Michelle Machie, M.D.

Pediatric Neurology
Fetal and neonatal neurology
Neonatal intensive neurological care

Biography

Michelle Machie, M.D., is an Assistant Professor in the Department of Pediatrics and the Department of Neurology at UT Southwestern Medical Center. She specializes in neonatal neurology, neonatal neuroimaging, and early childhood neurodevelopmental follow-up.

Dr. Machie earned her medical degree at UT Southwestern, where she also completed a residency in general pediatrics and a residency in child neurology, as well as a fellowship in fetal and neonatal neurology.

Certified by the American Board of Psychiatry and Neurology in child neurology, she joined the UT Southwestern faculty in 2020.

Dr. Machie’s clinical and research interests include hypoxic ischemic encephalopathy, perinatal brain injury, congenital malformations, and the use of advanced imaging techniques to better predict developmental outcomes of neonates after perinatal brain injuries. She is also interested in medical student outreach and mentorship to foster diversity in medicine.

She serves as Co-Director of the Fetal and Neonatal Neurology Education Committee and as Chair of Pediatric Neurology Social Media at UT Southwestern. She also is Co-Chair of the RedBird Pediatric Specialty Program Expansion for Pediatric Neurology for the Children’s Health and UT Southwestern Joint Pediatric Enterprise.[RR1]

Dr. Machie is a member of several professional societies, including the American Academy of Neurology, the Child Neurology Society, the Society for Pediatric Research, and the Newborn Brain Society, serving on the Communication and Networking Committee for the latter.

Education & Training

Residency - UT Southwestern/Children's Medical Center (2015-2018), Child Neurology
Medical School - UT Southwestern Medical School (2009-2013)
Residency - UT Southwestern/Children's Medical Center (2013-2015), Pediatrics

Professional Associations & Affiliations

American Academy of Neurology
Child Neurology Society
Newborn Brain Society
Society for Pediatric Research

Honors & Awards

Kennedy Krieger Minority Research Scholars Program/Child Neurologist Career Development Program and Travel Grant Award 2020, Child Neurology Society Meeting, Virtual Conference
Scott and White Annual Neonatal Conference and Travel Grant Award 2019, Baylor Scott and White Annual Neonatal Conference, Temple, TX
Pediatric Epilepsy Research Foundation Excellence in Research and Scholarly Activity Award 2018, Division of Child Neurology, UT Southwestern
Pediatric Neurology Resident Excellence in Care Award 2018, Neurosciences Nursing Staff, Children’s Health, Children’s Medical Center, Dallas, TX
Pellock Resident Seminar on Epilepsy and Travel Grant 2017, Child Neurology Society Meeting, Chicago, IL
Co-Administrative Chief Resident 2017-2018, Division of Child Neurology, UT Southwestern
President: Student National Medical Association 2011-2012, UT Southwestern

Books & Publications

Publications
- Correction: A collaborative “THRIVE Fetus to Five” neonatal brain program review (Pediatric Research, (2026), 10.1038/s41390-025-04709-3)
  Chalak L, Hoge MK, Hu J, Thomas J, Machie M, Lee L, Heyne ET, McDougald R, Tolentino-Plata K, Heyne RJ Pediatric Research 2026
- A collaborative “THRIVE Fetus to Five” neonatal brain program review
  Chalak L, Hoge MK, Hu J, Thomas J, Machie M, Lee L, Heyne ET, McDougald R, Plata KT, Heyne RJ Pediatric Research 2026
- Impact of fetal inflammatory response on brain MRI abnormalities in extremely preterm infants
  Mir IN, Machie M, Clarke R, Brown LS, Leon R, Wisnowski JL, Chalak L Pediatric Research 2025 Dec 98 2203-2210
- White matter injury and outcomes: what is the final verdict?
  Machie M, Chalak L Pediatric Research 2025 Nov 98 1613-1614
- Multi-organ involvement in preterm neonatal encephalopathy
  Bitar L, Kota S, Machie M, Mashat S, Liu YL, Chalak LF Early Human Development 2025 Sep 208
- Ketogenic diet in neonates: effects, pitfalls, and a paradigm from a preterm newborn affected by pyruvate dehydrogenase deficiency
  Katsoudas S, Umana LA, Clarke R, Thomas J, Machie M, Angelis D Journal of Perinatology 2025
- Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities
  Author Collaboration NM, Laptook A, Garvey AA, Adams C, Grant PE, Molloy EJ, Groenendaal F, Weeke LC, Benders M, Hwang M, El-Dib M, Badawi N, Robertson NJ, Pang R, Thayyil S, Inder T, Andelius TC, Kyng KJ, Chen X, Chau V, Steggerda SJ, Agarwal S, Teixeira SR, Lee S, Wintermark P, Huppi P, van der Aa N, Machie M, Meneses M, Ho ML, de Vries LS, Donald KA, Ferriero DM, Walle CV, Vossough A, Allen AA, Okumura A Pediatric Research 2025
- Advances in Neuroimaging Biomarkers and Scoring
  Machie M, de Vries LS, Inder T Clinics in Perinatology 2024 Sep 51 629-647
- Proceedings of the 15^th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal: Fota Island, Cork, Ireland, February 28^th - March 2^nd 2024
  Abdi K, Adams E, Agarwal S, Aliyu MH, Altamimi T, Andescavage N, Aral A, Arfi H, Armour E, Armstrong L, Mulkey SB, Bambi J, Basu S, Beaulieu LB, Belfort M, Bell K, Benner E, Bernard C, Bhattacharya S, Biselele T, Bitar L, Blaz W, Bolay H, Bray M, Bruckert L, Busnelli A, Mayorga PC, Carrasco M, Carter E, Cassidy M, Chalak L, Chao A, Chauhan P, Cherkerzian S, Chernova L, Chowdhury R, Christou H, Ciralli F, Coletti M, Comanducci A, Comstock B, Cooke A, Cornet MC, Corsi-Cabrera M, Coscia A, Côte-Corriveau G, Cubero-Rego AC, Cubero-Rego Md, Cuddyer D, Cuzzilla R, Dehaes M, Doyle E, Drobyshevsky A, Dubner S, Duerden EG, Dunne A, DuPlessis A, Eisch AJ, El-Dib M, Elmazoglu Z, Emrick L, Epstein A, Erdei C, Ergun MA, Fedeles B, Feldman H, Findley T, Flynn P, Gadra E, Gagnon MM, Gagnon M, Ganesh P, Gano D, Garbarini F, Geary M, Ghezzi E, Gibson K, Glass H, Gloire GM, Gonzalez F, Gorman A, Goswami I, Gregory S, Gulnerman EK, Harmony T, Harrington L, Harshbarger J, Hartley C, Hayakawa M, Hayes B, Heagerty P, Hicks M, Inder T, Iragavarapu M, Ito Y, Jain V, Johnson KJ, Joseph D, Jurkiewicz M, Juul S, Kamyshanskiy Y, Kapoor B, Kapse K, Kazan HH, Kebaya L, Kidokoro H, Klein R, Kling E, Kopobayeva I, Korf J, Kumai S, Lazarus M, Lebane D, Lee I, Lemmon M, Leon R, Limperopoulos C, Liu E, Liu YL, Ognean ML, Luu TM, Machie M, Marchant S, Marchman V, Marsh E, Martinez-Biarge M, Mătăcuţă I, Matei C, Maxfield C, Mayock D, McCullough L, Meyerink P, Miller K, Millman R, Minga S, Mitsumatsu T, Monsell S, Moulton TS, Murnick J, Nakata T, Narita H, Natsume J, Nichols ES, Nicolayevsky SE, Nuyt AM, O'Brien J, Ostrander B, Pacheco J, Pagano L, Pardo A, Peila C, Peyton C, Pineda R, Poblaciones R, Poles K, Quigley M, Reddy S, Remis S, Reynolds A, Ribaupierre Sd, Ricardo-Garcell J, Rikard B, Rodriguez B, Ronga I, Rosenberg P, Ross M, Roychaudhuri S, Russo S, Sadowska-Krawczenko I, Salihu HM, Sato Y, Saulino P, Sawamura F, Scala M, Scher M, Schindewolf E, Sebastiano AR, Shanahan J, Sharon D, Sheldon Y, Shiraki A, Simard MN, Singh E, Sirgiovanni I, Smego A, Steele T, Stein N, Suttin R, Suzui R, Świder M, Tady BP, Taga G, Tang S, Tarrant A, Tarui T, Topa EG, Trapp N, Tristao L, Tuka D, Turdybekova Y, Ushida T, Usman F, Venkatesan C, Vişa G, Wang J, Watanabe H, Watson T, Witulska-Alagöz A, Wood S, Wu Y, Yamamoto H, Yarnykh V, Young M, Yun NY, Zapolnik P, Zarrinnegar D Journal of Neonatal-Perinatal Medicine 2024 Aug 17 S285-S316
- Human Parechovirus (HPeV) infections: clinical presentations, patterns, and evolution of neonatal brain injury
  Oren MS, Clarke RL, Price M, Thomas JM, Machie M, Dolce AM, Chalak LF, Angelis D Journal of Perinatology 2024 Apr 44 581-583
- COL4A1/COL4A2 variants in 16 new pediatric patients: A Case Series of Stroke, Porencephaly, Schizencephaly and Other Findings
  Ozlu C, Laheji F, Bonnet WV, Muncy Thomas J, Singh S, Dowling MM, Machie M Pediatric Stroke 2024 9 29-75
- Lacosamide for the Treatment of Seizures in Neonates and Infants: A Retrospective Assessment of Efficacy and Tolerability
  Shoaib AB, Machie M, Thomas JM, Dolce A Pediatric Neurology 2023 Dec 149 176-181
- Neonatal Encephalopathy with Hiccups and an Updated Diagnostic Approach
  Chokshi RK, Cheng A, Ferrante L, Machie M, Scheuerle AE, Veltkamp D, Brion LP Pediatrics in Review 2023 Nov 24 E741-E743
- EEG and clinical characteristics of neonatal parechovirus encephalitis
  Sirsi D, Lowden A, Dolce A, Machie M, Thomas J, Joshi C Epilepsy Research 2023 May 192
- Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice
  McKnight D, Morales A, Hatchell KE, Bristow SL, Bonkowsky JL, Perry MS, Berg AT, Borlot F, Esplin ED, Moretz C, Angione K, Ríos-Pohl L, Nussbaum RL, Aradhya S, Haldeman-Englert CR, Levy RJ, Parachuri VG, Lay-Son G, De Montellano DJ, Ramirez-Garcia MA, Benítez Alonso EO, Ziobro J, Chirita-Emandi A, Felix TM, Kulasa-Luke D, Megarbane A, Karkare S, Chagnon SL, Humberson JB, Assaf MJ, Silva S, Zarroli K, Boyarchuk O, Nelson GR, Palmquist R, Hammond KC, Hwang ST, Boutlier SB, Nolan M, Batley KY, Chavda D, Reyes-Silva CA, Miroshnikov O, Zuccarelli B, Amlie-Wolf L, Wheless JW, Seinfeld S, Kanhangad M, Freeman JL, Monroy-Santoyo S, Rodriguez-Vazquez N, Ryan MM, MacHie M, Guerra P, Hassan MJ, Candee MS, Bupp CP, Park KL, Muller E, Lupo P, Pedersen RC, Arain AM, Murphy A, Schatz K, Mu W, Kalika PM, Plaza L, Kellogg MA, Lora EG, Carson RP, Svystilnyk V, Venegas V, Luke RR, Jiang H, Stetsenko T, Dueñas-Roque MM, Trasmonte J, Burke RJ, Hurst AC, Smith DM, Massingham LJ, Pisani L, Costin CE, Ostrander B, Filloux FM, Ananth AL, Mohamed IS, Nechai A, Dao JM, Fahey MC, Aliu E, Falchek S, Press CA, Treat L, Eschbach K, Starks A, Kammeyer R, Bear JJ, Jacobson M, Chernuha V, Meibos B, Wong K, Sweney MT, Espinoza AC, Van Orman CB, Weinstock A, Kumar A, Soler-Alfonso C, Nolan DA, Raza M, Rojas Carrion MD, Chari G, Marsh ED, Shiloh-Malawsky Y, Parikh S, Gonzalez-Giraldo E, Fulton S, Sogawa Y, Burns K, Malets M, Montiel Blanco JD, Habela CW, Wilson CA, Guzmán GG, Pavliuk M JAMA neurology 2022 Dec 79 1267-1276
- Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage
  Author Collaboration NS, Herzberg EM, Machie M, Glass HC, Shellhaas RA, Wusthoff CJ, Chang T, Abend NS, Chu CJ, Cilio MR, Bonifacio SL, Massey SL, McCulloch CE, Soul JS, Ferriero DM, Staley KJ, Bergin AM, Dlugos D Journal of Pediatrics 2022 Mar 242 121-128.e1
- Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring
  Abend N, Adams E, Al Balushi A, Alburaki W, Appendino J, Barbosa VS, Birca A, Bonifacio S, Branagan A, Chang T, Chowdhury R, Christou H, Chu C, Cilio MR, Comani S, Corsi-Cabrera M, Croce P, Cubero-Rego L, Dawoud F, de Vries L, Dehaes M, Devane D, Duncan A, El Ters N, El-Dib M, Elshibiny H, Esser M, Fairchild K, Finucane E, Franceschini MA, Gallagher A, Ghosh A, Glass H, Venkata SK, Baillet TH, Herzberg E, Hildrey E, Hurley T, Inder T, Jacobs E, Jefferies K, Jermendy A, Khazaei M, Kilmartin K, King G, Lauronen L, Lee S, Leijser L, Lind J, Llaguno NS, Machie M, Magalhães M, Mahdi Z, Maluomi J, Marandyuk B, Massey S, McCulloch C, Metsäranta M, Mikkonen K, Mohammad K, Molloy E, Momin S, Munster C, Murthy P, Netto A, Nevalainen P, Nguyen J, Nieves M, Nyman J, Oliver N, Peeters C, Pietrobom RF, Pijpers J, Pinchefksy E, Ping YB, Quirke F, Raeisi K, Ricardo-Garcell J, Robinson J, Rodrigues DP, Rosati J, Scott J, Scringer-Wilkes M, Shellhaas R, Smit L, Soul J, Srivastava A, Steggerda S, Sunwoo J, Szakmar E, Tamburro G, Thomas S, Toiviainen-Salo S, Toma AI, Vanhatalo S, Variane GF, Vein A, Vesoulis Z, Vilan A, Volpe J, Weeke L, Wintermark P, Wusthoff C, Zappasodi F, Zein H, Zempel J Journal of Neonatal-Perinatal Medicine 2022 15 467-485
- Predictors of Neurodevelopmental Impairment After Neonatal Bacterial Meningitis
  Haffner DN, Machie M, Hone E, Said RR, Maitre NL Journal of child neurology 2021 Oct 36 968-973
- Parent mental health and neurodevelopmental outcomes of children hospitalized in the neonatal intensive care unit
  Erdei C, Liu CH, Machie M, Church PT, Heyne R Early Human Development 2021 Mar 154
- MRI Score Ability to Detect Abnormalities in Mild Hypoxic-Ischemic Encephalopathy
  Machie M, Weeke L, de Vries LS, Rollins NK, Brown L, Chalak L Pediatric Neurology 2021 Mar 116 32-38

Research

Early childhood neurodevelopmental follow-up
Neonatal neuroimaging
Neonatal neurology, including hypoxic ischemic encephalopathy, perinatal brain injury, and congenital malformations

Clinical Focus

Fetal and neonatal neurology
Neonatal intensive neurological care
Neonatal neuroimaging
Post-NICU developmental follow-up