- Medical School - Ohio University Heritage College of Osteopathic Medicine (2015-2019)
- Residency - The Jewish Hospital Mercy Health (2019-2022), Internal Medicine
- Other Post Graduate Training - Michigan State University (2005-2007)
- Research Fellowship - University of Michigan Medical Center (2009-2010), Dermatology
- Research Fellowship - Harvard Medical School (2010-2012), Genetics
- Research Fellowship - University of Michigan Medical Center (2007-2010), Pathology
- Graduate School - Bowling Green State University (2000-2005), Biological Sciences
- Graduate School - Michigan State University (2005-2007), Statistics
- Other Post Graduate Training - Bowling Green State University (2000-2005)
William Swindell, D.O., Ph.D.
- Internal Medicine - Hospital Medicine - University Hospitals
Biography
William Swindell, D.O., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Hospital Medicine Division. His clinical interests include general internal medicine, geriatric medicine, and endocrinology.
Originally from Cleveland, Ohio, Dr. Swindell holds a bachelor's degree and a doctorate in biology from Bowling Green State University in Bowling Green, Ohio, and a master's degree in statistics from Michigan State University in East Lansing, Michigan. He completed postdoctoral research studies at the University of Michigan in Ann Arbor, Michigan, Brigham & Women's Hospital in Boston, Massachusetts, and at Harvard Medical School. He received his medical degree from the Ohio University Heritage College of Osteopathic Medicine in Athens, Ohio, and then completed internal medicine residency training at The Jewish Hospital — Mercy Health in Cincinnati, Ohio.
Dr. Swindell's research interests include bioinformatics, health data analytics, and inflammatory mechanisms of aging and disease. His investigations have resulted in more than 90 publications in peer-reviewed journals, and his findings have been presented at scientific conferences throughout the U.S. and around the world.
Dr. Swindell is active in professional societies such as the American College of Physicians and Texas Medical Association.
Outside of medicine, Dr. Swindell enjoys traveling, exercising, sports, and spending time with family.
Education & Training
Books & Publications
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Publications
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Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurdardottir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson J, Ward NL, JCI insight 2024 Mar -
HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, iScience 2024 Feb 27 2 108986 -
A Critical Role for IFN-β Signaling for IFN-κ Induction in Keratinocytes
Xu B, Musai J, Tan YS, Hile GA, Swindell WR, Klein B, Qin JT, Sarkar MK, Gudjonsson JE, Kahlenberg JM Frontiers in Lupus 2024 2 1359714 -
Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords.
Swindell WR, Frontiers in genetics 2024 15 1385114 -
FPR1 contributes to epidermal barrier dysfunction-induced skin inflammation through NLRC4-dependent keratinocyte activation.
Shao S, Sun Z, Chu M, Chen J, Cao T, Swindell WR, Bai Y, Li Q, Ma J, Zhu Z, Schuler A, Helfrich Y, Billi AC, Li Z, Hao J, Xiao C, Dang E, Gudjonsson JE, Wang G, The British journal of dermatology 2023 Nov -
Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging.
Meyer TA, Swindell WR, Chaudhuri RK, Antioxidants (Basel, Switzerland) 2023 May 12 6 -
Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs.
Swindell WR, Bojanowski K, Singh P, Randhawa M, Chaudhuri RK, JID innovations : skin science from molecules to population health 2023 May 3 3 100178 -
Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.
Wiedemann J, Billi AC, Bocci F, Kashgari G, Xing E, Tsoi LC, Meller L, Swindell WR, Wasikowski R, Xing X, Ma F, Gharaee-Kermani M, Kahlenberg JM, Harms PW, Maverakis E, Nie Q, Gudjonsson JE, Andersen B, Cell reports 2023 Jan 42 1 111994 -
Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis.
Swindell WR, Bojanowski K, Chaudhuri RK, International journal of molecular sciences 2022 Nov 23 22 -
Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis.
Parish AJ, Swindell WR, Aging cell 2022 Oct e13733 -
Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes.
Swindell WR, Bojanowski K, Chaudhuri RK, Pharmaceuticals (Basel, Switzerland) 2022 Apr 15 4 -
Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over time.
Skaug B, Lyons MA, Swindell WR, Salazar GA, Wu M, Tran TM, Charles J, Vershel CP, Mayes MD, Assassi S, Annals of the rheumatic diseases 2022 04 81 4 516-523 -
Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.
Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M, Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E, Missero C, Gudjonsson JE, Green KJ, The Journal of clinical investigation 2022 02 132 3 -
A Sensitization-Free Dimethyl Fumarate Prodrug, Isosorbide Di-(Methyl Fumarate), Provides a Topical Treatment Candidate for Psoriasis.
Bojanowski K, Ibeji CU, Singh P, Swindell WR, Chaudhuri RK, JID innovations : skin science from molecules to population health 2021 Dec 1 4 100040 -
IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.
Shao S, Tsoi LC, Swindell WR, Chen J, Uppala R, Billi AC, Xing X, Zeng C, Sarkar MK, Wasikowski R, Jiang Y, Kirma J, Sun J, Plazyo O, Wang G, Harms PW, Voorhees JJ, Ward NL, Ma F, Pellegrini M, Merleev A, Perez White BE, Modlin RL, Andersen B, Maverakis E, Weidinger S, Kahlenberg JM, Gudjonsson JE, The Journal of investigative dermatology 2021 10 141 10 2436-2448 -
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris.
Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, Wasikowski R, Smith KM, Honore P, Scott VE, Maverakis E, Kahlenberg JM, Wang G, Ward NL, Harms PW, Gudjonsson JE, JCI insight 2021 10 6 20 -
Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects.
Swindell WR, Randhawa M, Quijas G, Bojanowski K, Chaudhuri RK, International journal of molecular sciences 2021 Aug 22 16 -
Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration.
Bojanowski K, Swindell WR, Cantor S, Chaudhuri RK, The Journal of investigative dermatology 2021 06 141 6 1416-1427.e12 -
A simple ABCD score to stratify patients with respect to the probability of survival following in-hospital cardiopulmonary resuscitation.
Swindell WR, Gibson CG, Journal of community hospital internal medicine perspectives 2021 11 3 334-342 -
A novel fumarate, isosorbide di-(methyl fumarate) (IDMF), replicates astrocyte transcriptome responses to dimethyl fumarate (DMF) but specifically down-regulates genes linked to a reactive phenotype.
Swindell WR, Bojanowski K, Chaudhuri RK, Biochemical and biophysical research communications 2020 11 532 3 475-481 -
A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation.
Swindell WR, Bojanowski K, Chaudhuri RK, European journal of dermatology : EJD 2020 Oct 30 5 469-492 -
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL, The Journal of clinical investigation 2020 06 130 6 3151-3157 -
Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses.
Tsoi LC, Rodriguez E, Stölzl D, Wehkamp U, Sun J, Gerdes S, Sarkar MK, Hübenthal M, Zeng C, Uppala R, Xing X, Thielking F, Billi AC, Swindell WR, Shefler A, Chen J, Patrick MT, Harms PW, Kahlenberg JM, Perez White BE, Maverakis E, Gudjonsson JE, Weidinger S, The Journal of allergy and clinical immunology 2020 05 145 5 1406-1415 -
A Zingerone Analog, Acetyl Zingerone, Bolsters Matrisome Synthesis, Inhibits Matrix Metallopeptidases, and Represses IL-17A Target Gene Expression.
Swindell WR, Bojanowski K, Chaudhuri RK, The Journal of investigative dermatology 2020 03 140 3 602-614.e15 -
Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.
Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S, Annals of the rheumatic diseases 2020 03 79 3 379-386 -
Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.
Hoffman JM, Poonawalla A, Icyuz M, Swindell WR, Wilson L, Barnes S, Sun LY, Aging 2020 02 12 4 3473-3485 -
Frequency and outcomes of venous thrombus embolism in hospitalized patients with Behcet's disease
Gibson CG, Swindell WR, Strickland B, Ott SJ, Rosenberg IL. International Journal of Clinical Rheumatology 2020 15 3 67-72 -
Pyoderma Gangrenosum-Like Lesion in an Older Adult.
Swindell WR, Gau JT, The Journal of the American Osteopathic Association 2019 Sep -
Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.
Tsoi LC, Rodriguez E, Degenhardt F, Baurecht H, Wehkamp U, Volks N, Szymczak S, Swindell WR, Sarkar MK, Raja K, Shao S, Patrick M, Gao Y, Uppala R, Perez White BE, Getsios S, Harms PW, Maverakis E, Elder JT, Franke A, Gudjonsson JE, Weidinger S, The Journal of investigative dermatology 2019 07 139 7 1480-1489 -
ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia.
Swindell WR, Kruse CPS, List EO, Berryman DE, Kopchick JJ, Journal of translational medicine 2019 05 17 1 170 -
GM6 Attenuates Alzheimer's Disease Pathology in APP Mice.
Yu J, Zhu H, Taheri S, Mondy W, Kirstein C, Swindell W, Ko D, Kindy MS Molecular neurobiology 2019 Feb -
Putting a strain on diversity.
Selman C, Swindell WR, The EMBO journal 2018 11 37 22 -
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.
Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM, Annals of the rheumatic diseases 2018 11 77 11 1653-1664 -
Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.
Swindell WR, List EO, Berryman DE, Kopchick JJ, Aging 2018 04 10 4 701-746 -
GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis.
Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D, Translational neurodegeneration 2018 7 30 -
RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature.
Swindell WR, Beamer MA, Sarkar MK, Loftus S, Fullmer J, Xing X, Ward NL, Tsoi LC, Kahlenberg MJ, Liang Y, Gudjonsson JE, Frontiers in immunology 2018 9 80 -
RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin.
Swindell WR, Sarkar MK, Liang Y, Xing X, Baliwag J, Elder JT, Johnston A, Ward NL, Gudjonsson JE, Scientific reports 2017 12 7 1 18045 -
IFN-? and TNF-a synergism may provide a link between psoriasis and inflammatory atherogenesis.
Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, Baugous B, Johnston A, Joshi AA, Silverman J, Barnes DH, Wolterink L, Nair RP, Stuart PE, Playford M, Voorhees JJ, Sarkar MK, Elder JT, Gallagher K, Ganesh SK, Gudjonsson JE, Scientific reports 2017 10 7 1 13831 -
Rapamycin in mice.
Swindell WR, Aging 2017 Sep 9 9 1941-1942 -
Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse.
Swindell WR, The journals of gerontology. Series A, Biological sciences and medical sciences 2017 Aug 72 8 1024-1032 -
Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses.
Lambert S, Swindell WR, Tsoi LC, Stoll SW, Elder JT, The Journal of investigative dermatology 2017 07 137 7 1501-1511 -
Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation.
Sarkar MK, Kaplan N, Tsoi LC, Xing X, Liang Y, Swindell WR, Hoover P, Aravind M, Baida G, Clark M, Voorhees JJ, Nair RP, Elder JT, Budunova I, Getsios S, Gudjonsson JE, The Journal of investigative dermatology 2017 07 137 7 1474-1483 -
Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.
Liang Y, Xing X, Beamer MA, Swindell WR, Sarkar MK, Roberts LW, Voorhees JJ, Kahlenberg JM, Harms PW, Johnston A, Gudjonsson JE, The Journal of allergy and clinical immunology 2017 Apr 139 4 1217-1227 -
Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis-surrogate keratinocytes and skin substitutes.
Ma S, Gobis K, Swindell WR, Chaudhuri R, Bojanowski R, Bojanowski K, Clinical and experimental dermatology 2017 Apr 42 3 251-260 -
Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.
Fritz Y, Klenotic PA, Swindell WR, Yin ZQ, Groft SG, Zhang L, Baliwag J, Camhi MI, Diaconu D, Young AB, Foster AM, Johnston A, Gudjonsson JE, McCormick TS, Ward NL, The Journal of investigative dermatology 2017 03 137 3 696-705 -
Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.
Swindell WR, Michaels KA, Sutter AJ, Diaconu D, Fritz Y, Xing X, Sarkar MK, Liang Y, Tsoi A, Gudjonsson JE, Ward NL, Genome medicine 2017 03 9 1 24 -
A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases.
Liang Y, Tsoi LC, Xing X, Beamer MA, Swindell WR, Sarkar MK, Berthier CC, Stuart PE, Harms PW, Nair RP, Elder JT, Voorhees JJ, Kahlenberg JM, Gudjonsson JE, Nature immunology 2017 02 18 2 152-160 -
IL-17 Responses Are the Dominant Inflammatory Signal Linking Inverse, Erythrodermic, and Chronic Plaque Psoriasis.
Xing X, Liang Y, Sarkar MK, Wolterink L, Swindell WR, Voorhees JJ, Harms PW, Kahlenberg JM, Johnston A, Gudjonsson JE, The Journal of investigative dermatology 2016 12 136 12 2498-2501 -
Cross-Disease Transcriptomics: Unique IL-17A Signaling in Psoriasis Lesions and an Autoimmune PBMC Signature.
Swindell WR, Sarkar MK, Liang Y, Xing X, Gudjonsson JE, The Journal of investigative dermatology 2016 09 136 9 1820-1830 -
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.
Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL, JCI insight 2016 09 1 15 e88843 -
Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?
Rittié L, Tejasvi T, Harms PW, Xing X, Nair RP, Gudjonsson JE, Swindell WR, Elder JT, The Journal of investigative dermatology 2016 09 136 9 1792-1800 -
Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis.
Swindell WR, Xing X, Fritz Y, Diaconu D, Simon DI, Ward NL, Gudjonsson JE, Oncotarget 2016 Jun 7 24 35535-35551 -
The EGF receptor ligand amphiregulin controls cell division via FoxM1.
Stoll SW, Stuart PE, Swindell WR, Tsoi LC, Li B, Gandarillas A, Lambert S, Johnston A, Nair RP, Elder JT, Oncogene 2016 Apr 35 16 2075-86 -
Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis.
Assassi S, Swindell WR, Wu M, Tan FD, Khanna D, Furst DE, Tashkin DP, Jahan-Tigh RR, Mayes MD, Gudjonsson JE, Chang JT, Arthritis & rheumatology (Hoboken, N.J.) 2015 Nov 67 11 3016-26 -
Nuclear respiratory factor 2 induces SIRT3 expression.
Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC, Aging cell 2015 Oct 14 5 818-25 -
Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.
Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM, Oncotarget 2015 Sep 6 29 26702-15 -
Age-Associated Increase in Skin Fibroblast-Derived Prostaglandin E2 Contributes to Reduced Collagen Levels in Elderly Human Skin.
Li Y, Lei D, Swindell WR, Xia W, Weng S, Fu J, Worthen CA, Okubo T, Johnston A, Gudjonsson JE, Voorhees JJ, Fisher GJ, The Journal of investigative dermatology 2015 Sep 135 9 2181-2188 -
Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites.
Swindell WR, Sarkar MK, Stuart PE, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, Clinical and translational medicine 2015 4 13 -
Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.
Swindell WR, Remmer HA, Sarkar MK, Xing X, Barnes DH, Wolterink L, Voorhees JJ, Nair RP, Johnston A, Elder JT, Gudjonsson JE, Genome medicine 2015 7 1 86 -
Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.
Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M, The Journal of investigative dermatology 2015 Jan 135 1 151-159 -
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin.
Tsoi LC, Iyer MK, Stuart PE, Swindell WR, Gudjonsson JE, Tejasvi T, Sarkar MK, Li B, Ding J, Voorhees JJ, Kang HM, Nair RP, Chinnaiyan AM, Abecasis GR, Elder JT, Genome biology 2015 Jan 16 24 -
A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.
Gordon WM, Zeller MD, Klein RH, Swindell WR, Ho H, Espetia F, Gudjonsson JE, Baldi PF, Andersen B, The Journal of clinical investigation 2014 Dec 124 12 5205-18 -
Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome.
Swindell WR, Xing X, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, Physiological genomics 2014 Aug 46 15 533-46 -
IL-32 is a molecular marker of a host defense network in human tuberculosis.
Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL, Science translational medicine 2014 Aug 6 250 250ra114 -
Early tissue responses in psoriasis to the antitumour necrosis factor-a biologic etanercept suggest reduced interleukin-17 receptor expression and signalling.
Johnston A, Guzman AM, Swindell WR, Wang F, Kang S, Gudjonsson JE, The British journal of dermatology 2014 Jul 171 1 97-107 -
Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.
Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, Ding J, Stuart PE, Xing X, Kochkodan JJ, Voorhees JJ, Kang HM, Nair RP, Abecasis GR, Elder JT, The Journal of investigative dermatology 2014 Jul 134 7 1828-1838 -
Intertissue control of the nucleolus via a myokine-dependent longevity pathway.
Demontis F, Patel VK, Swindell WR, Perrimon N, Cell reports 2014 Jun 7 5 1481-1494 -
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.
Swindell WR, Stuart PE, Sarkar MK, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, BMC medical genomics 2014 May 7 27 -
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.
Sun LY, Spong A, Swindell WR, Fang Y, Hill C, Huber JA, Boehm JD, Westbrook R, Salvatori R, Bartke A, eLife 2013 Oct 2 e01098 -
Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients.
Swindell WR, Johnston A, Voorhees JJ, Elder JT, Gudjonsson JE, BMC genomics 2013 Aug 14 527 -
Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE, Human molecular genetics 2013 May 22 9 1807-15 -
Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis.
Gordon K, Kochkodan JJ, Blatt H, Lin SY, Kaplan N, Johnston A, Swindell WR, Hoover P, Schlosser BJ, Elder JT, Gudjonsson JE, Getsios S, The Journal of investigative dermatology 2013 Mar 133 3 712-722 -
Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation.
Swindell WR, Johnston A, Xing X, Voorhees JJ, Elder JT, Gudjonsson JE, PloS one 2013 8 11 e79253 -
Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation.
Swindell WR, Johnston A, Xing X, Little A, Robichaud P, Voorhees JJ, Fisher G, Gudjonsson JE, Scientific reports 2013 3 1215 -
Data mining identifies Digit Symbol Substitution Test score and serum cystatin C as dominant predictors of mortality in older men and women.
Swindell WR, Cummings SR, Sanders JL, Caserotti P, Rosano C, Satterfield S, Strotmeyer ES, Harris TB, Simonsick EM, Cawthon PM, Rejuvenation research 2012 Aug 15 4 405-13 -
Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan.
Swindell WR, Ageing research reviews 2012 Apr 11 2 254-70 -
Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis.
Swindell WR, Xing X, Stuart PE, Chen CS, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, PloS one 2012 7 3 e34594 -
Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature.
Swindell WR, Johnston A, Sun L, Xing X, Fisher GJ, Bulyk ML, Elder JT, Gudjonsson JE, PloS one 2012 7 3 e33204 -
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE, PloS one 2011 Apr 6 4 e18266 -
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R, Scientific reports 2011 1 70 -
Metallothionein and the biology of aging.
Swindell WR, Ageing research reviews 2011 Jan 10 1 132-45 -
Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival.
Swindell WR, Ensrud KE, Cawthon PM, Cauley JA, Cummings SR, Miller RA, BMC geriatrics 2010 Aug 10 55 -
Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice.
Swindell WR, Johnston A, Gudjonsson JE, PloS one 2010 Jul 5 7 e11861 -
In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.
Swindell WR, Masternak MM, Bartke A, Experimental gerontology 2010 May 45 5 366-74 -
Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse.
Swindell WR, BMC genomics 2009 Dec 10 585 -
Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations.
Swindell WR, Aging 2009 Jun 1 6 573-7 -
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice.
Swindell WR, Masternak MM, Kopchick JJ, Conover CA, Bartke A, Miller RA, Mechanisms of ageing and development 2009 Jun 130 6 393-400 -
Accelerated failure time models provide a useful statistical framework for aging research.
Swindell WR, Experimental gerontology 2009 Mar 44 3 190-200 -
Genes regulated by caloric restriction have unique roles within transcriptional networks.
Swindell WR, Mechanisms of ageing and development 2008 Oct 129 10 580-92 -
How long will my mouse live? Machine learning approaches for prediction of mouse life span.
Swindell WR, Harper JM, Miller RA, The journals of gerontology. Series A, Biological sciences and medical sciences 2008 Sep 63 9 895-906 -
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R, Cell metabolism 2008 Aug 8 2 157-68 -
Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues.
Swindell WR, Mechanisms of ageing and development 2008 Mar 129 3 138-53 -
Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging.
Swindell WR, BMC genomics 2007 Oct 8 353 -
Genotype-by-age interaction and identification of longevity-associated genes from microarray data.
Swindell WR, Age (Dordrecht, Netherlands) 2007 Sep 29 2-3 97-102 -
Plastic and adaptive gene expression patterns associated with temperature stress in Arabidopsis thaliana.
Swindell WR, Huebner M, Weber AP, Heredity 2007 Aug 99 2 143-50 -
Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways.
Swindell WR, Huebner M, Weber AP, BMC genomics 2007 May 8 125 -
The association among gene expression responses to nine abiotic stress treatments in Arabidopsis thaliana.
Swindell WR, Genetics 2006 Dec 174 4 1811-24 -
Reduced inbreeding depression due to historical inbreeding in Drosophila melanogaster: evidence for purging.
Swindell WR, Bouzat JL, Journal of evolutionary biology 2006 Jul 19 4 1257-64 -
Associations between environmental stress, selection history, and quantitative genetic variation in Drosophila melanogaster.
Swindell WR, Bouzat JL, Genetica 2006 May 127 1-3 311-20 -
Selection and inbreeding depression: effects of inbreeding rate and inbreeding environment.
Swindell WR, Bouzat JL, Evolution; international journal of organic evolution 2006 May 60 5 1014-22 -
Ancestral inbreeding reduces the magnitude of inbreeding depression in Drosophila melanogaster.
Swindell WR, Bouzat JL, Evolution; international journal of organic evolution 2006 Apr 60 4 762-7 -
Inbreeding depression and male survivorship in Drosophila: implications for senescence theory.
Swindell WR, Bouzat JL, Genetics 2006 Jan 172 1 317-27 -
Gene flow and adaptive potential in Drosophila melanogaster
Swindell WR, Bouzat JL Conservation Genetics 2006 7 1 79-89 -
Modeling the adaptive potential of isolated populations: experimental simulations using Drosophila.
Swindell WR, Bouzat JL, Evolution; international journal of organic evolution 2005 Oct 59 10 2159-69
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Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.