Trung Nguyen, M.D., Ph.D.

Peter O'Donnell Jr. Brain Institute

Neurology
Memory Disorders

Biography

Trung Phuoc Nguyen, M.D., Ph.D., is an Associate Professor in the Department of Neurology at UT Southwestern Medical Center. He specializes in memory disorders, particularly in evaluating patients with Alzheimer’s disease and other memory or cognitive disorders caused by neurodegenerative conditions.

Dr. Nguyen earned his medical degree and doctorate in neuroscience at The University of Texas Medical Branch at Galveston. He completed a residency in neurology at Emory University and received advanced training in behavioral neurology and dementia through a fellowship at UT Southwestern.

Certified by the American Board of Psychiatry and Neurology, Dr. Nguyen joined the UT Southwestern faculty in 2014.

Named a Texas Monthly Super Doctor Rising Star in 2019 and 2020, Dr. Nguyen is a member of the American Academy of Neurology.

Education & Training

Internship - Emory University School of Medicine (2010-2011), Internal Medicine
Fellowship - UT Southwestern Medical Center (2014-2016), Behavioral Neurology & Dementia
Medical School - UT Medical Branch at Galveston (2002-2010)
Residency - Emory University School of Medicine (2011-2014), Neurology
Other Post Graduate Training - The University of Texas Medical Branch at Galveston (2002-2010)

Honors & Awards

Texas Monthly Super Doctors, Rising Star 2020
Texas Monthly Super Doctors, Rising Star 2019

Books & Publications

Publications
- High definition transcranial direct current stimulation as an intervention for cognitive deficits in Alzheimer's dementia: A randomized controlled trial
  LoBue C, Chiang HS, Salter A, McClintock S, Nguyen TP, Logan R, Smernoff E, Pandya S, Hart J The journal of prevention of Alzheimer's disease 2025 Feb 12 100023
- Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
  Author Collaboration TA, Azevedo T, Bethlehem RA, Whiteside DJ, Swaddiwudhipong N, Rowe JB, Lió P, Rittman T, Li G, Petrie EC, Peskind ER, Villena T, Martinez W, Sadowsky C, Lee A, Ravdin L, Lin M, Chiang G, Relkin N, Santulli RB, Hynes ML, Seltzer M, Flashman LA, Anderson K, Blank K, Pearlson GD, Kittur S, Correia S, Malloy P, Salloway S, Potkin S, Newhouse P, Garcia A, Shi J, Masdeu J, Wiliams A, Mintzer J, O’Connelll A, Mintz A, Munic D, Bernick C, Ritter A, Drake JD, Daiello LA, Tremont G, Drake J, Ott BR, Kerwin D, Hajjar I, Quiceno M, Nguyen T Communications Medicine 2023 Dec 3
- Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
  Author Collaboration TA, Tuena C, Maestri S, Serino S, Pedroli E, Stramba-Badiale M, Riva G, Silbert LC, Lind B, Crissey R, Kaye JA, Carter R, Dolen S, Quinn J, Schneider LS, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann BM, Brewer J, Fleisher A, Vanderswag H, Ziolkowski J, Heidebrink JL, Zbizek-Nulph L, Lord JL, Albers CS, Petersen R, Mason SS, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass JS, Doody RS, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig LS, Mintz A, Kelley B, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D BMC Geriatrics 2023 Dec 23
- HBS-1.2: Lightweight Socially Assistive Robot with 6-Ply Twisted Coiled Polymer Muscle-Actuated Hand
  Singh AP, Palani D, Ahmed O, Matharu PS, Linn T, Nguyen T, Tadesse Y Actuators 2023 Aug 12
- Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression
  Author Collaboration AD, Massett RJ, Maher AS, Imms PE, Amgalan A, Chaudhari NN, Chowdhury NF, Irimia A, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey DT, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Gessert D, Kelley B, Nguyen T, Womack KB, Quiceno M, Hajjar I, Kerwin D Journals of Gerontology - Series A Biological Sciences and Medical Sciences 2023 Jun 78 872-881
- A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
  Author Collaboration TA, Inglese M, Patel N, Linton-Reid K, Loreto F, Win Z, Perry RJ, Carswell C, Grech-Sollars M, Crum WR, Lu H, Malhotra PA, Silbert LC, Lind B, Crissey R, Kaye JA, Carter R, Dolen S, Quinn J, Schneider LS, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann BM, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink JL, Lord JL, Zbizek-Nulph L, Petersen R, Mason SS, Albers CS, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass JS, Doody RS, Shibley V, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D, Kelley B Communications Medicine 2022 Dec 2
- A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels
  Author Collaboration AC, Dornbos P, Koesterer R, Ruttenburg A, Nguyen T, Cole JB, Leong A, Meigs JB, Florez JC, Rotter JI, Udler MS, Flannick J Nature genetics 2022 Nov 54 1609-1614
- Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature
  Chiang H, Khera A, Stopschinski BE, Stuve O, Hart J, Kelley B, Nguyen T Geriatrics (Switzerland) 2022 Jun 7
- New insights into the genetic etiology of Alzheimer’s disease and related dementias
  Author Collaboration E, Author Collaboration G, Author Collaboration D, Author Collaboration E, Author Collaboration G, Author Collaboration D, Author Collaboration F, Author Collaboration A, Author Collaboration C, Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bertelson J, Cullum M, Huebinger RM, Hynan LS, Nguyen T, Quiceno M, Reisch JS, Rosenberg RN, Williams B Nature genetics 2022 Apr 54 412-436
- Diagnostic Utility of Hippocampal Volumetric Data in a Memory Disorder Clinic Setting
  Ruchinskas R, Nguyen T, Womack K, Khera A, Yu FF, Kelley BJ Cognitive and Behavioral Neurology 2022 Mar 35 66-75
- Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
  Author Collaboration AD, Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Perrin RJ, Shaw LM, Kachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Montine T, Kaye JA, Silbert LC, Schneider LS, Pawluczyk S, Becerra M, Brewer J, Heidebrink JL, Knopman D, Villanueva-Meyer J, Doody RS, Kass JS, Stern Y, Honig LS, Mintz A, Kelley B, Nguyen T, Womack K Nature communications 2021 Dec 12
- Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status
  Author Collaboration AD, Shen XN, Huang YY, Chen SD, Guo Y, Tan L, Dong Q, Yu JT, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormos A, Gessert D, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D, Kelley B Translational psychiatry 2021 Dec 11
- Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
  Author Collaboration Ft, Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey DT, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Kelley B, Nguyen T, Womack K, Mathews D, Quiceno M, Hajjar I, Kerwin D Translational psychiatry 2021 Dec 11
- Risk factors for earlier dementia onset in autopsy-confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease
  Schaffert J, LoBue C, White CL, Wilmoth K, Didehbani N, Lacritz L, Nguyen T, Peters ME, Fields L, Li C, Cullum CM Alzheimer's and Dementia 2020 Mar 16 524-530
- Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies
  Nguyen TP, Schaffert J, Lobue C, Womack KB, Hart J, Cullum CM 2020 219-224
- Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts
  Royall DR, Bishnoi RJ, Palmer RF, Pavlik V, Massman P, Darby E, Rodriguear M, Ansari AK, DeToledo JC, Reddy H, Wilms H, Johnson K, Perez V, Fairchild T, Knebl J, O'Bryant SE, Hall JR, Johnson L, Barber RC, Mains D, Alvarez L, Cullum M, Rosenberg R, Williams B, Quiceno M, Reisch J, Hynan LS, Huebinger R, Smith J, Nguyen T, Palmer R, Polk M, Stevens A, Ory M, Paydarfar D, Bertelson J, Woon M, Ayres G, Aguirre A, Wilhelmsen KC, Tilson JL Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 2019 Dec 11 763-774
- Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging
  Author Collaboration TA, Woodward MR, Hafeez MU, Qi Q, Riaz A, Benedict RH, Yan L, Szigeti K, Pavlik V, Massman P, Darby E, Rodriguear M, Khaleeq Ansari A, DeToledo JC, Reddy H, Wilms H, Johnson K, Perez V, Fairchild T, Knebl J, O'Bryant SE, Hall JR, Johnson L, Barber RC, Mains D, Alvarez L, Cullum M, Rosenberg R, Williams B, Quiceno M, Reisch J, Hynan LS, Huebinger R, Smith J, Nguyen T, Royall D, Palmer R, Polk M, Stevens A, Ory M, Paydarfar D, Bertelson J, Woon M, Ayres G, Aguirre A, Wilhelmsen KC, Tilson JL American Journal of Geriatric Psychiatry 2018 Aug 26 835-846
- Traumatic brain injury and age of onset of dementia with lewy bodies
  Nguyen TP, Schaffert J, Lobue C, Womack KB, Hart J, Cullum CM Journal of Alzheimer's Disease 2018 66 717-723
- CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease
  Author Collaboration AD, Hu WT, Watts KD, Tailor P, Nguyen TP, Howell JC, Lee RC, Seyfried NT, Gearing M, Hales CM, Levey AI, Lah JJ, Lee EK Acta Neuropathologica Communications 2016 Feb 4 14
- Persistent "hijacking" of brain proteasomes in human immunodeficiency virus-associated dementia
  Nguyen T Rejuvenation Research 2011 Feb 14 90
- Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: Proteomic analysis of human synaptosomes
  Gelman BB, Nguyen TP Journal of Neuroimmune Pharmacology 2010 Mar 5 92-102
- Persistent hijacking of brain proteasomes in HIV-associated dementia
  Nguyen TP, Soukup VM, Gelman BB American Journal of Pathology 2010 Feb 176 893-902

Clinical Focus