Panagiotis Mastorakos, M.D., Ph.D.

Neurological Surgery
Cerebrovascular Disease
Aneurysms

New Patient Appointment Accepting Virtual Visits or 214-645-2300

Biography

Panagiotis Mastorakos, M.D., Ph.D., is an Assistant Professor in the Department of Neurological Surgery at UT Southwestern Medical Center. He specializes in the treatment of cerebrovascular diseases, aneurysms, vascular malformations, subarachnoid hemorrhage, and ischemic and hemorrhagic stroke.

Dr. Mastorakos earned his medical degree and a doctoral degree in neurosurgery at the University of Athens School of Health Sciences in Greece. He completed a residency in neurosurgery at the National Institutes of Health and the University of Virginia, during which he also gained advanced training through a fellowship in endovascular neurosurgery. Subsequently, he completed an additional fellowship in cerebrovascular and endovascular neurosurgery at Thomas Jefferson University Hospital.

He joined the faculty at UT Southwestern in 2023.

Parallel to his clinical practice, Dr. Mastorakos’ research interests focus on understanding the role of the immune system in damage and repair following stroke and subarachnoid hemorrhage. He aims to further the connection between bench research and clinical practice to improve our basic understanding of these diseases and improve patient care. In 2023, Dr. Mastorakos received the Disease-Oriented Clinical Scholars Program Award from UT Southwestern to pursue these goals.

A member of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, Dr. Mastorakos also serves as an ad hoc reviewer for numerous peer-reviewed journals.

Dr. Mastorakos has presented his research to audiences across the globe and has published scores of articles in peer-reviewed journals related to the treatment of cerebrovascular diseases, general neurosurgery, neuroimmunology, and nanomedicine. He also has contributed to books related to management of common neurosurgical diseases.

Education & Training

Fellowship - University of Virginia (2021-2022), Neurological Surgery
Medical School - University of Athens School of Health Sciences, Greece (2006-2012)
Fellowship - National Institute of Health (2015-2022), Neurological Surgery
Residency - National Institute of Health (2015-2022)
Other Post Graduate Training - University of Athens School of Health Sciences, Greece (2013-2017)
Fellowship - Thomas Jefferson University (2022-2023), Cerebrovascular Neurosurgery

Professional Associations & Affiliations

American Association of Neurological Surgeons
Congress of Neurological Surgeons

Honors & Awards

Disease-Oriented Clinical Scholars (DOCS) Program Award 2023, UT Southwestern
Excellence in Research Award 2022, Department of Neurosurgery, University of Virginia
Jane-Nugent Basic Science Presentation Award 2022, Neurosurgical Society of the Virginias
Donald O. Quest, MD, FAANS(L) Basic Science Award 2021, American Association of Neurological Surgeons Young Neurosurgeons Research Forum
Jane-Nugent Basic Science Presentation Award 2021, Neurosurgical Society of the Virginias
Clinical Research Excellence Award 2021, National Institute of Neurological Disorders and Stroke
Directors Award 2021, National Institute of Neurological Disorders and Stroke
Fellows Award for Research Excellence 2021, National Institutes of Health
Jane-Nugent Basic Science Presentation Award 2019, Neurosurgical Society of the Virginias
John A. Jane, Sr., Highest Board Score Award 2019, University of Virginia
Immunology Interest Group Award 2018, Neuroimmunology Session, National Institutes of Health
John A. Jane, Sr., Neuroanatomy Award 2017, University of Virginia
Award for Research Excellence 2014, Center for Nanomedicine, Johns Hopkins University
Scholarship for support of research fellowship 2014, Empeirikeion Foundation

Books & Publications

Books
- Predicting outcomes of stereotactic radiosurgery for dural arteriovenous fistulas in Cranial and Spinal Dural Arteriovenous Fistulas
  Chandrabhatla AS, Mastorakos P, Chen CJ, Ding D, Sheehan J (2022), New York, Springer Nature
- Treatment of the adult chiari I malformation in The Chiari Malformations
  Mastorakos P, Heiss J (2020), New York, Springer
- Perioperative challenges during cerebrovascular surgery in Essentials of Neurosurgical Anesthesia and Critical Care
  Mastorakos P, Raper DMS, Liu KC (2020), New York, Springer Nature
- Pituitary adenomas in Textbook of Pediatric Neurosurgery
  Taylor DG, Mastorakos P, Paisan GM, Pomeraniec IJ, Lopes MB, Jane JAJ (2019), New York, Springer
- General principles for the management of ruptured and unruptured intracranial aneurysms in Principles of Neurological Surgery
  Mastorakos P, Ding D, Starke R (2018), New York, Elsevier
Publications
- Proteostasis Modulation in Germline Missense von Hippel Lindau Disease.
  Chittiboina P, Mandal D, Bugarini A, Asuzu DT, Mullaney D, Mastorakos P, Stoica S, Alvarez R, Scott G, Maric D, Elkahloun A, Zhuang Z, Chew EY, Yang C, Linehan M, Lonser RR, Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Jun 29 12 2199-2209
- Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge (WEB) Device: a Retrospective Multicenter Observational Study.
  El Naamani K, Mastorakos P, Adeeb N, Lan M, Castiglione J, Khanna O, Diestro JDB, McLellan RM, Dibas M, Vranic JE, Aslan A, Cuellar-Saenz HH, Guenego A, Carnevale J, Saliou G, Ulfert C, Möhlenbruch M, Foreman PM, Vachhani JA, Hafeez MU, Waqas M, Tutino VM, Rabinov JD, Ren Y, Michelozzi C, Spears J, Panni P, Griessenauer CJ, Asadi H, Regenhardt RW, Stapleton CJ, Ghozy S, Siddiqui A, Patel NJ, Kan P, Boddu S, Knopman J, Aziz-Sultan MA, Zanaty M, Ghosh R, Abbas R, Amllay A, Tjoumakaris SI, Gooch MR, Cancelliere NM, Herial NA, Rosenwasser RH, Zarzour H, Schmidt RF, Pereira VM, Patel AB, Jabbour P, Dmytriw AA, Translational stroke research 2023 May
- Preclinical models of middle cerebral artery occlusion: new imaging approaches to a classic technique.
  Sokolowski JD, Soldozy S, Sharifi KA, Norat P, Kearns KN, Liu L, Williams AM, Yagmurlu K, Mastorakos P, Miller GW, Kalani MYS, Park MS, Kellogg RT, Tvrdik P, Frontiers in neurology 2023 14 1170675
- Mechanical Thrombectomy for the Treatment of Anterior Cerebral Artery Occlusion: A Systematic Review of the Literature.
  Dabhi N, Mastorakos P, Sokolowski J, Kellogg RT, Park MS, AJNR. American journal of neuroradiology 2022 Dec 43 12 1730-1735
- Quantification of hematoma and perihematomal edema volumes in intracerebral hemorrhage study: Design considerations in an artificial intelligence validation (QUANTUM) study.
  Ironside N, Patrie J, Ng S, Ding D, Rizvi T, Kumar JS, Mastorakos P, Hussein MZ, Naamani KE, Abbas R, Harrison Snyder M, Zhuang Y, Kearns KN, Doan KT, Shabo LM, Marfatiah S, Roh D, Lignelli-Dipple A, Claassen J, Worrall BB, Johnston KC, Jabbour P, Park MS, Sander Connolly E, Mukherjee S, Southerland AM, Chen CJ, Clinical trials (London, England) 2022 Oct 19 5 534-544
- Effects of hyperoxemia on aneurysmal subarachnoid hemorrhage outcomes: a systematic review and meta-analysis.
  Ahn J, Mastorakos P, Sokolowski JD, Chen CJ, Kellogg R, Park MS, Neurosurgical focus 2022 Mar 52 3 E7
- Flexible thecoscopy for extensive spinal arachnoiditis.
  Mastorakos P, Pomeraniec IJ, Bryant JP, Chittiboina P, Heiss JD, Journal of neurosurgery. Spine 2022 Feb 36 2 325-335
- Effect of drug use in the treatment of acute ischemic stroke: A scoping review.
  Dabhi N, Mastorakos P, Sokolowski JD, Kellogg RT, Park MS, Surgical neurology international 2022 13 367
- Antimicrobial immunity impedes CNS vascular repair following brain injury.
  Mastorakos P, Russo MV, Zhou T, Johnson K, McGavern DB, Nature immunology 2021 Oct 22 10 1280-1293
- Glia limitans superficialis oxidation and breakdown promote cortical cell death after repetitive head injury.
  Mason HD, Johnson AM, Mihelson NA, Mastorakos P, McGavern DB, JCI insight 2021 Oct 6 19
- Multiple VHL-related hemangioblastomas and holocord syrinx: identifying the causative lesion. Illustrative case.
  Mortazavi A, Nwokoye D, Asuzu DT, Scott G, Mastorakos P, Chittiboina P, Journal of neurosurgery. Case lessons 2021 Sep 2 11 CASE21296
- Experimental animal models for the study of moyamoya disease.
  Letchuman V, Ampie L, Mastorakos P, Raper DMS, Kellogg RT, Park MS, Neurosurgical focus 2021 Sep 51 3 E4
- Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management.
  Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P, Neurosurgery 2021 Apr 88 5 1012-1020
- Developmental vascular malformations in EPAS1 gain-of-function syndrome.
  Rosenblum JS, Wang H, Dmitriev PM, Cappadona AJ, Mastorakos P, Xu C, Jha A, Edwards N, Donahue DR, Munasinghe J, Nazari MA, Knutsen RH, Rosenblum BR, Smirniotopoulos JG, Pappo A, Spetzler RF, Vortmeyer A, Gilbert MR, McGavern DB, Chew E, Kozel BA, Heiss JD, Zhuang Z, Pacak K, JCI insight 2021 Mar 6 5
- Resection of a conus medullaris hemangioblastoma: Case report.
  Alvarez R, Mastorakos P, Chittiboina P, Interdisciplinary neurosurgery : Advanced techniques and case management 2021 Mar 23
- Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury.
  Mastorakos P, Mihelson N, Luby M, Burks SR, Johnson K, Hsia AW, Witko J, Frank JA, Latour L, McGavern DB, Nature neuroscience 2021 Feb 24 2 245-258
- Nimodipine after aneurysmal subarachnoid hemorrhage: Fourteen-day course for patients that meet criteria for early hospital discharge.
  Sokolowski JD, Chen CJ, Soldozy S, Mastorakos P, Burke RM, Nguyen JM, Myers KM, Kalani MYS, Park MS, Clinical neurology and neurosurgery 2021 Jan 200 106299
- Rerupture Following Flow Diversion of a Dissecting Aneurysm of the Vertebral Artery: Case Report and Review of the Literature.
  Pomeraniec IJ, Mastorakos P, Raper D, Park MS, World neurosurgery 2020 Nov 143 171-179
- Mobile Myxopapillary Ependymoma with Associated Filum Terminale Cyst.
  Mastorakos P, Pomeraniec IJ, Shah S, Shoushtarizadeh A, Quezado MM, Heiss J, World neurosurgery 2020 Jul 139 337-342
- Resection of Myxopapillary Ependymoma of the Filum Terminale: 2-Dimensional Operative Video.
  Mastorakos P, Lynes J, Maggio D, Quezado MM, Nduom EK, Operative neurosurgery (Hagerstown, Md.) 2020 Feb 18 2 E40
- Cerebrospinal fluid area and syringogenesis in Chiari malformation type I.
  Taylor DG, Chatrath A, Mastorakos P, Paisan G, Chen CJ, Buell TJ, Jane JA, Journal of neurosurgery 2020 Feb 134 3 825-830
- The anatomy and immunology of vasculature in the central nervous system.
  Mastorakos P, McGavern D, Science immunology 2019 Jul 4 37
- Tumor to Cerebellar Peduncle T2-Weighted Imaging Intensity Ratio Fails to Predict Pituitary Adenoma Consistency.
  Mastorakos P, Mehta GU, Chatrath A, Moosa S, Lopes MB, Payne SC, Jane JA, Journal of neurological surgery. Part B, Skull base 2019 Jun 80 3 252-257
- BRAF V600 Mutation and BRAF Kinase Inhibitors in Conjunction With Stereotactic Radiosurgery for Intracranial Melanoma Metastases: A Multicenter Retrospective Study.
  Mastorakos P, Xu Z, Yu J, Hess J, Qian J, Chatrath A, Taylor DG, Kondziolka D, Warnick R, Chiang V, Sheehan J, Neurosurgery 2019 Apr 84 4 868-880
- Gamma Knife Radiosurgery for Trigeminal Neuralgia Reduces Neurovascular Compression: A Case Report after 11 Years.
  Moosa S, Wang TR, Mastorakos P, Sheehan JP, Elias WJ, Stereotactic and functional neurosurgery 2019 97 3 202-206
- Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.
  Chatrath A, Mastorakos P, Mehta GU, Wildeman M, Moosa S, Jane JA, Pediatric neurosurgery 2019 54 1 36-45
- Prediction of cavernous sinus invasion in patients with Cushing's disease by magnetic resonance imaging.
  Mastorakos P, Taylor DG, Chen CJ, Buell T, Donahue JH, Jane JA, Journal of neurosurgery 2018 Jul 1-6
- Endoport-assisted surgical evacuation of a deep-seated cerebral abscess.
  Moosa S, Ding D, Mastorakos P, Sheehan JP, Liu KC, Starke RM, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2018 Jul 53 269-272
- Cyst formation after stereotactic radiosurgery for brain arteriovenous malformations: a systematic review.
  Ilyas A, Chen CJ, Ding D, Mastorakos P, Taylor DG, Pomeraniec IJ, Lee CC, Sheehan J, Journal of neurosurgery 2018 May 128 5 1354-1363
- Transtentorial dissemination of optic nerve glioblastoma: case report.
  Mastorakos P, Hays MA, Caruso JP, Chen CJ, Ding D, Taylor DG, Beatriz Lopes M, Shaffrey ME, Journal of neurosurgery 2018 Feb 128 2 406-413
- Sylvian Arteriovenous Malformation Resection and Associated Middle Cerebral Artery Aneurysm Clipping: Technical Nuances of Concurrent Surgical Treatment.
  Ding D, Buell TJ, Raper DM, Chen CJ, Mastorakos P, Liu KC, Vollmer DG, Cureus 2018 Feb 10 2 e2166
- Strategies to enhance the distribution of nanotherapeutics in the brain.
  Zhang C, Mastorakos P, Sobral M, Berry S, Song E, Nance E, Eberhart CG, Hanes J, Suk JS, Journal of controlled release : official journal of the Controlled Release Society 2017 Dec 267 232-239
- Endovascular mechanical thrombectomy for cerebral venous sinus thrombosis: a systematic review.
  Ilyas A, Chen CJ, Raper DM, Ding D, Buell T, Mastorakos P, Liu KC, Journal of neurointerventional surgery 2017 Nov 9 11 1086-1092
- Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.
  Zhang C, Nance EA, Mastorakos P, Chisholm J, Berry S, Eberhart C, Tyler B, Brem H, Suk JS, Hanes J, Journal of controlled release : official journal of the Controlled Release Society 2017 Oct 263 112-119
- Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors.
  Mastorakos P, Zhang C, Song E, Kim YE, Park HW, Berry S, Choi WK, Hanes J, Suk JS, Journal of controlled release : official journal of the Controlled Release Society 2017 Sep 262 37-46
- Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.
  Mead BP, Kim N, Miller GW, Hodges D, Mastorakos P, Klibanov AL, Mandell JW, Hirsh J, Suk JS, Hanes J, Price RJ, Nano letters 2017 Jun 17 6 3533-3542
- Two distinct populations of Chiari I malformation based on presence or absence of posterior fossa crowdedness on magnetic resonance imaging.
  Taylor DG, Mastorakos P, Jane JA, Oldfield EH, Journal of neurosurgery 2017 Jun 126 6 1934-1940
- Transorbital Approach for Endovascular Occlusion of Carotid-Cavernous Fistulas: Technical Note and Review of the Literature.
  Chen CJ, Mastorakos P, Caruso JP, Ding D, Schmitt PJ, Buell TJ, Raper DM, Evans A, Newman SA, Jensen ME, Cureus 2017 Jan 9 1 e976
- Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells.
  Oh Y, Park O, Swierczewska M, Hamilton JP, Park JS, Kim TH, Lim SM, Eom H, Jo DG, Lee CE, Kechrid R, Mastorakos P, Zhang C, Hahn SK, Jeon OC, Byun Y, Kim K, Hanes J, Lee KC, Pomper MG, Gao B, Lee S, Hepatology (Baltimore, Md.) 2016 Jul 64 1 209-23
- Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain.
  Mastorakos P, Song E, Zhang C, Berry S, Park HW, Kim YE, Park JS, Lee S, Suk JS, Hanes J, Small (Weinheim an der Bergstrasse, Germany) 2016 Feb 12 5 678-85
- Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.
  Mead BP, Mastorakos P, Suk JS, Klibanov AL, Hanes J, Price RJ, Journal of controlled release : official journal of the Controlled Release Society 2016 Feb 223 109-117
- Enhancing Intracranial Delivery of Clinically Relevant Non-viral Gene Vectors.
  Berry S, Mastorakos P, Zhang C, Song E, Patel H, Suk JS, Hanes J, RSC advances 2016 48 6 41665-41674
- Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells.
  Kambhampati SP, Mishra MK, Mastorakos P, Oh Y, Lutty GA, Kannan RM, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015 Sep 95 Pt B 239-49
- Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy.
  Mastorakos P, da Silva AL, Chisholm J, Song E, Choi WK, Boyle MP, Morales MM, Hanes J, Suk JS, Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 112 28 8720-5
- Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.
  Zhang F, Mastorakos P, Mishra MK, Mangraviti A, Hwang L, Zhou J, Hanes J, Brem H, Olivi A, Tyler B, Kannan RM, Biomaterials 2015 Jun 52 507-16
- Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain.
  Mastorakos P, Zhang C, Berry S, Oh Y, Lee S, Eberhart CG, Woodworth GF, Suk JS, Hanes J, Advanced healthcare materials 2015 May 4 7 1023-33
- Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.
  Xekouki P, Szarek E, Bullova P, Giubellino A, Quezado M, Mastroyannis SA, Mastorakos P, Wassif CA, Raygada M, Rentia N, Dye L, Cougnoux A, Koziol D, Sierra Mde L, Lyssikatos C, Belyavskaya E, Malchoff C, Moline J, Eng C, Maher LJ, Pacak K, Lodish M, Stratakis CA, The Journal of clinical endocrinology and metabolism 2015 May 100 5 E710-9
- Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells.
  Mastorakos P, Kambhampati SP, Mishra MK, Wu T, Song E, Hanes J, Kannan RM, Nanoscale 2015 Mar 7 9 3845-56
- Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.
  Schneider CS, Perez JG, Cheng E, Zhang C, Mastorakos P, Hanes J, Winkles JA, Woodworth GF, Kim AJ, Biomaterials 2015 Feb 42 42-51

Research

Immune response to acute intracranial pressure fluctuations
Innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage
Development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage

Clinical Focus

Cerebrovascular Disease
Aneurysms
Vascular Malformations
Subarachnoid Hemorrhage
Ischemic and Hemorrhagic Stroke