Andrew Koh, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pediatrics - Hematology-Oncology

Biography

Dr. Andrew Y. Koh received his bachelor’s degree in Biology from Harvard College. He was then awarded a Rhodes Scholarship and studied English Literature at Pembroke College, Oxford University. Dr. Koh obtained his MD degree from Harvard Medical School. He completed internship, residency, and chief residency at Children’s Hospital, Boston. He then completed a dual fellowship in hematology/oncology and infectious diseases at Children’s Hospital, Boston, and Dana Farber Cancer Institute. After serving as an attending physician on both the hematopoietic stem cell transplantation service and immunocompromised infectious diseases service for five years, Dr. Koh left Harvard to become Director of Pediatric Hematopoietic Stem Cell Transplantation at the University of Texas Southwestern Medical Center in 2009.

Education & Training

Medical School - Harvard Medical School (1990-1996)
Residency - Children's Hospital of Boston - Pediatric Program (1996-1999), Pediatric Medicine
Residency - Children's Hospital of Boston - Pediatric Program (1999-2000), Pediatric Medicine
Fellowship - Children's Hospital Boston - Hematology/Oncology (2001-2004), Pediatric Hematology/oncology
Fellowship - Children's Hospital Boston - Infectious Disease (2000-2004), Pediatric Infectious Diseases

Professional Associations & Affiliations

American Society for Microbiology (2003)
American Society for Blood and Marrow Transplantation (2009)
Society for Pediatric Research (2010)
American Society of Hematology (2010)
American Society for Pediatric Hematology/Oncology (2012)

Honors & Awards

Rhodes Scholarship 1988-1990
Glaser Pediatric Research Network Fellowship Award 2000-2002
Eleanor and Miles Shore Scholar 2006-2008

Books & Publications

Books
- Infectious Complications in Pediatric Cancer Patients in Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 7th ed.
  Ardura MI, Koh AY. (2016), Philadelphia: Wolters Kluwer; 1009-1056.
- Fever and Granulocytopenia; Infections in Children with Cancer in Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 4th ed.
  Koh AY, Pizzo PA. (2012), Elsevier Saunders; 567-578.
- Infectious Disease in the Pediatric Cancer Patient in Nathan and Oski's Hematology and Oncology of Infancy and Childhood. 8th ed.
  Sung L, Fisher BT, Koh AY. (2014), Elsevier Saunders.
Publications
- Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity.
  Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY, Science immunology 2023 Mar 8 81 eabo2003
- Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia.
  Koh AY, Priebe GP, Pier GB Infection and immunity 2005 Apr 73 4 2262-72
- Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia.
  Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB Infection and immunity 2009 Dec 77 12 5300-10
- Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes.
  Van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PØ, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Høiby N, Givskov M, Bjarnsholt T APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009 Jul 117 7 537-46
- Antibiotic-Induced Depletion of Anti-Inflammatory Clostridia is Associated with the Development of GVHD in Pediatric Stem Cell Transplant Patients.
  Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani MR, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Feb
- Activation of HIF-1a and LL-37 by commensal bacteria inhibits Candida albicans colonization.
  Fan D, Coughlin LA, Neubauer MM, Kim J, Kim MS, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY Nature medicine 2015 Jun
- Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome.
  Piper HG, Fan D, Coughlin LA, Ho EX, McDaniel MM, Channabasappa N, Kim J, Kim M, Zhan X, Xie Y, Koh AY JPEN. Journal of parenteral and enteral nutrition 2016 Jul
- Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.
  Frankel AE, Coughlin LA, Kim J, Froehlich TW, Xie Y, Frenkel EP, Koh AY Neoplasia (New York, N.Y.) 2017 Oct 19 10 848-855
- Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis.
  Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY PLoS pathogens 2015 Aug 11 8 e1005129
- FMAP: Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies.
  Kim J, Kim MS, Koh AY, Xie Y, Zhan X BMC bioinformatics 2016 Oct 17 1 420
- Mucosal damage and neutropenia are required for Candida albicans dissemination.
  Koh AY, Köhler JR, Coggshall KT, Van Rooijen N, Pier GB PLoS pathogens 2008 Feb 4 2 e35
- Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination.
  Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB PloS one 2010 5 12 e15131
- Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia.
  Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP The Journal of infectious diseases 2013 Jan 207 1 39-49
- Potential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant Patients.
  Koh AY Clinical chemistry 2017 Jul
- Food for Gut: Microbiota Fuels Immune Reconstitution after BMT.
  Simms-Waldrip TR, Koh AY Cell host & microbe 2018 Apr 23 4 423-424
- RNA isolation of Pseudomonas aeruginosa colonizing the murine gastrointestinal tract.
  Lopez-Medina E, Neubauer MM, Pier GB, Koh AY Journal of visualized experiments : JoVE 2011 55
- Identifying host immune effectors critical for protection against Candida albicans infections.
  Koh AY Virulence 2016 Jun 0
- Murine models of Candida gastrointestinal colonization and dissemination.
  Koh AY Eukaryotic cell 2013 Nov 12 11 1416-22
- Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model.
  Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB The Journal of infectious diseases 2010 Jan 201 1 71-80
- Intravenous Pentamidine Is Safe and Effective as Primary Pneumocystis Pneumonia Prophylaxis in Children and Adolescents Undergoing Hematopoietic Stem Cell Transplantation.
  Demasi JM, Cox JA, Leonard D, Koh AY, Aquino VM The Pediatric infectious disease journal 2013 Mar
- The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection.
  Koh AY PLoS pathogens 2017 Jun 13 6 e1006342

Research

Pseudomonas aeruginosa pathogenesis
Intestinal graft-versus-host-disease
Host pathogen interactions
Gut Microbiota (bacterial-fungal interactions)
Candida albicans pathogenesis

Links

New Patient Appointment