Causes and Risk Factors of Autoimmune Blistering Skin Diseases
Doctors aren’t sure what causes the immune system to mistake the skin and mucous membranes for harmful targets and attack them. Certain factors can increase the risk of autoimmune blistering skin diseases or make them worse, such as:
- Certain foods
- Certain medications, such as those for high blood pressure, diabetes mellitus, and bacterial infections
- Exposure to ultraviolet light
- Genetic predisposition
Symptoms of Autoimmune Blistering Skin Diseases
The main symptom of autoimmune blistering diseases is blisters or lesions on the skin or mucous membranes that can cause itching, pain, or sores. The blisters or lesions appear in different areas of the body, depending on the associated disease.
Other symptoms occur more rarely and include:
- Mouth pain
- Difficulty breathing
- Difficulty swallowing
- Gastrointestinal (digestive tract) bleeding
- Visual difficulties
Diagnosing Autoimmune Blistering Skin Diseases
Our skilled dermatologists have years of expertise evaluating symptoms and diagnosing autoimmune skin diseases. We begin with a complete evaluation, which includes a:
- Physical exam
- Review of personal and family medical history
- Discussion of symptoms
To confirm a diagnosis of a specific autoimmune blistering skin disease, we typically order further testing. Tests that patients might need include:
- Blood tests: Drawing of blood to check for the presence of a disease-specific autoantibody (for example, an immune protein that targets skin and causes the blistering disease)
- Skin biopsy: Removal of a small sample of affected skin for examination under a microscope for signs of disease
- Direct immunofluorescence: Removal of a small sample of normal skin for examination under a special microscope to allow detection of immune proteins deposited in patient skin
Treating Autoimmune Blistering Skin Diseases
Treatment of autoimmune blistering diseases can relieve symptoms and prevent complications. Medications can reduce the immune system response and prevent attacks on the skin and mucous membranes.
The primary treatment for these disorders is treatment with corticosteroids such as prednisone. Additional medications that our doctors might prescribe include:
- Immunosuppressive biological therapies such as rituximab
- Immunosuppressive drugs, such as azathioprine, cyclophosphamide, or mycophenolate
- Antibiotic, antifungal, or antiviral medications to prevent infections