Melissa DeFoe, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern. She specializes in rheumatology, especially myositis, rheumatoid arthritis, and rheumatologic side effects of cancer immunotherapy treatments.

Dr. DeFoe earned her medical degree at the McGovern Medical School at UTHealth Houston. She completed a residency in internal medicine at Washington University School of Medicine in St. Louis and received advanced training in rheumatology through a fellowship at UT Southwestern, where she served as Chief Fellow.

Certified in internal medicine by the American Board of Internal Medicine, she joined the UT Southwestern faculty in 2022.

Dr. DeFoe’s publications include a contribution to The Washington Manual: General Internal Medicine Consult.

Education & Training
  • Fellowship - UT Southwestern Medical Center (2020), Rheumatology
  • Medical School - McGovern Medical School at the University of Texas Health Science Center at Houston (2009-2013)
  • Residency - Washington University Barnes Jewish Hospital/ St. Louis Children's Hospital Consortium Program (2013-2016), Internal Medicine
Honors & Awards
  • Inductee 2011, Alpha Omega Alpha Honor Medical Society
Books & Publications
  • Books
    • Approach to the Patient with Hematuria in The Washington Manual: General Internal Medicine Consult, 3rd Edition
      DeFoe M, Blanchard M (2017)

Clinical Focus

  • Myositis
  • Rheumatoid Arthritis
  • Rheumatologic Manifestations of Checkpoint Inhibitor Toxicity

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