Timothy J. Brown, M.D.

Harold C. Simmons Comprehensive Cancer Center

Internal Medicine - Hematology/Oncology
Gastrointestinal Cancers
Pancreatic Cancer

New Patient Appointment Accepting Virtual Visits or 214-645-4673

Biography

Timothy J. Brown, M.D., MSCE, is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He specializes in the treatment of gastrointestinal cancers.

Dr. Brown earned his medical degree at the Penn State University College of Medicine and completed a residency in internal medicine at UT Southwestern, where he served as Chief Resident. He gained advanced training in hematology and oncology through a fellowship at the Hospital of the University of Pennsylvania, serving as Chief Fellow. He also earned a master’s degree in clinical epidemiology at the University of Pennsylvania.

Certified by the American Board of Internal Medicine, Dr. Brown joined the UT Southwestern faculty in 2023.

A prolific author and researcher, Dr. Brown has an interest in early phase clinical trial design and outcomes research for gastrointestinal malignancies. He has published numerous articles in peer-reviewed journals and serves as an ad hoc reviewer for several journals, including Annals of Internal Medicine, Journal of Clinical Oncology, and Trends in Cancer.

He is an associate member of the American Association for Cancer Research and the American College of Physicians.

In 2023, Dr. Brown earned the Conquer Cancer Merit Award at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium.

Personal Note

When he’s not at work, Dr. Brown enjoys lifting weights and spending time with his family.

Education & Training

Graduate School - University of Pennsylvania Perelman School of Medicine (2021-2023), Clinical Epidemiology
Medical School - Pennsylvania State University College of Medicine (2011-2015)
Residency - UT Southwestern Medical Center (2015-2019), Internal Medicine
Fellowship - Hospital of the University of Pennsylvania (2020-2023), Hematology Oncology

Professional Associations & Affiliations

American Association for Cancer Research
American College of Physicians
American Society of Clinical Oncology

Honors & Awards

Conquer Cancer Merit Award 2023, American Society of Clinical Oncology Gastrointestinal Cancers Symposium
Conquer Cancer Merit Award 2022, American Society of Clinical Oncology Annual Meeting
Chief Fellow in Hematology and Oncology 2021, Hospital of the University of Pennsylvania
Top Reviewer 2021, Annals of Internal Medicine
Chief Resident 2018, UT Southwestern Medical Center
Outstanding Recent Alumni 2019, College of Agriculture and Life Sciences, Virginia Tech
Top Reviewer 2018, Annals of Internal Medicine
Best Article by a Categorical Resident 2017, UT Southwestern Internal Medicine Residency
Distinction in Clinical Research — Second Place Resident 2016, 1st Annual Donald W. Seldin, M.D. Research Symposium
Graduation Award — Medical Student Research 2015, Pennsylvania State University
DocStars 2025, Cary Council

Books & Publications

Publications
- Bridging Knowledge Gaps in the Treatment of Advanced Hepatocellular Carcinoma.
  Brown TJ, JAMA network open 2025 Dec 8 12 e2551674
- Outcomes of Patients With Esophageal and Gastric Carcinoma at a Safety-net Health Care System: A Juncture to Explore Disparities in Diverse Socioeconomic Cohorts and Ethnicities.
  Narra K, Guthula S, Teigen KJ, Potti S, Bullock JC, Brown TJ, American journal of clinical oncology 2025 Dec
- A Real-World, Propensity-Matched Analysis of Second-Line FOLFIRI-Ramucirumab Versus Ramucirumab-Paclitaxel in Patients With Advanced Upper Gastrointestinal Cancers.
  Hyak JM, Ruan P, Jones AL, Verma N, Chung V, Grewal US, Vadehra D, Hornstein N, Wang SC, Porembka MR, Badiyan S, Sanford NN, Kazmi S, Brown TJ, American journal of clinical oncology 2025 Dec
- Treat the Tumor, Spare the Esophagus: The Case for Organ Preservation in Locally Advanced Esophageal/Gastroesophageal Junction Cancer.
  Grewal US, Sanford NN, Brown TJ, Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2025 Sep JCO2501197
- New Tool in the Toolbox: Patient Selection for Zolbetuximab in Advanced Treatment-Naïve Gastric/Gastroesophageal Junction Adenocarcinoma.
  Grewal US, Brown TJ, The oncologist 2025 Jun
- Demographic and prognostic factors affecting survival in invasive mucinous adenocarcinoma: a national cancer database analysis.
  Demangone MR, Hsia B, Malan A, Taghizadeh C, Moroz M, Brown TJ, Medical oncology (Northwood, London, England) 2025 May 42 7 224
- Survival Disparities in Adenocarcinoma Within Adenomatous Polyps: A National Cancer Database Analysis.
  Taghizadeh CS, Hsia B, Tade Y, Rafie S, Surendra A, Silberstein PT, Vadehra D, Brown TJ, Cureus 2025 May 17 5 e84792
- Evaluating the Safety and Efficacy of Adding Liver-Directed Radiation Therapy to Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma: A Single-Center Retrospective Cohort Analysis.
  Brown TJ, Amit U, Gheewala R, Ben-Josef E, Karasic TB, American journal of clinical oncology 2025 Apr
- A National Cancer Database Study on the Demographic, Prognostic, and Socioeconomic Factors Affecting Survival in Adenocarcinoma in Villous Adenoma.
  Hsia B, Tade Y, Rafie S, Toromani G, Silberstein PT, Vadehra D, Brown TJ, Cureus 2025 Apr 17 4 e82367
- A Text Message Intervention to Minimize the Time Burden of Cancer Care.
  Bange EM, Coughlin KQ, Li W, Brown TJ, Ragusano D, Balar E, Arasappan D, Nnaji M, Kim E, Alban C, Uppuluri S, Moriarty E, Bange T, Zinck L, Smith D, Josephs M, Harrigan JJ, Cohen RB, Zubka D, Rosin R, Balachandran M, Long Q, Bilger A, Schuchter LM, Mamtani M, Shulman LN, Guerra CE, Mamtani R, NEJM catalyst innovations in care delivery 2025 Mar 6 3
- Impact of Screening on Mortality for Patients Diagnosed with Hepatocellular Carcinoma in a Safety-Net Healthcare System: An Opportunity for Addressing Disparities.
  Narra K, Hull M, Teigen KJ, Reddy V, Bullock JC, Basha R, Alawi-Kakomanolis N, Gerber DE, Brown TJ, Cancers 2024 Nov 16 22
- Classification and Regression Trees to Predict for Survival for Patients With Hepatocellular Carcinoma Treated With Atezolizumab and Bevacizumab.
  Brown TJ, Gimotty PA, Mamtani R, Karasic TB, Yang YX, JCO clinical cancer informatics 2024 Aug 8 e2300220
- Targeted therapies in advanced biliary malignancies: a clinical review.
  Grewal US, Gaddam SJ, Beg MS, Brown TJ, Expert review of anticancer therapy 2024 Jul
- Clinical, pathological, and adjuvant chemotherapy use differences among microsatellite unstable and microsatellite stable colon cancers.
  Jafry BH, Buhaya MH, Milsap A, Jones AL, Goksu SY, Verma N, Brown TJ, Hughes A, Nair R, Sanford N, Su J, Huang E, Kazmi SMA, Journal of the National Cancer Center 2024 Jun 4 2 169-175
- Influences on the Hematopoietic Stem Cell Niche.
  Wang W, Brown TJ, Barth BM, SciBase hematology & blood disorders 2024 1 1
- Therapeutic Potential of Ceramide in Cancer Treatment.
  Wang W, Prince BF, Thorpe AJ, Brown TJ, Barth BM, Journal of cancer research and oncobiology 2024 4 1
- Oral Carbon Monoxide Enhances Autophagy Modulation in Prostate, Pancreatic, and Lung Cancers.
  Bi J, Witt E, McGovern MK, Cafi AB, Rosenstock LL, Pearson AB, Brown TJ, Karasic TB, Absler LC, Machkanti S, Boyce H, Gallo D, Becker SL, Ishida K, Jenkins J, Hayward A, Scheiflinger A, Bodeker KL, Kumar R, Shaw SK, Jabbour SK, Lira VA, Henry MD, Tift MS, Otterbein LE, Traverso G, Byrne JD, Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec e2308346
- The Clinical Implications of Reversions in Patients with Advanced Pancreatic Cancer and Pathogenic Variants in BRCA1, BRCA2, or PALB2 After Progression on Rucaparib.
  Brown TJ, Yablonovitch A, Till JE, Yen J, Kiedrowski LA, Hood R, O'Hara MH, Teitelbaum U, Karasic TB, Schneider C, Carpenter EL, Nathanson K, Domchek SM, Reiss KA, Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Jul
- Outcomes of hepatocellular carcinoma by etiology with first-line atezolizumab and bevacizumab: a real-world analysis.
  Brown TJ, Mamtani R, Gimotty PA, Karasic TB, Yang YX, Journal of cancer research and clinical oncology 2023 Jun 149 6 2345-2354
- Advancements in Systemic Therapy for Pancreatic Cancer.
  Brown TJ, Reiss KA, O'Hara MH, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2023 May 43 e397082
- Nonsteroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal hematodiaphyseal dysplasia.
  Brown TJ, Barrett N, Meng H, Ricciotti E, McDonnell C, Dancis A, Qualtieri J, FitzGerald GA, Cotter M, Babushok DV, Blood 2023 Mar 141 13 1553-1559
- Phase I Trial of Regorafenib, Hydroxychloroquine, and Entinostat in Metastatic Colorectal Cancer.
  Karasic TB, Brown TJ, Schneider C, Teitelbaum UR, Reiss KA, Mitchell TC, Massa RC, O'Hara MH, DiCicco L, Garcia-Marcano L, Amaravadi RK, O'Dwyer PJ, The oncologist 2022 Sep 27 9 716-e689
- Trends of Clinical Outcomes of Patients with Advanced Hepatocellular Carcinoma Treated with First-Line Sorafenib in Randomized Controlled Trials.
  Brown TJ, Gupta A, Sedhom R, Beg MS, Karasic TB, Yarchoan M, Gastrointestinal tumors 2022 Mar 9 1 19-26
- Importance of addressing malnutrition in cancer and implementation of a quality improvement project in a gastrointestinal cancer clinic.
  Levonyak NS, Hodges MP, Haaf N, Brown TJ, Hardy S, Mhoon V, Kainthla R, Beg MS, Kazmi SM, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2022 Feb 37 1 215-223
- Promoting High-Value Change by Addressing the Structure of Order Sets: Lessons From the Cardiac Catheterization Lab.
  Pokala N, Singh S, Hu G, Brown TJ, Pandey A, Das SR, Gupta A American journal of medical quality : the official journal of the American College of Medical Quality 2018 Sep 1062860618798920
- Applying the "COST" (Culture, Oversight, Systems Change, and Training) Framework to De-adopt the Neutropenic Diet.
  Gupta A, Brown TJ, Singh S, Sen A, Agrawal D, Li HC, Moriates C, Johnson DH, Sadeghi N The American journal of medicine 2018 Aug
- Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia.
  McGill CM, Tomco PL, Ondrasik RM, Belknap KC, Dwyer GK, Quinlan DJ, Kircher TA, Andam CP, Brown TJ, Claxton DF, Barth BM Phytotherapy research : PTR 2018 Apr
- Pasireotide for the treatment of refractory hypoglycaemia from malignant insulinoma.
  Hendren NS, Panach K, Brown TJ, Peng L, Beg MS, Weissler J, Mirfakhraee S Clinical endocrinology 2018 Feb 88 2 341-343
- Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia.
  McGill CM, Brown TJ, Cheng YY, Fisher LN, Shanmugavelandy SS, Gustafson SJ, Dunlap KL, Lila MA, Kester M, Toran PT, Claxton DF, Barth BM International journal of biopharmaceutical sciences 2018 Jan 1 1
- Cutaneous adnexal adenocarcinoma with exquisite sensitivity to trastuzumab.
  Brown TJ, Sher DJ, Nedzi LA, Hughes RS, Beg MS, Mull J, Sarode VR, Khan SA Head & neck 2017 05 39 5 E69-E71
- Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.
  Frismantas V, Dobay MP, Rinaldi A, Tchinda J, Dunn SH, Kunz J, Richter-Pechanska P, Marovca B, Pail O, Jenni S, Diaz-Flores E, Chang BH, Brown TJ, Collins RH, Uhrig S, Balasubramanian GP, Bandapalli OR, Higi S, Eugster S, Voegeli P, Delorenzi M, Cario G, Loh ML, Schrappe M, Stanulla M, Kulozik AE, Muckenthaler MU, Saha V, Irving JA, Meisel R, Radimerski T, Von Stackelberg A, Eckert C, Tyner JW, Horvath P, Bornhauser BC, Bourquin JP Blood 2017 03 129 11 e26-e37
- Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.
  Brown TJ, Gentry C, Hammer ST, Hwang CS, Vusirikala M, Patel PA, Matevosyan K, Tujios SR, Mufti AR, Collins RH ACG case reports journal 2017 4 e48
- Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
  Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M JAMA oncology 2016 Nov 2 11 1460-1469
- Metabolic changes during ovarian cancer progression as targets for sphingosine treatment.
  Anderson AS, Roberts PC, Frisard MI, McMillan RP, Brown TJ, Lawless MH, Hulver MW, Schmelz EM Experimental cell research 2013 Jun 319 10 1431-42

Research

Early phase clinical trial design
Outcomes in gastrointestinal malignancies

Clinical Focus

Gastrointestinal Cancers
Pancreatic Cancer
Liver Cancer
Bile duct cancer
Early phase clinical trials