- Medical School - University of California-San F, Medicine
- Graduate School - Princeton University, History
Marc Diamond, M.D.
Director, Center for Alzheimer's and Neurodegenerative Diseases
- Distinguished Chair in Basic Brain Injury and Repair
Marc Diamond, M.D., is a native of Berkeley, California. He graduated from Princeton University in 1987 with an A.B. in History. He entered the UCSF School of Medicine in 1987, and he carried out research on transcriptional regulation by the glucocorticoid receptor for two years with Keith Yamamoto, Ph.D. as a Howard Hughes Medical Student Research Fellow. Dr. Diamond received his M.D. from UCSF in 1993 where he also completed an internship, residency, and chief residency in Neurology in 1997. He completed a postdoctoral fellowship in the laboratory of Dr. Yamamoto until 2001, working on two polyglutamine diseases—spinobulbar muscular atrophy and Huntington’s disease.
Dr. Diamond joined the faculty of the Department of Neurology at UCSF from 2002-2009, before moving to Washington University in St. Louis in 2009, as the David Clayson Professor of Neurology. He joined the faculty of UT Southwestern Medical Center in 2014 as the founding director of the Center for Alzheimer’s and Neurodegenerative Diseases. He is interested in neurodegenerative diseases linked to protein aggregation, and the role of prion mechanisms in the normal and abnormal physiology of protein amyloids.
- Sandler Opportunity Award 2007
- Leadership Award 2007, Huntington's Disease Society of America
- Endowed Chari 2009, David Clayson Professor of Neurology
- Foundation Award 2010, Ruth K. Broad
- Scholar-Innovator Award 2012, Harrington
- Distinguished Chair 2014, Brain Injury and Repair
Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
Sanders DW, Kaufman SK, Holmes BB, Diamond MI Neuron 2016 Feb 89 3 433-48
Neuronal activity enhances tau propagation and tau pathology in vivo.
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE Nature neuroscience 2016 Jun
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J FEBS letters 2015 Jan 589 1 77-83
Proteopathic tau seeding predicts tauopathy in vivo.
Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI Proceedings of the National Academy of Sciences of the United States of America 2014 Sep
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 110 33 E3138-47
Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI Neuron 2016 Nov 92 4 796-812
FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples.
Furman JL, Diamond MI Methods in molecular biology (Clifton, N.J.) 2017 1523 349-359
Distinct therapeutic mechanisms of Tau antibodies: promoting microglial clearance vs. blocking neuronal uptake.
Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI The Journal of biological chemistry 2015 Jun
Advances in diagnostic testing for Alzheimer disease.
Schindler SE, McConathy J, Ances BM, Diamond MI Missouri medicine 2013 Sep-Oct 110 5 401-5
Distinct tau prion strains propagate in cells and mice and define different tauopathies.
Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI Neuron 2014 Jun 82 6 1271-88
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.
Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM Neuron 2013 Oct 80 2 402-14
Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-Suppressive Activity of Profilin-1.
Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J The Journal of biological chemistry 2015 Feb
- Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
- Cell and Molecular Biology
- Prion Biology
- Neurodegenerative Diseases