- Residency - Harvard/Brigham and Women's Hospital/Massachusetts General Hospital (2008-2012), Radiation Oncology
- Internship - Harvard/Brigham and Women's Hospital (2007-2008), Internal Medicine
- Medical School - Stanford University School of Medicine (1999-2007)
- Other Post Graduate Training - Stanford University
- Graduate School - Stanford University, Medical Scientist Training Program
Ken Westover, M.D., Ph.D.
Chief of Lung Radiation Oncology Service, Director of Clinical Innovation and Information Systems
- Radiation Oncology
- Radiation Therapy for Esophageal Cancer
- Chest Cancers
New Patient Appointment Accepting Virtual Visits or 214-645-8525
Biography
Ken Westover, M.D., Ph.D., started his research career as a summer undergraduate research fellow in the labs of Nobel Prize laureates Michael Brown, M.D., and Joseph Goldstein, M.D., at UT Southwestern. It was there that he learned the basics of biochemistry and became convinced that he wanted to become a physician-scientist.
After graduating with honors from Brigham Young University, with a B.S. in biochemistry, Dr. Westover entered the Stanford University Medical Scientist Training Program where he worked in the lab of Roger Kornberg, Ph.D., on the structural biology and biochemistry of gene transcription. Dr. Westover’s work was subsequently cited in the 2006 Nobel Prize for Chemistry awarded to Dr. Kornberg.
Radiation oncology was a natural fit for Dr. Westover given his laboratory experience, which had natural connections to cancer biology and included elements of imaging research, radiation science, and computer science. Most importantly, Dr. Westover found he was passionate about the practice of oncology.
Dr. Westover completed his residency in radiation oncology at the Harvard Radiation Oncology Program, where he simultaneously worked in the lab of Nathanael Gray, Ph.D., in the Dana Farber Cancer Institute, learning principles of structure-based drug design and chemical biology. He also completed Harvard’s Intensive Translational Research Program.
Now at UT Southwestern, Dr. Westover focuses his clinical efforts on lung cancer and his research efforts on improving cancer therapies. In addition to targeted drug design, Dr. Westover hopes to find new ways to combine radiation therapy and targeted drugs.
Meet Dr. Westover
Ken Westover, M.D., Ph.D., wears many hats. He is Chief of Lung Radiation Oncology Service, Director of Clinical Innovation and Information Systems for the Department of Radiation Oncology, and Director of the Westover Research Laboratory, located in the Department of Biochemistry, which is dedicated to cancer biology and the development of new drugs. "I look at cancer from its molecular basis to the physics of radiation treatment.”
After completion of the Stanford University Medical Scientist Training Program (1999-2007) and residency training in Harvard Radiation Oncology Program (2007-2012) where he distinguished himself as a fellow in radiation oncology and a scientist specializing in drug development for cancer, Dr. Westover was recruited to UT Southwestern.
Westover’s work has been published in numerous clinical and high-profile basic science journals. He has also authored several book chapters relating to radiation therapy. His scientific work shed light on the way genes are transcribed and was cited in the 2006 Nobel Prize in Chemistry awarded to his mentor Roger Kornberg, Ph.D.
“I want to relieve the burdens of cancer in any way I can. I am fully committed to serving cancer patients through basic research, clinical innovation, and the highest quality patient care,” says Dr. Westover. “I feel fortunate to work with several highly skilled teams that are making a difference for cancer patients.”
Clinically, Dr. Westover specializes in treating lung cancer and is particularly interested in using stereotactic body radiation therapy (SBRT) – also known as stereotactic ablative radiation therapy (SABR) – to treat cancer patients, an approach that was pioneered by another member of UT Southwestern’s radiation oncology team, Robert Timmerman, M.D. This stronger, “ablative” dose of radiation precisely targets and destroys tumors in just a few treatments.
In the lab, Dr. Westover is focused on developing targeted drugs and understanding how certain mutant proteins cause cancer. While at Harvard he was the first to publish clinical results showing that protons can be used to deliver effective SBRT for early stage lung cancer in patients with poor pulmonary function.
Education & Training
Professional Associations & Affiliations
- American Association for Cancer Research
- American College of Radiology
- American Society for Therapeutic Radiation and Oncology
Honors & Awards
- CPRIT Scholar 2012-2016
- V Scholar 2014-2016
Books & Publications
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Books
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Radiation in Pocket Neurology
Westover MB, Choi E, Awad K (2010), Philadelphia, PA, Lippincott Williams & Wilkins -
Liver in Human Radiation Injury
Shrieve D, Loeffler J, et al (2010), Philadelphia, PA, Lippincott Williams & Wilkins
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Radiation in Pocket Neurology
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Publications
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Another KRAS variant trapped
Westover K Nature chemical biology 2024 Sep 20 1096-1097 -
Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiation Therapy for Locally Advanced Lung Cancer
Li R, Zhuang T, Montalvo S, Wang K, Parsons D, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin MH, Westover K Practical Radiation Oncology 2024 Sep 14 e395-e406 -
Beyond conventional bounds: Surpassing system limits for stereotactic ablative (SAbR) lung radiotherapy using CBCT-based adaptive planning system
Gonzalez Y, Visak J, Overman L, Liao CY, Yen A, Zhuang T, Cai B, Godley A, Zhang Y, Timmerman R, Iyengar P, Westover K, Parsons D, Lin MH Journal of applied clinical medical physics 2024 Aug 25 -
CheckMate Check-In: Playbook for a Cancelled Surgery
Badiyan SN, Westover K International Journal of Radiation Oncology Biology Physics 2024 Mar 118 588-589 -
GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing
Yu DM, Zhao J, Lee EE, Kim D, Mahapatra R, Rose EK, Zhou Z, Hosler C, El Kurdi A, Choe JY, Abel ED, Hoxhaj G, Westover KD, Cho RJ, Cheng JB, Wang RC Journal of Clinical Investigation 2023 Nov 133 -
LIMS-Kinase provides sensitive and generalizable label-free in vitro measurement of kinase activity using mass spectrometry
Meyer C, McCoy M, Li L, Posner B, Westover KD Cell Reports Physical Science 2023 Oct 4 -
Dynamic ultrasound molecular-targeted imaging of senescence in evaluation of lapatinib resistance in HER2-positive breast cancer
Chen X, Li Y, Zhou Z, Zhang Y, Chang L, Gao X, Li Q, Luo H, Westover KD, Zhu J, Wei X Cancer Medicine 2023 Oct 12 19904-19920 -
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1
Lu W, Liu Y, Gao Y, Geng Q, Gurbani D, Li L, Ficarro SB, Meyer CJ, Sinha D, You I, Tse J, He Z, Ji W, Che J, Kim AY, Yu T, Wen K, Anderson KC, Marto JA, Westover KD, Zhang T, Gray NS Journal of Medicinal Chemistry 2023 Mar 66 3356-3371 -
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
Ramirez NG, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D’Orso I Nature communications 2022 Dec 13 -
Therapeutic Targeting the Allosteric Cysteinome of RAS and Kinase Families
Li L, Meyer C, Zhou ZW, Elmezayen A, Westover K Journal of Molecular Biology 2022 Sep 434 -
T Stage and Pretreatment Standardized Uptake Values Predict Tumor Recurrence With 5-Fraction SABR in Early-Stage Non-Small Cell Lung Cancer
Hsu EJ, Mendel JT, Ward KA, El-Ashmawy M, Lee M, Choy H, Westover KD, Vo D, Timmerman RD, Sher DJ, Iyengar P Advances in Radiation Oncology 2022 Sep 7 -
Case Report: Resolution of radiation pneumonitis with androgens and growth hormone
Yen A, Westover KD Frontiers in Oncology 2022 Aug 12 -
Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold
Li Z, Ishida R, Liu Y, Wang J, Li Y, Gao Y, Jiang J, Che J, Sheltzer JM, Robers MB, Zhang T, Westover KD, Nabet B, Gray NS European Journal of Medicinal Chemistry 2022 Aug 238 -
Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability
Kopra K, Valtonen S, Mahran R, Kapp JN, Hassan N, Gillette W, Dennis B, Li L, Westover KD, Plückthun A, Härmä H International journal of molecular sciences 2022 Jul 23 -
Lung Cancer Screening, Version 1.2022 Featured Updates to the NCCN Guidelines
Wood DE, Kazerooni EA, Aberle D, Berman A, Brown LM, Eapen GA, Ettinger DS, Ferguson JS, Hou L, Kadaria D, Klippenstein D, Kumar R, Lackner RP, Leard LE, Lennes IT, Leung AN, Mazzone P, Merritt RE, Midthun DE, Onaitis M, Pipavath S, Pratt C, Puri V, Raz D, Reddy C, Reid ME, Sandler KL, Sands J, Schabath MB, Studts JL, Tanoue L, Tong BC, Travis WD, Wei B, Westover K, Yang SC, McCullough B, Hughes M JNCCN Journal of the National Comprehensive Cancer Network 2022 Jul 20 754-764 -
PD-L1P146R is prognostic and a negative predictor of response to immunotherapy in gastric cancer
Li Q, Zhou ZW, Lu J, Luo H, Wang SN, Peng Y, Deng MS, Song GB, Wang JM, Wei X, Wang D, Westover KD, Xu CX Molecular Therapy 2022 Feb 30 621-631 -
Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry
Gondi SR, Shaik A, Westover KD Journal of Organic Chemistry 2022 Jan 87 125-136 -
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT
Li Q, Zhou ZW, Duan W, Qian CY, Wang SN, Deng MS, Zi D, Wang JM, Mao CY, Song G, Wang D, Westover KD, Xu CX Journal of Experimental and Clinical Cancer Research 2021 Dec 40 -
A structural model of a Ras–Raf signalosome
Mysore VP, Zhou ZW, Ambrogio C, Li L, Kapp JN, Lu C, Wang Q, Tucker MR, Okoro JJ, Nagy-Davidescu G, Bai X, Plückthun A, Jänne PA, Westover KD, Shan Y, Shaw DE Nature Structural and Molecular Biology 2021 Oct 28 847-857 -
Accelerated Hypofractionated Image-Guided vs Conventional Radiotherapy for Patients With Stage II/III Non–Small Cell Lung Cancer and Poor Performance Status A Randomized Clinical Trial
Iyengar P, Zhang-Velten E, Court L, Westover K, Yan Y, Lin MH, Xiong Z, Patel M, Rivera D, Chang J, Saunders M, Shivnani A, Lee A, Hughes R, Gerber D, Dowell J, Gao A, Heinzerling J, Li Y, Ahn C, Choy H, Timmerman R JAMA Oncology 2021 Oct 7 1497-1505 -
Lentiviral-driven discovery of cancer drug resistance mutations
Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R Cancer research 2021 Sep 81 4685-4695 -
Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay
Liu Y, Westover KD STAR Protocols 2021 Jun 2 -
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51
Park JM, Yang SW, Zhuang W, Bera AK, Liu Y, Gurbani D, von Hoyningen-Huene SJ, Sakurada SM, Gan H, Pruett-Miller SM, Westover KD, Potts MB PLoS biology 2021 Jun 19 -
The to and fro of Rho
Westover KD Structure 2021 Jun 29 507-509 -
Contact Tracing in Healthcare Settings During the COVID-19 Pandemic Using Bluetooth Low Energy and Artificial Intelligence—A Viewpoint
Tang G, Westover K, Jiang S Frontiers in Artificial Intelligence 2021 Apr 4 -
Loss of wild type KRAS in KRASMUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors
Liu Y, Gao GF, Minna JD, Williams NS, Westover KD Lung Cancer 2021 Mar 153 73-80 -
Phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost for metastatic cancer
Westover KD, Travis Mendel J, Dan T, Kumar K, Gao A, Pulipparacharuv S, Iyengar P, Nedzi L, Hannan R, Anderson J, Choe KS, Jiang W, Abdulrahman R, Rahimi A, Folkert M, Laine A, Presley C, Munro Cullum C, Choy H, Ahn C, Timmerman R Neuro-oncology 2020 Dec 22 1831-1839 -
Thirteen-Year Survival in a Patient With Diffuse Bilateral Lepidic-Predominant Adenocarcinoma: A Case Report of Lung Transplantation and Local Salvage
Zhang-Velten ER, Gerber DE, Westover KD JTO Clinical and Research Reports 2020 Nov 1 -
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD Cell Chemical Biology 2020 Oct 27 1229-1240.e4 -
Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma
Strong AL, Spreadborough PJ, Pagani CA, Haskins RM, Dey D, Grimm PD, Kaneko K, Marini S, Huber AK, Hwang C, Westover K, Mishina Y, Bradley MJ, Levi B, Davis TA Bone 2020 Oct 139 -
KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer
Zhou ZW, Ambrogio C, Bera AK, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ, Xu CX, Janne PA, Westover KD Cancer research 2020 Sep 80 3719-3731 -
Correction: Synthesis and structure−activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro‑6H‑benzo[e]pyrimido[5,4‑b][1,4]diazepin-6-one Scaffold (Journal of Medical Chemistry (2020) 63:14 (7817−7826) DOI: 10.1021/acs.jmedchem.0c00596)
Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS Journal of Medicinal Chemistry 2020 Sep 63 10088 -
Development of a real-time indoor location system using bluetooth low energy technology and deep learning to facilitate clinical applications
Tang G, Yan Y, Shen C, Jia X, Zinn M, Trivedi Z, Yingling A, Westover K, Jiang S Medical physics 2020 Aug 47 3277-3285 -
Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 H-benzo[ e]pyrimido[5,4- b][1,4]diazepin-6-one Scaffold
Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS Journal of Medicinal Chemistry 2020 Jul 63 7817-7826 -
Discovery of a selective inhibitor of doublecortin like kinase 1
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RW, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS Nature chemical biology 2020 Jun 16 635-643 -
GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R
Bera AK, Lu J, Lu C, Li L, Gondi S, Yan W, Nelson A, Zhang G, Westover KD Birth Defects Research 2020 Jun 112 708-717 -
Structure and Characterization of a Covalent Inhibitor of Src Kinase
Gurbani D, Du G, Henning NJ, Rao S, Bera AK, Zhang T, Gray NS, Westover KD Frontiers in Molecular Biosciences 2020 May 7 -
Dynamic surveillance of tamoxifen-resistance in ER-positive breast cancer by CAIX-targeted ultrasound imaging
Li Y, Chen X, Zhou ZW, Li Q, Westover KD, Wang M, Liu J, Zhang S, Zhang J, Xu B, Wei X Cancer Medicine 2020 Apr 9 2414-2426 -
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine
Du G, Rao S, Gurbani D, Henning NJ, Jiang J, Che J, Yang A, Ficarro SB, Marto JA, Aguirre AJ, Sorger PK, Westover KD, Zhang T, Gray NS Journal of Medicinal Chemistry 2020 Feb 63 1624-1641 -
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
Zeng M, Xiong Y, Safaee N, Nowak RP, Donovan KA, Yuan CJ, Nabet B, Gero TW, Feru F, Li L, Gondi S, Ombelets LJ, Quan C, Jänne PA, Kostic M, Scott DA, Westover KD, Fischer ES, Gray NS Cell Chemical Biology 2020 Jan 27 19-31.e6 -
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase
Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TA Journal of Biological Chemistry 2020 295 1565-1574 -
Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide
Gondi SR, Bera AK, Westover KD Scientific reports 2019 Dec 9 -
Publisher Correction: Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide (Scientific Reports, (2019), 9, 1, (14258), 10.1038/s41598-019-50776-y)
Gondi SR, Bera AK, Westover KD Scientific reports 2019 Dec 9 -
Structural basis of the atypical activation mechanism of KRASV14I
Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD Journal of Biological Chemistry 2019 Sep 294 13964-13972 -
Intergrated analysis of ELMO1, serves as a link between tumour mutation burden and epithelial-mesenchymal transition in hepatocellular carcinoma
Peng H, Zhang Y, Zhou Z, Guo Y, Huang X, Westover KD, Zhang Z, Chen B, Hua Y, Li S, Xu R, Lin N, Peng B, Shen S EBioMedicine 2019 Aug 46 105-118 -
Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation
Hsieh HH, Agarwal S, Cholok DJ, Loder SJ, Kaneko K, Huber A, Chung MT, Ranganathan K, Habbouche J, Li J, Butts J, Reimer J, Kaura A, Drake J, Breuler C, Priest CR, Nguyen J, Brownley C, Peterson J, Ozgurel SU, Niknafs YS, Li S, Inagaki M, Scott G, Krebsbach PH, Longaker MT, Westover K, Gray N, Ninomiya-Tsuji J, Mishina Y, Levi B STEM CELLS 2019 Jun 37 766-778 -
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype
Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS Cell Chemical Biology 2019 Jun 26 792-803.e10 -
Tissue-specific oncogenic activity of KRASA146T
Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, Destefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM Cancer discovery 2019 Jun 9 738-755 -
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome
Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS Cell Chemical Biology 2019 Jun 26 818-829.e9 -
Automated Text Message Reminders Improve Radiation Therapy Compliance
Tan J, Christie A, Montalvo SK, Wallace C, Yan Y, Folkerts M, Yingling A, Sher D, Choy H, Jiang S, Westover KD International Journal of Radiation Oncology Biology Physics 2019 Apr 103 1045-1052 -
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
Jin H, Jang Y, Cheng N, Li Q, Cui PF, Zhou ZW, Jiang HL, Cho MH, Westover KD, Tan QY, Xu CX Journal of Experimental and Clinical Cancer Research 2019 Apr 38 -
A pilot study using kernelled support tensor machine for distant failure prediction in lung SBRT
Li S, Yang N, Li B, Zhou Z, Hao H, Folkert MR, Iyengar P, Westover K, Choy H, Timmerman R, Jiang S, Wang J Medical Image Analysis 2018 Dec 50 106-116 -
Accurate real time localization tracking in a clinical environment using Bluetooth Low Energy and deep learning
Iqbal Z, Luo D, Henry P, Kazemifar S, Rozario T, Yan Y, Westover K, Lu W, Nguyen D, Long T, Wang J, Choy H, Jiang S PloS one 2018 Oct 13 -
GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level article
Li Q, Wei X, Zhou ZW, Wang SN, Jin H, Chen KJ, Luo J, Westover KD, Wang JM, Wang D, Xu CX, Shan JL Cell Death and Disease 2018 May 9 -
Three-dimensional printer-aided casting of soft, custom silicone boluses (SCSBs) for head and neck radiation therapy
Chiu T, Tan J, Brenner M, Gu X, Yang M, Westover K, Strom T, Sher D, Jiang S, Zhao B Practical Radiation Oncology 2018 May 8 e167-e174 -
Shell feature: A new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer
Hao H, Zhou Z, Li S, Maquilan G, Folkert MR, Iyengar P, Westover KD, Albuquerque K, Liu F, Choy H, Timmerman R, Yang L, Wang J Physics in medicine and biology 2018 May 63 -
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA Cell 2018 Feb 172 857-868.e15 -
KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation
Lu J, Bera AK, Gondi S, Westover KD Biochemistry 2018 Jan 57 324-333 -
Consolidative radiotherapy for limited metastatic non-small-cell lung cancer: A phase 2 randomized clinical trial
Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, Pulipparacharuvil S, Choy H, Timmerman RD JAMA Oncology 2018 Jan 4 -
KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry
Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD Structure 2017 Sep 25 1442-1448.e3 -
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease
Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TA, Derbyshire ER Cell Chemical Biology 2017 Aug 24 1029-1039.e7 -
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS Cell Chemical Biology 2017 Aug 24 1005-1016.e3 -
Multi-objective radiomics model for predicting distant failure in lung SBRT
Zhou Z, Folkert M, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Jiang S, Wang J Physics in medicine and biology 2017 May 62 4460-4478 -
Rationale for RAS mutation-tailored therapies
Montalvo SK, Li L, Westover KD Future Oncology 2017 Feb 13 263-271 -
Covalent guanosine mimetic inhibitors of G12C KRAS
Xiong Y, Lu J, Hunter J, Li L, Scott D, Choi HG, Lim SM, Manandhar A, Gondi S, Sim T, Westover KD, Gray NS ACS Medicinal Chemistry Letters 2017 Jan 8 61-66 -
Structure-guided development of covalent TAK1 inhibitors
Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS Bioorganic and Medicinal Chemistry 2017 25 838-846 -
GTP-Competitive Inhibitors of RAS Family Members
Hunter JC, Gray NS, Westover KD 2017 155-174 -
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
Tan L, Rao S, Mowafy S, Du G, Gray NS, Gurbani D, Weisberg EL, Jones DS, Singer WD, Bernard FM, Jenney A, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK Bioorganic and Medicinal Chemistry 2017 25 1320-1328 -
Structural and biochemical analyses reveal the mechanism of glutathione S-transferase Pi 1 inhibition by the anti-cancer compound piperlongumine
Harshbarger W, Gondi S, Ficarro SB, Hunter J, Udayakumar D, Gurbani D, Singer WD, Liu Y, Li L, Marto JA, Westover KD Journal of Biological Chemistry 2017 Jan 292 112-120 -
Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching
Harrison RA, Lu J, Carrasco M, Hunter J, Manandhar A, Gondi S, Westover KD, Engen JR Journal of Molecular Biology 2016 Nov 428 4723-4735 -
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM Nature chemical biology 2016 Jun 12 452-458 -
Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW Cell Reports 2016 Jun 16 28-36 -
Predicting distant failure in early stage NSCLC treated with SBRT using clinical parametersPredicting distant failure in lung SBRT
Zhou Z, Folkert M, Cannon N, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Yan J, Xie XJ, Jiang S, Wang J Radiotherapy and Oncology 2016 Jun 119 501-504 -
Torin2 suppresses ionizing radiation-induced DNA damage repair
Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD Radiation research 2016 May 185 527-538 -
Inhibition of cell proliferation in an NRAS mutant melanoma cell line by combining Sorafenib and α-Mangostin
Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE PloS one 2016 May 11 -
Progress on covalent inhibition of KRASG12C
Westover KD, Jänne PA, Gray NS Cancer discovery 2016 Mar 6 233-234 -
Data publication with the structural biology data grid supports live analysis
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P Nature communications 2016 Mar 7 -
Structural dataset for the fast-exchanging KRAS G13D
Lu J, Hunter J, Manandhar A, Gurbani D, Westover KD Data in Brief 2015 Dec 5 572-578 -
Precision hypofractionated radiation therapy in poor performing patients with non-small cell lung cancer: Phase 1 dose escalation trial
Westover KD, Loo BW, Gerber DE, Iyengar P, Choy H, Diehn M, Hughes R, Schiller J, Dowell J, Wardak Z, Sher D, Christie A, Xie XJ, Corona I, Sharma A, Wadsworth ME, Timmerman R International Journal of Radiation Oncology Biology Physics 2015 Sep 93 72-81 -
Biochemical and structural analysis of common cancer-associated KRAS mutations
Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD Molecular Cancer Research 2015 Sep 13 1325-1335 -
SABR for aggressive local therapy of metastatic cancer: A new paradigm for metastatic non-small cell lung cancer
Westover KD, Iyengar P, Sharma AN, Timmerman R Lung Cancer 2015 Aug 89 87-93 -
Development of small molecules targeting the pseudokinase Her3
Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS Bioorganic and Medicinal Chemistry Letters 2015 Jul 25 3382-3389 -
Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non-small-cell lung cancer
Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R Journal of Thoracic Oncology 2015 Feb 10 280-285 -
Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS Journal of Medicinal Chemistry 2015 Jan 58 183-196 -
Pharmacological targeting of the pseudokinase Her3
Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS Nature chemical biology 2014 Dec 10 1006-1012 -
Radiation therapy as a backbone of treatment of locally advanced non-small cell lung cancer
Laine AM, Westover KD, Choy H Seminars in oncology 2014 Feb 41 57-68 -
Therapeutic targeting of oncogenic K-ras by a covalent catalytic site inhibitor
Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, Gray NS Angewandte Chemie - International Edition 2014 Jan 53 199-204 -
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD Proceedings of the National Academy of Sciences of the United States of America 2014 111 8895-8900 -
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR
Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS Cancer research 2013 Apr 73 2574-2586 -
Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
Horikoshi N, Kumar P, Sharma GG, Chen M, Hunt CR, Westover K, Chowdhury S, Pandita TK Genome Integrity 2013 Apr 4 -
Stereotactic ablative radiotherapy (SABR) for non-small cell lung cancer
Iyengar P, Westover K, Timmerman RD Seminars in Respiratory and Critical Care Medicine 2013 34 845-854 -
Radical prostatectomy vs radiation therapy and androgen-suppression therapy in high-risk prostate cancer
Westover K, Chen MH, Moul J, Robertson C, Polascik T, Dosoretz D, Katin M, Salenius S, D'Amico AV BJU international 2012 Oct 110 1116-1121 -
Quantitative analysis of Hsp90-client interactions reveals principles of substrate recognition
Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S Cell 2012 Aug 150 987-1001 -
Proton SBRT for medically inoperable stage i NSCLC
Westover KD, Seco J, Adams JA, Lanuti M, Choi NC, Engelsman M, Willers H Journal of Thoracic Oncology 2012 Jun 7 1021-1025 -
Treatment of non-small cell lung cancer patients with proton beam-based stereotactic body radiotherapy: Dosimetric comparison with photon plans highlights importance of range uncertainty
Seco J, Panahandeh HR, Westover K, Adams J, Willers H International Journal of Radiation Oncology Biology Physics 2012 May 83 354-361 -
Liver
Westover KD, Hong TS 2012 Mar 831-840 -
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics
Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS Journal of Biological Chemistry 2012 Mar 287 9742-9752 -
SU‐E‐T‐545: Assessing the Impact of Proton Range Uncertainties on NSCLC Lung Patients Treated with Proton Beam‐Based SBRT
Seco J, Panahandeh H, Westover K, Adams J, Willers H Medical physics 2011 Jun 38 3614 -
Significance testing as perverse probabilistic reasoning
Westover MB, Westover KD, Bianchi MT BMC medicine 2011 Feb 9 -
SU‐GG‐T‐388: Assessing Dose Inaccuracies in the Superposition/Convolution Algorithm with Monte Carlo for SBRT Lung Tumors
Seco J, Westover K, Willers H Medical physics 2010 Jun 37 3275 -
Comprehensive and efficient HBB mutation analysis for detection of β-hemoglobinopathies in a pan-ethnic population
Chan OT, Westover KD, Dietz L, Zehnder JL, Schrijver I American journal of clinical pathology 2010 May 133 700-707 -
Structural basis of transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD Science 2009 May 324 1203-1206 -
SU‐FF‐T‐650: Dosimetric Benefit of a Combination of Respiratory‐Gating, Image‐Guidance and Intensity Modulated Radiation Therapy for Pancreatic Cancer Treatment
Park S, Westover K, O'farrell D, Mamon H, Berbeco R Medical Physics 2009 36 2674 -
Mycotic aneurysm of the left main coronary artery producing acute coronary occlusion and purulent pericarditis
Westover K, Benedick B International Journal of Cardiology 2007 Jan 114 E81-E82 -
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD Cell 2006 Dec 127 941-954 -
Structural basis of eukaryotic gene transcription
Boeger H, Bushnell DA, Davis R, Griesenbeck J, Lorch Y, Strattan JS, Westover KD, Kornberg RD FEBS Letters 2005 Feb 579 899-903 -
Erratum: Structural basis of transcription: Nucleotide selection by rotation in the RNA polymerase II active center (Cell (November 2004) 119 (481-489))
Westover KD, Bushnell DA, Kornberg RD Cell 2004 Dec 119 1055 -
Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
Batada NN, Westover KD, Bushnell DA, Levitt M, Kornberg RD Proceedings of the National Academy of Sciences of the United States of America 2004 Dec 101 17361-17364 -
Structural basis of transcription: Nucleotide selection by rotation in the RNA polymerase II active center
Westover KD, Bushnell DA, Kornberg RD Cell 2004 Nov 119 481-489 -
Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs
Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL American journal of veterinary research 2004 Jun 65 810-818 -
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
Bushnell DA, Westover KD, Davis RE, Kornberg RD Science 2004 Feb 303 983-988 -
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
Westover KD, Bushnell DA, Kornberg RD Science 2004 Feb 303 1014-1016 -
Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever
Simmons DL, Wagner D, Westover K Clinical Infectious Diseases 2000 31 S211-S218 -
Mechanism of Rab geranylgeranylation: Formation of the catalytic ternary complex
Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC Biochemistry 1998 Sep 37 12559-12568
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Another KRAS variant trapped
Research
- Use of technology to improve cancer care
- Structural biology
- Stereotactic radiation therapy
- RAS biology and inhibitor development
- Kinase biology and inhibitor development
- Cancer therapeutics
- Cancer imaging
Clinical Focus
- Radiation Therapy for Esophageal Cancer
- Chest Cancers
- Brain Metastases
- Pulmonary/Lung-Chest Wall-Mediastinal-Pleural Nodules
- Radiation Therapy for Lung Cancer
Q&A by Dr. Westover
Links
Results: 1 Locations
University Hospital Radiation Oncology Clinic
at Radiation Oncology Building 2280 Inwood RoadDallas, Texas 75390 214-645-8525 Directions to University Hospital Radiation Oncology Clinic
New Patient Appointment Accepting Virtual Visits or 214-645-8525