Yuanyuan Zhang, M.D., Ph.D.

Harold C. Simmons Comprehensive Cancer Center

Radiation Oncology
Radiation Therapy for Lung Cancer
Lung Cancer

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Biography

Yuanyuan Zhang, M.D., Ph.D., is an Assistant Professor of Radiation Oncology at UT Southwestern Medical Center specializing in treating lung cancer patients with radiotherapy.

Dr. Zhang earned her medical and doctorate degrees from UT Southwestern. Following graduation, she completed an internship with Memorial Sloan-Kettering Cancer Center and, subsequently, completed her residency at UT Southwestern.

“I like to care for patients and their families in ways that are meaningful and valuable to them by understanding their unique circumstance and challenges, involving them in the decision-making process, and providing the emotional support and care coordination every step along the way – just as I would do for my family members.”

When Dr. Zhang is not in the clinic, she researches ways to improve the effectiveness of radiotherapy in lung cancer in the lab. “We still need better treatments, both increasing the survival rate and quality of life for our patients. To me, staying at the forefront of research presents an element of hope and commitment to our patients.”

Dr. Zhang is a member of the American Society for Radiation Oncology (ASTRO), the Association of Residents in Radiation Oncology, the American Society of Clinical Oncology (ASCO), the American Association for Cancer Research (AACR), the Radiological Society of North America (RSNA), and the Society of Women in Radiation Oncology (SWRO).

Education & Training

Other Post Graduate Training - UT Southwestern Medical School (2009-2016)
Residency - UT Southwestern Medical Center (2017-2021), Radiation Oncology
Internship - Memorial Sloan-Kettering Cancer Center (2016-2017), Transitional Year
Medical School - UT Southwestern Medical School (2009-2016)
Graduate School - UT Southwestern Medical School (2009-2016), Medical Sciences

Professional Associations & Affiliations

American Society for Radiation Oncology (ASTRO)
American Society of Clinical Oncology (ASCO)
American Association for Cancer Research (AACR)
Radiological Society of North America (RSNA)
Society of Women in Radiation Oncology (SWRO)

Honors & Awards

Merrill Presidential Scholar (2007)
Christine Wilson Award for Outstanding Student Research Paper (2007)
The 29th Annual Ida M Green Award (2015)
Gold Humanism Honors Society (2015)
Holman Research Fellow (2018-2020)
Early Career Development Award (2020)
Travel Award (2020)
ASCO Young Investigator Award (2021)
Roentgen Resident/Fellow Research Award (2021)
Finalist for J. Mitchell, George and Stephen Brown Award for resident excellence in Radiation Oncology (2021)
Selected for Molecular Biology in Clinical Oncology Workshop (2021)
Clinical and Translational Research Scholar (KL2) Award (2021)

Books & Publications

Publications
- Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiation Therapy for Locally Advanced Lung Cancer
  Li R, Zhuang T, Montalvo S, Wang K, Parsons D, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin MH, Westover K Practical Radiation Oncology 2024 Sep 14 e395-e406
- Mitochondrial complex I promotes kidney cancer metastasis
  Bezwada D, Perelli L, Lesner NP, Cai L, Brooks B, Wu Z, Vu H, Sondhi V, Cassidy DL, Kasitinon SY, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, McDaniel P, Sudderth JA, Dumesnil D, House S, Rosales TI, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Garcia Bermudez J, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Genovese G, Margulis V, DeBerardinis RJ Nature 2024 Aug 633 923-931
- Concerning safety and efficacy of concurrent and consolidative durvalumab with thoracic radiotherapy in PDL1-unselected stage III non-small cell lung cancer: brief report
  Zhang Y, Iyengar P, Montalvo SK, Westover KD, Rashdan S, Donthireddy KR, Kim J, Dowell JE, Drapkin BJ, Bhalla S, Chukwuma C, Nadeem U, Ahn C, Timmerman R, Gerber DE International Journal of Radiation Oncology Biology Physics 2024 Aug S0360-3016 03177-8
- Beyond conventional bounds: Surpassing system limits for stereotactic ablative (SAbR) lung radiotherapy using CBCT-based adaptive planning system
  Gonzalez Y, Visak J, Overman L, Liao CY, Yen A, Zhuang T, Cai B, Godley A, Zhang Y, Timmerman R, Iyengar P, Westover K, Parsons D, Lin MH Journal of applied clinical medical physics 2024 Aug 25
- Electron transport chain inhibition increases cellular dependence on purine transport and salvage
  Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ Cell Metabolism 2024 Jul 36 1504-1520.e9
- Elucidating the Mechanism of Radiation Therapy on Mesenchymal Cell Fate in Preventing Heterotopic Ossification
  Hsieh M, Choi JH, Korlakunta S, Zhang Y, Levi B Annals of Surgery 2024 Jun
- Predictive Clinical Factors for Geometric Response to Adaptive Radiotherapy in Thoracic Malignancy
  Li R, Montalvo SK, Wang K, Parsons D, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin M Practical Radiation Oncology 2024 Apr S1879-8500
- An AI-based approach for modeling the synergy between radiotherapy and immunotherapy
  Peng H, Moore C, Zhang Y, Saha D, Jiang S, Timmerman R Scientific reports 2024 14
- Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors
  Mundra V, Yang Y, von Itzstein MS, Fattah F, Gonugunta AS, Hannan R, Pop LM, Zhang Y, Wang Y, Sheffield T, Xie Y, Dowell JE, Homsi J, Rashdan S, Park J, Li Q, Wakeland EK, Gerber DE Translational Oncology 2023 Aug 34
- DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism
  Chen WM, Chiang JC, Shang Z, Palchik G, Newman C, Zhang Y, Davis AJ, Lee H, Chen PB EMBO Journal 2023 Mar 42
- In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
  Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ Science Advances 2022 8
- Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma
  Schoenhals JE, Mohamad O, Christie A, Zhang Y, Li D, Singla N, Bowman I, Arafat W, Hammers H, Courtney K, Cole S, Bagrodia A, Margulis V, Desai N, Garant A, Choy H, Timmerman R, Brugarolas J, Hannan R Advances in Radiation Oncology 2021 Sep 6
- Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer
  Rahimi A, Morgan HE, Kim DW, Zhang Y, Leitch M, Wooldridge RD, Goudreau S, Haley BB, Rao R, Rivers A, Spangler AE, Jones RT, Stevenson S, Staley J, Albuquerque K, Ahn C, Neufeld S, Alluri PG, Ding C, Garwood D, Seiler S, Zhao B, Gu X, Timmerman R International Journal of Radiation Oncology Biology Physics 2021 Jul 110 772-782
- Risk Factors for Fat Necrosis After Stereotactic Partial Breast Irradiation for Early-Stage Breast Cancer in a Phase 1 Clinical Trial
  Rahimi A, Zhang Y, Kim DW, Morgan H, Hossain F, Leitch M, Wooldridge RD, Seiler S, Goudreau S, Haley BB, Rao R, Rivers A, Spangler AE, Ahn C, Stevenson S, Staley J, Albuquerque K, Ding C, Gu X, Zhao B, Timmerman R International Journal of Radiation Oncology Biology Physics 2020 Nov 108 697-706
- Stereotactic Ablative Radiation Therapy (SAbR) Used to Defer Systemic Therapy in Oligometastatic Renal Cell Cancer
  Zhang Y, Schoenhals J, Christie A, Mohamad O, Wang C, Bowman I, Singla N, Hammers H, Courtney K, Bagrodia A, Margulis V, Desai N, Garant A, Choy H, Timmerman R, Brugarolas J, Hannan R International Journal of Radiation Oncology Biology Physics 2019 Oct 105 367-375
- Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes
  Zhang Y, Zhang Y, Yu Y Journal of Proteome Research 2017 Aug 16 2825-2835
- Multi-objective radiomics model for predicting distant failure in lung SBRT
  Zhou Z, Folkert M, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Jiang S, Wang J Physics in medicine and biology 2017 May 62 4460-4478
- Predicting distant failure in early stage NSCLC treated with SBRT using clinical parametersPredicting distant failure in lung SBRT
  Zhou Z, Folkert M, Cannon N, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Yan J, Xie XJ, Jiang S, Wang J Radiotherapy and Oncology 2016 Jun 119 501-504
- Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone
  Zhang Y, Fang F, Goldstein JL, Brown MS, Zhao TJ Proceedings of the National Academy of Sciences of the United States of America 2015 Jan 112 1226-1231
- Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.
  Bettayeb K, Oumata N, Zhang Y, Luo W, Bustos V, Galons H, Greengard P, Meijer L, Flajolet M FASEB Journal 2012 Dec 26 5115-5123
- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
  Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 109 16184-16189
- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
  Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 109 16184 - 16189
- Premastication: The second arm of infant and young child feeding for health and survival?
  Pelto GH, Zhang Y, Habicht JP Maternal and Child Nutrition 2010 Jan 6 4-18

Research

Cancer metabolism
Radiobiology
Immunotherapy
Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR)

Clinical Focus

Radiation Therapy for Lung Cancer
Lung Cancer
Chest Cancers