- Medical School - Baylor College of Medicine (1974-1978)
- Fellowship - Baylor College of Medicine (1981-1984), Nephrology
- Residency - Baylor College of Medicine (1978-1981), Internal Medicine
- Chief Resident - Baylor College of Medicine (1982-1983), Internal Medicine
- Internship - Baylor College of Medicine (1978-1979)
Eleanor Lederer, M.D.
- John S. Fordtran, M.D. Professorship in Calcium Research
- Internal Medicine - Nephrology
- Chronic kidney disease complications
- Kidney Stones
Eleanor Lederer, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She specializes in chronic kidney disease complications, kidney stones, and kidney transplants.
Dr. Lederer earned her medical degree at Baylor College of Medicine, where she also completed her residency in internal medicine and fellowship in nephrology.
Certified by the American Board of Internal Medicine in internal medicine and nephrology, she joined the UT Southwestern faculty in 2020.
Dr. Lederer is the John S. Fordtran Endowed Professor in Calcium Research at UTSW’s Charles and Jane Pak Center for Mineral Metabolism. In addition, she serves as the Assistant Chief of Medical Services for Research and Co-Director of the Network of Dedicated Enrollment Sites (NODES) program at the affiliated VA North Texas Health Sciences Center.
Dr. Lederer is currently funded through the U.S. Department of Veterans Affairs to study the regulation of parathyroid hormone, phosphate, and calcium in chronic kidney disease. She has published a number of peer-reviewed articles and has authored or coauthored chapters in numerous books, including Essentials of Chronic Kidney Disease and Principles of Geriatric Medicine and Gerontology.
She is a past president of the American Society of Nephrology and an active member of many other professional organizations, including the Renal Physicians Association, the American College of Physicians, the International Society of Nephrology, and the American Association for the Advancement of Science.
Among many other honors, in 2020 Dr. Lederer received the Excellence in Patient Care Award from the National Kidney Foundation of Kentucky.
- American Association for the Advancement of Science
- American Physiological Society
- American Society for Bone and Mineral Research
- American Society of Nephrology
- Kentucky Medical Association
- American Heart Association’s Council on the Kidney in Cardiovascular Disease
- National Kidney Foundation
- Southern Salt, Water and Kidney Society
- American College of Physicians
- Renal Physicians Association
- International Society of Nephrology
- Top Doctor in Nephrology 2020, Castle Connolly
- Excellence in Patient Care Award 2020, National Kidney Foundation of Kentucky
- Excellence in Leadership 2019, Robley Rex VA Medical Center
- Top Doctor, (2014, 2017, 2019) Who’s Who Louisville
- Internal Medicine Faculty Award 2010, American College of Physicians, Kentucky Chapter
- Distinguished Teaching Professor Award 2009, University of Louisville
- Partnership Award 2009, National Kidney Foundation of Kentucky
- Teaching Award, Internal Medicine Residency, (2003, 2004, 2006, 2009, 2010, 2018) American Society of Nephrology
Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein.
Khundmiri SJ, Rane MJ, Lederer ED, The Journal of biological chemistry 2003 Mar 278 12 10134-41
Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.
Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED, The American journal of pathology 2019 Jun 189 6 1190-1200
Phosphate Transport in Epithelial and Nonepithelial Tissue.
Hernando N, Gagnon KB, Lederer ED, Physiological reviews 2020 Apr
Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation.
Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED, American journal of physiology. Renal physiology 2008 Oct 295 4 F1254-8
Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.
Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ, Life sciences 2020 Feb 243 117226
Novel regulatory function for NHERF-1 in Npt2a transcription.
Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED, American journal of physiology. Renal physiology 2008 Apr 294 4 F840-9
Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter.
Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED, American journal of physiology. Renal physiology 2015 Jul 309 2 F109-19
Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1.
Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016 39 1 1-12
Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.
Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED, American journal of physiology. Cell physiology 2016 Feb 310 3 C205-15
Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.
Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ, American journal of physiology. Cell physiology 2017 Aug 313 2 C197-C206
Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter.
Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011 27 6 703-14
Chronic kidney disease.
Lederer E, Ouseph R, American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 Jan 49 1 162-71
- Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein.
- Chronic kidney disease complications
- Kidney Stones
- Kidney Transplantation