Netanya Utay, M.D.

Clinical Chief, Division of Infectious Diseases and Geographic Medicine

Internal Medicine - Infectious Diseases and Geographic Medicine
HIV
COVID-19

Biography

Netanya Utay, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She serves as the Infectious Diseases Service Line Chief for Parkland Health and Hospital System, specializing in HIV, COVID-19, and other infectious diseases.

Dr. Utay earned her medical degree at Baylor College of Medicine. She completed her residency in internal medicine at the University of Washington and gained advanced training in infectious diseases through a fellowship at the National Institutes of Health.

Certified by the American Board of Internal Medicine in infectious disease and internal medicine, she joined the UT Southwestern faculty in 2021.

Dr. Utay is Chair of the AIDS Clinical Trials Group (ACTG) Comorbidities Transformative Science Group (CTSG). Her research interests include comorbidities in people with HIV and the role of chronic inflammation in promoting disease.

She serves as the HIV Pathogenesis and Treatment section editor for Current HIV/AIDS Reports. Additionally, she is a member of the Infectious Diseases Society of America, the Texas Medical Association, and the Dallas County Medical Society.

She has contributed to numerous peer-reviewed articles and delivered many international, national, and regional invited lectures.

Education & Training

Medical School - Baylor College of Medicine (1998-2003)
Residency - University of Washington Medical Center (2003-2006), Internal Medicine
Fellowship - National Institutes of Health (2006-2013), Infectious Diseases

Professional Associations & Affiliations

Infectious Diseases Society of America
Texas Medical Association
Dallas County Medical Society

Honors & Awards

Texas Super Doctors Rising Star 2015-2017, Texas Monthly
Top Doctors of Houston 2014, H Texas Magazine
Young Investigator Award 2010-2013, Conference on Retroviruses and Opportunistic Infections
Research Scholar 2001, Howard Hughes Medical Institute, National Institutes of Health

Books & Publications

Publications
- Potential use of serum-derived bovine immunoglobulin/protein isolate for the management of COVID-19.
  Utay NS, Asmuth DM, Gharakhanian S, Contreras M, Warner CD, Detzel CJ, Drug development research 2021 Jun
- IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus.
  Meissner EG, Chung D, Tsao B, Haas DW, Utay NS, AIDS research and human retroviruses 2021 03 37 3 184-188
- Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease.
  Saldarriaga OA, Freiberg B, Krishnan S, Rao A, Burks J, Booth AL, Dye B, Utay N, Ferguson M, Akil A, Yi M, Beretta L, Stevenson HL, Hepatology communications 2020 May 4 5 708-723
- Immune Activation and Inflammation in People With Human Immunodeficiency Virus: Challenging Targets.
  Utay NS, Overton ET, The Journal of infectious diseases 2020 04 221 10 1567-1570
- Timing of Antiretroviral Therapy Initiation Determines Rectal Natural Killer Cell Populations.
  Utay NS, Vigil KJ, Somasunderam A, Aulicino PC, Smulevitz B, Chiadika S, Wolf DS, Kimata JT, Arduino RC, AIDS research and human retroviruses 2020 04 36 4 314-323
- Abnormal Intestinal Microbiome in Medical Disorders and Potential Reversibility by Fecal Microbiota Transplantation.
  DuPont HL, Jiang ZD, DuPont AW, Utay NS, Digestive diseases and sciences 2020 03 65 3 741-756
- Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV.
  Utay NS, Monczor AN, Somasunderam A, Lupo S, Jiang ZD, Alexander AS, Finkelman M, Vigil KJ, Lake JE, Hanson B, DuPont HL, Arduino RC, Pathogens & immunity 2020 5 1 364-381
- Delayed gastrointestinal-associated lymphoid tissue reconstitution in duodenum compared with rectum in HIV-infected patients initiating antiretroviral therapy.
  Sainz T, Serrano-Villar S, Mann S, Ma ZM, Utay NS, Thompson CG, Chun TW, Kashuba AD, Siewe B, Albanese A, Troia-Cancio P, Sinclair E, Somasunderam A, Yotter T, Moreno S, Pollard RB, Landay A, Miller CJ, Asmuth DM, AIDS (London, England) 2019 12 33 15 2289-2298
- Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants.
  Zambruni M, Ochoa TJ, Somasunderam A, Cabada MM, Morales ML, Mitreva M, Rosa BA, Acosta GJ, Vigo NI, Riveros M, Arango S, Durand D, Berends MN, Melby P, Utay NS, The American journal of tropical medicine and hygiene 2019 11 101 5 1009-1017
- Direct-Acting Antiviral Treatment of Patients with Hepatitis C Resolves Serologic and Histopathologic Features of Autoimmune Hepatitis.
  Simoes CC, Saldarriaga OA, Utay NS, Stueck AE, Merwat SK, Merwat SN, Schiano TD, Fiel MI, Stevenson HL, Hepatology communications 2019 Aug 3 8 1113-1123
- Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System.
  Akil A, Endsley M, Shanmugam S, Saldarriaga O, Somasunderam A, Spratt H, Stevenson HL, Utay NS, Ferguson M, Yi M, Scientific reports 2019 01 9 1 568
- Stability of plasma indices of inflammation/coagulation and homeostasis after fatty and non-fatty meals in treated people with HIV.
  Dorazio D, Kitch DW, Utay NS, Macatangay BJ, Landay A, Brown T, Bosch RJ, Pelger AL, Baum JE, Asaad R, Rodriguez B, Lederman MM, Journal of virus eradication 2019 Jan 5 1 28-32
- Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.
  Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM, Pathogens & immunity 2019 4 1 124-146
- Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments.
  Crowell TA, Colby DJ, Pinyakorn S, Fletcher JLK, Kroon E, Schuetz A, Krebs SJ, Slike BM, Leyre L, Chomont N, Jagodzinski LL, Sereti I, Utay NS, Dewar R, Rerknimitr R, Chomchey N, Trichavaroj R, Valcour VG, Spudich S, Michael NL, Robb ML, Phanuphak N, Ananworanich J, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 05 66 10 1540-1549
- Telmisartan Therapy Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued Antiretroviral Therapy Alone.
  Utay NS, Kitch DW, Yeh E, Fichtenbaum CJ, Lederman MM, Estes JD, Deleage C, Magyar C, Nelson SD, Klingman KL, Bastow B, Luque AE, McComsey GA, Douek DC, Currier JS, Lake JE, The Journal of infectious diseases 2018 05 217 11 1770-1781
- Adiponectin and the steatosis marker Chi3L1 decrease following switch to raltegravir compared to continued PI/NNRTI-based antiretroviral therapy.
  Offor O, Utay N, Reynoso D, Somasunderam A, Currier J, Lake J, PloS one 2018 13 5 e0196395
- Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea.
  Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM, HIV clinical trials 2017 Nov-Dec 18 5-6 205-213
- Long-term Use of Proton Pump Inhibitors Is Associated With Increased Microbial Product Translocation, Innate Immune Activation, and Reduced Immunologic Recovery in Patients With Chronic Human Immunodeficiency Virus-1 Infection.
  Serpa JA, Rueda AM, Somasunderam A, Utay NS, Lewis D, Couturier JP, Breaux KG, Rodriguez-Barradas M, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 Oct 65 10 1638-1643
- Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy.
  Asmuth DM, Thompson CG, Chun TW, Ma ZM, Mann S, Sainz T, Serrano-Villar S, Utay NS, Garcia JC, Troia-Cancio P, Pollard RB, Miller CJ, Landay A, Kashuba AD, The Journal of infectious diseases 2017 10 216 7 813-818
- Maternal and pregnancy-related factors affecting human milk cytokines among Peruvian mothers bearing low-birth-weight neonates.
  Zambruni M, Villalobos A, Somasunderam A, Westergaard S, Nigalye M, Turin CG, Zegarra J, Bellomo S, Mercado E, Ochoa TJ, Utay NS, Journal of reproductive immunology 2017 04 120 20-26
- Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection.
  Sereti I, Krebs SJ, Phanuphak N, Fletcher JL, Slike B, Pinyakorn S, O'Connell RJ, Rupert A, Chomont N, Valcour V, Kim JH, Robb ML, Michael NL, Douek DC, Ananworanich J, Utay NS, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 Jan 64 2 124-131
- Circulating LOXL₂ Levels Reflect Severity of Intestinal Fibrosis and GALT CD4⁺ T Lymphocyte Depletion in Treated HIV Infection.
  Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE, Pathogens & immunity 2017 2 2 239-252
- A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy.
  O'Brien MP, Hunt PW, Kitch DW, Klingman K, Stein JH, Funderburg NT, Berger JS, Tebas P, Clagett B, Moisi D, Utay NS, Aweeka F, Aberg JA, Open forum infectious diseases 2017 4 1 ofw278
- Unchanged Levels of Soluble CD14 and IL-6 Over Time Predict Serious Non-AIDS Events in HIV-1-Infected People.
  Sunil M, Nigalye M, Somasunderam A, Martinez ML, Yu X, Arduino RC, Utay NS, Bell TK, AIDS research and human retroviruses 2016 12 32 12 1205-1209
- Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment.
  Lefebvre E, Gottwald M, Lasseter K, Chang W, Willett M, Smith PF, Somasunderam A, Utay NS, Clinical and translational science 2016 06 9 3 139-48
- MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.
  Utay NS, Roque A, Timmer JK, Morcock DR, DeLeage C, Somasunderam A, Weintrob AC, Agan BK, Estes JD, Crum-Cianflone NF, Douek DC, PLoS pathogens 2016 Apr 12 4 e1005580
- Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naive to Antiretroviral Therapy: A Pilot Randomized Trial.
  Serrano-Villar S, Sainz T, Ma ZM, Utay NS, Chun TW, Wook-Chun T, Mann S, Kashuba AD, Siewe B, Albanese A, Troia-Cancio P, Sinclair E, Somasunderam A, Yotter T, Deeks SG, Landay A, Pollard RB, Miller CJ, Moreno S, Asmuth DM, PLoS pathogens 2016 Jan 12 1 e1005381
- A Paradoxical Treatment for a Paradoxical Condition: Infliximab Use in Three Cases of Mycobacterial IRIS.
  Hsu DC, Faldetta KF, Pei L, Sheikh V, Utay NS, Roby G, Rupert A, Fauci AS, Sereti I, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Jan 62 2 258-261
- Raised Venous Lactate and Markers of Intestinal Translocation Are Associated With Mortality Among In-Patients With HIV-Associated TB in Rural South Africa.
  Subbarao S, Wilkinson KA, van Halsema CL, Rao SS, Boyles T, Utay NS, Wilkinson RJ, Meintjes G, Journal of acquired immune deficiency syndromes (1999) 2015 Dec 70 4 406-13
- T-Cell Depletion in the Colonic Mucosa of Patients With Idiopathic CD4+ Lymphopenia.
  Kovacs SB, Sheikh V, Thompson WL, Morcock DR, Perez-Diez A, Yao MD, Rupert AW, Utay NS, Roby G, Freeman AF, Estes JD, Sereti I, The Journal of infectious diseases 2015 Nov 212 10 1579-87
- Liver injury is associated with mortality in sickle cell disease.
  Feld JJ, Kato GJ, Koh C, Shields T, Hildesheim M, Kleiner DE, Taylor JG, Sandler NG, Douek D, Haynes-Williams V, Nichols JS, Hoofnagle JH, Jake Liang T, Gladwin MT, Heller T, Alimentary pharmacology & therapeutics 2015 Oct 42 7 912-21
- Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif.
  Breed MW, Elser SE, Torben W, Jordan AP, Aye PP, Midkiff C, Schiro F, Sugimoto C, Alvarez-Hernandez X, Blair RV, Somasunderam A, Utay NS, Kuroda MJ, Pahar B, Wiseman RW, O'Connor DH, LaBranche CC, Montefiori DC, Marsh M, Li Y, Piatak M, Lifson JD, Keele BF, Fultz PN, Lackner AA, Hoxie JA, Journal of virology 2015 Oct 89 20 10156-75
- Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
  Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, Khoruts A, Estes JD, Anderson J, Callisto SP, Schmidt TE, Thorkelson A, Reilly C, Perkey K, Reimann TG, Utay NS, Nganou Makamdop K, Stevenson M, Douek DC, Haase AT, Schacker TW, Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 112 10 E1126-34
- Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation.
  Schuetz A, Deleage C, Sereti I, Rerknimitr R, Phanuphak N, Phuang-Ngern Y, Estes JD, Sandler NG, Sukhumvittaya S, Marovich M, Jongrakthaitae S, Akapirat S, Fletscher JL, Kroon E, Dewar R, Trichavaroj R, Chomchey N, Douek DC, O Connell RJ, Ngauy V, Robb ML, Phanuphak P, Michael NL, Excler JL, Kim JH, de Souza MS, Ananworanich J, PLoS pathogens 2014 Dec 10 12 e1004543
- Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.
  Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G, Darko S, Contijoch E, Todd JP, Silvestri G, Nason M, Norgren RB, Keele BF, Rao S, Langer JA, Lifson JD, Schreiber G, Douek DC Nature 2014 Jul 511 7511 601-5
- Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 But Does Decrease Soluble Tissue Factor, LDL, and Oxidized LDL Levels in Untreated HIV Infection.
  Sandler NG, Zhang X, Bosch RJ, Funderburg NT, Choi AI, Robinson JK, Fine DM, Coombs RW, Jacobson JM, Landay AL, Douek DC, Tressler R, Read SW, Wilson CC, Deeks SG, Lederman MM, Gandhi RT The Journal of infectious diseases 2014 May
- Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts.
  Mandell DT, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek DC, Keele BF, Apetrei C, Pandrea I Journal of virology 2014 Apr
- Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates.
  Ault A, Tennant SM, Gorres JP, Eckhaus M, Sandler NG, Roque A, Livio S, Bao S, Foulds KE, Kao SF, Roederer M, Schmidlein P, Boyd MA, Pasetti MF, Douek DC, Estes JD, Nabel GJ, Levine MM, Rao SS, Vaccine 2013 Dec 31 49 5879-88
- Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.
  Naranbhai V, Samsunder N, Sandler NG, Roque A, Abdool Karim Q, Ndung'u T, Carr WH, Altfeld M, Douek DC, Abdool Karim SS, Journal of acquired immune deficiency syndromes (1999) 2013 Jul 63 3 294-8
- Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection.
  Bixler SL, Sandler NG, Douek DC, Mattapallil JJ, Journal of virology 2013 Jun 87 12 7093-101
- Oral Serum-Derived Bovine Immunoglobulin Improves Duodenal Immune Reconstitution and Absorption Function in Patients with HIV Enteropathy.
  Asmuth DM, Ma ZM, Albanese A, Sandler NG, Devaraj S, Knight TH, Flynn NM, Yotter T, Tsuchida E, Wu TT, Douek DC, Miller CJ AIDS (London, England) 2013 May
- Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
  Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M, Lifson JD, Keele BF, Hoxie JA, Lackner AA, Journal of virology 2013 Feb 87 3 1528-43
- Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease.
  Gunay-Aygun M, Font-Montgomery E, Lukose L, Tuchman Gerstein M, Piwnica-Worms K, Choyke P, Daryanani KT, Turkbey B, Fischer R, Bernardini I, Sincan M, Zhao X, Sandler NG, Roque A, Douek DC, Graf J, Huizing M, Bryant JC, Mohan P, Gahl WA, Heller T, Gastroenterology 2013 Jan 144 1 112-121.e2
- CD4 T follicular helper cell dynamics during SIV infection.
  Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA, The Journal of clinical investigation 2012 Sep 122 9 3281-94
- Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation.
  Melenhorst JJ, Tian X, Xu D, Sandler NG, Scheinberg P, Biancotto A, Scheinberg P, McCoy JP, Hensel NF, McIver Z, Douek DC, Barrett AJ, Haematologica 2012 Jun 97 6 867-73
- Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection.
  Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC, Gastroenterology 2011 Oct 141 4 1220-30, 1230.e1-3
- Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
  Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger SE, Martinez R, Sandler NG, Roque A, Liebner J, Battegay M, Bernasconi E, Descombes P, Erkizia I, Fellay J, Hirschel B, Miró JM, Palou E, Hoffmann M, Massanella M, Blanco J, Woods M, Günthard HF, de Bakker P, Douek DC, Silvestri G, Martinez-Picado J, Telenti A, The Journal of clinical investigation 2011 Jun 121 6 2391-400
- Plasma levels of soluble CD14 independently predict mortality in HIV infection.
  Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, Pedersen C, Ruxrungtham K, Lewin SR, Emery S, Neaton JD, Brenchley JM, Deeks SG, Sereti I, Douek DC, The Journal of infectious diseases 2011 Mar 203 6 780-90
- Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
  De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL, Blood 2010 Aug 116 8 1263-71
- An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.
  Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R The New England journal of medicine 2009 Jun 360 23 2426-37
- Liver abscess caused by magA+ Klebsiella pneumoniae in North America.
  Fang FC, Sandler N, Libby SJ, Journal of clinical microbiology 2005 Feb 43 2 991-2
- P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor.
  Wynn TA, Hesse M, Sandler NG, Kaviratne M, Hoffmann KF, Chiaramonte MG, Reiman R, Cheever AW, Sypek JP, Mentink-Kane MM, Hepatology (Baltimore, Md.) 2004 Mar 39 3 676-87
- Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair.
  Sandler NG, Mentink-Kane MM, Cheever AW, Wynn TA, Journal of immunology (Baltimore, Md. : 1950) 2003 Oct 171 7 3655-67

Research

HIV and chronic inflammation
Comorbidities in people with HIV
Intestinal damage and inflammation in people with COVID-19

Clinical Focus

HIV
COVID-19
Infectious Diseases

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