Veena Rajaram, M.D.

Pathology

Education & Training

Fellowship - Washington University in St. Louis School of Medicine (2000-2001), Surgical Pathology
Fellowship - Washington University in St. Louis School of Medicine (2001-2002), Pediatric Pathology
Fellowship - Washington University in St. Louis School of Medicine (2002-2004), Neuropathology
Medical School - Maharaja Krishna Chandra Gajapati Medical College (1982-1987)
Internship - Maharaja Krishna Chandra Gajapati Medical College (1987-1988), Rotating
Residency - Winthrop University Hospital (1997-1998), Anatomic & Clinical Pathology
Residency - Washington University in St. Louis School of Medicine (1998-2000), Anatomic & Clinical Pathology

Professional Associations & Affiliations

Pediatric Brain Tumor Consortium (2006-2012), Pathology reviewer
American Association of Neuropathologists (2003), Member
Children's Oncology Group (2008), Associate member
Society for Pediatric Pathology (2002), Member
United States and Canadian Academy of Pathology (1999), Member
American Society for Clinical Pathology (1997-2005), Member
College of American Pathology (1997), Member

Books & Publications

Books
- Cytopathology of the central nervous system in Diagnostic Pediatric Cytopathology and Histopathologic Correlation
  Rajaram V (2016), Cambridge CB2 8BS, United Kingdom, Cambridge University Press
- Brain and Spinal cord in Color Atlas of Fetal and Neonatal Histology
  Rajaram V (2011), New York, Springer
Publications
- Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers.
  Rajaram V, Brat DJ, Perry A Human pathology 2004 Nov 35 11 1413-8
- Postoperative radiation therapy for grade II and III intracranial ependymoma.
  Mansur DB, Perry A, Rajaram V, Michalski JM, Park TS, Leonard JR, Luchtman-Jones L, Rich KM, Grigsby PW, Lockett MA, Wahab SH, Simpson JR International journal of radiation oncology, biology, physics 2005 Feb 61 2 387-91
- EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma.
  Covinsky M, Gong S, Rajaram V, Perry A, Pfeifer J Human pathology 2005 Jan 36 1 74-81
- Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors.
  Bridge RS, Rajaram V, Dehner LP, Pfeifer JD, Perry A Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Jan 19 1 1-8
- High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum.
  Xie H, Wang M, Bonaldo Mde F, Smith C, Rajaram V, Goldman S, Tomita T, Soares MB Nucleic acids research 2009 Jul 37 13 4331-40
- Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study.
  McLendon RE, Adekunle A, Rajaram V, Koçak M, Blaney SM Archives of pathology & laboratory medicine 2011 Aug 135 8 984-93
- Evaluating the incidence and utility of microscopic metastatic dissemination as diagnosed by lumbar cerebro-spinal fluid (CSF) samples in children with newly diagnosed intracranial ependymoma.
  Fangusaro J, Van Den Berghe C, Tomita T, Rajaram V, Aguilera D, Wang D, Goldman S Journal of neuro-oncology 2011 Jul 103 3 693-8
- BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors.
  Wang M, Xie H, Stellpflug W, Rajaram V, Bonaldo Mde F, Goldman S, Tomita T, Soares MB Neuroinformatics 2011 Mar 9 1 59-67
- Genome-wide quantitative assessment of variation in DNA methylation patterns.
  Xie H, Wang M, de Andrade A, Bonaldo Mde F, Galat V, Arndt K, Rajaram V, Goldman S, Tomita T, Soares MB Nucleic acids research 2011 May 39 10 4099-108
- Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.
  Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL The Journal of molecular diagnostics : JMD 2011 Nov 13 6 669-77
- REST is a novel prognostic factor and therapeutic target for medulloblastoma.
  Taylor P, Fangusaro J, Rajaram V, Goldman S, Helenowski IB, MacDonald T, Hasselblatt M, Riedemann L, Laureano A, Cooper L, Gopalakrishnan V Molecular cancer therapeutics 2012 Aug 11 8 1713-23
- Efficacy of interstitial continuous vincristine infusion in a bioluminescent rodent intracranial tumor model.
  Xi G, Mania-Farnell B, Rajaram V, Mayanil CS, Soares MB, Tomita T, Goldman S Journal of neuro-oncology 2012 Jan 106 2 261-70
- Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation.
  Sun MA, Sun Z, Wu X, Rajaram V, Keimig D, Lim J, Zhu H, Xie H Scientific reports 2016 6 32298
- NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors.
  Georgescu MM, Mobley BC, Orr BA, Shang P, Lehman NL, Zhu X, O'Neill TJ, Rajaram V, Hatanpaa KJ, Timmons CF, Raisanen JM Acta neuropathologica communications 2016 4 1 55
- Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy.
  Xi G, Li YD, Grahovac G, Rajaram V, Wadhwani N, Pundy T, Mania-Farnell B, James CD, Tomita T Molecular cancer 2017 Jan 16 1 21
- Pan-Trk Immunohistochemistry Identifies NTRK rearrangements in Pediatric Mesenchymal Tumors.
  Rudzinski ER, Lockwood CM, Stohr BA, Vargas SO, Sheridan R, Black JO, Rajaram V, Laetsch TW, Davis JL The American journal of surgical pathology 2018 Apr
- Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets.
  Sredni ST, Bonaldo Mde F, Costa FF, Huang CC, Hamm CA, Rajaram V, Tomita T, Goldman S, Bischof JM, Soares MB Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2010 Mar 26 3 279-83
- Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis.
  Daoud EV, Rajaram V, Cai C, Oberle RJ, Martin GR, Raisanen JM, White CL, Foong C, Mickey BE, Pan E, Hatanpaa KJ Journal of neuropathology and experimental neurology 2018 Feb
- Pilomatricoma of Childhood: A Common Pathologic Diagnosis Yet a Rare Radiologic One.
  Bulman JC, Ulualp SO, Rajaram V, Koral K AJR. American journal of roentgenology 2016 Jan 206 1 182-8
- Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.
  Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S Cell reports 2018 Jan 22 5 1169-1184
- Nasal chondromesenchymal hamartoma: correlation of typical MR, CT and pathological findings.
  Yao-Lee A, Ryan M, Rajaram V Pediatric radiology 2011 May 41 5 675-7
- Epigenomic analysis of Alu repeats in human ependymomas.
  Xie H, Wang M, Bonaldo Mde F, Rajaram V, Stellpflug W, Smith C, Arndt K, Goldman S, Tomita T, Soares MB Proceedings of the National Academy of Sciences of the United States of America 2010 Apr 107 15 6952-7
- Alterations of protein 4.1 family members in ependymomas: a study of 84 cases.
  Rajaram V, Gutmann DH, Prasad SK, Mansur DB, Perry A Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 Jul 18 7 991-7
- 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases.
  Rajaram V, Leuthardt EC, Singh PK, Ojemann JG, Brat DJ, Prayson RA, Perry A Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004 Jan 17 1 9-14
- An experimental brainstem tumor model using in vivo bioluminescence imaging in rat.
  Kondo A, Goldman S, Vanin EF, Sredni ST, Rajaram V, Soares MB, Tomita T Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2009 May 25 5 527-33
- Longitudinal assessment of regional directed delivery in a rodent malignant glioma model.
  Kondo A, Goldman S, Lulla RR, Mania-Farnell B, Vanin EF, Sredni ST, Rajaram V, Soares MB, Tomita T Journal of neurosurgery. Pediatrics 2009 Dec 4 6 592-8
- Rotavirus infection in small bowel transplant: a histologic comparison with acute cellular rejection.
  Eisengart LJ, Chou PM, Iyer K, Cohran V, Rajaram V Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2009 Mar-Apr 12 2 85-8
- MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
  Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG Molecular cell 2018 Jun 70 5 825-841.e6
- Personalized Treatment for a Patient With a BRAF V600E Mutation Using Dabrafenib and a Tumor Treatment Fields Device in a High-Grade Glioma Arising From Ganglioglioma.
  Meletath SK, Pavlick D, Brennan T, Hamilton R, Chmielecki J, Elvin JA, Palma N, Ross JS, Miller VA, Stephens PJ, Snipes G, Rajaram V, Ali SM, Melguizo-Gavilanes I Journal of the National Comprehensive Cancer Network : JNCCN 2016 Nov 14 11 1345-1350
- Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum.
  Rajaram V, Hill DA, Doherty GM, Liapis H, Dehner LP International journal of surgical pathology 2004 Apr 12 2 161-5
- DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation.
  Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD Genes, chromosomes & cancer 2007 May 46 5 508-13
- Identification of microRNAs as potential prognostic markers in ependymoma.
  Costa FF, Bischof JM, Vanin EF, Lulla RR, Wang M, Sredni ST, Rajaram V, Bonaldo Mde F, Wang D, Goldman S, Tomita T, Soares MB PloS one 2011 6 10 e25114
- Review of low-grade gliomas in children-evolving molecular era and therapeutic insights.
  Khatua S, Wang J, Rajaram V Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2015 Feb
- Medulloblastoma arising from an immature teratoma of the posterior fossa. Case report.
  Das S, Muro K, Goldman S, Rajaram V, DiPatri AJ Journal of neurosurgery 2007 Jan 106 1 Suppl 61-4
- Cellular injury and neuroinflammation in children with chronic intractable epilepsy.
  Choi J, Nordli DR, Alden TD, DiPatri A, Laux L, Kelley K, Rosenow J, Schuele SU, Rajaram V, Koh S Journal of neuroinflammation 2009 6 38
- Interstitial continuous infusion therapy in a malignant glioma model in rats.
  Tange Y, Kondo A, Egorin MJ, Mania-Farnell B, Daneriallis GM, Nakazaki H, Sredni ST, Rajaram V, Goldman S, Soares MB, Tomita T Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2009 Jun 25 6 655-62
- Glioblastoma multiforme in a patient with chronic granulomatous disease treated with subtotal resection, radiation, and thalidomide: case report of a long-term survivor.
  Aguilera DG, Tomita T, Rajaram V, Fangusaro J, Katz BZ, Shulman S, Goldman S Journal of pediatric hematology/oncology 2009 Dec 31 12 965-9
- Immunoglobulin A nephropathy.
  Rajaram V, Liapis H Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001 16 Suppl 6 77-9
- Efficacy of vincristine administered via convection-enhanced delivery in a rodent brainstem tumor model documented by bioluminescence imaging.
  Xi G, Rajaram V, Mania-Farnell B, Mayanil CS, Soares MB, Tomita T, Goldman S Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2012 Apr 28 4 565-74
- The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.
  Das CM, Taylor P, Gireud M, Singh A, Lee D, Fuller G, Ji L, Fangusaro J, Rajaram V, Goldman S, Eberhart C, Gopalakrishnan V Oncogene 2012 Jun
- Persistence of parenchymal and perivascular T-cells in treatment-refractory anti-N-methyl-D-aspartate receptor encephalitis.
  Filatenkov A, Richardson TE, Daoud E, Johnson-Welch SF, Ramirez DM, Torrealba J, Greenberg B, Monson NL, Rajaram V Neuroreport 2017 Sep 28 14 890-895
- Juvenile pilocytic astrocytoma in association with arteriovenous malformation.
  Soltanolkotabi M, Schoeneman SE, Dipatri AJ, Hurley MC, Ansari SA, Rajaram V, Tomita T, Shaibani A Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2012 Jun 18 2 140-7
- Targeted MAPK Pathway Inhibitors in Patients With Disseminated Pilocytic Astrocytomas.
  Drobysheva A, Klesse LJ, Bowers DC, Rajaram V, Rakheja D, Timmons CF, Wang J, Koral K, Gargan L, Ramos E, Park JY Journal of the National Comprehensive Cancer Network : JNCCN 2017 Aug 15 8 978-982
- Trichofolliculoma of the vulva associated with vulvar intraepithelial neoplasia: report of three cases and review of the literature.
  Peterdy GA, Huettner PC, Rajaram V, Lind AC International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2002 Jul 21 3 224-30
- REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature.
  Shaik S, Kennis B, Maegawa S, Schadler K, Yanwen Y, Callegari K, Lulla RR, Goldman S, Nazarian J, Rajaram V, Fangusaro J, Gopalakrishnan V Oncotarget 2018 Jan 9 4 5233-5250
- Mixed glioneuronal tumors of the spinal cord in two children.
  Syed S, Rajaram V, Leonard JR, Perry A, Raghavan R Acta neuropathologica 2006 Jan 111 1 53-5
- Integration of gene-based markers in a pearl millet genetic map for identification of candidate genes underlying drought tolerance quantitative trait loci.
  Sehgal D, Rajaram V, Armstead IP, Vadez V, Yadav YP, Hash CT, Yadav RS BMC plant biology 2012 12 9
- The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.
  Das CM, Taylor P, Gireud M, Singh A, Lee D, Fuller G, Ji L, Fangusaro J, Rajaram V, Goldman S, Eberhart C, Gopalakrishnan V Oncogene 2016 Jul

Research

Malformations of the central nervous system
Embryonal and pediatric brain tumors