Amanda Fox, M.D., M.P.H.

Vice Chair of Research in the Department of Anesthesiology and Pain Management

Anesthesiology and Pain Management
Adult Cardiothoracic Anesthesiology

Biography

Amanda Fox, M.D., M.P.H., is a Professor in the Department of Anesthesiology and Pain Management at UT Southwestern Medical Center. She specializes in providing anesthesia for adults undergoing cardiovascular and thoracic surgeries or interventions.

Dr. Fox earned her medical degree at the University of California San Francisco and her master’s degree in public health with a concentration in clinical effectiveness at the Harvard School of Public Health. She performed her residency in anesthesiology and critical care medicine at Johns Hopkins Hospital and then went on to complete a clinical fellowship in adult cardiothoracic anesthesiology at the Texas Heart Institute in Houston.

Board certified in anesthesiology and in advanced perioperative transesophageal echocardiography, she joined the UT Southwestern faculty in 2014. She served as Division Chief of Cardiovascular and Thoracic Anesthesiology from 2015 to 2022 and in 2021 became the Vice Chair of Research in the Department of Anesthesiology and Pain Management.

Among her other roles, Dr. Fox serves as lead investigator and founder of a multispecialty perioperative genomics, biomarker, and outcomes research group at UT Southwestern. She is also the principal investigator of NIH-funded research focused on biomarkers of acute postoperative kidney injury in cardiac surgical patients and how these relate to adverse renal and cardiovascular outcomes during the years following surgery.

Dr. Fox is an editor for Anesthesiology, the journal of the American Society of Anesthesiologists, and active in multiple professional organizations, including the American Society of Anesthesiologists, the Society of Cardiovascular Anesthesiologists, and the American Heart Association. In addition, she has served as the Secretary/Treasurer and is now President Elect for the Society of Cardiovascular Anesthesiologists.

She has delivered many regional, national, and international invited lectures, contributed to several textbooks, and published numerous academic articles and research papers related to care and outcomes of cardiothoracic surgical and interventional patients.

Education & Training

Other Post Graduate Training - Harvard T. H. Chan School of Public Health (2008-2010)
Internship - Beth Israel Deaconess Medical Center (1998-1999), Internal Medicine
Medical School - University of California, San Francisco (1994-1998), Anesthesiology
Residency - John Hopkins Hospital (1999-2002), Anesthesiology/critical Care
Fellowship - Texas Heart Institute, St. Luke's Hospital (2002-2003), Cardiovascular Anesthesiology

Professional Associations & Affiliations

American Heart Association
American Society of Anesthesiologists
American Society of Echocardiography
Association of Cardiac Anesthesiologists
Association of University Anesthesiologists
International Anesthesia Research Society
Society of Cardiovascular Anesthesiologists
Texas Society of Anesthesiologists

Honors & Awards

Best Abstracts of the Meeting Award, 2011, 2019, Society of Cardiovascular Anesthesiologists Annual Meeting
Featured in “Member Spotlight- AWEsome Women (Anesthesiology Women of Excellence)” series 2018, Society of Cardiovascular Anesthesiologists Newsletter
Research Faculty of the Year 2018, UT Southwestern Department of Anesthesiology and Pain Management
Clinician of the Month – December 2016, UT Southwestern Department of Anesthesiology and Pain Management
Chairman’s Recognition Award 2016, UT Southwestern Department of Anesthesiology and Pain Management
A.H. "Buddy" Giesecke, Jr., M.D. Distinguished Professorship 2015, UT Southwestern Medical Center
Best Research Abstract of Meeting Award 2014, International Anesthesia Research Society Annual Meeting
Best Abstracts of the Meeting – Anesthesiology Editors’ Pick 2008, American Society of Anesthesiologists’ Annual Meeting
Faculty Excellence Award 2005, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA

Books & Publications

Books
- Carotid endarterectomy with local versus general anesthesia: Is there a difference in perioperative morbidity and mortality? in Evidence Based Practice of Anesthesiology
  Fox AA, Fleisher LA (2004), New York, NY, WB Saunders Co.
- Anesthetic management for thoracic aortic aneurysms and dissections in A Practical Approach to Cardiac Anesthesia (4th ed.)
  Fox AA, Cooper JR Jr. (2007), Philadelphia, PA, Lippincott, Williams & Wilkins
- Statins and perioperative risk in Case-Based Learning in Anesthesia
  Fox AA, Collard CD (2009), Philadelphia, PA, Lippincott, Williams & Wilkins
- Ventricular assist devices in Essential Clinical Anesthesia
  Fox AA, Fox JA (2011), New York, Cambridge University Press
- Anesthestic considerations for surgical repair of the thoracic aorta in Essential Clinical Anesthesia
  Gelfand BJ, Fox AA (2011), New York, Cambridge University Press
- Anesthetic management for thoracic aortic aneurysms and dissections in A Practical Approach to Cardiac Anesthesia (5th ed.)
  Fox AA, Cooper JR Jr. (2012), Philadelphia, PA, Lippincott, Williams & Wilkins
- Molecular and genetic cardiovascular medicine in Kaplan’s Cardiac Anesthesia (7th ed.)
  Fox AA, Sharma S, Mounsey JP, Durieux ME (2016), St. Louis, Mo, Elsevier Inc
- Anesthetic management for thoracic aortic aneurysms and dissections in A Practical Approach to Cardiac Anesthesia (6th ed.)
  Fox AA, Cooper JR Jr. (2018), Philadelphia, PA, Wolters Kluwer
- Anesthetic management in open descending thoracic aorta surgery in Evidence-Based Practice in Perioperative Cardiac Anesthesia and Surgery (1st ed.)
  Cheruku S, Fox AA (2021), New York, NY, Springer Publishing Company
Publications
- Thoracic Interfascial Plane Blocks and Outcomes After Minithoracotomy for Valve Surgery.
  Cheruku SR, Fox AA, Heravi H, Doolabh N, Davis J, He J, Deonarine C, Bereuter L, Reisch J, Ahmed F, Skariah L, Machi A, Seminars in cardiothoracic and vascular anesthesia 2022 Oct 10892532221136386
- Identifying Patients Vulnerable to Inadequate Pain Resolution After Cardiac Surgery.
  Kelly I, Fields K, Sarin P, Pang A, Sigurdsson MI, Shernan SK, Fox AA, Body SC, Muehlschlegel JD, Seminars in thoracic and cardiovascular surgery 2022 Sep
- Society of Cardiovascular Anesthesiologists Clinical Practice Update for Management of Acute Kidney Injury Associated With Cardiac Surgery.
  Peng K, McIlroy DR, Bollen BA, Billings FT, Zarbock A, Popescu WM, Fox AA, Shore-Lesserson L, Zhou S, Geube MA, Ji F, Bhatia M, Schwann NM, Shaw AD, Liu H, Anesthesia and analgesia 2022 May
- Preoperative Thoracic CT Findings Associated With Postoperative Mechanical Ventilation in Patients Undergoing Major Abdominal or Pelvic Surgery: A Matched Case-Control Study.
  Canan A, Kandathil A, Li JL, Xi Y, Wehrmann L, Bryson T, Browning T, Abbara S, Fox AA, AJR. American journal of roentgenology 2021 Sep
- A Combined Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation.
  Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D Circulation. Arrhythmia and electrophysiology 2015 Jan
- GNAS Gene Variants Affect ?-blocker-related Survival after Coronary Artery Bypass Grafting.
  Frey UH, Muehlschlegel JD, Ochterbeck C, Fox AA, Shernan SK, Collard CD, Lichtner P, Peters J, Body S Anesthesiology 2014 May 120 5 1109-17
- Increased perioperative b-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery.
  Fox AA, Nascimben L, Body SC, Collard CD, Mitani AA, Liu KY, Muehlschlegel JD, Shernan SK, Marcantonio ER Anesthesiology 2013 Aug 119 2 284-94
- Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.
  Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM American journal of hematology 2012 Feb 87 2 161-6
- Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery.
  Fox AA, Marcantonio ER, Collard CD, Thoma M, Perry TE, Shernan SK, Muehlschlegel JD, Body SC Anesthesiology 2011 Apr 114 4 807-16
- Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.
  Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE PloS one 2011 6 9 e24593
- Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery.
  Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC Anesthesia and analgesia 2010 Nov 111 5 1101-9
- Heparin dose response is independent of preoperative antithrombin activity in patients undergoing coronary artery bypass graft surgery using low heparin concentrations.
  Garvin S, Fitzgerald D, Muehlschlegel JD, Perry TE, Fox AA, Shernan SK, Collard CD, Aranki S, Body SC Anesthesia and analgesia 2010 Oct 111 4 856-61
- Postoperative activity, but not preoperative activity, of antithrombin is associated with major adverse cardiac events after coronary artery bypass graft surgery.
  Garvin S, Muehlschlegel JD, Perry TE, Chen J, Liu KY, Fox AA, Collard CD, Aranki SF, Shernan SK, Body SC Anesthesia and analgesia 2010 Oct 111 4 862-9
- Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery.
  Muehlschlegel JD, Liu KY, Perry TE, Fox AA, Collard CD, Shernan SK, Body SC Circulation 2010 Sep 122 11 Suppl S60-5
- Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients.
  Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC Anesthesia and analgesia 2010 Jun 110 6 1541-7
- Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting.
  Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK Anesthesiology 2010 Mar 112 3 607-13
- Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.
  Liu KY, Muehlschlegel JD, Perry TE, Fox AA, Collard CD, Body SC, Shernan SK The Journal of thoracic and cardiovascular surgery 2010 Feb 139 2 483-8, 488.e1-2
- Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
  Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D Circulation. Cardiovascular genetics 2009 Oct 2 5 499-506
- Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting.
  Muehlschlegel JD, Perry TE, Liu KY, Nascimben L, Fox AA, Collard CD, Avery EG, Aranki SF, D'Ambra MN, Shernan SK, Body SC European heart journal 2009 Jul 30 13 1574-83
- Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
  Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC Anesthesiology 2009 Apr 110 4 738-47
- C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.
  Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK BMC medical genetics 2009 10 38
- Preoperative B-type natriuretic peptide is as independent predictor of ventricular dysfunction and mortality after primary coronary artery bypass grafting.
  Fox AA, Shernan SK, Collard CD, Liu KY, Aranki SF, DeSantis SM, Jarolim P, Body SC The Journal of thoracic and cardiovascular surgery 2008 Aug 136 2 452-61
- The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery.
  Collard CD, Shernan SK, Fox AA, Bernig T, Chanock SJ, Vaughn WK, Takahashi K, Ezekowitz AB, Jarolim P, Body SC Circulation 2007 Sep 116 11 Suppl I106-12
- Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage.
  Walsh MC, Shaffer LA, Guikema BJ, Body SC, Shernan SK, Fox AA, Collard CD, Fung M, Taylor RP, Stahl GL Journal of immunological methods 2007 Jun 323 2 147-59
- Effects of diet and exercise on common cardiovascular disease risk factors in moderately obese older women.
  Fox AA, Thompson JL, Butterfield GE, Gylfadottir U, Moynihan S, Spiller G The American journal of clinical nutrition 1996 Feb 63 2 225-33

Research

Perioperative outcomes research
Biomarkers
Genomics

Clinical Focus

Adult Cardiothoracic Anesthesiology