- Medical School - Harvard Medical School (1990-1996)
- Residency - Children's Hospital of Boston - Pediatric Program (1996-1999), Pediatric Medicine
- Residency - Children's Hospital of Boston - Pediatric Program (1999-2000), Pediatric Medicine
- Fellowship - Children's Hospital Boston - Hematology/Oncology (2001-2004), Pediatric Hematology/oncology
- Fellowship - Children's Hospital Boston - Infectious Disease (2000-2004), Pediatric Infectious Diseases
Andrew Koh, M.D.
- Grant A. Dove Distinguished Chair for Research in Oncology
- Pediatrics - Hematology-Oncology
- Cellular Therapy
- Cancer Immunotherapy
Biography
Andrew Koh, M.D., is a Professor in the Department of Pediatrics and the Department of Microbiology and the Grant A. Dove Distinguished Chair for Research in Oncology at UT Southwestern Medical Center. A member of the Harold C. Simmons Comprehensive Cancer Center, he specializes in pediatric hematology-oncology; cellular therapy, including stem cell transplantation, CAR T-cell therapy and gene therapy; and cancer immunotherapy.
Dr. Koh earned his medical degree at Harvard Medical School. He completed his residency in pediatric medicine at Boston Children’s Hospital, where he served as Chief Resident. He then completed a dual fellowship in hematology-oncology and infectious diseases at Boston Children’s Hospital and the Dana-Farber Cancer Institute.
He is certified by the American Board of Pediatrics in pediatric hematology and oncology.
After serving as an attending physician on both the hematopoietic stem cell transplantation service and immunocompromised infectious diseases service for five years, Dr. Koh left Harvard to become Director of Pediatric Hematopoietic Stem Cell Transplantation at UT Southwestern in 2009.
He is currently the Director of the Pediatric Cellular and ImmunoTherapeutics Program at Children’s Health and Associate Division Chief of Basic Science and Innovation for the Division of Pediatric Hematology and Oncology at UTSW.
The Koh Lab focuses on understanding how the gut microbiome influences host immune responses in cancer and stem cell transplant patients, with a focus on bacterial and fungal infections originating from the gut, autoimmune complications, and anti-tumor immune responses in the context of cancer immunotherapy. These research efforts are funded by the National Institutes of Health (NIH), industry, and foundations.
The lab’s recent work has focused on developing novel gut microbiome-derived therapeutics for enhancing cancer immunotherapy efficacy. These efforts have resulted in the filing of two patents, the acquisition of NIH and American Cancer Society funding, and the co-founding of a startup company, Aumenta Biosciences.
Dr. Koh serves on the NIH Interspecies Microbial Interactions and Infections study section and the Cancer Prevention and Research Institute of Texas Advisory Committee on Childhood Cancers.
Personal Note
When he’s not at work, Dr. Koh enjoys writing and recording music. His main instruments are vocals and guitar, but he also plays keyboards and bass guitar.
Education & Training
Professional Associations & Affiliations
- American Society of Hematology
- American Society for Microbiology
- Children’s Oncology Group
- Pediatric Transplantation and Cellular Therapy Consortium
- Society for Pediatric Research
Honors & Awards
- BrightEdge Entrepreneurs Program 2024, American Cancer Society
- Selected Member, Texas Medical Center Accelerator for Cancer Therapeutics 2021, Texas Medical Center, Cancer Prevention and Research Institute of Texas (CPRIT)
- Rhodes Scholarship 1988-1990, University of Oxford
Books & Publications
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Books
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Infections in children with cancer; Fever and granulocytopenia in Principles and Practice of Pediatric Infectious Diseases (5th ed.)
Koh AY, Pizzo PA (2017), Philadelphia, PA, W.B. Saunders -
Infectious complications in pediatric cancer patients in Principles and Practice of Pediatric Oncology (7th ed.)
Ardura MI, Koh AY (2015), Philadelphia, PA, Wolters Kluwer -
Infectious disease in the pediatric cancer patient in Nathan and Oski's Hematology and Oncology of Infancy and Childhood (8th ed.)
Sung L, Fisher BT, Koh AY (2014), Philadelphia, PA, W.B. Saunders -
Infections in children with cancer; Fever and granulocytopenia in Principles and Practice of Pediatric Infectious Diseases (4th ed.)
Koh AY, Pizzo PA (2012), Philadelphia, PA, W.B. Saunders -
Prolonged febrile neutropenia in the pediatric patient with cancer in 2012 ASCO Educational Book
Koh AY (2012), Alexandria, VA, American Society of Clinical Oncology -
Infectious complications in pediatric cancer patients in Principles and Practice of Pediatric Oncology (6th ed.)
Koh AY, Pizzo PA (2011), Philadelphia, PA, Lippincott Williams & Wilkins -
Infectious complications in children with hematologic disorders in Nathan and Oski’s Hematology of Infancy and Childhood (7th ed.)
Koh AY, Pizzo PA (2009), Philadelphia, PA, W.B. Saunders -
Infections in children with cancer; Fever and granulocytopenia in Principles and Practice of Pediatric Infectious Diseases (3rd ed.)
Koh AY, Pizzo PA (2008), Philadelphia, PA, Churchill Livingstone -
Infections in children with cancer; Fever and granulocytopenia in Principles and Practice of Pediatric Infectious Diseases (2nd ed.)
Koh AY, Pizzo PA (2003), Philadelphia, PA, Churchill Livingstone -
Infectious complications in children with hematologic disorders in Nathan and Oski’s Hematology of Infancy and Childhood (6th ed.)
Koh AY, Pizzo PA (2003), Philadelphia, PA, W.B. Saunders -
Antimicrobial therapy’ management of infections in immunocompromised patients in Management of Infections in Immunocompromised Patients
Glauser MP, Koh AY (2000), London, UK, W.B. Saunders/Churchill Livingstone
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Infections in children with cancer; Fever and granulocytopenia in Principles and Practice of Pediatric Infectious Diseases (5th ed.)
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Publications
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Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity.
Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY, Science immunology 2023 Mar 8 81 eabo2003 -
Food for Gut: Microbiota Fuels Immune Reconstitution after BMT.
Simms-Waldrip TR, Koh AY Cell host & microbe 2018 Apr 23 4 423-424 -
Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.
Frankel AE, Coughlin LA, Kim J, Froehlich TW, Xie Y, Frenkel EP, Koh AY Neoplasia (New York, N.Y.) 2017 Oct 19 10 848-855 -
Potential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant Patients.
Koh AY Clinical chemistry 2017 Jul -
The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection.
Koh AY PLoS pathogens 2017 Jun 13 6 e1006342 -
Antibiotic-Induced Depletion of Anti-Inflammatory Clostridia is Associated with the Development of GVHD in Pediatric Stem Cell Transplant Patients.
Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani MR, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Feb -
FMAP: Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies.
Kim J, Kim MS, Koh AY, Xie Y, Zhan X BMC bioinformatics 2016 Oct 17 1 420 -
Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome.
Piper HG, Fan D, Coughlin LA, Ho EX, McDaniel MM, Channabasappa N, Kim J, Kim M, Zhan X, Xie Y, Koh AY JPEN. Journal of parenteral and enteral nutrition 2016 Jul -
Identifying host immune effectors critical for protection against Candida albicans infections.
Koh AY Virulence 2016 Jun 0 -
Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis.
Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY PLoS pathogens 2015 Aug 11 8 e1005129 -
Activation of HIF-1a and LL-37 by commensal bacteria inhibits Candida albicans colonization.
Fan D, Coughlin LA, Neubauer MM, Kim J, Kim MS, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY Nature medicine 2015 Jun -
Murine models of Candida gastrointestinal colonization and dissemination.
Koh AY Eukaryotic cell 2013 Nov 12 11 1416-22 -
Intravenous Pentamidine Is Safe and Effective as Primary Pneumocystis Pneumonia Prophylaxis in Children and Adolescents Undergoing Hematopoietic Stem Cell Transplantation.
Demasi JM, Cox JA, Leonard D, Koh AY, Aquino VM The Pediatric infectious disease journal 2013 Mar -
Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia.
Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP The Journal of infectious diseases 2013 Jan 207 1 39-49 -
RNA isolation of Pseudomonas aeruginosa colonizing the murine gastrointestinal tract.
Lopez-Medina E, Neubauer MM, Pier GB, Koh AY Journal of visualized experiments : JoVE 2011 55 -
Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model.
Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB The Journal of infectious diseases 2010 Jan 201 1 71-80 -
Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination.
Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB PloS one 2010 5 12 e15131 -
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia.
Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB Infection and immunity 2009 Dec 77 12 5300-10 -
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes.
Van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PØ, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Høiby N, Givskov M, Bjarnsholt T APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009 Jul 117 7 537-46 -
Mucosal damage and neutropenia are required for Candida albicans dissemination.
Koh AY, Köhler JR, Coggshall KT, Van Rooijen N, Pier GB PLoS pathogens 2008 Feb 4 2 e35 -
Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia.
Koh AY, Priebe GP, Pier GB Infection and immunity 2005 Apr 73 4 2262-72
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Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity.
Research
- Antibiotic resistance
- Cancer immunotherapy
- Fungal pathogenesis
- Gut microbiome
- Gut microbiota (bacterial-fungal interactions)
- Host immune anti-tumor response
- Host-pathogen interactions
- Intestinal graft-versus-host disease
Clinical Focus
- Cellular Therapy
- Cancer Immunotherapy
- Stem Cell Transplantation
- CAR T-Cell Therapy
- Gene Therapy
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas