Vishal Patel, M.D.

Yin Quan-Yuen Distinguished Professorship in Nephrology

Internal Medicine - Nephrology

New Patient Appointment or 214-645-1919

Biography

Vishal Patel, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Nephrology. He specializes in polycystic kidney disease (PKD).

Originally from India, Dr. Patel received his medical degree from Pramukhswami Medical School in Gujarat. He then completed residency training in internal medicine at Northwestern University Medical School in Evanston, Illinois, and advanced training in nephrology through a fellowship program at UT Southwestern, where he also completed a fellowship in research.

Certified by the American Board of Internal Medicine in nephrology, he joined the UT Southwestern faculty in 2009 as an Assistant Professor, and was promoted to Associate Professor in 2018.

Dr. Patel serves on the editorial board of Scientific Reports, and serves as an ad hoc reviewer for a number of other peer-reviewed journals, including the New England Journal of Medicine, Cell Metabolism, Journal of the American Society of Nephrology, and the Journal of Clinical Investigation. In 2021, he served as guest editor of the Frontiers in Physiology special issue on non-coding RNAs, and in 2022 he served as guest editor of the Scientific Reports special collection on RNA therapeutics.

He is also an active member of the American Society of Nephrology.

Education & Training

Medical School - Pramukhswami Medical School, India (1994-2000)
Research Fellowship - UT Southwestern Medical Center (2005-2008), Research
Fellowship - UT Southwestern Medical Center (2004-2006), Nephrology
Residency - McGaw Medical Center of Northwestern University (2002-2004), Internal Medicine
Internship - Mount Sinai Hospital Medical Center (2001-2002), Internal Medicine

Professional Associations & Affiliations

American Society of Nephrology

Honors & Awards

Chief Fellow, UT Southwestern Medical Center-Nephrology fellowship 2006
SSCI Young Investigator Travel award 2007
UT Southwestern O’Brien Center-Pilot and Feasibility Grant 2009
NIDDK-Career Development Award 2009
Rising star in Nephrology - State of Texas 2012, Super Doctors

Books & Publications

Publications
- PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
  Lakhia R, Ramalingam H, Chang CM, Cobo-Stark P, Biggers L, Flaten A, Alvarez J, Valencia T, Wallace DP, Lee EC, Patel V, Nature communications 2022 Aug 13 1 4765
- A methionine-Mettl3-N⁶-methyladenosine axis promotes polycystic kidney disease.
  Ramalingam H, Kashyap S, Cobo-Stark P, Flaten A, Chang CM, Hajarnis S, Hein KZ, Lika J, Warner GM, Espindola-Netto JM, Kumar A, Kanchwala M, Xing C, Chini EN, Patel V, Cell metabolism 2021 Jun 33 6 1234-1247.e7
- Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression.
  Lakhia R, Yheskel M, Flaten A, Ramalingam H, Aboudehen K, Ferrè S, Biggers L, Mishra A, Chaney C, Wallace DP, Carroll T, Igarashi P, Patel V, JCI insight 2020 Apr 5 7
- Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.
  Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben S, Bentley P, Wright T, Patel V, Nature communications 2019 Sep 10 1 4148
- Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth.
  Yheskel M, Lakhia R, Cobo-Stark P, Flaten A, Patel V Scientific reports 2019 Feb 9 1 1920
- microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism.
  Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V Nature communications 2017 Feb 8 14395
- Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.
  Brzóska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA Kidney international 2016 Dec 90 6 1274-1284
- MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease.
  Lakhia R, Hajarnis S, Williams D, Aboudehen K, Yheskel M, Xing C, Hatley ME, Torres VE, Wallace DP, Patel V Journal of the American Society of Nephrology : JASN 2016 Aug 27 8 2319-30
- Transcription Factor Hepatocyte Nuclear Factor-1? Regulates Renal Cholesterol Metabolism.
  Aboudehen K, Kim MS, Mitsche M, Garland K, Anderson N, Noureddine L, Pontoglio M, Patel V, Xie Y, DeBose-Boyd R, Igarashi P Journal of the American Society of Nephrology : JASN 2015 Dec
- Transcription Factor HNF-1? Regulates MicroRNA-200 Expression Through a Long Noncoding RNA.
  Hajarnis SS, Patel V, Aboudehen K, Attanasio M, Cobo-Stark P, Pontoglio M, Igarashi P The Journal of biological chemistry 2015 Aug
- miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.
  Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P Proceedings of the National Academy of Sciences of the United States of America 2013 Jun
- MicroRNAs regulate renal tubule maturation through modulation of Pkd1.
  Patel V, Hajarnis S, Williams D, Hunter R, Huynh D, Igarashi P Journal of the American Society of Nephrology : JASN 2012 Dec 23 12 1941-8
- MicroRNAs and fibrosis.
  Patel V, Noureddine L Current opinion in nephrology and hypertension 2012 Jul 21 4 410-6
- Primary cilia regulate mTORC1 activity and cell size through Lkb1.
  Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW Nature cell biology 2010 Nov 12 11 1115-22
- Loss of oriented cell division does not initiate cyst formation.
  Nishio S, Tian X, Gallagher AR, Yu Z, Patel V, Igarashi P, Somlo S Journal of the American Society of Nephrology : JASN 2010 Feb 21 2 295-302
- Aberrant planar cell polarity induced by urinary tract obstruction.
  Li L, Zepeda-Orozco D, Patel V, Truong P, Karner CM, Carroll TJ, Lin F American journal of physiology. Renal physiology 2009 Dec 297 6 F1526-33
- Advances in the pathogenesis and treatment of polycystic kidney disease.
  Patel V, Chowdhury R, Igarashi P Current opinion in nephrology and hypertension 2009 Mar 18 2 99-106
- Renal Dysgenesis (Chapter),
  Fangming Lin, Vishal Patel, and Peter Igarashi Genetic Diseases of the Kidney 2009, Edited by Lifton, Somlo, Giebisch, and Seldin 2009
- Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
  Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P Human molecular genetics 2008 Jun 17 11 1578-90
- Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.
  Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS Journal of the National Cancer Institute 2008 Jan 100 2 140-54
- Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.
  Ma Z, Gong Y, Patel V, Karner CM, Fischer E, Hiesberger T, Carroll TJ, Pontoglio M, Igarashi P Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 104 51 20386-91

Research

Polycystic Kidney Disease
MicroRNAs
Kidney Development and Homeostasis