Malgorzata Kozak, M.D.

Harold C. Simmons Comprehensive Cancer Center

Radiation Oncology
Pediatrics
Lymphoma

New Patient Appointment Accepting Virtual Visits or 214-645-8525

Biography

Margaret Kozak, M.D., is an Assistant Professor in the Department of Radiation Oncology at UT Southwestern Medical Center. She specializes in pediatrics, lymphoma, and sarcoma.

Dr. Kozak earned her medical degree at the University of Central Florida College of Medicine in Orlando, Florida. She completed her residency in radiation oncology at Stanford University in Palo Alto, California.

Certified by the American Board of Radiology in radiation oncology, Dr. Kozak joined the UT Southwestern faculty in 2023. She previously served on the faculty at the University of Iowa.

Dr. Kozak has contributed to scores of peer-reviewed publications and has given numerous presentations in her areas of expertise. She also has contributed to the ASCO Post Evening News and Oncology Times.

In 2022, she earned the ARRO Educator of the Year Award.

Personal Note

When she’s not at work, Dr. Kozak enjoys running, doing yoga, cooking, and spending time with her family.

Education & Training

Medical School - University of Central Florida College of Medicine (2010-2015)
Internship - Santa Clara Valley Medical Center (2015-2016), Internal Medicine
Residency - Stanford University (2016-2020), Radiation Oncology

Honors & Awards

ARRO Educator of the Year Award 2022, University of Iowa

Books & Publications

Publications
- Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
  Williams HL, Costa AD, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM Cancer research 2023 Feb 83 441-455
- Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer
  Costa AD, Väyrynen SA, Chawla A, Zhang J, Väyrynen JP, Lau MC, Williams HL, Yuan C, Morales-Oyarvide V, Elganainy D, Singh H, Cleary JM, Perez K, Ng K, Freed-Pastor W, Mancias JD, Dougan SK, Wang J, Rubinson DA, Dunne RF, Kozak MM, Brais L, Reilly E, Clancy T, Linehan DC, Chang DT, Hezel AF, Koong AC, Aguirre AJ, Wolpin BM, Nowak JA Clinical Cancer Research 2022 Dec 28 5167-5179
- Incidence of Brain Metastases in Women Treated With Neoadjuvant Chemotherapy for Breast Cancer: Implications for Screening
  Kozak MM, Karl J, von Eyben R, Guo F, Gutkin P, Horst K Clinical breast cancer 2022 Dec 22 e916-e921
- Initial clinical applications treating pediatric and adolescent patients using MR-guided radiotherapy
  Kozak MM, Crompton D, Gross BA, Harshman L, Dickens D, Snyder J, Shepard A, St-Aubin J, Dunkerley D, Hyer D, Buatti JM Frontiers in Oncology 2022 Nov 12
- Locoregional and Distant Outcomes in Women With cT1-3N1 Breast Cancer Treated With Neoadjuvant Chemotherapy With or Without Adjuvant Radiotherapy
  Kozak MM, von Eyben R, Gutkin PM, Vemuri M, Jacobson CE, Karl JJ, Walck E, Marquez C, Horst KC Clinical breast cancer 2021 Aug 21 373-382
- Prospective randomized trial of email and/or telephone reminders to enhance vaginal dilator compliance in patients undergoing brachytherapy for gynecologic malignancies
  Kozak MM, Usoz M, Fujimoto D, von Eyben R, Kidd E Brachytherapy 2021 Jul 20 788-795
- Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer
  Vayrynen SA, Zhang J, Yuan C, Vayrynen JP, Costa AD, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais L, Reilly E, Rahma O, Clancy T, Wang J, Linehan DC, Aguirre AJ, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM Clinical Cancer Research 2021 Feb 27 1069-1081
- Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States
  Kinslow CJ, May MS, Kozak M, Pollom EL, Chang DT HPB 2020 Dec 22 1759-1765
- Lymphopenia and clinical outcomes in patients with residual nodal disease after neoadjuvant chemotherapy for breast cancer
  Gutkin PM, Kozak MM, von Eyben R, Horst KC Cancer Causes and Control 2020 Nov 31 1021-1026
- Patterns of Failure in Women Who Have Residual Nodal Disease After Neoadjuvant Chemotherapy for Breast Cancer According to Extent of Lymph Node Surgery
  Kozak MM, Horst KC, Gutkin PM, Jacobson CE, Walck E, von Eyben R, Dirbas FM Clinical breast cancer 2020 Oct 20 431-438
- Insulin-like growth factor-1 receptor expression and disease recurrence and survival in patients with resected pancreatic ductal adenocarcinoma
  Du C, Silva Ad, Morales-Oyarvide V, Costa AD, Kozak MM, Dunne RF, Rubinson DA, Perez K, Masugi Y, Hamada T, Brais LK, Yuan C, Babic A, Ducar MD, Thorner AR, Aguirre A, Kulke MH, Ng K, Clancy TE, Findeis-Hosey JJ, Chang DT, Hornick JL, Fuchs CS, Ogino S, Koong AC, Hezel AF, Wolpin BM, Nowak JA Cancer Epidemiology Biomarkers and Prevention 2020 Aug 29 1586-1595
- Central Nervous System Relapse After Stem Cell Transplantation in Adolescents and Young Adults with Acute Lymphoblastic Leukemia: A Single-Institution Experience
  Kozak MM, Yoo CH, Gutkin PM, Von Eyben R, Agarwal R, Donaldson SS, Muffly L, Hiniker SM Journal of Adolescent and Young Adult Oncology 2020 Apr 9 166-171
- Stereotactic Body Radiation Therapy for Cholangiocarcinoma: Optimizing Locoregional Control With Elective Nodal Irradiation
  Kozak MM, Toesca DA, von Eyben R, Pollom EL, Chang DT Advances in Radiation Oncology 2020 Jan 5 77-84
- Depth of invasion alone as a prognostic factor in low-risk early-stage oral cavity carcinoma
  Kozak MM, Shah JL, Chen M, Schaberg K, von Eyben R, Chen JJ, Bui T, Kong C, Kaplan M, Divi V, Hara W Laryngoscope 2019 Sep 129 2082-2086
- SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer
  Ma C, Olevian D, Miller C, Herbst C, Jayachandran P, Kozak MM, Chang DT, Pai RK Modern Pathology 2019 Jul 32 1217-1231
- Adjuvant treatment and survival in older women with triple negative breast cancer: A Surveillance, Epidemiology, and End Results analysis
  Kozak MM, Xiang M, Pollom EL, Horst KC Breast Journal 2019 May 25 469-473
- Less Than Whole Uterus Irradiation for Locally Advanced Cervical Cancer Maintains Locoregional Control and Decreases Radiation Dose to Bowel
  Kozak MM, Koenig JL, von Eyben R, Kidd EA Practical Radiation Oncology 2019 Mar 9 e164-e171
- Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer
  Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM Genetics in Medicine 2019 Jan 21 213-223
- Comparison of definitive chemoradiation with 5-fluorouracil versus capecitabine in anal cancer
  Pumpalova Y, Kozak MM, von Eyben R, Kunz P, Fisher G, Chang DT, Haraldsdottir S Journal of Gastrointestinal Oncology 2019 10 605-615
- Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance
  Chiou SH, Dorsch M, Kusch E, Naranjo S, Kozak MM, Koong AC, Winslow MM, Grüner BM Scientific reports 2018 Dec 8
- Loss of SATB2 Expression in Colorectal Carcinoma Is Associated with DNA Mismatch Repair Protein Deficiency and BRAF Mutation
  Ma C, Olevian DC, Lowenthal BM, Jayachandran P, Kozak MM, Chang DT, Pai RK American Journal of Surgical Pathology 2018 Oct 42 1409-1417
- Patterns of Distant Failure by Intrinsic Breast Cancer Subtype in Premenopausal Women Treated With Neoadjuvant Chemotherapy
  Kozak MM, Jacobson CE, von Eyben R, Walck E, Pollom EL, Telli M, Horst KC Clinical breast cancer 2018 Oct 18 e1077-e1085
- Outcomes following neoadjuvant chemotherapy for breast cancer in women aged 40 years and younger: Impact of pathologic nodal response
  Kozak MM, Jacobson CE, von Eyben R, Pollom EL, Telli M, Horst KC JNCCN Journal of the National Comprehensive Cancer Network 2018 Jul 16 845-850
- Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma
  Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM JAMA Oncology 2018 Mar 4
- Albumin and Neutrophil-Lymphocyte Ratio (NLR) Predict Survival in Patients with Pancreatic Adenocarcinoma Treated with SBRT
  Alagappan M, Pollom EL, Von Eyben R, Kozak MM, Aggarwal S, Poultsides GA, Koong AC, Chang DT American Journal of Clinical Oncology: Cancer Clinical Trials 2018 41 242-247
- BLIMP1 induces transient metastatic heterogeneity in pancreatic cancer
  Chiou SH, Risca VI, Wang GX, Yang D, Gruner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM Cancer discovery 2017 Oct 7 1184-1199
- A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
  Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD Cancer Cell 2017 Oct 32 460-473.e6
- The Prognostic Significance of Pretreatment Hematologic Parameters in Patients Undergoing Resection for Colorectal Cancer
  Kozak MM, Von Eyben R, Pai JS, Anderson EM, Welton ML, Shelton AA, Kin C, Koong AC, Chang DT American Journal of Clinical Oncology: Cancer Clinical Trials 2017 40 405-412
- Lymph node metastases in resected pancreatic ductal adenocarcinoma: Predictors of disease recurrence and survival
  Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM British journal of cancer 2017 117 1874-1882
- Acridine derivatives as inhibitors of the IRE1α-XBP1 pathway are cytotoxic to human multiple myeloma
  Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC Molecular Cancer Therapeutics 2016 Sep 15 2055-2065
- Statin and Metformin Use Prolongs Survival in Patients with Resectable Pancreatic Cancer
  Kozak MM, Anderson EM, Von Eyben R, Pai JS, Poultsides GA, Visser BC, Norton JA, Koong AC, Chang DT Pancreas 2016 Jan 45 64-70
- Smad4 inactivation predicts for worse prognosis and response To fluorouracil-based treatment in colorectal cancer
  Kozak MM, Von Eyben R, Pai J, Vossler SR, Limaye M, Jayachandran P, Anderson EM, Shaffer JL, Longacre T, Pai RK, Koong AC, Chang DT Journal of clinical pathology 2015 May 68 341-345
- Value of surveillance studies for patients with stage i to ii diffuse large b-cell lymphoma in the rituximab Era
  Hiniker SM, Pollom EL, Khodadoust MS, Kozak MM, Xu G, Quon A, Advani RH, Hoppe RT International Journal of Radiation Oncology Biology Physics 2015 May 92 99-106
- Inappropriate p53 activation during development induces features of CHARGE syndrome
  Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attié-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD Nature 2014 Oct 514 228-232
- Impact of chemotherapy on normal tissue complication probability models of acute hematologic toxicity in patients receiving pelvic intensity modulated radiation therapy
  Bazan JG, Luxton G, Kozak MM, Anderson EM, Hancock SL, Kapp DS, Kidd EA, Koong AC, Chang DT International Journal of Radiation Oncology Biology Physics 2013 Dec 87 983-991
- Erratum: Stereotactic body radiotherapy for colorectal liver metastases: A pooled analysis (Cancer (2011) 117 (4060-9))
  Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, Dinniwell R, Brierley J, Kavanagh BD, Dawson LA, Schefter TE Cancer 2012 May 118 2776
- Results from a single institution phase II trial of concurrent docetaxel/carboplatin/radiotherapy followed by surgical resection and consolidation docetaxel/carboplatin in stage III non-small-cell lung cancer
  Das M, Donington JS, Murphy J, Kozak M, Eclov N, Whyte RI, Hoang CD, Zhou L, Le QT, Loo BW, Wakelee H Clinical lung cancer 2011 Sep 12 280-285
- Stereotactic body radiotherapy for colorectal liver metastases: A pooled analysis
  Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, Dinniwell R, Brierley J, Kavanagh BD, Dawson LA, Schefter TE Cancer 2011 Sep 117 4060-4069
- Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: Patterns of failure and predictors of local control
  Daly ME, Le QT, Kozak MM, Maxim PG, Murphy JD, Hsu A, Loo BW, Kaplan MJ, Fischbein NJ, Chang DT International Journal of Radiation Oncology Biology Physics 2011 Aug 80 1412-1422
- Tumor volume as a potential imaging-based risk-stratification factor in trimodality therapy for locally advanced non-small cell lung cancer
  Kozak MM, Murphy JD, Schipper ML, Donington JS, Zhou L, Whyte RI, Shrager JB, Hoang CD, Bazan J, Maxim PG, Graves EE, Diehn M, Hara WY, Quon A, Le QT, Wakelee HA, Loo BW Journal of Thoracic Oncology 2011 May 6 920-926
- Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
  Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, Broz DK, Basak S, Park EJ, McLaughlin ME, Karnezis AN, Attardi LD Cell 2011 May 145 571-583

Clinical Focus

Pediatrics
Lymphoma
Sarcoma