Ezra Burstein, M.D., Ph.D.

Division Chief

  • Berta M. and Dr. Cecil O. Patterson Chair in Gastroenterology
  • Internal Medicine - Digestive and Liver Diseases
  • Gastroenterology
  • Cancer Screening


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Dr. Burstein received his medical degree from Cayetano Heredia University in Lima, Peru. He completed Internal Medicine residency training at UT Southwestern and Gastroenterology fellowship training at the University of Michigan. Thereafter, he was also a research fellow at the Vaccine Research Center at the NIH. After completion of his training, he joined the Faculty at University of Michigan (2002-2008), and was later recruited to UT Southwestern, joining the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Biology. 

Dr. Burstein′s research training and expertise is in the area of molecular immunology. Broadly, the work in his laboratory is focused on basic mechanisms that control inflammatory responses in human disease, particularly inflammatory bowel disease (IBD). Work from the laboratory has investigated the regulation of the NF-kB transcription factor, which led to the discovery of the COMMD protein family. Thereafter, his group has also investigated the basic functions of these factors in immune regulation, including the recent discovery of their role in endosomal protein sorting. More recently, the lab began investigating the genetic and molecular basis of altered immunity in patients with defined Mendelian disorders. These studies have led to important discoveries, including the identification of cytosolic RNA:DNA hybrids as regulators of the interferon pathway.

Education & Training
  • Medical School - Cayetano Heredia Peruvian University (1986-1994)
  • Graduate School - University of Groningen, Molecular Genetics
  • Fellowship - University of Michigan Hospitals & Health Centers (1998-2001), Gastroenterology
  • Residency - UT Southwestern Medical Center (1995-1998), Internal Medicine
Professional Associations & Affiliations
  • American Gastroenterological Association (AGA) (1999)
  • American Society for Clinical Investigation (ASCI) (2012)
Honors & Awards
  • Valedictorian 1994, Medical School of Cayetano Heredia University
  • John S. Miller Award 1998, Outstanding Performance as a House Officer, UT Southwestern Medical School
  • AGA Research Scholar Award 2003, Foundation for Digestive Health and Nutrition
  • Helmsley Scholar 2010, Crohn’s and Colitis Foundation of America
  • Member 2012, The American Society for Clinical Investigation (ASCI)
  • Physician of the Year 2017, North Texas Chapter, Crohn's and Colitis Foundation
Books & Publications
  • Mucosal immunity and immune-tumor interactions in the GI tract
  • Genetics of inflammatory disorders: Out lab investigates the genetic basis of disorders of immune function, particularly affecting the GI tract
  • COMMD proteins: We study the regulation of endosomal protein sorting and immune function by members of this protein family.

Clinical Focus

  • Gastroenterology
  • Cancer Screening
  • Inflammatory Bowel Disease

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