Elena Hsieh, M.D.

Biography

Wen-Yuan “Elena” Hsieh, M.D., is an Associate Professor in the Department of Pediatrics and Internal Medicine, and in the Eugene McDermott Center for Human Growth and Development at UT Southwestern Medical Center where she also serves as Chief of the Division of Pediatric Allergy and Immunology. Certified by The American Board of Pediatrics and the American Board of Allergy and Immunology, Dr. Hsieh joined the UT Southwestern faculty in 2026. 

Dr. Hsieh is an active physician-scientist specializing in inborn errors of immunity, with a focus on defining the molecular and cellular mechanisms that drive immune dysregulation. Her research leverages high-dimensional single-cell and multi-omic approaches to identify pathogenic pathways and translate these discoveries into precision, pathway-targeted therapies. Her work has led to the identification and mechanistic characterization of novel immune dysregulation disorders, including defining the role of IL2RB, LCK, and other T-cell receptor signaling defects in human disease, providing key insights into immune homeostasis and autoimmunity and informing the development of targeted immunotherapies. 

By bridging rare genetic disorders to more common conditions, her research has advanced understanding of diseases such as lupus and inflammatory bowel disease and informed the development of targeted therapeutic strategies. Her program is continuously supported by the National Institutes of Health and major foundations, including the Lupus Research Alliance and Arthritis Foundation.  

Prior to joining UT Southwestern, Dr. Hsieh was an Associate Professor at the University of Colorado Anschutz School of Medicine, where she directed the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies and led a Federation of Clinical Immunology Societies (FOCiS) Center of Excellence.