Shlipak MG, Kestenbaum B, Peralta CA, Kramer H, Jacobs DR, de Boer IH, Cushman M, Siscovick D, Sarnak MJ American journal of kidney diseases : the official journal of the National Kidney Foundation 2011 Jun 57 6 832-40
- Effect of beta blockers on sudden cardiac death: A propensity score analysis of the HEMO study
  Tangri N, Shastri S, Tighiouart H, Beck GJ, Cheung A, Eknoyan G, Sarnak M. Am J Kidney Dis 2011 58 939-945
- Blood pressure target in individuals without diabetes: what is the evidence?
  Shastri S, Sarnak MJ American journal of kidney diseases : the official journal of the National Kidney Foundation 2010 Sep 56 3 434-8

Research

Aging
Cardiovascular outcomes in kidney disease
Epidemiology and outcomes in chronic kidney disease
Epidemiology and outcomes in hemodialysis and peritoneal dialysis

Clinical Focus

Chronic Kidney Disease
Peritoneal dialysis
Hemodialysis