Victor Aquino, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pediatrics - Hematology-Oncology
Pediatric Hematopoietic Stem Cell Transplant
Pediatric Cellular Therapy

Biography

Victor Aquino, M.D., is a Professor in the Department of Pediatrics at UT Southwestern Medical Center. He specializes in pediatric hematopoietic stem cell transplant, pediatric cellular therapy, and pediatric hematopoietic stem cell transplant for immunodeficiency.

Dr. Aquino earned his medical degree and completed a residency in pediatrics at SUNY Upstate Medical University in Syracuse, New York. He gained advanced training through a fellowship in pediatric hematology and oncology and bone marrow transplant at UT Southwestern, where he served as Chief Fellow. He received additional bone marrow transplant fellowship training at the Fred Hutchinson Cancer Center in Seattle, Washington.

Certified by the American Board of Pediatrics in pediatrics and pediatric hematology and oncology, he joined the UT Southwestern faculty in 1995.

Dr. Aquino serves as Director of the Pediatric Stem Cell Collection Center at Children's Medical Center Dallas. He is a member of several committees at Children’s and UT Southwestern, serving as Chair of both the Radiation Safety Committee and the Institutional Review Board IV.

He has contributed to numerous research projects and clinical trials focused on the prevention and management of infection in children with cancer who are receiving chemotherapy and those who undergo hematopoietic stem cell transplantation. His interests include immune reconstitution, management of infections, and developing protocols for outpatient management of febrile neutropenia. He is actively involved in the Pediatric Blood and Marrow Transplant Consortium and the Children’s Oncology Group and has served as a principal investigator on studies for both groups.

Dr. Aquino has delivered scores of presentations, contributed to the books Pediatric Bone Marrow Transplantation, Principles and Practice of Pediatric Oncology, and Essentials of Pediatric Intensive Care, and published numerous academic articles related to his areas of expertise.

He serves as Associate Editor for Frontiers in Pediatrics and as a reviewer for several other journals. He is a Fellow of the American Academy of Pediatrics and a member of several other professional organizations, including the American Society of Clinical Oncology, the American Society of Hematology, and the Society for Pediatric Research.

Personal Note

When he’s not at work, Dr. Aquino enjoys running, cooking, and traveling.

Education & Training

Medical School - State University of New York - Syracuse (1987-1989)
Residency - State University of New York Upstate Medical University (1989-1992), Pediatrics
Fellowship - UT Southwestern/Children's Medical Center (1992-1995), Pediatric Hematology/oncology

Professional Associations & Affiliations

American Academy of Pediatrics
American Society of Clinical Oncology
American Society of Hematology
Dallas County Medical Society
Society for Pediatric Research
Texas Medical Association

Books & Publications

Books
- Supportive care of the pediatric hematopoietic stem cell transplant patient in Pediatric Bone Marrow Transplantation
  Aquino VM, Sandler ES (2007), New York, NY, Informa Health Care USA, Inc.
- Hematologic supportive care and hematopoietic cytokines in Principles and Practice of Pediatric Oncology (4th ed.)
  Rogers ZR, Aquino VM, Buchanan GR (2001), Philadelphia, PA, Lippincott-Raven Publishers
- Methemoglobinemia in Essentials of Pediatric Intensive Care (2nd ed.)
  Aquino VM, Buchanan GR (1997), St. Louis, MO, Quality Medical Publishing
Publications
- The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).
  Dvorak CC, Haddad E, Buckley RH, Cowan MJ, Logan B, Griffith LM, Kohn DB, Pai SY, Notarangelo L, Shearer W, Prockop S, Kapoor N, Heimall J, Chaudhury S, Shyr D, Chandra S, Cuvelier G, Moore T, Shenoy S, Goldman F, Smith AR, Sunkersett G, Vander Lugt M, Caywood E, Quigg T, Torgerson T, Chandrakasan S, Craddock J, Dávila Saldaña BJ, Gillio A, Shereck E, Aquino V, DeSantes K, Knutsen A, Thakar M, Yu L, Puck JM, The Journal of allergy and clinical immunology 2019 Jan 143 1 405-407
- SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery.
  Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Prockop SE, Small TN, Chaisson J, Dvorak CC, Murnane M, Kapoor N, Abdel-Azim H, Hanson IC, Martinez C, Bleesing JJH, Chandra S, Smith AR, Cavanaugh ME, Jyonouchi S, Sullivan KE, Burroughs L, Skoda-Smith S, Haight AE, Tumlin AG, Quigg TC, Taylor C, Dávila Saldaña BJ, Keller MD, Seroogy CM, Desantes KB, Petrovic A, Leiding JW, Shyr DC, Decaluwe H, Teira P, Gillio AP, Knutsen AP, Moore TB, Kletzel M, Craddock JA, Aquino V, Davis JH, Yu LC, Cuvelier GDE, Bednarski JJ, Goldman FD, Kang EM, Shereck E, Porteus MH, Connelly JA, Fleisher TA, Malech HL, Shearer WT, Szabolcs P, Thakar MS, Vander Lugt MT, Heimall J, Yin Z, Pulsipher MA, Pai SY, Kohn DB, Puck JM, Cowan MJ, O'Reilly RJ, Notarangelo LD, Blood 2018 Oct 132 17 1737-1749
- Successful engraftment after hematopoietic stem cell transplantation with infusion of donor stem cells through the extracorporeal membrane oxygenation circuit.
  Anton-Martin P, Darnell-Bowens C, Aquino VM, Jones T, Raman L Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2016 Oct 20 10 617-619
- Long term outcomes of 176 patients with X-linked hyper IgM syndrome treated with or without hematopoietic cell transplantation.
  de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla F, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Espanol T, Shcherbina A, Hanson C, Litzman J, Routes J, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, Gonzalez-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Grunebaum E, Dorsey M, Costa Carvalho BT, Condino-Neto A, Cunningham-Rundles C, Knutsen AP, Sleasman J, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman C The Journal of allergy and clinical immunology 2016 Sep
- Safety, pharmacokinetics and efficacy of palifermin in children and adolescents with acute leukemias undergoing myeloablative therapy and allogeneic hematopoietic stem cell transplantation: a Pediatric Blood and Marrow Transplant Consortium Trial.
  Morris J, Rudebeck M, Neudorf S, Moore T, Duerst R, Shah AJ, Graham M, Aquino V, Morris C, Olsson B Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2016 Mar
- Incidence and outcome of rhinovirus in children undergoing hematopoietic stem cell transplantation.
  DeMasi J, Aquino V, Simms-Waldrip TR, Koh AY, Holmes S. Biology of Blood and Marrow Transplantation 2015 15 2 S248
- One-unit versus two-unit cord-blood transplantation for hematologic cancers.
  Wagner JE, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J The New England journal of medicine 2014 Oct 371 18 1685-94
- Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
  Pai SY, Logan BR, Griffith LM, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Hanson IC, Filipovich AH, Jyonouchi S, Sullivan KE, Small TN, Burroughs L, Skoda-Smith S, Haight AE, Grizzle A, Pulsipher MA, Chan KW, Fuleihan RL, Haddad E, Loechelt B, Aquino VM, Gillio A, Davis J, Knutsen A, Smith AR, Moore TB, Schroeder ML, Goldman FD, Connelly JA, Porteus MH, Xiang Q, Shearer WT, Fleisher TA, Kohn DB, Puck JM, Notarangelo LD, Cowan MJ, O'Reilly RJ The New England journal of medicine 2014 Jul 371 5 434-46
- Intravenous Pentamidine Is Safe and Effective as Primary Pneumocystis Pneumonia Prophylaxis in Children and Adolescents Undergoing Hematopoietic Stem Cell Transplantation.
  Demasi JM, Cox JA, Leonard D, Koh AY, Aquino VM The Pediatric infectious disease journal 2013 Mar
- 50 years ago in the Journal of Pediatrics: neuroblastoma.
  Aquino VM, Rogers ZR The Journal of pediatrics 2012 Sep 161 3 416
- Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia.
  Aquino VM, Cost C, Gomez A, Bowers DC, Ramilo O, Ahmad N, Winick N, Leavey PJ Journal of pediatric hematology/oncology 2012 Aug 34 6 e241-5
- Unrelated donor cord blood transplantation for children with severe sickle cell disease: results of one cohort from the phase II study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).
  Kamani NR, Walters MC, Carter S, Aquino V, Brochstein JA, Chaudhury S, Eapen M, Freed BM, Grimley M, Levine JE, Logan B, Moore T, Panepinto J, Parikh S, Pulsipher MA, Sande J, Schultz KR, Spellman S, Shenoy S Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Aug 18 8 1265-72
- The diagnostic utility of routine chest radiography in the evaluation of the initial fever in patients undergoing hematopoietic stem cell.
  Cox JA, DeMasi J, McCollom S, Jackson G, Scothorn D, Aquino VM Pediatric blood & cancer 2011 Oct 57 4 666-8
- Hematopoietic stem cell transplantation in children.
  Kolins JA, Zbylut C, McCollom S, Aquino VM Critical care nursing clinics of North America 2011 Jun 23 2 349-76
- Dose of prophylactic platelet transfusions and prevention of hemorrhage.
  Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno CS, McFarland JG, Hess JR, Leissinger C, Granger S The New England journal of medicine 2010 Feb 362 7 600-13
- A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia.
  Herrera L, Bostrom B, Gore L, Sandler E, Lew G, Schlegel PG, Aquino V, Ghetie V, Vitetta ES, Schindler J Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2009 Dec 31 12 936-41
- Extracorporeal membrane oxygenation (ECMO) initiation without intubation in two children with mediastinal malignancy.
  Wickiser JE, Thompson M, Leavey PJ, Quinn CT, Garcia NM, Aquino VM Pediatric blood & cancer 2007 Oct 49 5 751-4
- A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study.
  Aquino VM, Harvey AR, Garvin JH, Godder KT, Nieder ML, Adams RH, Jackson GB, Sandler ES Bone marrow transplantation 2005 Oct 36 7 611-6
- Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis.
  Karandikar NJ, Kroft SH, Yegappan S, Rogers BB, Aquino VM, Lee KM, Kumar V, Guenaga FJ, Jaffe ES, Douek DC, McKenna RW Blood 2004 Oct 104 7 2007-9
- Phase I trial of tirapazamine and cyclophosphamide in children with refractory solid tumors: a pediatric oncology group study.
  Aquino VM, Weitman SD, Winick NJ, Blaney S, Furman WL, Kepner JL, Bonate P, Krailo M, Qu W, Bernstein M Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 Apr 22 8 1413-9
- Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors.
  Bowers DC, Aquino VM, Leavey PJ, Bash RO, Journeycake JM, Tomlinson G, Mulne AF, Haynes HJ, Winick NJ Pediatric blood & cancer 2004 Jan 42 1 93-8
- Extraskeletal myxoid chondrosarcoma as a second malignancy after bone marrow transplantation.
  Aquino VM, Tomlinson G, Weinberg AG, Eshelman DA Medical and pediatric oncology 2003 May 40 5 336-7
- Evaluation of thymic output by measurement of T-cell-receptor gene rearrangement excisional circles (TREC) in patients who have received fludarabine.
  Aquino VM, Douek DC, Berryman B, Johnson M, Jain VK, Collins RH Leukemia & lymphoma 2003 Feb 44 2 343-8
- A prospective double-blind randomized trial of urokinase flushes to prevent bacteremia resulting from luminal colonization of subcutaneous central venous catheters.
  Aquino VM, Sandler ES, Mustafa MM, Steele JW, Buchanan GR Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2002 Dec 24 9 710-3
- Rapidly fatal acute bacterial myocarditis in a nonneutropenic child with acute lymphoblastic leukemia in remission.
  Scothorn DJ, Winick NJ, Timmons CF, Aquino VM Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2002 Nov 24 8 662-5
- Acute myelogenous leukemia.
  Aquino VM Current problems in pediatric and adolescent health care 2002 Feb 32 2 50-8
- Clinical parameters associated with low bacteremia risk in 1100 pediatric oncology patients with fever and neutropenia.
  Baorto EP, Aquino VM, Mullen CA, Buchanan GR, DeBaun MR Cancer 2001 Aug 92 4 909-13
- Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia.
  Walters MC, Patience M, Leisenring W, Rogers ZR, Aquino VM, Buchanan GR, Roberts IA, Yeager AM, Hsu L, Adamkiewicz T, Kurtzberg J, Vichinsky E, Storer B, Storb R, Sullivan KM Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001 7 12 665-73
- Feasibility of oral ciprofloxacin for the outpatient management of febrile neutropenia in selected children with cancer.
  Aquino VM, Herrera L, Sandler ES, Buchanan GR Cancer 2000 Apr 88 7 1710-4
- Carboplatin for the treatment of children with newly diagnosed optic chiasm gliomas: a phase II study.
  Aquino VM, Fort DW, Kamen BA Journal of neuro-oncology 1999 Feb 41 3 255-9
- Early discharge of low-risk febrile neutropenic children and adolescents with cancer.
  Aquino VM, Tkaczewski I, Buchanan GR Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997 Jul 25 1 74-8
- A pilot study of outpatient management of febrile neutropenic children with cancer at low risk of bacteremia.
  Mustafa MM, Aquino VM, Pappo A, Tkaczewski I, Buchanan GR The Journal of pediatrics 1996 Jun 128 6 847-9
- The changing epidemiology of bacteremia in neutropenic children with cancer.
  Aquino VM, Pappo A, Buchanan GR, Tkaczewski I, Mustafa MM The Pediatric infectious disease journal 1995 Feb 14 2 140-3

Research

Development of treatment strategies to manage the complications of stem cell transplant and chemotherapy
Management of bacterial and fungal infections in children with malignancies
Outpatient management of febrile neutropenia in selected patients with cancer
Phase I and II trials of new chemotherapeutic agents in children with cancer
Development of stem cell transplant protocols for children with malignant and nonmalignant disorders

Clinical Focus

Pediatric Hematopoietic Stem Cell Transplant
Pediatric Cellular Therapy
Pediatric Hematopoietic Stem Cell Transplant for Immunodeficiency

Links

New Patient Appointment