- Medical School - UT Southwestern Medical School (1995-2004)
- Internship - Harvard/Brigham and Women's Hospital (2004-2005), Internal Medicine
- Residency - Harvard/Brigham and Women's Hospital (2005-2006), Internal Medicine
- Fellowship - Massachusetts General Hospital (2006-2009), Endocrinology & Metabolism
David McFadden, M.D., Ph.D.
- Internal Medicine - Endocrinology
- Adrenal Conditions
- Parathyroid & Thyroid Conditions
Dr. McFadden is an Assistant Professor of Internal Medicine and Biochemistry at UT Southwestern. He obtained his M.D. and Ph.D. degrees at UT Southwestern Medical Center and subsequently completed his post-graduate medical training at Harvard Medical School with internship and residency in Internal Medicine at Brigham and Women’s Hospital and Endocrinology at the Massachusetts General Hospital (MGH). At MGH he was a member of the Center for Endocrine Tumors and a staff physician in the Thyroid Associates and Endocrine Tumor Genetics clinics. After completing postdoctoral work at Massachusetts Institute of Technology, he returned to UT Southwestern as an Assistant Professor in the Division of Endocrinology. Dr. McFadden’s clinical interest is in the treatment of tumors arising from endocrine glands, including thyroid cancer. He is a member of the American Thyroid Association and the International Thyroid Oncology Group, and has been awarded research grants from the National Institutes of Health, American Thyroid Association, the Disease Oriented Clinical Scholars (DOCS) program at UT Southwestern, and the Cancer Prevention and Research Institute of Texas (CPRIT). His current research focuses on using genetic engineering and chemical screens to discover new treatments for cancer.
- Alpha Omega Alpha (2004), Medical Honor Society
- American Thyroid Association (2007), Member
- American Association for Cancer Research (2010), Member
- International Thyroid Oncology Group (2014), Member
- Scholar in Training Award 2013, Bristol-Myers Squibb
- "Rookie of the Year" Philanthropy Award 2013, Massachusetts General Hospital
- Disease Oriented Clinical Scholar 2014, UT Southwestern
- CPRIT Scholar 2014, UT Southwestern
Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
Bunn PA, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016 Apr 11 4 453-74
The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.
Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015 Feb
Integrated genomic characterization of papillary thyroid carcinoma.
Cell 2014 Oct 159 3 676-90
Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma.
McFadden DG, Dias-Santagata D, Sadow PM, Lynch KD, Lubitz C, Donovan SE, Zheng Z, Le L, Iafrate AJ, Daniels GH The Journal of clinical endocrinology and metabolism 2014 Nov 99 11 E2457-62
The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma.
Vanden Borre P, McFadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S Thyroid : official journal of the American Thyroid Association 2014 Apr 24 4 705-14
Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.
McFadden DG, McAnally J, Richardson JA, Charité J, Olson EN Development (Cambridge, England) 2002 Jul 129 13 3077-88
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.
Charité J, McFadden DG, Olson EN Development (Cambridge, England) 2000 Jun 127 11 2461-70
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN Proceedings of the National Academy of Sciences of the United States of America 2000 Dec 97 25 13655-60
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.
McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T Cell 2014 Mar 156 6 1298-311
p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 111 16 E1600-9
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.
McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN Development (Cambridge, England) 2005 Jan 132 1 189-201
Cabanillas ME, McFadden DG, Durante C Lancet (London, England) 2016 May
Heart development: learning from mistakes.
McFadden DG, Olson EN Current opinion in genetics & development 2002 Jun 12 3 328-35
Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer.
Vanden Borre P, Gunda V, McFadden DG, Sadow PM, Varmeh S, Bernasconi M, Parangi S Oncotarget 2014 Jun 5 12 3996-4010
Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenib.
Rothenberg SM, McFadden DG, Palmer EL, Daniels GH, Wirth LJ Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Dec
Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM Developmental biology 2003 Mar 255 2 230-7
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer.
Charité J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN Genes & development 2001 Nov 15 22 3039-49
A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.
McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN Development (Cambridge, England) 2000 Dec 127 24 5331-41
Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.
Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN Nature genetics 1998 Mar 18 3 266-70
- Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
- Tumor Progression
- Thyroid Cancer
- Targeted Therapies
- Cancer Genetics
- Cancer Biology
- Adrenal Conditions
- Parathyroid & Thyroid Conditions