Christian Wysocki, M.D., Ph.D.

  • Internal Medicine - Allergy and Immunology
  • Primary immunodeficiency
  • Immune dysregulation


Christian A. Wysocki, M.D., Ph.D., is an Associate Professor in the Departments of Internal Medicine and Pediatrics at UT Southwestern Medical Center. A specialist in allergy and immunology, he has also, since 2018, been the Clinical Director of the Primary Immunodeficiency Program in the Division of Allergy and Immunology at UT Southwestern and Children’s Health. The program is a Jeffrey Modell Foundation Diagnostic and Research Center.

Dr. Wysocki earned his medical degree and doctoral degree in microbiology and immunology at the University of North Carolina at Chapel Hill School of Medicine. He completed a residency in internal medicine at Yale University, where he also received advanced training through a fellowship in allergy and clinical immunology, with additional focused training in clinical immunology and primary immunodeficiency through the Clinical Immunology Society Summer School and USIDNET Visiting Immunology Scholars Program.

Certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology, he joined the UT Southwestern faculty in 2013.

Dr. Wysocki is a member of the American Academy of Allergy, Asthma, and Immunology and the Clinical Immunology Society. In addition, he serves as an immunologist consultant for the newborn screen lab for severe combined immunodeficiency (SCID) for the Texas Department of State Health Services.

The Primary Immunodeficiency Program is a comprehensive clinical program dedicated to the diagnosis and multidisciplinary care of pediatric (and adult) patients with primary immunodeficiency disorders. The clinic offers multidisciplinary care to patients with these complex disorders.

As Clinical Director of the program, Dr. Wysocki oversees the close collaboration of a number of disciplines, including bone marrow transplant, gastroenterology, rheumatology, hematology/oncology, infectious diseases, and basic immunology and translational research scientists.

He additionally sees adult immunocompromised patients at UT Southwestern and Parkland Memorial Hospital, allowing for the seamless transition of patients with good continuity of care.

His ongoing research initiatives include a program directed at discovery of new genetic abnormalities causing immunodeficiency or other immunologic disorders, which for Dr. Wysocki represents a longstanding collaboration with Nicolai Van Oers, Ph.D., in the Department of Immunology. He also works in concert with Dr. Van Oers on projects focused on the development of the thymus (a crucial organ in the development of the immune system) and genetic disorders that impact this process.

Other interests include collaborative projects focused on hemophagocytic lymphohistiocytosis (HLH) in both pediatric and adult patients, as well as projects focused on the autoimmune and inflammatory complications of common variable immunodeficiency (CVID).

Dr. Wysocki has been a D Magazine Best Doctor for multiple years.

Education & Training
  • Residency - Yale University School of Medicine (2008-2010), Internal Medicine
  • Fellowship - Yale University School of Medicine (2010-2013), Allergy & Immunology
  • Medical School - University of North Carolina at Chapel Hill (1999-2007)
  • Internship - Yale New Haven Hospital (2007-2010), Internal Medicine
Professional Associations & Affiliations
  • Clinical Immunology Society
  • American Academy of Allergy, Asthma and Immunology
Honors & Awards
  • D Magazine Best Doctor, 2016, 2019 – 2022
  • Director, Jeffrey Modell Diagnostic and Research Center 2018, Jeffrey Modell Foundation
  • Expert Immunologist 2017, Jeffrey Modell Foundation
Books & Publications
  • Primary immunodeficiency
  • Immune dysregulation
  • Transplant immunology
  • Autoinflammatory disorders
  • Hemophagocytic lymphohistiocytosis

Clinical Focus

  • Primary immunodeficiency
  • Immune dysregulation
  • Autoinflammatory disorders
  • DiGeorge syndrome/22q11.2 deletion syndrome
  • Hemophagocytic lymphohistiocytosis (HLH)

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