David McFadden, M.D., Ph.D.

Internal Medicine - Endocrinology
Adrenal Conditions
Parathyroid & Thyroid Conditions

Biography

David McFadden, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Endocrinology. He holds a secondary appointment in the Department of Biochemistry. His clinical interests include the treatment of tumors arising from endocrine glands, particularly thyroid cancer.

Originally from Midland, Texas, Dr. McFadden holds a bachelor's degree in microbiology from Texas A&M University at College Station, where he graduated with honors. He obtained his medical degree and his doctoral degree in genetics at UT Southwestern. He then received internal medicine residency training at Brigham & Women's Hospital in Boston, followed by advanced training through a fellowship program in endocrinology and metabolism at Massachusetts General Hospital, where he was a member of the Center for Endocrine Tumors and a staff physician in the Thyroid Associates and Endocrine Tumor Genetics clinics.

Prior to joining the UT Southwestern faculty in 2015, he completed postdoctoral research at the Massachusetts Institute of Technology.

Dr. McFadden's research interests include using genetic engineering and chemical screens to discover new treatments for cancer. He has received research grants from the National Institutes of Health, American Thyroid Association, Cancer Prevention and Research Institute of Texas (CPRIT), and UT Southwestern's Disease Oriented Clinical Scholars (DOCS) program.

Dr. McFadden is an active member of the American Thyroid Association, the International Thyroid Oncology Group, and the American Association for Cancer Research.

Education & Training

Internship - Harvard/Brigham and Women's Hospital (2004-2005), Internal Medicine
Medical School - UT Southwestern Medical School (1995-2004)
Fellowship - Massachusetts General Hospital (2006-2009), Endocrinology & Metabolism
Residency - Harvard/Brigham and Women's Hospital (2005-2006), Internal Medicine

Professional Associations & Affiliations

Alpha Omega Alpha (2004), Medical Honor Society
American Thyroid Association (2007), Member
American Association for Cancer Research (2010), Member
International Thyroid Oncology Group (2014), Member

Honors & Awards

Scholar in Training Award 2013, Bristol-Myers Squibb
"Rookie of the Year" Philanthropy Award 2013, Massachusetts General Hospital
Disease Oriented Clinical Scholar 2014, UT Southwestern
CPRIT Scholar 2014, UT Southwestern

Books & Publications

Publications
- Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors
  Frank AR, Vandiver F, McFadden DG ACS chemical biology 2024 Feb 19 471-482
- Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
  Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJ, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D Cell Chemical Biology 2023 Nov 30 1453-1467.e8
- Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid
  Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers LM, Xie Y, Williams NS, Mishra P, McFadden DG Cancer discovery 2023 Aug 13 1884-1903
- Differential requirements for mitochondrial electron transport chain components in the adult murine liver
  Lesner NP, Wang X, Chen Z, Frank A, Menezes C, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, Deberardinis RJ, Mishra P eLife 2022 Sep 11
- TK216 targets microtubules in Ewing sarcoma cells
  Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG Cell Chemical Biology 2022 Aug 29 1325-1332.e4
- Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms
  McFadden DG, Sadow PM Frontiers in Endocrinology 2021 Jun 12
- Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer
  Tasdogan A, McFadden DG, Mishra P Trends in Cancer 2020 Dec 6 1044-1058
- A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins
  Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice L, De Brabander JK, McFadden DG Journal of Medicinal Chemistry 2020 Nov 63 14054-14066
- New Approaches to SCLC Therapy: From the Laboratory to the Clinic
  Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG Journal of Thoracic Oncology 2020 Apr 15 520-540
- Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification
  Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG Cell Chemical Biology 2019 Sep 26 1315-1321.e3
- Short Review: Genomic Alterations in Hürthle Cell Carcinoma
  Ganly I, McFadden DG Thyroid 2019 Apr 29 471-479
- Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma
  Gopal RK, Kübler K, Calvo SE, Polak P, Livitz D, Rosebrock D, Sadow PM, Campbell B, Donovan SE, Amin S, Gigliotti BJ, Grabarek Z, Hess JM, Stewart C, Braunstein LZ, Arndt PF, Mordecai S, Shih AR, Chaves F, Zhan T, Lubitz CC, Kim J, Iafrate AJ, Wirth L, Parangi S, Leshchiner I, Daniels GH, Mootha VK, Dias-Santagata D, Getz G, McFadden DG Cancer Cell 2018 Aug 34 242-255.e5
- Thyroid cancer
  Cabanillas ME, McFadden DG, Durante C The Lancet 2016 Dec 388 2783-2795
- Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma
  McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 113 E6409-E6417
- Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?
  Bunn PA, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR Journal of Thoracic Oncology 2016 11 453-474
- The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung
  Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, Macpherson D, Mcfadden DG, Farago A, Jacks T, Travis WD, Brambilla E Journal of Thoracic Oncology 2015 Apr 10 553-564
- Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenib
  Rothenberg SM, McFadden DG, Palmer EL, Daniels GH, Wirth LJ Clinical Cancer Research 2015 Mar 21 1028-1035
- Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma
  McFadden DG, Dias-Santagata D, Sadow PM, Lynch KD, Lubitz C, Donovan SE, Zheng Z, Le L, Iafrate AJ, Daniels GH Journal of Clinical Endocrinology and Metabolism 2014 Nov 99 E2457-E2462
- Integrated Genomic Characterization of Papillary Thyroid Carcinoma
  Agrawal N, Akbani R, Aksoy BA, Ally A, Arachchi H, Asa SL, Auman JT, Balasundaram M, Balu S, Baylin SB, Behera M, Bernard B, Beroukhim R, Bishop JA, Black AD, Bodenheimer T, Boice L, Bootwalla MS, Bowen J, Bowlby R, Bristow CA, Brookens R, Brooks D, Bryant R, Buda E, Butterfield YS, Carling T, Carlsen R, Carter SL, Carty SE, Chan TA, Chen AY, Cherniack AD, Cheung D, Chin L, Cho J, Chu A, Chuah E, Cibulskis K, Ciriello G, Clarke A, Clayman GL, Cope L, Copland JA, Covington K, Danilova L, Davidsen T, Demchok JA, DiCara D, Dhalla N, Dhir R, Dookran SS, Dresdner G, Eldridge J, Eley G, El-Naggar AK, Eng S, Fagin JA, Fennell T, Ferris RL, Fisher S, Frazer S, Frick J, Gabriel SB, Ganly I, Gao J, Garraway LA, Gastier-Foster JM, Getz G, Gehlenborg N, Ghossein R, Gibbs RA, Giordano TJ, Gomez-Hernandez K, Grimsby J, Gross B, Guin R, Hadjipanayis A, Harper HA, Hayes DN, Heiman DI, Herman JG, Hoadley KA, Hofree M, Holt RA, Hoyle AP, Huang FW, Huang M, Hutter CM, Ideker T, Iype L, Jacobsen A, Jefferys SR, Jones CD, Jones SJ, Kasaian K, Kebebew E, Khuri FR, Kim J, Kramer R, Kreisberg R, Kucherlapati R, Kwiatkowski DJ, Ladanyi M, Lai PH, Laird PW, Lander E, Lawrence MS, Lee D, Lee E, Lee S, Lee W, Leraas KM, Lichtenberg TM, Lichtenstein L, Lin P, Ling S, Liu J, Liu W, Liu Y, LiVolsi VA, Lu Y, Ma Y, Mahadeshwar HS, Marra MA, Mayo M, McFadden DG, Meng S, Meyerson M, Mieczkowski PA, Miller M, Mills G, Moore RA, Mose LE, Mungall AJ, Murray BA, Nikiforov YE, Noble MS, Ojesina AI, Owonikoko TK, Ozenberger BA, Pantazi A, Parfenov M, Park PJ, Parker JS, Paull EO, Pedamallu CS, Perou CM, Prins JF, Protopopov A, Ramalingam SS, Ramirez NC, Ramirez R, Raphael BJ, Rathmell WK, Ren X, Reynolds SM, Rheinbay E, Ringel MD, Rivera M, Roach J, Robertson AG, Rosenberg MW, Rosenthal M, Sadeghi S, Saksena G, Sander C, Santoso N, Schein JE, Schultz N, Schumacher SE, Seethala RR, Seidman J, Senbabaoglu Y, Seth S, Sharpe S, Shaw KR, Shen JP, Shen R, Sherman S, Sheth M, Shi Y, Shmulevich I, Sica GL, Simons JV, Sinha R, Sipahimalani P, Smallridge RC, Sofia HJ, Soloway MG, Song X, Sougnez C, Stewart C, Stojanov P, Stuart JM, Sumer SO, Sun Y, Tabak B, Tam A, Tan D, Tang J, Tarnuzzer R, Taylor BS, Thiessen N, Thorne L, Thorsson V, Tuttle RM, Umbricht CB, Van Den Berg DJ, Vandin F, Veluvolu U, Verhaak RG, Vinco M, Voet D, Walter V, Wang Z, Waring S, Weinberger PM, Weinhold N, Weinstein JN, Weisenberger DJ, Wheeler D, Wilkerson MD, Wilson J, Williams M, Winer DA, Wise L, Wu J, Xi L, Xu AW, Yang L, Yang L, Zack TI, Zeiger MA, Zeng D, Zenklusen JC, Zhao N, Zhang H, Zhang J, Zhang J, Zhang W, Zmuda E, Zou L Cell 2014 Oct 159 676-690
- The next generation of orthotopic thyroid cancer models: Immunocompetent orthotopic mouse models of BRAF^V600E-positive papillary and anaplastic thyroid carcinoma
  Vanden Borre P, Mcfadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S Thyroid 2014 Apr 24 705-714
- p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer
  McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 111 E1600-E1609
- Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
  McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T Cell 2014 Mar 156 1298-1311
- Combined BRAF^V600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
  Borre PV, Gunda V, McFadden DG, Sadow PM, Varmeh S, Bernasconi M, Parangi S Oncotarget 2014 5 3996-4010
- The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
  McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN Development 2005 Jan 132 189-201
- Gα_q and Gα₁₁ proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
  Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM Developmental Biology 2003 Mar 255 230-237
- Heart development: Learning from mistakes
  McFadden DG, Olson EN Current Opinion in Genetics and Development 2002 Jun 12 328-335
- Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding
  McFadden DG, McAnally J, Richardson JA, Charité J, Olson EN Development 2002 129 3077-3088
- Role of D1x6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer
  Charité J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN Genes and Development 2001 Nov 15 3039-3049
- Members of the HRT family of basic helix-loop-helix proteins act as transcriptional downstream of Notch signaling
  Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN Proceedings of the National Academy of Sciences of the United States of America 2000 Dec 97 13655-13660
- The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
  Charité J, McFadden DG, Olson EN Development 2000 Jun 127 2461-2470
- A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart
  McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN Development 2000 127 5331-5341
- Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
  Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN Nature genetics 1998 18 266-270

Research

Tumor Progression
Thyroid Cancer
Targeted Therapies
Cancer Genetics
Cancer Biology

Clinical Focus

Adrenal Conditions
Parathyroid & Thyroid Conditions