- American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology
- Association of American Rhodes Scholars
- North American Vascular Biology Organization
Laurel Lee, M.D., Ph.D.
- Internal Medicine - Cardiology
- General Cardiology
Biography
Laurel Y. Lee, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. She specializes in general cardiology.
Dr. Lee received bachelor’s degrees in biology and neuroscience from the Massachusetts Institute of Technology (MIT) and earned her doctoral degree in T-cell immunology as a Rhodes Scholar at the University of Oxford in England. She completed her medical degree at Harvard Medical School through the Harvard-MIT Health Sciences and Technology physician-scientist program. She received internal medicine residency training, cardiology fellowship training, and National Institutes of Health T32 grant-funded postdoctoral fellowship training in vascular biology and metabolism at Harvard Medical School and Brigham and Women’s Hospital.
Certified by the American Board of Internal Medicine in cardiovascular disease, Dr. Lee joined the UT Southwestern faculty in 2024. She previously served as a faculty member at Harvard and Brigham and Women’s Hospital.
As a physician-scientist, Dr. Lee combines clinical cardiology practice with vascular biology and immunology basic science laboratory research. Her vascular immunology laboratory focuses on molecular and cellular mechanisms by which immune activation perturbs vascular homeostasis, which makes blood vessels susceptible to various cardiovascular and metabolic pathologies such as atherosclerosis. The ultimate goal of her scientific program is to improve patients’ vascular resilience and help prevent myocardial infarction, stroke, and ischemic limb loss.
Dr. Lee’s scientific discoveries have been presented at multiple national and international scientific meetings, and she has also served as a co-chair for the vascular research program at the American College of Cardiology Scientific Sessions. She is an active member of the American Heart Association and the North American Vascular Biology Organization and serves as an early-career editorial board member for the American Heart Association’s journal Arteriosclerosis, Thrombosis, and Vascular Biology.
Dr. Lee has received multiple awards, including a National Heart, Lung, and Blood Institute K08 grant, the Lerner Cardiology Faculty Research Award from Brigham and Women’s Hospital, and the Martha Grey Research Award from Harvard-MIT Health Sciences and Technology.
Personal Note
When she’s not at work, Dr. Lee enjoys music, rowing, and spending time in nature.
Professional Associations & Affiliations
Honors & Awards
- K08 Clinical Scientist Research Career Development Award 2023-2028, National Institutes of Health, National Heart, Lung, and Blood Institute
- T32 Postdoctoral Fellowship Award 2018-2020, National Institutes of Health, National Heart, Lung, and Blood Institute
- Chair’s Research Award 2023, Brigham and Women’s Hospital
- Lerner Cardiology Faculty Research Award 2022, Brigham and Women’s Hospital
- Student Teaching Award 2013, Harvard Medical School and Brigham and Women’s Hospital
- Rhodes Scholarship 2005-2008
- Exceptional Student Research Award 2004, National Institutes of Health, National Institute of Neurological Disorders and Stroke
Books & Publications
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Books
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Systems biology and network medicine: An integrated approach to redox biology and pathobiology in Oxidative Stress: Eustress and Distress
Lee LY, Loscalzo J (2020), London, UK, Academic Press
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Systems biology and network medicine: An integrated approach to redox biology and pathobiology in Oxidative Stress: Eustress and Distress
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Publications
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Metabolic Responses to Redox Stress in Vascular Cells.
Xiao W, Lee LY, Loscalzo J, Antioxidants & redox signaling 2024 Jul -
Interferon-γ Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation.
Lee LY, Oldham WM, He H, Wang R, Mulhern R, Handy DE, Loscalzo J, Circulation 2021 Nov 144 20 1612-1628 -
Network medicine in Cardiovascular Research.
Lee LY, Pandey AK, Maron BA, Loscalzo J, Cardiovascular research 2021 Aug 117 10 2186-2202 -
Network Medicine in Pathobiology.
Lee LY, Loscalzo J, The American journal of pathology 2019 Jul 189 7 1311-1326 -
Defining ELISpot cut-offs from unreplicated test and control wells.
Alexander N, Fox A, Lien VT, Dong T, Lee LY, Hang Nle K, Mai le Q, Horby P, Journal of immunological methods 2013 Jun 392 1-2 57-62 -
Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections.
Powell TJ, Fox A, Peng Y, Quynh Mai le T, Lien VT, Hang NL, Wang L, Lee LY, Simmons CP, McMichael AJ, Farrar JJ, Askonas BA, Duong TN, Thai PQ, Thu Yen NT, Rowland-Jones SL, Hien NT, Horby P, Dong T, The Journal of infectious diseases 2012 Jan 205 1 20-7 -
Mouse transmembrane BAX inhibitor Motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system.
Nielsen JA, Chambers MA, Romm E, Lee LY, Berndt JA, Hudson LD Molecular and cellular biochemistry 2011 May 73-81 -
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V, The Journal of clinical investigation 2008 Dec 118 12 4036-48 -
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals.
Lee LY, Ha do LA, Simmons C, de Jong MD, Chau NV, Schumacher R, Peng YC, McMichael AJ, Farrar JJ, Smith GL, Townsend AR, Askonas BA, Rowland-Jones S, Dong T, The Journal of clinical investigation 2008 Oct 118 10 3478-90
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Metabolic Responses to Redox Stress in Vascular Cells.
Research
- Vascular disorders
- Endothelial biology
- Vascular smooth muscle cell biology
- Atherosclerosis
- Metabolism
- Adaptive immunity
- T-cell biology
Clinical Focus
- General Cardiology