Lai Xue, M.D.

Surgery - Colon and Rectal Surgery
Pelvic Floor Disorders
Inflammatory Bowel Disease

New Patient Appointment Accepting Virtual Visits or 214-645-2900

Biography

Lai Xue, M.D., is an Assistant Professor in the Department of Surgery at UT Southwestern Medical Center. He specializes in colorectal surgery and minimally invasive surgical techniques.

Dr. Xue earned his medical degree at the University of Chicago Pritzker School of Medicine. He completed a residency in general surgery at the University of Chicago and gained advanced training through a fellowship in colon and rectal surgery at the University of Minnesota.

Certified by the American Board of Surgery, he joined the UT Southwestern faculty in 2022.

Dr. Xue is a member of the American Society of Colon and Rectal Surgeons and the Society of Asian Academic Surgeons.

His clinical interests include using advanced minimally invasive procedures to address pelvic floor disorders, inflammatory bowel disease, and colorectal malignancy. He has delivered numerous presentations and published peer-reviewed articles related to his areas of expertise.

Education & Training

Fellowship - University of Minnesota Medical Center (2021-2022), Colon & Rectal Surgery
Residency - University of Chicago Medical Center (2014-2021), General Surgery
Medical School - University of Chicago Pritzker School of Medicine (2010-2014)

Professional Associations & Affiliations

American Society of Colon and Rectal Surgeons
Society of Asian Academic Surgeons

Honors & Awards

Academic Achievement Award 2015-2019, The University of Chicago Department of Surgery
3rd place in Founder’s Competition 2018, American College of Surgery Illinois Chapter
Core Grant 2017, Institute for Translational Medicine
Summer Research Scholarship 2011, American Academy of Neurology

Books & Publications

Publications
- Heterogeneity in PD-L1 expression in malignant peritoneal mesothelioma with systemic or intraperitoneal chemotherapy.
  White MG, Schulte JJ, Xue L, Berger Y, Schuitevoerder D, Vining CC, Kindler HL, Husain A, Turaga KK, Eng OS, British journal of cancer 2021 02 124 3 564-566
- 4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.
  Bryan DS, Stack M, Krysztofiak K, Cichon U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR, Proceedings of the National Academy of Sciences of the United States of America 2020 09 117 36 22423-22429
- Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
  Shi Y, Zheng W, Yang K, Harris KG, Ni K, Xue L, Lin W, Chang EB, Weichselbaum RR, Fu YX, The Journal of experimental medicine 2020 May 217 5
- Peritoneal Metastases in Colorectal Cancer: Biology and Barriers.
  Xue L, Hyman NH, Turaga KK, Eng OS, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 03 24 3 720-727
- Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer.
  Chan C, Guo N, Duan X, Han W, Xue L, Bryan D, Wightman SC, Khodarev NN, Weichselbaum RR, Lin W, Biomaterials 2019 Jul 210 94-104
- Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.
  Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR Nature communications 2018 May 9 1 1793
- Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma.
  Wang A, Wu L, Lin J, Han L, Bian J, Wu Y, Robson SC, Xue L, Ge Y, Sang X, Wang W, Zhao H, Nature communications 2018 03 9 1 894
- An Update on Colorectal Cancer.
  Xue L, Williamson A, Gaines S, Andolfi C, Paul-Olson T, Neerukonda A, Steinhagen E, Smith R, Cannon LM, Polite B, Umanskiy K, Hyman N, Current problems in surgery 2018 Mar 55 3 76-116
- Update on the endoscopic management of colonic neoplasia ? how endoscopy is replacing surgery
  Jennifer L. Paruch, Lai Xue Techniques and Innovations in Gastrointestinal Endoscopy 2018 20 4 189-193
- Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.
  Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN Journal of visualized experiments : JoVE 2016 Nov 117
- Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats.
  Roth S, Dreixler JC, Mathew B, Balyasnikova I, Mann JR, Boddapati V, Xue L, Lesniak MS, Investigative ophthalmology & visual science 2016 06 57 7 3522-32
- Characterizing the interactions between a naturally primed immunoglobulin A and its conserved Bacteroides thetaiotaomicron species-specific epitope in gnotobiotic mice.
  Peterson DA, Planer JD, Guruge JL, Xue L, Downey-Virgin W, Goodman AL, Seedorf H, Gordon JI, The Journal of biological chemistry 2015 May 290 20 12630-49
- A novel locus for X-linked retinitis pigmentosa.
  Tong Z, Yang Z, Meyer JJ, McInnes AW, Xue L, Azimi AM, Baird J, Zhao Y, Pearson E, Wang C, Chen Y, Zhang K Annals of the Academy of Medicine, Singapore 2006 Jul 35 7 476-8

Research

Colorectal cancer in the young
Functional outcomes in the treatment of pelvic floor dysfunction

Clinical Focus

Pelvic Floor Disorders
Inflammatory Bowel Disease
Colorectal Malignancy
Transanal Minimally Invasive Surgery (TAMIS)