- Other Post Graduate Training - University of Maryland School of Medicine (2017-2019)
- Fellowship - University of Florida Health Science Center (2009-2012), Pulmonary & Critical Care Medicine
- Residency - Cleveland Clinic Foundation (2004-2007), Internal Medicine
- Medical School - Carol Davila University of Medicine & Pharmacy (1996-2002)
- Fellowship - University of Pittsburgh Medical Center (2012-2013), Lung Transplant
![Irina Timofte, M.D.](https://s3-us-west-2.amazonaws.com/utsw-patientcare-web-production/original_images/timofte-irine-206651-400x400.jpg)
Irina Timofte, M.D.
- Internal Medicine - Pulmonary and Critical Care Medicine
- Lung Transplant Medicine
- Interstitial Lung Disease (Pulmonary Fibrosis)
New Patient Appointment Accepting Virtual Visits or 214-645-6616
Biography
Irina Timofte, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She specializes in lung transplantation, interstitial lung disease, and pulmonary hypertension.
Dr. Timofte earned her medical degree at Carol Davila University of Medicine and Pharmacy in Bucharest, Romania. She completed an internal medicine residency at Cleveland Clinic’s Huron Hospital and received advanced training through fellowships in pulmonary and critical care at the University of Florida and lung transplantation at the University of Pittsburgh Medical Center. She also holds a master’s degree in epidemiology and clinical research from the University of Maryland.
Certified by the American Board of Internal Medicine in critical care medicine and pulmonary medicine, Dr. Timofte joined the UT Southwestern faculty in 2021.
Dr. Timofte is the Lung Transplant Fellowship Program Director at UT Southwestern. She serves on the Lung Transplant Selection Committee, the Endoscopy Lab High Performance Committee, and the Compliance Committee, among others.
She is also a member of the National Heart, Lung, and Blood Institute’s Genomic Research Alliance for Transplantation and the International Society for Heart and Lung Transplantation, for which she serves on the Consensus Statement Committee on Lung Transplant Patients with Connective Tissue Disease.
Dr. Timofte's clinical interests include critical care medicine and many advanced lung diseases, such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), scleroderma, rheumatoid arthritis-related interstitial lung disease, and pulmonary hypertension.
Her research focuses on discovering safer noninvasive diagnostic approaches for evaluating graft integrity and predicting lung rejection through the integration of data obtained from cell-free DNA microbiome and microarray analyses. She seeks to improve clinical outcomes and develop superior immunosuppressive strategies for patients who have had lung transplants by using a less toxic immunosuppressive regimen.
Dr. Timofte has served as Principal Investigator and Co-investigator in several National Institutes of Health-sponsored clinical trials; has given multiple local, national, and international lectures; and has written several peer-reviewed articles and abstracts in her areas of expertise.
Education & Training
Professional Associations & Affiliations
- International Society for Heart and Lung Transplantation
Honors & Awards
- Certificate of Appreciation for Dedicated Service 2009, Cleveland Clinic
Books & Publications
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Publications
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Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD).
Keller M, Bush E, Diamond JM, Shah P, Matthew J, Brown AW, Sun J, Timofte I, Kong H, Tunc I, Luikart H, Iacono A, Nathan SD, Khush KK, Orens J, Jang M, Agbor-Enoh S, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Jun 40 6 488-493 -
Dapsone as an Effective Treatment for Arthritis Secondary to Hidradenitis Suppurativa.
Timofte I, Smith H, Bulletin of the Hospital for Joint Disease (2013) 2021 Jun 79 2 137-140 -
Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study.
Jang MK, Tunc I, Berry GJ, Marboe C, Kong H, Keller MB, Shah PD, Timofte I, Brown AW, Ponor IL, Mutebi C, Philogene MC, Yu K, Iacono A, Orens JB, Nathan SD, Agbor-Enoh S, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Apr -
Molecular T-cell?mediated rejection in transbronchial and mucosal lung transplant biopsies is associated with future risk of graft loss.
Halloran K, Parkes MD, Timofte I, Snell G, Westall G, Havlin J, Lischke R, Hachem R, Kreisel D, Levine D, Kubisa B, Piotrowska M, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Hirji A, Weinkauf J, Halloran PF, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020 12 39 12 1327-1337 -
Survival benefit of lung transplantation compared with medical management and pulmonary rehabilitation for patients with end-stage COPD.
Timofte I, Wijesinha M, Vesselinov R, Kim J, Reed R, Sanchez PG, Ladikos N, Pham S, Kon Z, Rajagopal K, Scharf SM, Wise R, Sternberg AL, Kaczorowski D, Griffith B, Terrin M, Iacono A, ERJ open research 2020 Apr 6 2 -
Molecular phenotyping of rejection-related changes in mucosal biopsies from lung transplants.
Halloran K, Parkes MD, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Levine D, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Hirji A, Weinkauf J, Halloran PF, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 04 20 4 954-966 -
Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease.
Timofte I, Tonelli A, Diaz-Abad M, Verceles A, Ladikos N, Iacono A, Terrin ML, Wijesinha M, Akindipe O, Baz M, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2020 Feb 90 1 -
A randomised single-centre trial of inhaled liposomal cyclosporine for bronchiolitis obliterans syndrome post-lung transplantation.
Iacono A, Wijesinha M, Rajagopal K, Murdock N, Timofte I, Griffith B, Terrin M, ERJ open research 2019 Oct 5 4 -
Molecular assessment of rejection and injury in lung transplant biopsies.
Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 05 38 5 504-513 -
Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.
Agbor-Enoh S, Wang Y, Tunc I, Jang MK, Davis A, De Vlaminck I, Luikart H, Shah PD, Timofte I, Brown AW, Marishta A, Bhatti K, Gorham S, Fideli U, Wylie J, Grimm D, Goodwin N, Yang Y, Patel K, Zhu J, Iacono A, Orens JB, Nathan SD, Marboe C, Berry GJ, Quake SR, Khush K, Valantine HA, EBioMedicine 2019 Feb 40 541-553 -
Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: Evidence from cell-free DNA analysis.
Agbor-Enoh S, Jackson AM, Tunc I, Berry GJ, Cochrane A, Grimm D, Davis A, Shah P, Brown AW, Wang Y, Timofte I, Shah P, Gorham S, Wylie J, Goodwin N, Jang MK, Marishta A, Bhatti K, Fideli U, Yang Y, Luikart H, Cao Z, Pirooznia M, Zhu J, Marboe C, Iacono A, Nathan SD, Orens J, Valantine HA, Khush K, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 07 37 7 925-932 -
Adaptive periodic paralysis allows weaning deep sedation overcoming the drowning syndrome in ECMO patients bridged for lung transplantation: A case series.
Timofte I, Terrin M, Barr E, Kim J, Rinaldi J, Ladikos N, Menaker J, Tabatabai A, Kon Z, Griffith B, Pierson R, Pham S, Iacono A, Herr D, Journal of critical care 2017 12 42 157-161 -
Belatacept for renal rescue in lung transplant patients.
Timofte I, Terrin M, Barr E, Sanchez P, Kim J, Reed R, Britt E, Ravichandran B, Rajagopal K, Griffith B, Pham S, Pierson RN, Iacono A, Transplant international : official journal of the European Society for Organ Transplantation 2016 Apr 29 4 453-63 -
Venous Thromboembolic Complications of Lung Transplantation: A Contemporary Single-Institution Review.
Evans CF, Iacono AT, Sanchez PG, Goloubeva O, Kim J, Timofte I, Cheema FH, Pham SM, Griffith BP, Rajagopal K, The Annals of thoracic surgery 2015 Dec 100 6 2033-9; discussion 2039-40 -
Diaphragmatic herniation due to massive hepatomegaly in a patient with pulmonary arterial hypertension.
Timofte I, Potosky D, Ramani GV, Reed RM, BMJ case reports 2015 Jun 2015 -
Tuberous sclerosis complex: multisystem hamartomas.
Naderi N, Timofte I, McCurdy MT, Reed RM, BMJ case reports 2015 Jan 2015 -
Pulmonary hypertension before first and second lung transplantation.
Tonelli AR, Timofte I, Minai OA, Baz M, Akindipe O, Clinical transplantation 2012 Sep-Oct 26 5 672-8
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Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD).
Research
- Cell-free DNA
- Chronic obstructive pulmonary disease (COPD)
- Interstitial lung disease
- Lung transplantation
- Metabolome
- Microbiome
- Pulmonary fibrosis
- Pulmonary hypertension
- Rejection and immunosuppression
Clinical Focus
- Lung Transplant Medicine
- Interstitial Lung Disease (Pulmonary Fibrosis)
- Pulmonary Hypertension
Results: 1 Locations
University Hospital Heart and Lung Clinic
at Professional Office Building 2 5939 Harry Hines Blvd., 6th Floor, Suite 600Dallas, Texas 75390 214-645-5505 Directions to University Hospital Heart and Lung Clinic Parking Info for University Hospital Heart and Lung Clinic
New Patient Appointment Accepting Virtual Visits or 214-645-6616