- Fellowship - Duke University School of Medicine (1997-2001), Cardiology
- Fellowship - UT Southwestern Medical Center (1996-1997), Cardiology
- Residency - UT Southwestern Medical Center (1994-1996), Internal Medicine
- Internship - UT Southwestern Medical Center (1993-1994), Internal Medicine
- Medical School - Johns Hopkins University School of Medicine (1989-1993)
Darren McGuire, M.D.
- Dallas Heart Ball Chair for Research on Heart Disease in Women
- Distinguished Teaching Professor
- Internal Medicine - Cardiology
- Diabetes & Heart Disease
Darren K. McGuire, M.D., M.H.Sc., is a Professor in the Department of Internal Medicine at UT Southwestern. He is also the Director of the Parkland Hospital and Health System Outpatient Cardiology clinics.
Dr. McGuire earned his medical degree at the Johns Hopkins University School of Medicine and completed an internal medicine residency at UT Southwestern. He then received advanced training in cardiology through a fellowship at Duke University, where he also conducted research for two years, working on a number of large-scale, international clinical trials and registries at the Duke Clinical Research Institute (DCRI). He also earned a master’s degree in health sciences in clinical trials at the Duke University School of Medicine.
He joined the cardiology faculty at UT Southwestern in 2001. His main clinical and research interests are in the long-term prevention of and risk-modification for cardiovascular disease, especially among patients with diabetes.
Dr. McGuire is Deputy Editor of Circulation, Senior Editor of Diabetes and Vascular Disease Research, and editor of the textbook Diabetes in Cardiovascular Disease: a companion to Braunwald’s Heart Disease.
He is a Fellow of the American Heart Association (AHA), the American College of Cardiology and the European Society of Cardiology; a former Chair of the AHA Diabetes Committee; and a former member of and present ad hoc consultant for the FDA Cardiovascular and Renal Drugs Advisory Committee.
Dr. McGuire has received numerous teaching awards, most notably the UT System Board of Regents Outstanding Teaching Award in 2013.
Meet Dr. McGuire
Dallas Cardiologist Specializing in Diabetes
Over the past 25 years, cardiologist Darren McGuire, M.D., M.H.Sc., has worked together with a small but powerful – and growing – group of clinical researchers around the world who have changed the landscape for diabetes patient care.
Today we know that people with Type 2 diabetes are twice as likely as other people to develop heart disease and stroke, but when Dr. McGuire began his career, there were no clinical studies showing how diabetes treatments affect heart disease and stroke.
“It was a complete desert for clinical outcomes data,” he recalls, noting that diabetes medications were judged solely on their ability to affect the levels of glucose in the blood. “We had no data that proved whether or not changing a person’s blood sugar level actually made that person live longer or feel better from a cardiovascular perspective.”
So he set out to change that. Dr. McGuire scoured the globe seeking people who had an interest in conducting large-scale, international clinical trials, like the work he was training to do while at the Duke Clinical Research Institute.
Through the resulting collaborations, these early efforts of Dr. McGuire and collaborators around the globe have taken the number of clinical outcomes trials for diabetes and heart disease from zero to more than 20 initiated over the past 10 years.
“We’ve had amazing success,” he says. “Until six months ago there was not a single positive cardiovascular clinical outcomes trial in the entire field of diabetes research. Now we have four different diabetes medications that have been statistically proven to improve patient outcomes in terms of heart attack, death, and stroke, all reported just since September 2015.”
Having a vibrant, leading-edge research program gives Dr. McGuire an advantage in offering the latest treatment strategies for diabetes patients in his cardiology clinic. His research proves that it’s valuable for patients with diabetes to see a cardiologist who specializes in diabetes.
“We can make nuanced distinctions about the medications we use for heart conditions – what might be more effective in patients with diabetes and whether those medications will affect the medications we may also be using for blood sugar control,” he says.
Dr. McGuire expects today’s clinical trials will continue to shape and reshape the future of diabetes treatment.
“It’s been a community effort,” he says of the groundbreaking research he has contributed to. “Our international group of clinical researchers has been working together for 20 years now – these are some of my best friends in the world, and we’re communicating back and forth regularly about how we can take the next step forward. To me, the future has never been more exciting.
“UT Southwestern’s motto is The future of medicine, today, and I like to think that’s what my patients get when they come to my clinic. It’s not just the goal; we’re actually generating the future of medicine in our research and clinical work – in my case, for patients with diabetes and heart disease.”
- Fellow, American Heart Association
- Fellow, American College of Cardiology
- American Diabetes Association
- Alpha Omega Alpha Medical Honor Society 1993, Johns Hopkins University School of Medicine
- Outstanding Fellow in Clinical Research 2001, Duke University Cardiology Fellowship Award
- Outstanding Teacher Award 2006, UT Southwestern Internal Medicine Housestaff
- Hendrix College Odyssey Award in Research 2009, Career Achievement in Clinical Research
- Outstanding Research Mentor Award 2011, UT Southwestern Internal Medicine Housestaff
- L. David Hillis Award for Excellence in Teaching 2012, UT Southwestern Cardiology Fellowship
- Regents Outstanding Teaching Award 2013, UT System Board of Regents
Diabetes in Cardiovascular Disease: A Companion to Braunwald?s Heart Disease
edited by McGuire DK and Marx N. (2014), Philadelphia, PA:, Saunders, an imprint of Elsevier Inc
American College of Cardiology Foundation Diabetes Self-Assessment Program
edited by McGuire DK and Sperling L (2011), Washington DC, American College of Cardiology Foundation, 2011
Diabetes and the cardiovascular system in Braunwald?s Heart Disease: A textbook of cardiovascular medicine 9E
McGuire DK. (2010), Philadelphia, Saunders Elsevier, 2010.
Cardiovascular Considerations for the Use of Thiazolidinedione Medications, in Harrison?s Online Textbook of Internal Medicine, 17e
McGuire DK, Inzucchi SE. (2009), edited by Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, and Loscalzo J.
Epidemiology of Diabetes Mellitus and Cardiovascular Disease in in The Textbook of Diabetes Mellitus and Cardiovascular Disease. David Stern and Steven P. Marso, editors.
Rao SV, McGuire DK. (2003), Philadelphia, Lippincott Williams & Wilkins
Diabetes and the cardiovascular system in Braunwald?s Heart Disease: A textbook of cardiovascular medicine 10E
McGuire DK. (2015), Philadelphia, Saunders Elsevier
- Diabetes in Cardiovascular Disease: A Companion to Braunwald?s Heart Disease
Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators.
McGuire DK, Emanuelsson H, Granger CB, Magnus Ohman E, Moliterno DJ, White HD, Ardissino D, Box JW, Califf RM, Topol EJ European heart journal 2000 Nov 21 21 1750-8
Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function.
McGuire DK, Abdullah SM, See R, Snell PG, McGavock J, Szczepaniak LS, Ayers CR, Drazner MH, Khera A, de Lemos JA European heart journal 2010 Sep 31 18 2262-70
No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction.
Britton KA, Aggarwal V, Chen AY, Alexander KP, Amsterdam E, Fraulo E, Muntner P, Thomas L, McGuire DK, Wiviott SD, Roe MT, Schubart UK, Fox CS American heart journal 2011 Apr 161 4 657-663.e1
Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.
Roe MT, Armstrong PW, Fox KA, White HD, Prabhakaran D, Goodman SG, Cornel JH, Bhatt DL, Clemmensen P, Martinez F, Ardissino D, Nicolau JC, Boden WE, Gurbel PA, Ruzyllo W, Dalby AJ, McGuire DK, Leiva-Pons JL, Parkhomenko A, Gottlieb S, Topacio GO, Hamm C, Pavlides G, Goudev AR, Oto A, Tseng CD, Merkely B, Gasparovic V, Corbalan R, Cinteza M, McLendon RC, Winters KJ, Brown EB, Lokhnygina Y, Aylward PE, Huber K, Hochman JS, Ohman EM The New England journal of medicine 2012 Oct 367 14 1297-309
Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
Gore MO, Lüneburg N, Schwedhelm E, Ayers CR, Anderssohn M, Khera A, Atzler D, de Lemos JA, Grant PJ, McGuire DK, Böger RH Arteriosclerosis, thrombosis, and vascular biology 2013 Nov 33 11 2682-8
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I The New England journal of medicine 2013 Oct 369 14 1317-26
Inaccuracy of Estimated Resting Oxygen Uptake in the Clinical Setting.
Narang N, Thibodeau JT, Levine BD, Gore MO, Ayers CR, Lange RA, Cigarroa JE, Turer AT, de Lemos JA, McGuire DK Circulation 2013 Sep
Contemporary Patterns of Discharge Aspirin Dosing After Acute Myocardial Infarction in the United States: Results From the National Cardiovascular Data Registry (NCDR).
Hall HM, de Lemos JA, Enriquez JR, McGuire DK, Peng SA, Alexander KP, Roe MT, Desai N, Wiviott SD, Das SR Circulation. Cardiovascular quality and outcomes 2014 Aug
Metformin in patients with type 2 diabetes and kidney disease: a systematic review.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK JAMA 2014 Dec 24-31 312 24 2668-75
Heart Failure, Saxagliptin and Diabetes Mellitus: Observations from the SAVOR - TIMI 53 Randomized Trial.
Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL Circulation 2014 Sep
High prevalence of elevated haemoglobin A1C among adolescent blood donors: Results from a voluntary screening programme including 31,546 adolescents.
Gore MO, Eason SJ, Ayers CR, Turer AT, Khera A, de Lemos JA, McGuire DK, Sayers M Diabetes & vascular disease research 2015 Jul 12 4 272-8
Metabolic Effects of Exercise Training Among Fitness Nonresponsive Patients With Type 2 Diabetes Mellitus: The HART-D Study.
Pandey A, Swift DL, McGuire DK, Ayers CR, Neeland IJ, Blair SN, Johannsen N, Earnest CP, Berry JD, Church TS Diabetes care 2015 Jun
Revascularization Trends in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Presenting With Non-ST Elevation Myocardial Infarction: Insights From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get with the Guidelines (NCDR ACTION Registry-GWTG).
Pandey A, McGuire DK, de Lemos JA, Das SR, Berry JD, Brilakis ES, Banerjee S, Marso SP, Barsness GW, Simon DN, Roe M, Goyal A, Kosiborod M, Amsterdam EA, Kumbhani DJ Circulation. Cardiovascular quality and outcomes 2016 May 9 3 197-205
Predicting Adverse Outcomes After Myocardial Infarction Among Patients With Diabetes Mellitus.
Arnold SV, Spertus JA, Jones PG, McGuire DK, Lipska KJ, Xu Y, Stolker JM, Goyal A, Kosiborod M Circulation. Cardiovascular quality and outcomes 2016 May
Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: more support for cardiovascular outcome assessments.
Gore MO, McGuire DK European heart journal 2011 Aug 32 15 1832-4
Diabetes mellitus and trends in hospital survival after myocardial infarction, 1994 to 2006: data from the national registry of myocardial infarction.
Gore MO, Patel MJ, Kosiborod M, Parsons LS, Khera A, de Lemos JA, Rogers WJ, Peterson ED, Canto JC, McGuire DK Circulation. Cardiovascular quality and outcomes 2012 Nov 5 6 791-7
Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial.
Udell JA, Bhatt DL, Braunwald E, Cavender MA, Mosenzon O, Steg PG, Davidson JA, Nicolau JC, Corbalan R, Hirshberg B, Frederich R, Im K, Umez-Eronini AA, He P, McGuire DK, Leiter LA, Raz I, Scirica BM Diabetes care 2014 Dec
Age and Sex Dependent Upper Reference Limits for the High Sensitivity Cardiac Troponin T Assay.
Gore MO, Seliger SL, Defilippi CR, Nambi V, Christenson RH, Hashim IA, Hoogeveen RC, Ayers CR, Sun W, McGuire DK, Ballantyne CM, de Lemos JA Journal of the American College of Cardiology 2014 Jan
The relationship of body mass and fat distribution with incident hypertension: observations from the dallas heart study.
Chandra A, Neeland IJ, Berry JD, Ayers CR, Rohatgi A, Das SR, Khera A, McGuire DK, de Lemos JA, Turer AT Journal of the American College of Cardiology 2014 Sep 64 10 997-1002
Association between hyper- and hypoglycaemia and 2 year all-cause mortality risk in diabetic patients with acute coronary events.
Svensson AM, McGuire DK, Abrahamsson P, Dellborg M European heart journal 2005 Jul 26 13 1255-61
New Drugs for the Treatment of Diabetes: Thiazolidinediones and their Evolving Cardiovascular Implications
McGuire DK, Inzucchi SE Circulation 2008 117 440-449
New Drugs for the Treatment of Diabetes: Incretin-based Therapy and Beyond
Inzucchi SE, McGuire DK. Circulation 2008 117 574-584
New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications.
McGuire DK, Inzucchi SE Circulation 2008 Jan 117 3 440-9
Association Between Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) and Risk for Atherosclerosis: the Dallas Heart Study
Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK. Diabetes Care 2009 32 1218-1220
Evaluation of the Glycometabolic Effects of Ranolazine in Patients With and Without Diabetes Mellitus in the MERLIN-TIMI 36 Randomized Controlled Trial.
Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E Circulation 2009 119 20032-20039
Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial.
Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E Circulation 2009 Apr 119 15 2032-9
Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.
Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK Diabetes care 2009 Jul 32 7 1218-20
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.
de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK JAMA : the journal of the American Medical Association 2010 Dec 304 22 2503-12
Glucose-lowering targets for patients with cardiovascular disease: focus on inpatient management of patients with acute coronary syndromes.
Kosiborod M, McGuire DK Circulation 2010 Dec 122 25 2736-44
Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.
Banks K, Puttagunta D, Murphy S, Lo M, McGuire DK, de Lemos JA, Chang AY, Grundy SM, Khera A JACC. Cardiovascular imaging 2011 Jan 4 1 65-73
Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults.
Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA JAMA : the journal of the American Medical Association 2012 Sep 308 11 1150-9
Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB Circulation 2013 Jan 127 1 143-52
Glycated hemoglobin in 14,850 adolescent blood donors: a pilot screening program.
Gore MO, Eason SJ, Ayers CR, Turer A, Khera A, de Lemos JA, McGuire DK, Sayers M Diabetes care 2014 Jan 37 1 e3-4
Effects of Ranolazine on Quality of Life Among Patients With Diabetes Mellitus and Stable Angina.
Arnold SV, Kosiborod M, McGuire DK, Li Y, Yue P, Ben-Yehuda O, Spertus JA JAMA internal medicine 2014 Jun
Body fat distribution and incident cardiovascular disease in obese adults.
Neeland IJ, Turer AT, Ayers CR, Berry JD, Rohatgi A, Das SR, Khera A, Vega GL, McGuire DK, Grundy SM, de Lemos JA Journal of the American College of Cardiology 2015 May 65 19 2150-1
- Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators.
- Epidemiology of coronary heart disease risk and prevention
- Disparities in health care and outcomes by race and sex
- Diabetes and Vascular Disease
- Cardiovascular Clinical Outcomes trials
- Diabetes & Heart Disease