Charuta Joshi, M.D.

Roy D. and Ragen S. Elterman Distinguished Chair in Pediatric Epilepsy

Pediatric Neurology
Developmental and epileptic encephalopathies
Doose syndrome/EMAS

Biography

Charuta Joshi, M.D., is a Professor in the Departments of Pediatrics and Neurology and the Roy D. and Ragen S. Elterman Distinguished Chair in Pediatric Epilepsy at UT Southwestern Medical Center. She specializes in developmental and epileptic encephalopathies and surgical and nonsurgical therapy for medically intractable epilepsy in children.

Dr. Joshi earned her medical degree at Grant Medical College in Mumbai, India. She completed a residency in pediatric neurology at NewYork-Presbyterian/Weill Cornell Medical Center and gained advanced training through a clinical neurophysiology fellowship at Children’s Hospital Michigan.

Certified in child neurology and epilepsy by the American Board of Psychiatry and Neurology, Dr. Joshi joined the UT Southwestern faculty in 2022. Previously, she served as Director of Regional Neurology Services and Director of Pediatric Epilepsy Fellowship at Children’s Hospital Colorado, where she was also the epilepsy team lead.

At UT Southwestern, Dr. Joshi is the Program Director of the Advanced EEG and Epilepsy Research Fellowship. An investigator on several clinical trials, her clinical research focuses on surgical and nonsurgical therapies for medically intractable epilepsy in children. She is also interested in global health and developmental and epileptic encephalopathies.

Dr. Joshi has delivered scores of presentations and published a broad range of scholarly articles, abstracts, and book chapters. She serves as an ad hoc reviewer for numerous scholarly journals and is a contributing editor for Epilepsy Currents.

An elected member of the Pediatric Epilepsy Research Consortium Steering Committee, she serves on the International Affairs Committee of the Child Neurology Society and is a member of several other professional organizations, including the American Epilepsy Society and the International Child Neurology Association.

In 2021, Dr. Joshi received the Exceptional Women in Medicine Award from Castle Connolly.

Education & Training

Fellowship - Wayne State University/Detroit Medical Center (2000-2001), Clinical Neurophysiology
Fellowship - The New York Presbyterian Hospital (1997-2000), Child Neurology
Residency - The Brooklyn Hospital Center (1995-1997), Pediatrics
Medical School - University of Bombay( Mumbai), India (1989-1993)

Professional Associations & Affiliations

American Epilepsy Society
Child Neurology Society
International Child Neurology Association

Honors & Awards

Exceptional Women in Medicine Award 2021, Castle Connolly
Patient Family Satisfaction Services Award 2020, Children’s Hospital Colorado
Best Doctor in America 2009-2018, Best Doctors in America
Nominee, Teacher of the Year Award 2012-2013, University of Iowa Carver College of Medicine
Educator of the Year (Department of Pediatrics) 2011, University of Iowa Carver College of Medicine
Educator of the Year (Department of Pediatrics) 2004, University of Manitoba, Health Sciences Center
Teaching Excellence by a Fellow Award 1999, NewYork-Presbyterian Hospital/Weill Cornell Medical Center, Pediatric House staff

Books & Publications

Books
- Hypothalamic hamartoma in The Treatment of Epilepsy
  Joshi C, Wilfong A (2015)
- EEG interpretation in childhood epilepsies in Clinical Neurophysiology in Pediatrics: A Practical Approach to Neurodiagnostic Testing and Management
  Joshi C, Yamada T (2015), Demos Publication
- Pediatric febrile seizures in Clinical Neurophysiology in Pediatrics: A Practical Approach to Neurodiagnostic Testing and Management
  Joshi C, Yamada T (2015), Demos Publication
- Intractable Epilepsy: Cracking the Code in Pediatric Clinics of India
  Joshi C (2011)
Publications
- Electroencephalographic Seizure or Electroencephalographic Status Epilepticus in the ICU? Is it Time to Focus Just on Electroencephalographic Status Epilepticus?
  Joshi C, Epilepsy currents 2021 Nov-Dec 21 6 421-423
- Infantile Spasms in Tuberous Sclerosis Complex: Lesion or Network?
  Joshi C, Bear JJ, Epilepsy currents 2021 Oct 21 5 349-350
- Comparison of subdural grid and stereoelectroencephalography in a cohort of pediatric patients.
  Talai A, Eschbach K, Stence NV, Palmer C, Bird W, Alexander A, O'Neill BR, Chapman KE, Joshi C, Epilepsy research 2021 Sep 177 106758
- Risk of Admission to the Emergency Room/Inpatient Service After a Neurology Telemedicine Visit During COVID-19 Pandemic.
  Joshi C, Jacobson M, Silveira L, Shea S, Yang M, Eschbach K, Pediatric neurology 2021 Jun 122 15-19
- Quality and Safety Analysis of 2,999 Telemedicine Encounters During the COVID-19 Pandemic.
  Joshi CN, Yang ML, Eschbach K, Tong S, Jacobson MP, Stillman C, Kropp AE, Shea SA, Frunzi GM, Thomas JF, Olson CA, Neurology. Clinical practice 2021 Apr 11 2 e73-e82
- Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial.
  Thiele EA, Bebin EM, Bhathal H, Jansen FE, Kotulska K, Lawson JA, O'Callaghan FJ, Wong M, Sahebkar F, Checketts D, Knappertz V, JAMA neurology 2021 03 78 3 285-292
- Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/ Doose syndrome.
  Joshi C, Nickels K, Demarest S, Eltze C, Cross JH, Wirrell E, Seizure 2021 Feb 85 12-18
- Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
  Nickels K, Kossoff EH, Eschbach K, Joshi C, Epilepsia 2021 01 62 1 120-127
- When development is at stake: Fear the disease, not the vaccine.
  Joshi C, Thio LL, Neurology 2020 07 95 3 103-104
- Learning to drive: resident physicians' perceptions of how attending physicians promote and undermine autonomy.
  Crockett C, Joshi C, Rosenbaum M, Suneja M, BMC medical education 2019 Jul 19 1 293
- "Chance Takers Are Accident Makers": Are Patients With Epilepsy Really Taking a Chance When They Drive?
  Joshi CN, Vossler DG, Spanaki M, Draszowki JF, Towne AR, Epilepsy currents 2019 Jul-Aug 19 4 221-226
- The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield.
  Epilepsia 2019 05 60 5 797-806
- Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures.
  Angione K, Eschbach K, Smith G, Joshi C, Demarest S, Epilepsy research 2019 02 150 70-77
- Yield of laboratory testing in pediatric ketogenic diet patients: Critical assessment of abnormal results and impact on clinical care.
  Joshi C, Stillman C, Criteser S, Oliver J, Conley A, Sillau S, Zupec-Kania B, Epilepsy research 2019 01 149 70-75
- Diagnosis switching and outcomes in a cohort of patients with potential epilepsy with myoclonic-atonic seizures.
  Eschbach K, Moss A, Joshi C, Angione K, Smith G, Dempsey A, Juarez-Colunga E, Demarest ST, Epilepsy research 2018 11 147 95-101
- Semiautomated Spike Detection Software Persyst 13 Is Noninferior to Human Readers When Calculating the Spike-Wave Index in Electrical Status Epilepticus in Sleep.
  Joshi CN, Chapman KE, Bear JJ, Wilson SB, Walleigh DJ, Scheuer ML, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2018 Sep 35 5 370-374
- How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey.
  Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff EH, Joshi C, Nangia S, Shellhaas R, Epilepsy research 2018 08 144 14-19
- Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results.
  Szaflarski JP, Bebin EM, Comi AM, Patel AD, Joshi C, Checketts D, Beal JC, Laux LC, De Boer LM, Wong MH, Lopez M, Devinsky O, Lyons PD, Zentil PP, Wechsler R Epilepsia 2018 Jul
- Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report.
  Nagahama Y, Kovach CK, Ciliberto M, Joshi C, Rhone AE, Vesole A, Gander PE, Nourski KV, Oya H, Howard MA, Kawasaki H, Dlouhy BJ, Journal of neurosurgery 2018 07 129 1 157-164
- Facial Weakness and Ophthalmoplegia in a 4-Day-Old Infant.
  Kouri I, Mathews K, Joshi C, Seminars in pediatric neurology 2018 07 26 63-66
- Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
  Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K Neurology 2018 Apr 90 14 e1204-e1211
- Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.
  Thiele EA, Marsh ED, French JA, Mazurkiewicz-Beldzinska M, Benbadis SR, Joshi C, Lyons PD, Taylor A, Roberts C, Sommerville K, Lancet (London, England) 2018 03 391 10125 1085-1096
- Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype.
  Sadleir LG, Mountier EI, Gill D, Davis S, Joshi C, DeVile C, Kurian MA, Mandelstam S, Wirrell E, Nickels KC, Murali HR, Carvill G, Myers CT, Mefford HC, Scheffer IE, Neurology 2017 Sep 89 10 1035-1042
- Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.
  Devinsky O, Cross JH, Wright S, The New England journal of medicine 2017 08 377 7 699-700
- DNM1 encephalopathy: A new disease of vesicle fission.
  von Spiczak S, Helbig KL, Shinde DN, Huether R, Pendziwiat M, Lourenço C, Nunes ME, Sarco DP, Kaplan RA, Dlugos DJ, Kirsch H, Slavotinek A, Cilio MR, Cervenka MC, Cohen JS, McClellan R, Fatemi A, Yuen A, Sagawa Y, Littlejohn R, McLean SD, Hernandez-Hernandez L, Maher B, Møller RS, Palmer E, Lawson JA, Campbell CA, Joshi CN, Kolbe DL, Hollingsworth G, Neubauer BA, Muhle H, Stephani U, Scheffer IE, Pena SDJ, Sisodiya SM, Helbig I, Neurology 2017 Jul 89 4 385-394
- Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings.
  Nagahama Y, Joshi C, Dlouhy B, Wu AY, Abel TJ, Baumbach G, Kawasaki H, Epilepsy & behavior case reports 2017 7 24-27
- Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.
  Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED, Journal of child neurology 2017 01 32 1 35-40
- Delayed diagnosis of shunt overdrainage following functional hemispherotomy and ventriculoperitoneal shunt placement in a hemimegalencephaly patient.
  Nagahama Y, Peters D, Kumonda S, Vesole A, Joshi C, J Dlouhy B, Kawasaki H, Epilepsy & behavior case reports 2017 7 34-36
- Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort.
  Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L, Epilepsia 2016 11 57 11 1834-1842
- Ketogenic diet - A novel treatment for early epileptic encephalopathy due to PIGA deficiency.
  Joshi C, Kolbe DL, Mansilla MA, Mason S, Smith RJ, Campbell CA, Brain & development 2016 Oct 38 9 848-51
- Rethinking the Magnetic Resonance Imaging Findings in Early Rasmussen Encephalitis: A Case Report and Review of the Literature.
  Holec M, Nagahama Y, Kovach C, Joshi C, Pediatric neurology 2016 06 59 85-9
- Do Patients Require Inpatient Admission to Receive Adrenocorticotropic Hormone (ACTH)? A Survey of US-Based Prescribers.
  Joshi C, Berg AT, Wirrell E, Journal of child neurology 2016 Feb 31 2 164-9
- Reducing the Cost of the Diagnostic Odyssey in Early Onset Epileptic Encephalopathies.
  Joshi C, Kolbe DL, Mansilla MA, Mason SO, Smith RJ, Campbell CA, BioMed research international 2016 2016 6421039
- Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss.
  Tanaka AJ, Cho MT, Millan F, Juusola J, Retterer K, Joshi C, Niyazov D, Garnica A, Gratz E, Deardorff M, Wilkins A, Ortiz-Gonzalez X, Mathews K, Panzer K, Brilstra E, van Gassen KL, Volker-Touw CM, van Binsbergen E, Sobreira N, Hamosh A, McKnight D, Monaghan KG, Chung WK, American journal of human genetics 2015 Sep 97 3 457-64
- Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report.
  Saade D, Joshi C, Pediatric neurology 2015 May 52 5 544-7
- How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium.
  Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG, Epilepsia 2015 Apr 56 4 617-25
- Pediatric optic neuritis: does a prolonged course of steroids reduce relapses? A preliminary study.
  Jayakody H, Bonthius DJ, Longmuir R, Joshi C, Pediatric neurology 2014 Nov 51 5 721-5
- Telemedicine in pediatric neurology.
  Joshi C, Pediatric neurology 2014 Aug 51 2 189-91
- Fatal outcome in hemiconvulsion-hemiplegia syndrome.
  Jayakody H, Joshi C, Journal of child neurology 2014 Mar 29 3 406-11
- International Paediatric Stroke Study: stroke associated with cardiac disorders.
  Dowling MM, Hynan LS, Lo W, Licht DJ, McClure C, Yager JY, Dlamini N, Kirkham FJ, Deveber G, Pavlakis S International journal of stroke : official journal of the International Stroke Society 2012 Dec
- Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study.
  Kirton A, Armstrong-Wells J, Chang T, Deveber G, Rivkin MJ, Hernandez M, Carpenter J, Yager JY, Lynch JK, Ferriero DM Pediatrics 2011 Dec 128 6 e1402-10
- Behavioral effects of congenital ventromedial prefrontal cortex malformation.
  Boes AD, Grafft AH, Joshi C, Chuang NA, Nopoulos P, Anderson SW, BMC neurology 2011 Dec 11 151
- Gelastic seizures in tuberous sclerosis complex: case report and literature review.
  Cook T, Joshi C, Journal of child neurology 2011 Jan 26 1 83-6
- Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study.
  Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel KM, deVeber G, Ashwal S, The Journal of pediatrics 2010 May 156 5 704-10, 710.e1-710.e2
- Ketogenic diet in Alpers-Huttenlocher syndrome.
  Joshi CN, Greenberg CR, Mhanni AA, Salman MS, Pediatric neurology 2009 Apr 40 4 314-6
- Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study.
  Golomb MR, Fullerton HJ, Nowak-Gottl U, Deveber G, Stroke 2009 Jan 40 1 52-7
- A V139M mutation also causes the reversible CNS phenotype in CMTX.
  Halbrich M, Barnes J, Bunge M, Joshi C, The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2008 Jul 35 3 372-4
- GLUT1 deficiency without epilepsy: yet another case.
  Joshi C, Greenberg CR, De Vivo D, Dong WangChan-Lui W, Booth FA, Journal of child neurology 2008 Jul 23 7 832-4
- A picture worth remembering: posttraumatic Purtscher's retinopathy in a child.
  Joshi C, Shuckett P, Stockl F, Journal of child neurology 2008 Mar 23 3 353-5
- Eyelid myoclonia with absences: routine EEG is sufficient to make a diagnosis.
  Joshi CN, Patrick J, Seizure 2007 Apr 16 3 254-60
- Postictal psychosis in a child.
  Joshi CN, Booth FA, Sigurdson ES, Bolton JM, Shah NS, Pediatric neurology 2006 May 34 5 388-91
- Neurogenic stunned myocardium and transient severe tricuspid regurgitation in a child following nonaccidental head trauma.
  Divekar A, Shah S, Joshi C, Pediatric cardiology 2006 May-Jun 27 3 376-7
- Congenital indifference to pain and deletion of chromosome 10q-: new association.
  Joshi C, Dawson AJ, Sanders SR, Prasad C, Journal of child neurology 2006 Feb 21 2 174-7
- Do clinical variables predict an abnormal EEG in patients with complex febrile seizures?
  Joshi C, Wawrykow T, Patrick J, Prasad A, Seizure 2005 Sep 14 6 429-34

Research

DEI in pediatric epilepsy
Epileptic encephalopathies
Ketogenic diet
Medically intractable epilepsy in children
Telemedicine in epilepsy

Clinical Focus

Developmental and epileptic encephalopathies
Doose syndrome/EMAS
Surgical and nonsurgical therapy for medically intractable epilepsies
Tuberous sclerosis