Jaehyuk Choi, M.D., Ph.D.

Inaugural Director of the Center for Cellular Therapies and Cancer Immunology in the Harold C. Simmons Comprehensive Cancer Center | Vice Chair for Translational Research and Innovation in the Department of Dermatology

Scheryle Simmons Patigian Distinguished Chair in Cancer Immunobiology

Dermatology - General
Skin Lymphomas
Merkel Cell Carcinomas

New Patient Appointment or 214-645-2400

See Dr. Choi's Locations

Biography

Jaehyuk Choi, M.D., Ph.D., is a Professor in the Department of Dermatology and the Scheryle Simmons Patigian Distinguished Chair in Cancer Immunobiology at UT Southwestern Medical Center. A physician-scientist, he specializes in skin lymphomas, melanoma, Merkel cell carcinomas, bone marrow transplants, autoimmune diseases, and cell therapies.

Dr. Choi earned his medical degree and a doctoral degree in immunology at Yale University. He completed a residency in dermatology at Yale New Haven Hospital and gained advanced training through a postdoctoral research fellowship in genetics, also at Yale.

Certified by the American Board of Dermatology, he joined the UT Southwestern faculty in 2025. He previously served as the Jack W. Graffin Associate Professor of Dermatology, Biochemistry, and Molecular Genetics at the Northwestern University Feinberg School of Medicine.

Dr. Choi is the inaugural Director of the Center for Cellular Therapies and Cancer Immunology at UT Southwestern. He also serves as Vice Chair of Translational Science and Innovation in the Department of Dermatology. His research uses genomic and computational approaches to study the molecular and cellular defects in cancer and autoimmune disease. His lab has made important discoveries about T-cell lymphomas that could lead to enhanced cellular therapies for solid tumors.

His work has been published in broadly read journals such as Nature, Nature Cancer, and Blood. His work has been funded by the Mark Foundation for Cancer Research, the V Foundation, the Leukemia & Lymphoma Society, the National Institutes of Health, and the American Cancer Society, among others.

Dr. Choi is a member of numerous professional associations, including the American Society for Clinical Investigation, the American Dermatological Association, the American Association for Cancer Research, and the Cutaneous Lymphoma Foundation Research Advisory Council. He is an Associate Editor of the Journal of Clinical Investigation.

He has delivered numerous international and national presentations, contributed to books including Hematopoietic Stem Cell Transplantation, and published many academic articles related to his areas of expertise.

Personal Note

When he’s not at work, Dr. Choi enjoys reading, rooting for Philadelphia sports teams, and hiking at national parks.

Education & Training

Medical School - Yale University School of Medicine
Residency - Yale New Haven Hospital (2006-2007), Internal Medicine
Fellowship - Yale New Haven Hospital (2007-2010), Dermatology

Professional Associations & Affiliations

American Dermatological Association
American Association for Cancer Research
American Academy of Dermatology
American Society for Clinical Investigation
American Society of Hematology
Cutaneous Lymphoma Foundation Research Advisory Council
International Society for Cutaneous Lymphomas
International Workshop on Merkel Cell Carcinoma Research
Merkel Cell Carcinoma Forum
Society for Immunotherapy of Cancer
Society for Investigative Dermatology
United States Cutaneous Lymphoma Consortium

Honors & Awards

Researcher to Know 2024, Illinois Science & Technology Coalition
Investigator 2024, Chan Zuckerburg Biohub Chicago
Travel Award 2023, Korean Association of Immunologists Annual Meeting
Emerging Leader Award 2022, The Mark Foundation for Cancer Research
Scholar 2020, Leukemia & Lymphoma Society
Research Scholar 2020, American Cancer Society
New Innovator 2017, National Institutes of Health

Books & Publications

Books
- Photopheresis in Hematopoietic Stem Cell Transplantation: A Handbook for Clinicians (2nd ed.)
  Sokhn JG, Choi J, Foss FM (2014), Bethesda, MD, AABB Press
- Extracorporeal photochemotherapy in Comprehensive Drug Therapy (3rd ed.)
  Choi J, Heald PW, Girardi M (2012), China, Elsevier-Saunders
- Choi J, Foss FM in Apheresis: Principles and Practice (3rd ed.)
  Photopheresis (2010), Bethesda, MD, AABB Press
- Dermatologic diseases and disorders in Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine (7th ed.)
  Aasi S, Choi J (2008), New York, American Geriatrics Society
Publications
- Primary cutaneous CD8⁺ aggressive epidermotropic cytotoxic T-cell lymphoma with novel FGFR1 fusion treated with pemigatinib
  Torres-Cabala CA, Yescas JA, Zhang Y, Huen A, Sumit G, Tefft K, Tang G, Curry JL, Gunther J, Dabaja B, Iyer S, Miranda RN, Choi J, Nardi V Blood Advances 2025 Apr 9 1786-1790
- Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
  Zhang Y, Yescas JA, Tefft K, Ng S, Qiu K, Wang EB, Akhtar S, Walker A, Welborn M, Zaiac M, Guitart J, Qureshi AM, Kim YH, Khodadoust MS, Issa NT, Choi J Journal of Clinical Investigation 2025 Apr 135
- A phase-2 study of pembrolizumab in patients with biologically selected subtypes of relapsed/refractory aggressive lymphomas
  Merrill MH, Redd RA, Fisher DC, Abramson JS, Barnes J, Choi J, Jacobson CA, Kim AI, Lunning MA, Jester HD, Jeter EL, McDonough MM, Armand P, Jacobsen ED Leukemia and Lymphoma 2025 66 1354-1357
- Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations
  Myers CS, Williams E, Cornejo CB, Pongas G, Toomey NL, Sanches JA, Battistella M, Mo S, Pulitzer M, Moskaluk CA, Bhagat G, Ofori K, Davick JJ, Servitje O, Miyashiro D, Climent F, Ringbloom K, Duenas D, Law C, Zambrano SC, Malpica L, Beltran BE, Castro D, Barreto L, Brites C, Chapman JR, Choi J, Gru AA, Ramos JC Haematologica 2024 Dec 109 4021-4039
- Inhibitory co-receptor Lag3 supports Foxp3⁺ regulatory T cell function by restraining Myc-dependent metabolic programming
  Kim D, Kim G, Yu R, Lee J, Kim S, Gleason MR, Qiu K, Montauti E, Wang LL, Fang D, Choi J, Chandel NS, Weinberg S, Min B Immunity 2024 Nov 57 2634-2650.e5
- Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
  Reinstein ZZ, Zhang Y, Ospina OE, Nichols MD, Chu VA, de Mingo Pulido A, Prieto K, Nguyen JV, Yin R, Segura CM, Usman A, Sell B, Ng S, de la Iglesia JV, Chandra S, Sosman JA, Cho RJ, Cheng JB, Ivanova E, Koralov SB, Slebos RJ, Chung CH, Khushalani NI, Messina JL, Sarnaik AA, Zager JS, Sondak VK, Vaske C, Kim S, Brohl AS, Mi X, Pierce BG, Wang X, Fridley BL, Tsai KY, Choi J Cancer discovery 2024 Sep 14 1631-1652
- Circulating Tumor DNA Assay Detects Merkel Cell Carcinoma Recurrence, Disease Progression, and Minimal Residual Disease: Surveillance and Prognostic Implications
  Akaike T, Thakuria M, Silk AW, Hippe DS, Park SY, So NA, Maloney NJ, Gunnell L, Eschholz A, Kim EY, Sinha S, Hall ET, Bhatia S, Reddy S, Rodriguez AA, Aleshin A, Choi JS, Tsai KY, Yom SS, Yu SS, Choi J, Chandra S, Nghiem P, Zaba LC Journal of Clinical Oncology 2024 Sep 42 3151-3161
- Correction to: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus (Nature, (2024), 631, 8022, (857-866), 10.1038/s41586-024-07627-2)
  Author Collaboration AM, Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE, Wyse A, Cordle A, Zhu Z, Zhang F, Xiao Q, Weisman M, Weisenfeld D, Weinand K, Wei K, Watts GF, Utz PJ, Tabechian D, Smith M, Slowikowski K, Singaraju A, Scheel-Toellner D, Seifert JA, Sakaue S, Sahbudin I, Rumker L, Robinson WH, Rivellese F, Ritchlin C, Reshef Y, Choi J Nature 2024 Aug 632 E6
- Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus
  Author Collaboration AM, Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE, Albrecht J, Anolik JH, Apruzzese W, Barnas JL, Bathon JM, Ben-Artzi A, Boyce BF, Boyle DL, Bridges SL, Bykerk VP, Campbell D, Ceponis A, Chicoine A, Curtis M, Deane KD, DiCarlo E, Donlin LT, Dunn P, Filer A, Carr H, Firestein GS, Forbess L, Geraldino-Pardilla L, Goodman SM, Choi J Nature 2024 Jul 631 857-866
- KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
  Assatova B, Willim R, Trevisani C, Haskett G, Kariya KM, Chopra K, Park SR, Tolstorukov MY, McCabe SM, Duffy J, Louissaint A, Huuhtanen J, Bhattacharya D, Mustjoki S, Koh MJ, Powers F, Morgan EA, Yang L, Pinckney B, Cotton MJ, Crabbe A, Ziemba JB, Brain I, Heavican-Foral TB, Iqbal J, Nemec R, Rider AB, Ford JG, Koh MJ, Scanlan N, Feith DJ, Loughran TP, Kim WS, Choi J, Roels J, Boehme L, Putteman T, Taghon T, Barnes JA, Johnson PC, Jacobsen ED, Greenberg SA, Weinstock DM, Jain S Clinical Cancer Research 2024 Jun 30 2514-2530
- Single-Cell Analysis Uncovers Striking Cellular Heterogeneity of Lung-Infiltrating Regulatory T Cells during Eosinophilic versus Neutrophilic Allergic Airway Inflammation
  Iamsawat S, Yu R, Kim S, Dvorina N, Qiu K, Choi J, Baldwin WM, Min B Journal of Immunology 2024 Jun 212 1867-1876
- Interstitial mycosis fungoides: A rare presentation of mycosis fungoides with overlapping granulomatous and folliculotropic features
  Chung C, Wu B, LeWitt T, Griffin T, Hooper M, Zhou X, Choi J, Guitart J Journal of Cutaneous Pathology 2024 Jun 51 459-467
- Reply to Wu et al's US SEER analysis of sepsis in Black patients with CTCL
  Hooper MJ, Veon FL, Enriquez GL, Nguyen M, Grimes CB, LeWitt TM, Pang Y, Case S, Choi J, Guitart J, Burns MB, Zhou XA Journal of the American Academy of Dermatology 2024 Feb 90 e79
- Naturally occurring T cell mutations enhance engineered T cell therapies
  Garcia J, Daniels J, Lee Y, Zhu I, Cheng K, Liu Q, Goodman D, Burnett C, Law C, Thienpont C, Alavi J, Azimi C, Montgomery G, Roybal KT, Choi J Nature 2024 Feb 626 626-634
- Genetic Risk Factors for Early-Onset Merkel Cell Carcinoma
  Mohsin N, Hunt D, Yan J, Jabbour AJ, Nghiem P, Choi J, Zhang Y, Freeman AF, Bergerson JR, Dell'Orso S, Lachance K, Kulikauskas R, Collado L, Cao W, Lack J, Similuk M, Seifert BA, Ghosh R, Walkiewicz MA, Brownell I JAMA Dermatology 2024 Feb 160 172-178
- A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response
  Wu D, Hailer AA, Wang S, Yuan M, Chan J, Kurdi AE, Han D, Ali H, Angio BD, Mayer A, Rahim M, Kondo A, Klufas DM, Kim EA, Hunter Shain A, Choi J, Bhutani T, Simpson GL, Grekin RC, Ricardo-Gonzalez RR, Purdom E, North JP, Cheng JB, Cho RJ Science Immunology 2024 Jan 9
- TCR Pathway Mutations in Mature T Cell Lymphomas
  Zhang Y, Cheng K, Choi J Journal of Immunology 2023 Nov 211 1450-1458
- PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma
  Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FH, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland J Nature Cancer 2023 Oct 4 1508-1525
- Lifestyle, demographic and Skindex measures associated with cutaneous T-cell lymphoma: a single institution cohort study
  Nguyen M, LeWitt T, Pang Y, Bagnowski K, Espinosa ML, Choi J, Guitart J, Liszewski W, Zhou XA Archives of Dermatological Research 2023 Mar 315 275-278
- Disease-Defining Molecular Features of Primary Cutaneous B-Cell Lymphomas: Implications for Classification and Treatment
  Zhang Y, LeWitt TM, Louissaint A, Guitart J, Zhou XA, Choi J Journal of Investigative Dermatology 2023 Feb 143 189-196
- Retrospective analysis of sepsis in cutaneous T-cell lymphoma reveals significantly greater risk in Black patients
  Hooper MJ, Veon FL, Enriquez GL, Nguyen M, Grimes CB, LeWitt TM, Pang Y, Case S, Choi J, Guitart J, Burns MB, Zhou XA Journal of the American Academy of Dermatology 2023 Feb 88 329-337
- The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in Cutaneous T-Cell Lymphoma Can Be Reproduced by ΔNp73 Depletion
  Zhao L, Hsiao T, Stonesifer C, Daniels J, Garcia-Saleem TJ, Choi J, Geskin L, Rook AH, Wood GS Journal of Investigative Dermatology 2022 Dec 142 3253-3261.e4
- Acceleration of skin involvement may predict disease progression in early-stage mycosis fungoides: A retrospective cohort study
  Chung C, Espinosa ML, Walker CJ, Choi J, Zhou X(, LeWitt T, Liszewski W, Guitart J Journal of the American Academy of Dermatology 2022 Nov 87 1140-1141
- Narrowband ultraviolet B response in cutaneous T-cell lymphoma is characterized by increased bacterial diversity and reduced Staphylococcus aureus and Staphylococcus lugdunensis
  Hooper MJ, Enriquez GL, Veon FL, LeWitt TM, Sweeney D, Green SJ, Seed PC, Choi J, Guitart J, Burns MB, Zhou XA Frontiers in immunology 2022 Nov 13
- Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease
  Hooper MJ, LeWitt TM, Pang Y, Veon FL, Chlipala GE, Feferman L, Green SJ, Sweeney D, Bagnowski KT, Burns MB, Seed PC, Choi J, Guitart J, Zhou XA Journal of the European Academy of Dermatology and Venereology 2022 Sep 36 1552-1563
- Cutaneous T-Cell-Rich Lymphoid Infiltrates after SARS-CoV-2 Vaccination
  Hooper MJ, Veon FL, Lewitt TM, Chung C, Choi J, Zhou XA, Guitart J JAMA Dermatology 2022 Sep 158 1073-1076
- Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma
  Church C, Pulliam T, Longino N, Park SY, Smythe KS, Makarov V, Riaz N, Jing L, Amezquita R, Campbell JS, Gottardo R, Pierce RH, Choi J, Chan TA, Koelle DM, Nghiem P Journal for ImmunoTherapy of Cancer 2022 Sep 10
- A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity
  Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SB, Cheng JB, Cho RJ Cell Reports Medicine 2022 Aug 3
- Differences in Merkel cell carcinoma survival by site of primary presentation
  Zaidi AJ, Choi J, Nardone B, Liszewski W Journal of the American Academy of Dermatology 2022 May 86 1120-1123
- Classification of human chronic inflammatory skin disease based on single-cell immune profiling
  Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB Science Immunology 2022 Apr 7
- Partial remission of advanced untreated Sézary syndrome after COVID-19
  Snowden C, Ng S, Choi J JAAD Case Reports 2022 Mar 21 165-168
- Epigenetic Regulation of Apoptosis in Cutaneous T-Cell Lymphoma: Implications for Therapy with Methotrexate, Jak Inhibitors, and Resveratrol
  Nihal M, Wu J, Stonesifer CJ, Daniels J, Choi J, Geskin L, Rook AH, Wood GS Journal of Investigative Dermatology 2022 Feb 142 493-496.e7
- Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway
  Lee K, Evans MG, Yang L, Ng S, Snowden C, Khodadoust M, Brown RA, Trum NA, Querfeld C, Doan LT, Song J, Zhang H, Gru AA, Wood GS, Wada DA, Shanmugam V, Haun PL, Aster JC, Duncan LM, Guitart J, Weinstock DM, Nardi V, Choi J Blood 2021 Dec 138 2435-2440
- BACH2 is a putative T-cell lymphoma tumor suppressor that may play a role in product-derived CAR T-cell lymphomas
  Daniels J, Choi J Blood 2021 Dec 138 2731-2733
- Scarring alopecia developing after mogamulizumab-associated rash
  Raval NS, Snowden CK, De Monnin KS, Yokoyama CC, Choi J, Mehta-Shah N, Rosman IS, Pavlisin J, Musiek AC European Journal of Dermatology 2021 Nov 31 841-843
- Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity
  Park J, Daniels J, Wartewig T, Ringbloom KG, Martinez-Escala ME, Choi S, Thomas JJ, Doukas PG, Yang J, Snowden C, Law C, Lee Y, Lee K, Zhang Y, Conran C, Tegtmeyer K, Mo SH, Pease DR, Jothishankar B, Kwok PY, Abdulla FR, Pro B, Louissaint A, Boggon TJ, Sosman J, Guitart J, Rao D, Ruland J, Choi J Blood 2021 Oct 138 1225-1236
- ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
  Qian Y, Arellano G, Ifergan I, Lin J, Snowden C, Kim T, Thomas JJ, Law C, Guan T, Balabanov RD, Kaech SM, Miller SD, Choi J Cell Reports 2021 Aug 36
- Cutting edge: Steroid responsiveness in Foxp31 regulatory T cells determines steroid sensitivity during allergic airway inflammation in mice
  Nguyen QT, Kim D, Iamsawat S, Le HT, Kim S, Qiu KT, Hinds TD, Bazeley P, O'Shea JJ, Choi J, Asosingh K, Erzurum SC, Min B Journal of Immunology 2021 Aug 207 765-770
- Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features
  Zhou XA, Yang J, Ringbloom KG, Martinez-Escala ME, Stevenson KE, Wenzel AT, Fantini D, Martin HK, Moy AP, Morgan EA, Harkins S, Paxton CN, Hong B, Andersen EF, Guitart J, Weinstock DM, Cerroni L, Choi J, Louissaint A Blood Advances 2021 Feb 5 649-661
- Pembrolizumab and palliative radiotherapy in 2 cases of refractory mycosis fungoides
  Walker CJ, Donnelly ED, Moreira J, Mehta J, Mittal BB, Choi J, Zhou XA, Guitart J, Pro B JAAD Case Reports 2021 Jan 7 87-90
- Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
  Daniels J, Doukas PG, Escala ME, Ringbloom KG, Shih DJ, Yang J, Tegtmeyer K, Park J, Thomas JJ, Selli ME, Altunbulakli C, Gowthaman R, Mo SH, Jothishankar B, Pease DR, Pro B, Abdulla FR, Shea C, Sahni N, Gru AA, Pierce BG, Louissaint A, Guitart J, Choi J Nature communications 2020 Dec 11
- Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation
  Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB iScience 2020 Oct 23
- Progression of cutaneous T-cell lymphoma after dupilumab: Case review of 7 patients
  Espinosa ML, Nguyen MT, Aguirre AS, Martinez-Escala ME, Kim J, Walker CJ, Pontes DS, Silverberg JI, Choi J, Pro B, Pincus LB, Guitart J, Zhou XA Journal of the American Academy of Dermatology 2020 Jul 83 197-199
- Drug-induced hypersensitivity syndrome with myocardial involvement treated with tofacitinib
  Damsky WE, Vesely MD, Lee AI, Choi J, Meyer AC, Chen M, Ahmad T, King B JAAD Case Reports 2019 Dec 5 1018-1026
- Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis
  Allen SD, Liu YG, Kim T, Bobbala S, Yi S, Zhang X, Choi J, Scott EA Biomaterials Science 2019 Feb 7 657-668
- The coincidence between increasing age, immunosuppression, and the incidence of patients with glioblastoma
  Ladomersky E, Scholtens DM, Kocherginsky M, Hibler EA, Bartom ET, Otto-Meyer S, Zhai L, Lauing KL, Choi J, Sosman JA, Wu JD, Zhang B, Lukas RV, Wainwright DA Frontiers in Pharmacology 2019 10
- Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type
  Zhou XA, Louissaint A, Wenzel A, Yang J, Martinez-Escala ME, Moy AP, Morgan EA, Paxton CN, Hong B, Andersen EF, Guitart J, Behdad A, Cerroni L, Weinstock DM, Choi J Journal of Investigative Dermatology 2018 Nov 138 2365-2376
- Are MicroRNAs Key to Developing Biomarkers for Cutaneous T-Cell Lymphoma?
  Martinez-Escala ME, Choi J Journal of Investigative Dermatology 2018 Sep 138 1906-1908
- Hemophagocytic lymphohistiocytosis in cutaneous T-cell lymphoma
  Lee DE, Martinez-Escala ME, Serrano LM, Zhou XA, Kaplan JB, Pro B, Choi J, Guitart J JAMA Dermatology 2018 Jul 154 828-831
- Progression of undiagnosed cutaneous lymphoma after anti–tumor necrosis factor-alpha therapy
  Martinez-Escala ME, Posligua AL, Wickless H, Rutherford A, Sable KA, Rubio-Gonzalez B, Zhou XA, Kaplan JB, Pro B, Choi J, Querfeld C, Rosen ST, Guitart J Journal of the American Academy of Dermatology 2018 Jun 78 1068-1076
- Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC)
  Chae YK, Arya A, Iams W, Cruz MR, Chandra S, Choi J, Giles F Journal for ImmunoTherapy of Cancer 2018 May 6
- Are there multiple cells of origin of Merkel cell carcinoma?
  Sunshine JC, Jahchan NS, Sage J, Choi J Oncogene 2018 Mar 37 1409-1416
- Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure
  Haugh AM, Zhang B, Quan VL, Garfield EM, Bubley JA, Kudalkar E, Verzi AE, Walton K, VandenBoom T, Merkel EA, Lee CY, Tan T, Isales MC, Kong BY, Wenzel AT, Bunick CG, Choi J, Sosman J, Gerami P Journal of Investigative Dermatology 2018 Feb 138 384-393
- Merkel cell carcinoma patients presenting without a primary lesion have elevated markers of immunity, higher tumor mutation burden, and improved survival
  Vandeven N, Lewis CW, Makarov V, Riaz N, Paulson KG, Hippe D, Bestick A, Doumani R, Marx T, Takagishi S, Chan TA, Choi J, Nghiem P Clinical Cancer Research 2018 Feb 24 963-971
- Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)
  Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, Kim J, Martinez-Escala E, Amankulor N, Pro B, Guitart J, Mendillo ML, Savas JN, Boggon TJ, Choi J Blood 2017 Sep 130 1430-1440
- CD8⁺ mycosis fungoides: A low-grade lymphoproliferative disorder
  Martinez-Escala ME, Kantor RW, Cices A, Zhou XA, Kaplan JB, Pro B, Choi J, Guitart J Journal of the American Academy of Dermatology 2017 Sep 77 489-496
- Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma
  Gmyrek GB, Pingel J, Choi J, Green JM Cellular Immunology 2017 Sep 319 28-34
- Photopheresis: Advances and Use in Systemic Sclerosis
  Zhou XA, Choi J Current Rheumatology Reports 2017 Jun 19
- Treatment of Hypereosinophilic Syndrome with Cutaneous Involvement with the JAK Inhibitors Tofacitinib and Ruxolitinib
  King B, Lee AI, Choi J Journal of Investigative Dermatology 2017 Apr 137 951-954
- FISH Panel for Leukemic CTCL
  Weed J, Gibson J, Lewis J, Carlson K, Foss F, Choi J, Li P, Girardi M Journal of Investigative Dermatology 2017 Mar 137 751-753
- Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy?
  Chae YK, Arya A, Chiec L, Shah H, Rosenberg A, Patel S, Raparia K, Choi J, Wainwright DA, Villaflor V, Cristofanilli M, Giles F Oncotarget 2017 8 100863-100898
- IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression
  Zhang X, Rao A, Sette P, Deibert C, Pomerantz A, Kim WJ, Kohanbash G, Chang Y, Park Y, Engh J, Choi J, Chan T, Okada H, Lotze M, Grandi P, Amankulor N Neuro-oncology 2016 Oct 18 1402-1412
- Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi
  Yélamos O, Merkel EA, Sholl LM, Zhang B, Amin SM, Lee CY, Guitart GE, Yang J, Wenzel AT, Bunick CG, Yazdan P, Choi J, Gerami P Journal of Investigative Dermatology 2016 Sep 136 1858-1865
- Genetics of Cutaneous T Cell Lymphoma: From Bench to Bedside
  Damsky WE, Choi J Current treatment options in oncology 2016 Jul 17
- Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
  Pinzaru AM, Hom RA, Beal A, Phillips AF, Ni E, Cardozo T, Nair N, Choi J, Wuttke DS, Sfeir A, Denchi EL Cell Reports 2016 Jun 15 2170-2184
- Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction
  Gibson JF, Huang J, Liu KJ, Carlson KR, Foss F, Choi J, Edelson R, Hussong JW, Mohl R, Hill S, Girardi M Journal of the American Academy of Dermatology 2016 May 74 870-877
- A discordant cutaneous eruption in a neonatal twin
  Damsky WE, Craiglow BG, Choi J JAMA Dermatology 2016 Apr 152 463-464
- Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: Counselling and management recommendations
  Ziai J, Matloff E, Choi J, Kombo N, Materin M, Bale AE Genetics Research 2016 Mar 98
- Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma
  Bi M, Zhao S, Said JW, Merino MJ, Adeniran AJ, Xie Z, Nawaf CB, Choi J, Belldegrun AS, Pantuck AJ, Kluger HM, Bilgövar K, Lifton RP, Shuch B Proceedings of the National Academy of Sciences of the United States of America 2016 Feb 113 2170-2175
- Identification of a gain-of-function stat3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome
  Walker S, Wang C, Walradt T, Hong BS, Tanner JR, Levinsohn JL, Goh G, Subtil A, Lessin SR, Heymann WR, Vonderheid EC, King BA, Lifton RP, Choi J Blood 2016 Feb 127 948-951
- Mutational landscape of MCPyV-positive and MCPyV-negative merkel cell carcinomas with implications for immunotherapy
  Goh G, Walradt T, Markarov V, Blom A, Riaz N, Doumani R, Stafstrom K, Moshiri A, Yelistratova L, Levinsohn J, Chan TA, Nghiem P, Lifton RP, Choi J Oncotarget 2016 7 3403-3415
- Genomic landscape of cutaneous T cell lymphoma
  Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP Nature genetics 2015 Aug 47 1011-1019
- Rapidly enlarging nodular plaque on the leg
  Little AJ, Subtil A, Choi J JAMA Dermatology 2014 Oct 150 1107-1108
- Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
  Choi J, Landrette SF, Wang T, Evans P, Bacchiocchi A, Bjornson R, Cheng E, Stiegler AL, Gathiaka S, Acevedo O, Boggon TJ, Krauthammer M, Halaban R, Xu T Pigment Cell and Melanoma Research 2014 Mar 27 253-262
- Activation of GILZ gene by photoactivated 8-methoxypsoralen: Potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy
  Futterleib JS, Feng H, Tigelaar RE, Choi J, Edelson RL Transfusion and Apheresis Science 2014 50 379-387
- Extracorporeal photochemotherapy (photopheresis)
  Choi J, Heald PW, Girardi M 2012 Nov 291-298
- Pityriasis rubra pilaris: the clinical context of acantholysis and other histologic features
  Ko CJ, Milstone LM, Choi J, Mcniff JM International Journal of Dermatology 2011 Dec 50 1480-1485
- Cutaneous T-cell Lymphoma
  Lansigan F, Choi J, Foss FM Hematology/Oncology Clinics of North America 2008 Oct 22 979-996
- Carpal tunnel syndrome associated with the use of aromatase inhibitors in breast cancer
  Nishihori T, Choi J, DiGiovanna MP, Thomson JG, Kohler PC, McGurn J, Chung GG Clinical breast cancer 2008 Aug 8 362-365
- Cutaneous T-cell lymphoma: Biologic targets for therapy
  Choi J, Foss F Current Hematologic Malignancy Reports 2007 Dec 2 272-277
- Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia
  Choi J, Foss F Yale Journal of Biology and Medicine 2006 Dec 79 169-172
- Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT
  Choi J, Walker J, Talbert-Slagle K, Wright P, Pober JS, Alexander L Journal of virology 2005 Sep 79 11194-11204
- Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4⁺ T cells in a Nef-dependent manner in vitro and in vivo
  Choi J, Walker J, Boichuk S, Kirkiles-Smith N, Torpey N, Pober JS, Alexander L Journal of virology 2005 Jan 79 264-276
- T lymphocyte-endothelial cell interactions
  Choi J, Enis DR, Koh KP, Shiao SL, Pober JS Annual review of immunology 2004 22 683-709
- Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
  Madge LA, Li JH, Choi J, Pober JS Journal of Biological Chemistry 2003 Jun 278 21295-21306

Research

Skin cancer
Skin immunology
Cancer immunology
Autoimmune diseases
Immunotherapy
Cellular therapies

Clinical Focus

Skin Lymphomas
Merkel Cell Carcinomas
Melanoma
Bone Marrow Transplant
Bone Marrow Cell Therapies